메뉴 건너뛰기




Volumn 66, Issue , 2017, Pages S9-S20

The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis

Author keywords

Mast cell; Osteoarthritis; Rheumatoid arthritis; Substance P; Synovium

Indexed keywords

CHYMASE; FC EPSILON RECEPTOR I; FC RECEPTOR; HISTAMINE; IMMUNOGLOBULIN G; LENTIVIRUS VECTOR; MASTER RELATED GENE X2; MESSENGER RNA; PROTEIN; SHORT HAIRPIN RNA; STEM CELL FACTOR; SUBSTANCE P; TACHYKININ; TACHYKININ 1; UNCLASSIFIED DRUG; AUTACOID; BIOLOGICAL MARKER; CYTOKINE;

EID: 85016483020     PISSN: 13238930     EISSN: 14401592     Source Type: Journal    
DOI: 10.1016/j.alit.2017.03.002     Document Type: Article
Times cited : (35)

References (45)
  • 1
    • 84906827120 scopus 로고    scopus 로고
    • Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets
    • Furst, D.E., Emery, P., Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets. Rheumatology (Oxford) 53 (2014), 1560–1569.
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 1560-1569
    • Furst, D.E.1    Emery, P.2
  • 5
    • 0023100630 scopus 로고
    • Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis
    • Lotz, M., Carson, D.A., Vaughan, J.H., Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science 235 (1987), 893–895.
    • (1987) Science , vol.235 , pp. 893-895
    • Lotz, M.1    Carson, D.A.2    Vaughan, J.H.3
  • 6
    • 0031903047 scopus 로고    scopus 로고
    • Substance P enhances cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) expression on cultured rheumatoid fibroblast-like synoviocytes
    • Lambert, N., Lescoulie, P.L., Yassine-Diab, B., Enault, G., Mazieres, B., De Preval, C., et al. Substance P enhances cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) expression on cultured rheumatoid fibroblast-like synoviocytes. Clin Exp Immunol 113 (1998), 269–275.
    • (1998) Clin Exp Immunol , vol.113 , pp. 269-275
    • Lambert, N.1    Lescoulie, P.L.2    Yassine-Diab, B.3    Enault, G.4    Mazieres, B.5    De Preval, C.6
  • 7
    • 0033738840 scopus 로고    scopus 로고
    • Neurotransmitter modulation of interleukin 6 (IL-6) and IL-8 secretion of synovial fibroblasts in patients with rheumatoid arthritis compared to osteoarthritis
    • Raap, T., Justen, H.P., Miller, L.E., Cutolo, M., Scholmerich, J., Straub, R.H., Neurotransmitter modulation of interleukin 6 (IL-6) and IL-8 secretion of synovial fibroblasts in patients with rheumatoid arthritis compared to osteoarthritis. J Rheumatol 27 (2000), 2558–2565.
    • (2000) J Rheumatol , vol.27 , pp. 2558-2565
    • Raap, T.1    Justen, H.P.2    Miller, L.E.3    Cutolo, M.4    Scholmerich, J.5    Straub, R.H.6
  • 8
    • 0028901921 scopus 로고
    • Distribution of neuropeptide-containing nerve fibers in the synovium and adjacent bone of the rat knee joint
    • Iwasaki, A., Inoue, K., Hukuda, S., Distribution of neuropeptide-containing nerve fibers in the synovium and adjacent bone of the rat knee joint. Clin Exp Rheumatol 13 (1995), 173–178.
    • (1995) Clin Exp Rheumatol , vol.13 , pp. 173-178
    • Iwasaki, A.1    Inoue, K.2    Hukuda, S.3
  • 9
    • 0028932493 scopus 로고
    • Increased levels of substance P and calcitonin gene-related peptide in rat adjuvant arthritis. A combined immunohistochemical and radioimmunoassay analysis
    • Ahmed, M., Bjurholm, A., Schultzberg, M., Theodorsson, E., Kreicbergs, A., Increased levels of substance P and calcitonin gene-related peptide in rat adjuvant arthritis. A combined immunohistochemical and radioimmunoassay analysis. Arthritis Rheum 38 (1995), 699–709.
    • (1995) Arthritis Rheum , vol.38 , pp. 699-709
    • Ahmed, M.1    Bjurholm, A.2    Schultzberg, M.3    Theodorsson, E.4    Kreicbergs, A.5
  • 10
    • 0021129334 scopus 로고
    • Intraneuronal substance P contributes to the severity of experimental arthritis
    • Levine, J.D., Clark, R., Devor, M., Helms, C., Moskowitz, M.A., Basbaum, A.I., Intraneuronal substance P contributes to the severity of experimental arthritis. Science 226 (1984), 547–549.
