Immunogenicity of multiple-epitope antigen gene of HCV carried by novel biodegradable polymers

Comparative Immunology, Microbiology and Infectious Diseases

Volumn 34, Issue 1, 2011, Pages 65-72

  Yang, Yuan ^a   Kuang, Yu ^a   Liu, Yu ^c   Li, Wanyi ^a   Jiang, Zhonghua ^a   Xiao, Liying ^b   Li, Mingyuan ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Biodegradable polymers; DNA vaccine; HCV; MA

Indexed keywords

COPOLYMER; EPITOPE; HEPATITIS C ANTIGEN; HEPATITIS C VACCINE; PLASMID DNA; POLYGLACTIN CO MACROGOL CO POLYGLACTIN; POLYLACTIC ACID CO MACROGOL CO POLYLACTIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CONSENSUS SEQUENCE; CONTROLLED STUDY; DRUG SYNTHESIS; ENCAPSULATION; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATITIS C VIRUS; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MICELLE; MOLECULAR CLONING; MOUSE; NONHUMAN; TRANSGENIC MOUSE;

ANIMALS; EPITOPES; HEP G2 CELLS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; POLYETHYLENE GLYCOLS; VACCINATION; VACCINES, DNA;

HEPATITIS C VIRUS; MUS MUSCULUS;

EID: 79551624169     PISSN: 01479571     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cimid.2010.02.003     Document Type: Article

References (30)

1. Shiina M., Rehermann B. Hepatitis C vaccines: inducing and challenging memory T cells. Hepatology 2006, 43:1395-1398.
2. Kaplan D.E., Sugimoto K., Newton K., Valiga M.E., Ikeda F., Aytaman A., et al. Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 2007, 132:654-666.
3. Antonella F., Stefania C., Lionello R., Annalisa M., Elisabetta S., Bruno B.E., et al. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat Med 2006, 12:190-197.
4. Bartosch B., Bukh J., Meunier J.C. In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes. Proc Natl Acad Sci USA 2003, 100:14199-14204.
5. Schulze zur Wiesch J., Lauer G.M., Day C.L., Kim A.Y., Ouchi K., Duncan J.E., et al. Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol 2005, 175:3603-3613.
6. Kuen Y.L., Soon H.Y. Polymeric protein delivery systems. Prog Polym Sci 2007, 32:669-697.
7. Yu L., Chang G.T., Ding J.D. Injectable block copolymer hydrogels for sustained release of a PEGylated drug. Int J Pharm 2008, 348:95-106.
8. Jayanth P., Vinod L. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003, 55:329-347.
9. Ji H.J., Sung W.K., Tae G.P. Biodegradable triblock copolymer of PLGA-PEG-PLGA enhances gene transfection efficiency. Pharm Res 2004, 21:50-54.
10. Lee H., Jeong J.H., Park T.G. PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity. J Control Release 2002, 79:283-291.
11. Yang Y., Jia W.X., Qi X., Yang C., Liu L., Zhang Z.R., et al. Novel biodegradable polymers as gene carriers. Macromol Biosci 2004, 4:1113-1117.
12. Mok H., Park T.G. Water-free microencapsulation of proteins within PLGA microparticles by spray drying using PEG-assisted protein solubilization technique in organic solvent. Eur J Pharm Biopharm 2008, 70(1):137-144.
13. Satoko M., Akira Y., Yukari T., Mayumi T., Nobukazu K., Shigeru Y., et al. A new epitope peptide derived from hepatitis C virus 1b possessing the capacity to induce cytotoxic T-lymphocytes in HCV 1b-infected patients with HLA-A11, -A31, and -A33. Cancer Immunol Immunother 2007, 56:1359-1366.
14. Zhang S.M., Zhuang H., Li H.M., Anders W., Qi Z.B., Zhang H.Y. Cloning of HCV envelope region of different genotype and analysis of their hydrophilicity and hydrophobicity. Chin J Micrbiol Immunol 2001, 21:217-220.
15. Chien W.C., Donghoon C., Won J.K., James W.Y., Lane V.C., Yong H.K., et al. Non-ionic amphiphilic biodegradable PEG-PLGA-PEG copolymer enhances gene delivery efficiency in rat skeletal muscle. J Control Release 2007, 11:245-253.
16. Marie G., Virginie F., Vincent P., François S., Anne D.R., Laurence P., et al. PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination. J Control Release 2007, 195-204.
17. Jacob N., Hans D.N., Valeska H., Golo A., Henning Z., Ludger L., et al. The HLA-A2 restricted T cell epitope HCV core35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells. Am J Pathol 2005, 166:443-453.
18. Keck Z.Y., Op De Beeck A., Hadlock K.G. Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions. J Virol 2004, 78:9224-9232.
19. David G.B., Christopher M.W. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 2005, 466:946-952.
20. Lechner F., Wong D.K.H., Dunbar P.R., Chapman R., Chung R.T., Dohrenwend P., et al. Analysis of successful immune responses in persons with hepatitis C virus. J Exp Med 2000, 9:1499-1512.
21. Smyk P.S., Tester I.A., Lezotte D., Sasaki A.W., Lewinsohn D.M., Rosen H.R. Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design. J Infect Dis 2006, 194:454-463.
22. Stanley M., Richard J.C. Uptake characteristics of NGR-coupled stealth PEI/pDNA nanoparticles loaded with PLGA-PEG-PLGA tri-block copolymer for targeted delivery to human monocyte-derived dendritic cells. Int J Pharm 2006, 321:143-154.
23. Hamilton S.E., Wolkers M.C., Schoenberger S.P., Jameson S.C. The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells. Nat Immunol 2006, 7:475-481.
24. Penna A., Pilli M., Zerbini A., Orlandini A., Mezzadri S., Sacchelli L., et al. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology 2007, 45:588-601.
25. Susan S.P., Ian A.T., Jared K., Brent E.P., Jean M.P., Lucy G.M., et al. Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help. J Virol 2008, 82:1827-1837.
26. Vezys V., Masopust D., Kemball C.C., Barber D.L., O'Mara L.A., Larsen C.P., et al. Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J Exp Med 2006, 203:2263-2269.
27. Urbani S., Amadei B., Fisicaro P., Tola D., Orlandini A., Sacchelli L., et al. Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses. Hepatology 2006, 44:126-139.
28. Oran A.E., Harriet L.R. DNA vaccines, combining form of antigen and method of delivery to raise a spectrum of IFN-γ and IL-4-producing CD4+ and CD8+ T cells. J Immunol 2003, 17:1999-2005.
29. Farnaz E., Mohammad H.G., Behnaz E., Mohammad R.K., Fatemeh A., Rassoul D. PLGA nanoparticles of different surface properties: preparation and evaluation of their body distribution. Int J Pharm 2008, 349:249-255.
30. Fernández C.A., Pastoriza P., Barcia E., Montejo C., Negro S. PLGA/PEG-derivative polymeric matrix for drug delivery system applications: characterization and cell viability studies. Int J Pharm 2008, 352:50-57.