Synthesis, characterization and evaluation of novel triblock copolymer based nanoparticles for vaccine delivery against hepatitis B

Journal of Controlled Release

Volumn 136, Issue 2, 2009, Pages 161-169

  Jain, Arvind K ^a   Goyal, Amit K ^a   Gupta, Prem N ^a   Khatri, Kapil ^a   Mishra, Neeraj ^a   Mehta, Abhinav ^a   Mangal, Sharad ^a   Vyas, Suresh P ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

HBsAg; Nanoparticles; PLA PEG; Triblock copolymer; Vaccine delivery

Indexed keywords

ACIDIC MICROENVIRONMENT; H NMR SPECTROSCOPIES; HBSAG; HEPATITIS-B; HYDROPHOBIC NATURES; IMMUNE RESPONSE; IMMUNOGENICITY; IN-VITRO; MUCOSAL VACCINES; PLA-PEG; POLY-LACTIC ACIDS; POLYMERIC NANOPARTICLES; SDS-PAGE ANALYSIS; SINGLE DOSE; STRUCTURAL STABILITIES; TRIBLOCK COPOLYMER; VACCINE DELIVERY;

ANTIGENS; BIODEGRADABLE POLYMERS; BLOCK COPOLYMERS; CHROMATOGRAPHIC ANALYSIS; COPOLYMERIZATION; DIFFUSERS (OPTICAL); ENZYME ACTIVITY; GELATION; IMMUNOLOGY; LACTIC ACID; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC ACIDS; PLASTIC PRODUCTS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMERS; STABILITY; SULFATE MINERALS; SYNTHESIS (CHEMICAL); VACCINES; ZETA POTENTIAL;

NANOPARTICLES;

ALUMINUM POTASSIUM SULFATE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; NANOPARTICLE; POLYGLACTIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTRON MICROSCOPY; FEMALE; FLUORESCENCE MICROSCOPY; HEPATITIS B; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; VACCINATION;

ANIMALS; DRUG DELIVERY SYSTEMS; FEMALE; HEPATITIS B; HEPATITIS B VACCINES; LACTIC ACID; MICE; MICE, INBRED BALB C; NANOPARTICLES; POLYMERS;

EID: 67349174712     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.02.010     Document Type: Article

References (46)

