Peptide crosslinked micelles: A new strategy for the design and synthesis of peptide vaccines

International Journal of Nanomedicine

Volumn 1, Issue 1, 2006, Pages 97-103

  Hao, Jihua ^a   Kwissa, Marcin ^b   Pulendran, Bali ^b   Murthy, Niren ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Composite; Crosslinking; Peptide; Vaccine

Indexed keywords

CROSS LINKING REAGENT; DRUG CARRIER; NANOMATERIAL; SUBUNIT VACCINE;

ARTICLE; CHEMISTRY; DRUG DESIGN; MATERIALS TESTING; MICELLE; SYNTHESIS;

CROSS-LINKING REAGENTS; DRUG CARRIERS; DRUG DESIGN; MATERIALS TESTING; MICELLES; NANOSTRUCTURES; VACCINES, SUBUNIT;

EID: 34548633832     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/nano.2006.1.1.97     Document Type: Article

References (17)

1. Agrawal S, Agrawal A, Doughty B, et al. 2003. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol, 171:4984-9.
2. Belyakov IM, Ahlers JD, Brandwein BY, et al. 1998. The importance of local mucosal HIV-specific CD8+ cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12. J Clin Invest, 102: 2072-81.
3. BenMohamed L, Wechsler SL, Nesburn AB. 2002. Lipopeptide vaccines-yesterday, today, and tomorrow. Lancet Infect Dis, 2:425-31.
4. Berzofsky JA, Ahlers JD, Derby MA, et al. 1999. Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections. Immunol Rev, 170:151-72.
5. Brander C, Corradin G, Hasler T, et al. 1996. Peptide immunization in humans: a combined CD8+/CD4+ T cell-targeted vaccine restimulates the memory CD4 T cell response but fails to induce cytotoxic T lymphocytes (CTL). Clin Exp Immunol, 105:18-25
6. Craiu A, Akopian T, Goldberg A, et al. 1997. Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide. Prod Natl Acad Sci U S A, 94:10850-5.
7. Ertl HCJ, Varga I, Xiang Z, et al. 1996. Poly(DL-lactide-co-glycolide) microspheres as carriers for peptide vaccines. Vaccine, 14:879-85.
8. Harada A, Kataoka K. 1995. Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments. Macromolecules, 28:5294-9.
9. Hunziker IP, Grabscheid B, Zurbriggen R, et al. 2002. In vitro studies of core peptide-bearing immunopotentiating reconstituted influenza virosomes as a non-live prototype vaccine against hepatitis C virus. Int Immunol, 14:615-26.
10. Jackson DC, O'Brien-Simpson N, Ede NJ, et al. 1997. Free radical induced polymerization of synthetic peptides into polymeric immunogens. Vaccine, 15:1697-705.
11. Kakizawa Y, Harada A, Kataoka K. 1999. Environment-sensitive stabilization of core-shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond. J Am Chem Soc, 121:11247-8.
12. Kakizawa Y, Harada A, Kataoka K. 2001. Glutathione-sensitive stabilization of block copolymer micelles composed of antisense DNA and thiolated poly(ethylene glycol)-block-poly(L-lysine): A potential carrier for systemic delivery of antisense DNA. Biomacromolecules, 2:491-7.
13. Miyata M, Kakizawa Y, Nishiyama N, et al. 2004. Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J Am Chem Soc, 126:2355-61.
14. Park Y, Kwok KY, Boukarim C, et al. 2002. Synthesis of sulfhydryl cross-linking poly(ethylene glycol)-peptides and glycopeptides as carriers for gene delivery. Bioconjug Chem, 13:232-9.
15. Purcell AW, Zeng W, Mifsud NA, et al. 2003. Dissecting the role of peptides in the immune response: Theory, practice and the application to vaccine design. J Pept Sci, 9:255-81.
16. Shirai M, Okada H, Nishioka M, et al. 1994. An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans. J Virol, 68:3334-42.
17. van Endert, PM. 2001. Designing peptide vaccines for cellular cross-presentation. Biologicals, 29:285-8.