Milk protein isolate (MPI) as a source of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides

Food Chemistry

Volumn 231, Issue , 2017, Pages 202-211

  Nongonierma, Alice B ^a   Lalmahomed, Mehdeeyah ^a   Paolella, Sara ^a   FitzGerald, Richard J ^a  

^a UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

Bioactive peptides; Dipeptidyl peptidase IV inhibition; Milk protein isolate; Response surface methodology

Indexed keywords

DESIGN OF EXPERIMENTS; HYDROLYSIS; INTEGRATED CIRCUITS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEINS;

BIOACTIVE PEPTIDES; BOVINE MILK PROTEINS; DIPEPTIDYL PEPTIDASE IV; GASTROINTESTINAL DIGESTION; INHIBITORY CONCENTRATION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MILK PROTEIN; RESPONSE SURFACE METHODOLOGY;

PEPTIDES;

DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; MILK PROTEIN; PEPTIDE; PROTEIN HYDROLYSATE;

ARTICLE; EXPERIMENTAL DESIGN; GLUCOSE BLOOD LEVEL; HUMAN; HYDROLYSIS; IC50; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; REVERSED PHASE LIQUID CHROMATOGRAPHY; TEMPERATURE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BOVINE; TANDEM MASS SPECTROMETRY;

ANIMALS; CATTLE; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HUMANS; MILK PROTEINS; PEPTIDES; TANDEM MASS SPECTROMETRY;

EID: 85016389741     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2017.03.123     Document Type: Article

References (40)