1. Moynihan J.S., Jones D.H., Farrar G.H., and Howard C.R. A novel microencapsulated peptide vaccine against hepatitis B. Vaccine 19 (2001) 3292-3300
2. O'Hagan D.T., and Singh M. Microparticles as vaccine adjuvants and delivery systems. Expert. Rev. Vaccines 2 (2003) 269-283
3. Jaganathan K.S., Singh P., Prabakaran D., Mishra V., and Vyas S.P. Development of a single-dose stabilized poly(d,l-lactic-co-glycolic acid) microspheres-based vaccine against hepatitis B. J. Pharm. Pharmacol. 56 (2004) 1243-1250
4. Vila A., Sanchez A., Tobio M., Calvo P., and Alonso M.J. Design of biodegradable particles for protein delivery. J. Control. Release 78 (2002) 15-24
5. Koping-Hoggard M., Sanchez A., and Alonso M.J. Nanoparticles as carriers for nasal vaccine delivery. Expert. Rev. Vaccines 4 (2005) 185-196
6. Wendorf J., Singh M., Chesko J., Kazzaz J., Soewanan E., Ugozzoli M., and O'Hagan D. A practical approach to the use of nanoparticles for vaccine delivery. J. Pharm. Sci. 95 (2006) 2738-2750
7. Eyles J.E., Williamson E.D., and Alpar H.O. Immunological responses to nasal delivery of free and encapsulated tetanus toxoid: studies on the effect of vehicle volume. Int. J. Pharm. 189 (1999) 75-79
8. Raghuvanshi R.S., Katare Y.K., Lalwani K., Ali M.M., Singh O., and Panda A.K. Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants. Int. J. Pharm. 245 (2002) 109-121
9. Goyal A.K., Rawat A., Mahor S., Gupta P.N., Khatri K., and Vyas S.P. Nanodecoy system: a novel approach to design hepatitis B vaccine for immunopotentiation. Int. J. Pharm. 309 (2006) 227-233
10. Perrin D.E., and English J.P. Handbook of biodegradable polymers. In: Domb A.J., Kost J., and Wiseman D.M. (Eds). Polyglycolide and Polylactide vol. 9 (1997), Taylor and francis group 1-67
11. Abou-Zeid D.M., Muller R.J., and Deckwer W.D. Degradation of natural and synthetic polyesters under anaerobic conditions. J. Biotechnol. 86 (2001) 113-126
12. Anderson J.M., and Shive M.S. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv. Drug Del. Rev. 21 (1997) 5-24
13. O'Hagan D.T., Singh M., and Gupta R.K. Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines. Adv. Drug Del. Rev. 32 (1998) 225-246
14. Johnson B.M., Charman W.N., and Porter C.J. An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine. AAPS Pharm. Sci. 4 (2002) E40
15. Sanchez A., Villamayor B., Guo Y., McIver J., and Alonso M.J. Formulation strategies for the stabilization of tetanus toxoid in poly(lactide-co-glycolide) microspheres. Int. J. Pharm. 185 (1999) 255-266
16. Zhu G., Millery S.R., and Schwendeman S.P. Stabilization of protein encapsulated in injectable poly(lactide-co-glycolide). Nat. Biotechnol. 18 (2000) 52-57
17. Boury F., Ivanova T., Panaiotov I., Proust J.E., Bios A., and Richou J. Dynamic properties of poly(dl-lactide) and polyvinyl alcohol monolayers at the air/water and dichloromethane/waterintrfaces. J. Colloid Interface Sci. 169 (1995) 380-392
18. Vila A., Gill H., McCallion O., and Alonso M.J. Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density. J. Control. Release 98 2 (2004) 231-244
19. Vila A., Sanchez A., Evorab C., Sorianob I., McCallionc O., and Alonso M.J. PLA-PEG particles as nasal protein carriers: the influence of the particle size. Int. J. Pharm. 292 (2005) 43-52
20. Jung T., Koneberg R., Hungerer K.D., and Kissel T. Tetanus toxoid microspheres consisting of biodegradable poly(lactide-co-glycolide)- and ABA-triblock-copolymers: immune response in mice. Int. J. Pharm. 234 (2002) 75-90
21. He G., Ma L.L., Pan J., and Venkatraman S. ABA and BAB type triblock copolymers of PEG and PLA: A comparative study of drug release properties and "stealth" particle characteristics. Int. J. Pharm. 334 (2007) 48-55
22. Burkersoda F.V., Gref R., and Gopferich A. Erosion of biodegradable block copolymers made of poly(d,l-lactic acid) and poly(ethylene glycol). Biomaterials 18 (1997) 1599-1607
23. Jeong B., Bae Y.H., Lee D.S., and Kim S.W. Biodegradable block copolymers as injectable drug-delivery systems. Nature 388 (1997) 860-862
