Feasibility of a subcutaneously administered block/homo-mixed polyplex micelle as a carrier for DNA vaccination in a mouse tumor model

Journal of Controlled Release

Volumn 206, Issue , 2015, Pages 220-231

  Cui, Lin ^a   Osada, Kensuke ^b,c   Imaizumi, Akira ^a   Kataoka, Kazunori ^b,d   Nakano, Kenji ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

CTL; DNA vaccine; Polyplex micelle; Subcutaneous administration; Tumor rejection immunity

Indexed keywords

BODY FLUIDS; DNA; HISTOLOGY; MAMMALS; MICELLES; POLYMERASE CHAIN REACTION; TISSUE; TUMORS;

CONFOCAL LASER MICROSCOPY; CTL; DNA VACCINE; IMMUNOHISTOCHEMISTRY; POLYPLEX MICELLES; PROINFLAMMATORY CYTOKINES; THERAPEUTIC EFFECTS; TRANSGENE EXPRESSION;

VACCINES;

BLOCK HOMO MIXED POLYPLEX MICELLE; CD4 ANTIGEN; CD40 LIGAND; CD8ALPHA ANTIGEN; DNA VACCINE; DRUG CARRIER; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; NAKED DNA; TUMOR ANTIGEN; UNCLASSIFIED DRUG; CANCER VACCINE; MICELLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD EXAMINATION; BODY WEIGHT; CANCER INFILTRATION; CANCER TISSUE; COLORECTAL CARCINOMA; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA IMMUNIZATION; DRUG EFFICACY; DRUG SAFETY; ELECTROPORATION; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; IMMUNOHISTOCHEMISTRY; IN VIVO GENE TRANSFER; IN VIVO STUDY; INGUINAL LYMPH NODE; INJECTION SITE; LIVER; LYMPHOMA; MESENTERY LYMPH NODE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN; SPLEEN CELL; SURVIVAL RATE; T LYMPHOCYTE; THERAPY EFFECT; TRANSGENE; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; GENETICS; HOMINID; INTRADERMAL DRUG ADMINISTRATION; MICELLE; NEOPLASMS; PATHOLOGY; TUMOR CELL LINE; VACCINATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS, NEOPLASM; CANCER VACCINES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ELECTROPORATION; FEMALE; HOMINIDAE; MICE, INBRED BALB C; MICELLES; NEOPLASMS; TRANSGENES; VACCINATION; VACCINES, DNA;

EID: 84926153065     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.03.029     Document Type: Article

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