    • (1984) Science , vol.226 , pp. 547-549
    • Levine, J.D.1    Clark, R.2    Devor, M.3    Helms, C.4    Moskowitz, M.A.5    Basbaum, A.I.6
  • 11
    • 0037937249 scopus 로고    scopus 로고
    • Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation
    • Seegers, H.C., Hood, V.C., Kidd, B.L., Cruwys, S.C., Walsh, D.A., Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J Pharmacol Exp Ther 306 (2003), 8–12.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 8-12
    • Seegers, H.C.1    Hood, V.C.2    Kidd, B.L.3    Cruwys, S.C.4    Walsh, D.A.5
  • 12
    • 0037192420 scopus 로고    scopus 로고
    • Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat
    • Hong, S.K., Han, J.S., Min, S.S., Hwang, J.M., Kim, Y.I., Na, H.S., et al. Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat. Neurosci Lett 322 (2002), 21–24.
    • (2002) Neurosci Lett , vol.322 , pp. 21-24
    • Hong, S.K.1    Han, J.S.2    Min, S.S.3    Hwang, J.M.4    Kim, Y.I.5    Na, H.S.6
  • 13
    • 77249118278 scopus 로고    scopus 로고
    • Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats
    • Lam, F.F., Ng, E.S., Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats. Br J Pharmacol 159 (2010), 958–969.
    • (2010) Br J Pharmacol , vol.159 , pp. 958-969
    • Lam, F.F.1    Ng, E.S.2
  • 14
    • 0027393613 scopus 로고
    • Calcitonin gene-related peptide II, substance P and vasoactive intestinal peptide in plasma and synovial fluid from patients with inflammatory joint disease
    • Hernanz, A., De Miguel, E., Romera, N., Perez-Ayala, C., Gijon, J., Arnalich, F., Calcitonin gene-related peptide II, substance P and vasoactive intestinal peptide in plasma and synovial fluid from patients with inflammatory joint disease. Br J Rheumatol 32 (1993), 31–35.
    • (1993) Br J Rheumatol , vol.32 , pp. 31-35
    • Hernanz, A.1    De Miguel, E.2    Romera, N.3    Perez-Ayala, C.4    Gijon, J.5    Arnalich, F.6
  • 15
    • 0029240239 scopus 로고
    • Co-variation of neuropeptide Y, calcitonin gene-related peptide, substance P and neurokinin A in joint fluid from patients with temporomandibular joint arthritis
    • Alstergren, P., Appelgren, A., Appelgren, B., Kopp, S., Lundeberg, T., Theodorsson, E., Co-variation of neuropeptide Y, calcitonin gene-related peptide, substance P and neurokinin A in joint fluid from patients with temporomandibular joint arthritis. Arch Oral Biol 40 (1995), 127–135.
    • (1995) Arch Oral Biol , vol.40 , pp. 127-135
    • Alstergren, P.1    Appelgren, A.2    Appelgren, B.3    Kopp, S.4    Lundeberg, T.5    Theodorsson, E.6
  • 16
    • 0035668197 scopus 로고    scopus 로고
    • Increased content of bombesin/GRP in human synovial fluid in early arthritis: different pattern compared with substance P
    • Westermark, T., Rantapaa-Dahlqvist, S., Wallberg-Jonsson, S., Kjorell, U., Forsgren, S., Increased content of bombesin/GRP in human synovial fluid in early arthritis: different pattern compared with substance P. Clin Exp Rheumatol 19 (2001), 715–720.
    • (2001) Clin Exp Rheumatol , vol.19 , pp. 715-720
    • Westermark, T.1    Rantapaa-Dahlqvist, S.2    Wallberg-Jonsson, S.3    Kjorell, U.4    Forsgren, S.5
  • 17
    • 20144370371 scopus 로고    scopus 로고
    • Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis
    • Grimsholm, O., Rantapaa-Dahlqvist, S., Forsgren, S., Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis. Arthritis Res Ther 7 (2005), R416–R426.