1. Agarwal, S., Beausire, R.L., Patel, S., Patel, H., Innovative uses of milk protein concentrates in product development. Journal of Food Science 80 (2015), A23–A29.
2. Connolly, A., O'Keeffe, M.B., Nongonierma, A.B., Piggott, C.O., FitzGerald, R.J., Isolation of peptides from a novel brewers spent grain protein isolate with potential to modulate glycaemic response. International Journal of Food Science & Technology 52 (2017), 146–153.
3. Eckert, E., Zambrowicz, A., Pokora, M., Setner, B., Dąbrowska, A., Szołtysik, M., Chrzanowska, J., Egg-yolk protein by-product as a source of ACE-inhibitory peptides obtained with using unconventional proteinase from Asian pumpkin (Cucurbita ficifolia). Journal of Proteomics 110 (2014), 107–116.
4. Hogan, S., Zhang, L., Li, J., Wang, H., Zhou, K., Development of antioxidant rich peptides from milk protein by microbial proteases and analysis of their effects on lipid peroxidation in cooked beef. Food Chemistry 117 (2009), 438–443.
5. Hsieh, C.-H., Wang, T.-Y., Hung, C.-C., Jao, C.-L., Hsieh, Y.-L., Wu, S.-X., Hsu, K.-C., In silico, in vitro and in vivo analyses of dipeptidyl peptidase IV inhibitory activity and the antidiabetic effect of sodium caseinate hydrolysate. Food & Function 7 (2016), 1122–1128.
6. Juillerat-Jeanneret, L., Dipeptidyl peptidase IV and its inhibitors: Therapeutics for type 2 diabetes and what else?. Journal of Medicinal Chemistry 57 (2014), 2197–2212.
7. Lacroix, I.M.E., Li-Chan, E.C.Y., Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins. Peptides 54 (2014), 39–48.
8. Lacroix, I.M.E., Li-Chan, E.C.Y., Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations. Trends in Food Science & Technology 54 (2016), 1–16.
9. Lan, V.T.T., Ito, K., Ohno, M., Motoyama, T., Ito, S., Kawarasaki, Y., Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175 (2015), 66–73.
10. Le Maux, S., Nongonierma, A.B., Barre, C., FitzGerald, R.J., Enzymatic generation of whey protein hydrolysates under pH-controlled and non pH-controlled conditions: Impact on physicochemical and bioactive properties. Food Chemistry 199 (2016), 246–251.
11. Madsen, J.S., Ahmt, T.Ø., Otte, J., Halkier, T., Qvist, K.B., Hydrolysis of β-lactoglobulin by four different proteinases monitored by capillary electrophoresis and high performance liquid chromatography. International Dairy Journal 7 (1997), 399–409.
12. Neves, A.C., Harnedy, P.A., O'Keeffe, M.B., FitzGerald, R.J., Bioactive peptides from Atlantic salmon (Salmo salar) with angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory, and antioxidant activities. Food Chemistry 218 (2017), 396–405.
13. Nongonierma, A.B., FitzGerald, R.J., Tryptophan-containing milk protein-derived dipeptides inhibit xanthine oxidase. Peptides 37 (2012), 263–272.
14. Nongonierma, A.B., FitzGerald, R.J., Dipeptidyl peptidase IV inhibitory and antioxidative properties of milk-derived dipeptides and hydrolysates. Peptides 39 (2013), 157–163.
15. Nongonierma, A.B., FitzGerald, R.J., Dipeptidyl peptidase IV inhibitory properties of a whey protein hydrolysate: Influence of fractionation, stability to simulated gastrointestinal digestion and food-drug interaction. International Dairy Journal 32 (2013), 33–39.
16. Nongonierma, A.B., FitzGerald, R.J., Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing peptides. Journal of Functional Foods 5 (2013), 1909–1917.
17. Nongonierma, A.B., FitzGerald, R.J., Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides. Food & Function 4 (2013), 1843–1849.
18. Nongonierma, A.B., FitzGerald, R.J., An in silico model to predict the potential of dietary proteins as sources of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides. Food Chemistry 165 (2014), 489–498.
19. Nongonierma, A.B., FitzGerald, R.J., Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chemistry 145 (2014), 845–852.
20. Nongonierma, A.B., FitzGerald, R.J., The scientific evidence for the role of milk protein-derived bioactive peptides in humans: a Review. Journal of Functional Foods 640 (2015), 640–656.
21. Nongonierma, A.B., FitzGerald, R.J., Utilisation of the isobole methodology to study dietary peptide–drug and peptide–peptide interactive effects on dipeptidyl peptidase IV (DPP-IV) inhibition. Food & Function 6 (2015), 312–319.
22. Nongonierma, A.B., FitzGerald, R.J., Learnings from quantitative structure-activity relationship (QSAR) studies with respect to food protein-derived bioactive peptides: a review. RSC Advances 6 (2016), 75400–75413.
23. Nongonierma, A.B., FitzGerald, R.J., Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity. Peptides 79 (2016), 1–7.
24. Nongonierma, A.B., Mazzocchi, C., Paolella, S., FitzGerald, R.J., Release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from milk protein isolate (MPI) during enzymatic hydrolysis. Food Research International 94 (2017), 79–89.
25. Norris, R., Poyarkov, A., O'Keeffe, M.B., FitzGerald, R.J., Characterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine β-casein and determination of ACE inhibitory activity. Food Chemistry 156 (2014), 29–36.
26. O'Keeffe, M.B., FitzGerald, R.J., Identification of short peptide sequences in complex milk protein hydrolysates. Food Chemistry 184 (2015), 140–146.
27. Sila, A., Martinez-Alvarez, O., Haddar, A., Gómez-Guillén, M.C., Nasri, M., Montero, M.P., Bougatef, A., Recovery, viscoelastic and functional properties of Barbel skin gelatine: investigation of anti-DPP-IV and anti-prolyl endopeptidase activities of generated gelatine polypeptides. Food Chemistry 168 (2015), 478–486.
28. Silveira, S.T., Martínez-Maqueda, D., Recio, I., Hernández-Ledesma, B., Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in β-lactoglobulin. Food Chemistry 141 (2013), 1072–1077.
29. Spellman, D., O'Cuinn, G., FitzGerald, R.J., Bitterness in Bacillus proteinase hydrolysates of whey proteins. Food Chemistry 114 (2009), 440–446.
30. Tulipano, G., Faggi, L., Nardone, A., Cocchi, D., Caroli, A.M., Characterisation of the potential of β-lactoglobulin and α-lactalbumin as sources of bioactive peptides affecting incretin function: In silico and in vitro comparative studies. International Dairy Journal 48 (2015), 62–72.
31. Uchida, M., Ohshiba, Y., Mogami, O., Novel dipeptidyl peptidase-4-inhibiting peptide derived from β-lactoglobulin. Journal of Pharmacological Sciences 117 (2011), 63–66.
32. Uenishi, H., Kabuki, T., Seto, Y., Serizawa, A., Nakajima, H., Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats. International Dairy Journal 22 (2012), 24–30.
33. Umezawa, H., Aoyagi, T., Ogawa, K., Naganawa, H., Hamada, M., Takeuchi, T., Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria. Journal of Antibiotics 37 (1984), 422–425.
34. van der Ven, C., Gruppen, H., de Bont, D.B.A., Voragen, A.G.J., Optimisation of the angiotensin converting enzyme inhibition by whey protein hydrolysates using response surface methodology. International Dairy Journal 12 (2002), 813–820.
35. Walsh, D.J., Bernard, H., Murray, B.A., MacDonald, J., Pentzien, A.K., Wright, G.A., FitzGerald, R.J., In vitro generation and stability of the lactokinin β-lactoglobulin fragment (142–148). Journal of Dairy Science 87 (2004), 3845–3857.
36. Zambrowicz, A., Eckert, E., Pokora, M., Bobak, Ł., Dąbrowska, A., Szołtysik, M., Chrzanowska, J., Antioxidant and antidiabetic activities of peptides isolated from a hydrolysate of an egg-yolk protein by-product prepared with a proteinase from Asian pumpkin (Cucurbita ficifolia). RSC Advances 5 (2015), 10460–10467.
37. Zhang, Y., Chen, R., Chen, X., Zeng, Z., Ma, H., Chen, S., Dipeptidyl peptidase IV-Inhibitory peptides derived from silver carp (Hypophthalmichthys molitrix Val.) proteins. Journal of Agricultural and Food Chemistry 64 (2016), 831–839.
38. Zhang, Y., Chen, R., Ma, H., Chen, S., Isolation and identification of dipeptidyl peptidase IV-inhibitory peptides from trypsin/chymotrypsin-treated goat milk casein hydrolysates by 2D-TLC and LC–MS/MS. Journal of Agricultural and Food Chemistry 63 (2015), 8819–8828.
39. Zhang, Y., Chen, R., Zuo, F., Ma, H., Zhang, Y., Chen, S., Comparison of dipeptidyl peptidase IV-inhibitory activity of peptides from bovine and caprine milk casein by in silico and in vitro analyses. International Dairy Journal 53 (2016), 37–44.
40. Zhao, J.-Y., Wang, H.-P., Wang, H.-J., Yao, J.-M., Wu, X.-Y., Dong, J.-J., Liao, L., Efficacy and safety of sitagliptin in patients with type 2 diabetes mellitus: A meta-analysis. International Journal of Clinical and Experimental Medecine 9 (2016), 11202–11210.