24. Gupta P.N., Mahor S., Rawat A., Khatri K., Goyal A., and Vyas S.P. Lectin anchored stabilized biodegradable nanoparticles for oral immunization 1. Development and in vitro evaluation. Int. J. Pharm. 318 (2006) 163-173
25. Sharif S., and O'Hagan D.T. A comparison of alternative methods for the determination of the levels of proteins entrapped in poly(lactide-co-glycolide) microparticles. Int. J. Pharm. 115 (1995) 259-263
26. Joshi D.P., Lan-Chun-Fung Y.L., and Pritchard J.G. Determination of poly(vinylalcohol) via its complex with boric acid and iodide. Anal. Chim. Acta 104 (1979) 153-160
27. Jain S., Singh P., Mishra V., and Vyas S.P. Mannosylated niosomes as adjuvant-carrier system for oral genetic immunization against hepatitis B. Immunol. Lett. 101 (2005) 41-49
28. Jaganathan K.S., and Vyas S.P. Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally. Vaccine 24 (2006) 4201-4211
29. Elson C.O., Ealding W., and Lefkowitz J. A lavage technique following repeated measurement of IgA antibody in mouse intestinal secretions. J. Immunol. Methods 67 (1984) 101-108
30. Khatri K., Goyal A.K., Gupta P.N., Mishra N., Mehta A., and Vyas S.P. Surface modified liposomes for nasal delivery of DNA vaccine. Vaccine 26 (2008) 2225-2233
31. Zambaux M.F., Bonneaux F., Gref R., Maincent P., Dellacherie E., Alonso M.J., Labrude P., and Vigneron C. Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J. Control. Release 50 (1998) 31-40
32. Hueper W.C. Carcinogenic studies on water-soluble and insoluble macromolecules. Arch. Pathol. 67 (1959) 589-617
33. Sahoo S.K., Panyam J., Prabha S., and Labhasetwar V. Residual polyvinyl alcohol associated with poly(dl-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J. Control. Release 82 (2002) 105-114
34. Riley T., Govender T., Stolnik S., Xiong C.D., Garnett M.C., Illum L., and Davis S.S. Colloidal stability and drug incorporation aspects of micellar-like PLA-PEG nanoparticles. Colloids Surf., B 16 (1999) 147-159
35. Jani P., Halbert G.W., Langridge J., and Florence A.T. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42 (1990) 821-826
36. Brooking J., Davis S.S., and Illum L. Transport of nanoparticles across the rat nasal mucosa. J. Drug Target. 9 (2001) 267-279
37. Ascentiis A.D., deGrazia J.L., Bowman C.N., Colombo P., and Peppas N.A. Mucoadhesion of poly(2-hydroxyethyl methacrylate) is improved when linear poly(ethylene oxide) chains are added to the polymer network. J.Control. Release 33 (1995) 197-201
38. Cleland J.L., and Jones A.J.S. Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres. Pharm. Res. 13 (1996) 1464-1475
39. Johanson P., Men Y., Audran R., Corradin G., Merkel H.P., and Gander B. Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives. Pharm. Res. 15 7 (1998) 1103-1110
40. Audran R., Men Y., Johanson P., Gander B., and Corradin G. Enhanced immunogenicity of microencapsulated tetanus toxiod with stabilizing agent. Pharm. Res. 15 7 (1998) 1111-1116
41. Perez C., Castellanos I.J., Costantino H.R., Al-Azzam W., and Griebenow K. Recent trends in stabilizing proteins structure upon encapsulation and release from bioerodible polymers. J. Pharm. Pharmacol. 54 (2002) 301-313
42. Tobio M., Gref R., Sanchez A., Langer R., and Alonso M.J. Stealth PLA-PEG nanoparticles as protein carriers for nasal administration. Pharm. Res. 15 2 (1998) 270-275
43. Isaka M., Yasuda Y., Mizokami M., Kozuka S., Taniguchi T., and Matano K. Mucosal immunization against hepatitis B virus by intranasal co-administration of recombinant hepatitis B surface antigen and recombinant cholera toxin B subunit as an adjuvant. Vaccine 19 (2001) 1460-1466
44. Brandtzaeg P. Induction of secretory immunity and memory at mucosal surfaces. Vaccine 21 24 (2007) 5467-5484
45. Wang S., Liu X., and Caulfield M.J. Adjuvant synergy in the response to hepatitis B vaccines. Vaccine 21 (2003) 4297-4306
46. Gupta P.N., Khatri K., Goyal A.K., Mishra N., and Vyas S.P. M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B. J. Drug Target 15 10 (2007) 701-713