    • (2005) Arthritis Res Ther , vol.7 , pp. R416-R426
    • Grimsholm, O.1    Rantapaa-Dahlqvist, S.2    Forsgren, S.3
  • 18
    • 0026408677 scopus 로고
    • Substance P and somatostatin levels in rheumatoid arthritis, osteoarthritis, and psoriatic arthritis synovial fluid
    • Marabini, S., Matucci-Cerinic, M., Geppetti, P., Del Bianco, E., Marchesoni, A., Tosi, S., et al. Substance P and somatostatin levels in rheumatoid arthritis, osteoarthritis, and psoriatic arthritis synovial fluid. Ann N Y Acad Sci 632 (1991), 435–436.
    • (1991) Ann N Y Acad Sci , vol.632 , pp. 435-436
    • Marabini, S.1    Matucci-Cerinic, M.2    Geppetti, P.3    Del Bianco, E.4    Marchesoni, A.5    Tosi, S.6
  • 19
    • 0027174537 scopus 로고
    • Substance P levels in the synovium and synovial fluid from patients with rheumatoid arthritis and osteoarthritis
    • Menkes, C.J., Renoux, M., Laoussadi, S., Mauborgne, A., Bruxelle, J., Cesselin, F., Substance P levels in the synovium and synovial fluid from patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 20 (1993), 714–717.
    • (1993) J Rheumatol , vol.20 , pp. 714-717
    • Menkes, C.J.1    Renoux, M.2    Laoussadi, S.3    Mauborgne, A.4    Bruxelle, J.5    Cesselin, F.6
  • 20
    • 0033815007 scopus 로고    scopus 로고
    • The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages
    • Miller, L.E., Justen, H.P., Scholmerich, J., Straub, R.H., The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J 14 (2000), 2097–2107.
    • (2000) FASEB J , vol.14 , pp. 2097-2107
    • Miller, L.E.1    Justen, H.P.2    Scholmerich, J.3    Straub, R.H.4
  • 21
    • 11344253294 scopus 로고    scopus 로고
    • Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium
    • Weidler, C., Holzer, C., Harbuz, M., Hofbauer, R., Angele, P., Scholmerich, J., et al. Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann Rheum Dis 64 (2005), 13–20.
    • (2005) Ann Rheum Dis , vol.64 , pp. 13-20
    • Weidler, C.1    Holzer, C.2    Harbuz, M.3    Hofbauer, R.4    Angele, P.5    Scholmerich, J.6
  • 22
    • 37349070140 scopus 로고    scopus 로고
    • Lower density of synovial nerve fibres positive for calcitonin gene-related peptide relative to substance P in rheumatoid arthritis but not in osteoarthritis
    • Dirmeier, M., Capellino, S., Schubert, T., Angele, P., Anders, S., Straub, R.H., Lower density of synovial nerve fibres positive for calcitonin gene-related peptide relative to substance P in rheumatoid arthritis but not in osteoarthritis. Rheumatology (Oxford) 47 (2008), 36–40.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 36-40
    • Dirmeier, M.1    Capellino, S.2    Schubert, T.3    Angele, P.4    Anders, S.5    Straub, R.H.6
  • 24
    • 0022490819 scopus 로고
    • Mast cell numbers and histamine levels in synovial fluids from patients with diverse arthritides
    • Malone, D.G., Irani, A.M., Schwartz, L.B., Barrett, K.E., Metcalfe, D.D., Mast cell numbers and histamine levels in synovial fluids from patients with diverse arthritides. Arthritis Rheum 29 (1986), 956–963.
    • (1986) Arthritis Rheum , vol.29 , pp. 956-963
    • Malone, D.G.1    Irani, A.M.2    Schwartz, L.B.3    Barrett, K.E.4    Metcalfe, D.D.5
  • 25
    • 0028806277 scopus 로고
    • Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies
    • Tetlow, L.C., Woolley, D.E., Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies. Ann Rheum Dis 54 (1995), 896–903.
    • (1995) Ann Rheum Dis , vol.54 , pp. 896-903
    • Tetlow, L.C.1    Woolley, D.E.2
  • 26
    • 0029014542 scopus 로고
    • Distribution, activation and tryptase/chymase phenotype of mast cells in the rheumatoid lesion
    • Tetlow, L.C., Woolley, D.E., Distribution, activation and tryptase/chymase phenotype of mast cells in the rheumatoid lesion. Ann Rheum Dis 54 (1995), 549–555.
    • (1995) Ann Rheum Dis , vol.54 , pp. 549-555
    • Tetlow, L.C.1    Woolley, D.E.2
  • 27
    • 34248186535 scopus 로고    scopus 로고
    • Mast cells in the pathogenesis of rheumatic diseases and as potential targets for anti-rheumatic therapy
    • Eklund, K.K., Mast cells in the pathogenesis of rheumatic diseases and as potential targets for anti-rheumatic therapy. Immunol Rev 217 (2007), 38–52.
