Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 4, 2015, Pages 1019-1030.e8

  Sumpter, Tina L ^a   Ho, Chin H ^a   Pleet, Anna R ^a   Tkacheva, Olga A ^a   Shufesky, William J ^b,c   Rojas Canales, Darling M ^b,c   Morelli, Adrian E ^b,c   Larregina, Adriana T ^a,b  

^a PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

airway inflammation; Fc RI; Hemokinin 1; IgE; IL 6; mast cells; neurokinin 1 receptor; passive anaphylaxis; substance P; TNF

Indexed keywords

HEMOKININ 1; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; NEUROKININ 1 RECEPTOR; NEUROPEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; STRESS ACTIVATED PROTEIN KINASE; SUBSTANCE P; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; HEMOKININ-1; IMMUNOGLOBULIN E RECEPTOR; TACHYKININ;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BONE MARROW DERIVED MAST CELL; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MATURATION; CROSS LINKING; CYTOKINE RELEASE; EXPERIMENTAL AIRWAY INFLAMMATION; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; SYSTEMIC ANAPHYLAXIS; ANAPHYLAXIS; ANIMAL; AUTOCRINE EFFECT; BIOSYNTHESIS; DISEASE MODEL; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; MAST CELL; METABOLISM; PATHOLOGY;

ANAPHYLAXIS; ANIMALS; AUTOCRINE COMMUNICATION; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOGLOBULIN E; INFLAMMATION; INTERLEUKIN-6; LUNG; MAST CELLS; MICE; MICE, KNOCKOUT; RECEPTORS, IGE; RECEPTORS, NEUROKININ-1; SIGNAL TRANSDUCTION; TACHYKININS; TUMOR NECROSIS FACTORS;

EID: 84926215488     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.036     Document Type: Article

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