    • (2007) Immunol Rev , vol.217 , pp. 38-52
    • Eklund, K.K.1
  • 29
    • 84871778491 scopus 로고    scopus 로고
    • Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through FcγRI and FcγRII
    • Lee, H.K.J., Matsuda, A., Watanabe, Y., Sakamoto-Sasaki, T., Matsumoto, K., Hashimoto, N., et al. Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through FcγRI and FcγRII. Arthritis Rheum 65 (2013), 109–119.
    • (2013) Arthritis Rheum , vol.65 , pp. 109-119
    • Lee, H.K.J.1    Matsuda, A.2    Watanabe, Y.3    Sakamoto-Sasaki, T.4    Matsumoto, K.5    Hashimoto, N.6
  • 30
    • 84926215488 scopus 로고    scopus 로고
    • Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses
    • e1018
    • Sumpter, T.L., Ho, C.H., Pleet, A.R., Tkacheva, O.A., Shufesky, W.J., Rojas-Canales, D.M., et al. Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses. J Allergy Clin Immunol 135 (2015), 1019–1030 e1018.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 1019-1030
    • Sumpter, T.L.1    Ho, C.H.2    Pleet, A.R.3    Tkacheva, O.A.4    Shufesky, W.J.5    Rojas-Canales, D.M.6
  • 31
    • 33748801203 scopus 로고    scopus 로고
    • Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors
    • Tatemoto, K., Nozaki, Y., Tsuda, R., Konno, S., Tomura, K., Furuno, M., et al. Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors. Biochem Biophys Res Commun 349 (2006), 1322–1328.
    • (2006) Biochem Biophys Res Commun , vol.349 , pp. 1322-1328
    • Tatemoto, K.1    Nozaki, Y.2    Tsuda, R.3    Konno, S.4    Tomura, K.5    Furuno, M.6
  • 32
    • 84927676812 scopus 로고    scopus 로고
    • Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria
    • e629
    • Fujisawa, D., Kashiwakura, J., Kita, H., Kikukawa, Y., Fujitani, Y., Sasaki-Sakamoto, T., et al. Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. J Allergy Clin Immunol 134 (2014), 622–633 e629.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 622-633
    • Fujisawa, D.1    Kashiwakura, J.2    Kita, H.3    Kikukawa, Y.4    Fujitani, Y.5    Sasaki-Sakamoto, T.6
  • 33
    • 0031301905 scopus 로고    scopus 로고
    • Human monocytes and macrophages express substance P and neurokinin-1 receptor
    • Ho, W.Z., Lai, J.P., Zhu, X.H., Uvaydova, M., Douglas, S.D., Human monocytes and macrophages express substance P and neurokinin-1 receptor. J Immunol 159 (1997), 5654–5660.
    • (1997) J Immunol , vol.159 , pp. 5654-5660
    • Ho, W.Z.1    Lai, J.P.2    Zhu, X.H.3    Uvaydova, M.4    Douglas, S.D.5
  • 34
    • 0038297113 scopus 로고    scopus 로고
    • Comparison of FcɛRI- and FcγRI-mediated degranulation and TNF-α synthesis in human mast cells: selective utilization of phosphatidylinositol-3-kinase for FcγRI-induced degranulation
    • Okayama, Y., Tkaczyk, C., Metcalfe, D.D., Gilfillan, A.M., Comparison of FcɛRI- and FcγRI-mediated degranulation and TNF-α synthesis in human mast cells: selective utilization of phosphatidylinositol-3-kinase for FcγRI-induced degranulation. Eur J Immunol 33 (2003), 1450–1459.
    • (2003) Eur J Immunol , vol.33 , pp. 1450-1459
    • Okayama, Y.1    Tkaczyk, C.2    Metcalfe, D.D.3    Gilfillan, A.M.4
  • 35
    • 0023875638 scopus 로고
    • Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase
    • Caughey, G.H., Leidig, F., Viro, N.F., Nadel, J.A., Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J Pharmacol Exp Ther 244 (1988), 133–137.
    • (1988) J Pharmacol Exp Ther , vol.244 , pp. 133-137
    • Caughey, G.H.1    Leidig, F.2    Viro, N.F.3    Nadel, J.A.4
  • 36
    • 0344172844 scopus 로고    scopus 로고
    • Inhibitors of chymase as mast cell-stabilizing agents: contribution of chymase in the activation of human mast cells
    • He, S., Gaca, M.D., McEuen, A.R., Walls, A.F., Inhibitors of chymase as mast cell-stabilizing agents: contribution of chymase in the activation of human mast cells. J Pharmacol Exp Ther 291 (1999), 517–523.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 517-523
    • He, S.1    Gaca, M.D.2    McEuen, A.R.3    Walls, A.F.4
  • 38
    • 84942878137 scopus 로고    scopus 로고
    • Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies
    • Suurmond, J., Rivellese, F., Dorjee, A.L., Bakker, A.M., Rombouts, Y.J., Rispens, T., et al. Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies. Ann Rheum Dis 74 (2015), 1915–1923.
    • (2015) Ann Rheum Dis , vol.74 , pp. 1915-1923
    • Suurmond, J.1    Rivellese, F.2    Dorjee, A.L.3    Bakker, A.M.4    Rombouts, Y.J.5    Rispens, T.6
  • 39
    • 84940116796 scopus 로고    scopus 로고
    • Human mast cells triggered with interleukin-33 and immune complexes down-regulate monocyte-mediated immune responses
    • Rivellese, F., Suurmond, J., Habets, K., Dorjee, A.L., Ramamoorthi, N., Townsend, M.J., et al. Human mast cells triggered with interleukin-33 and immune complexes down-regulate monocyte-mediated immune responses. Arthritis Rheumatol 67 (2015), 2343–2353.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2343-2353
    • Rivellese, F.1    Suurmond, J.2    Habets, K.3    Dorjee, A.L.4    Ramamoorthi, N.5    Townsend, M.J.6
  • 40
    • 0021133558 scopus 로고
    • Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion
    • Bromley, M., Woolley, D.E., Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion. Arthritis Rheum 27 (1984), 857–863.
    • (1984) Arthritis Rheum , vol.27 , pp. 857-863
    • Bromley, M.1    Woolley, D.E.2
  • 41
    • 0034809563 scopus 로고    scopus 로고
    • Human skin mast cells rapidly release preformed and newly generated TNF-α and IL-8 following stimulation with anti-IgE and other secretagogues
    • Gibbs, B.F., Wierecky, J., Welker, P., Henz, B.M., Wolff, H.H., Grabbe, J., Human skin mast cells rapidly release preformed and newly generated TNF-α and IL-8 following stimulation with anti-IgE and other secretagogues. Exp Dermatol 10 (2001), 312–320.
    • (2001) Exp Dermatol , vol.10 , pp. 312-320
    • Gibbs, B.F.1    Wierecky, J.2    Welker, P.3    Henz, B.M.4    Wolff, H.H.5    Grabbe, J.6
  • 42
    • 18844373919 scopus 로고    scopus 로고
    • Evidence for a restricted rather than generalized stimulatory response of skin-derived human mast cells to substance P
    • Guhl, S., Lee, H.H., Babina, M., Henz, B.M., Zuberbier, T., Evidence for a restricted rather than generalized stimulatory response of skin-derived human mast cells to substance P. J Neuroimmunol 163 (2005), 92–101.
    • (2005) J Neuroimmunol , vol.163 , pp. 92-101
    • Guhl, S.1    Lee, H.H.2    Babina, M.3    Henz, B.M.4    Zuberbier, T.5
  • 43
    • 38649084996 scopus 로고    scopus 로고
    • Neuropeptides activate human mast cell degranulation and chemokine production
    • Kulka, M., Sheen, C.H., Tancowny, B.P., Grammer, L.C., Schleimer, R.P., Neuropeptides activate human mast cell degranulation and chemokine production. Immunology 123 (2008), 398–410.
    • (2008) Immunology , vol.123 , pp. 398-410
    • Kulka, M.1    Sheen, C.H.2    Tancowny, B.P.3    Grammer, L.C.4    Schleimer, R.P.5
  • 44
    • 0025719076 scopus 로고
    • Mediator secretion from human skin mast cells provoked by immunological and non-immunological stimulation
    • Church, M.K., Okayama, Y., el-Lati, S., Mediator secretion from human skin mast cells provoked by immunological and non-immunological stimulation. Skin Pharmacol 4:Suppl 1 (1991), 15–24.
    • (1991) Skin Pharmacol , vol.4 , pp. 15-24
    • Church, M.K.1    Okayama, Y.2    el-Lati, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.