Transcriptomic analyses of the anti-adipogenic effects of oleuropein in human mesenchymal stem cells

Food and Function

Volumn 8, Issue 3, 2017, Pages 1254-1270

  Casado Díaz, Antonio ^a,d   Anter, Jaouad ^b   Müller, Sören ^c   Winter, Peter ^c   Quesada Gómez, José Manuel ^a,d   Dorado, Gabriel ^b,d  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b UNIVERSITY OF CÓRDOBA   (Spain)

^c GENXPRO GMBH   (Germany)

^d CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes)   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELL CULTURE; CELL SIGNALING; CELLS; CYTOLOGY; DISEASES; GENE EXPRESSION; GENES; POLYPHENOLIC COMPOUNDS; STEM CELLS;

ADIPOGENIC DIFFERENTIATIONS; BIOLOGICAL PROPERTIES; DIFFERENTIAL GENE EXPRESSIONS; EXTRA VIRGIN OLIVE OIL; HUMAN BONE MARROW MESENCHYMAL STEM CELLS; HUMAN MESENCHYMAL STEM CELLS; MITOCHONDRIAL ACTIVITY; SIGNALING PATHWAYS;

OLIVE OIL;

BETA CATENIN; IRIDOID; OLEUROPEIN; PLANT EXTRACT; VEGETABLE OIL;

ADIPOGENESIS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FRUIT; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; OLIVE TREE;

ADIPOGENESIS; BETA CATENIN; FRUIT; GENE EXPRESSION PROFILING; HUMANS; IRIDOIDS; MESENCHYMAL STROMAL CELLS; OLEA; PLANT EXTRACTS; PLANT OILS;

EID: 85016329139     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c7fo00045f     Document Type: Article

References (55)

1. V. Uylaşer G. Yildiz The historical development and nutritional importance of olive and olive oil constituted an important part of the Mediterranean diet. Crit. Rev. Food Sci. Nutr. 2014 54 1092-1101
2. E. Gotsis P. Anagnostis A. Mariolis A. Vlachou N. Katsiki A. Karagiannis Health Benefits of the Mediterranean Diet: An Update of Research Over the Last 5 Years. Angiology 2014 66 304-318
3. R. Ghanbari, F.Anwar, K. M.Alkharfy, A. H.Gilani and N.Saari, Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)-a review, 2012, vol. 13
4. B. Barbaro G. Toietta R. Maggio M. Arciello M. Tarocchi A. Galli C. Balsano Effects of the Olive-Derived Polyphenol Oleuropein on Human Health. Int. J. Mol. Sci. 2014 15 18508-18524
5. R. Santiago-Mora A. Casado-Díaz M. D. De Castro J. M. Quesada-Gómez Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow Osteoporosis Int. 2011 22 675-684
6. R. Drira S. Chen K. Sakamoto Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells. Life Sci. 2011 89 708-716
7. C. Veciana-Galindo E. Cortes-Castell L. Torro-Montell A. Palazon-Bru E. Sirvent-Segura M. M. Rizo-Baeza V. F. Gil-Guillen Anti-adipogenic activity of an olive seed extract in mouse fibroblasts Nutr. Hosp. 2015 31 2747-2751
8. M. Svobodova I. Andreadou A.-L. Skaltsounis J. Kopecky P. Flachs Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 9 376
9. I. Moreno-Indias F. J. Tinahones Impaired adipose tissue expandability and lipogenic capacities as ones of the main causes of metabolic disorders J. Diabetes Res. 2015 2015, 970375
10. M. E. Nuttall F. Shah V. Singh C. Thomas-Porch T. Frazier J. M. Gimble Adipocytes and the regulation of bone remodeling: A balancing act Calcif. Tissue Int. 2014 94 78-87
11. M. Colitti S. Grasso Nutraceuticals and regulation of adipocyte life: Premises or promises BioFactors 2014 40 398-418
12. A. Casado-Díaz R. Santiago-Mora R. Jiménez J. Caballero-Villarraso C. Herrera A. Torres G. Dorado J. M. Quesada-Gómez Cryopreserved human bone marrow mononuclear cells as a source of mesenchymal stromal cells: application in osteoporosis research. Cytotherapy 2008 10 460-468
13. A. Casado-Díaz J. Anter S. Müller P. Winter J. M. Quesada-Gómez G. Dorado Transcriptomic Analyses of Adipocyte Differentiation From Human Mesenchymal Stromal-Cells (MSC) J. Cell. Physiol. 2016 771-784
14. S. Müller L. Rycak F. Afonso-Grunz P. Winter A. M. Zawada E. Damrath J. Scheider J. Schmäh I. Koch G. Kahl B. Rotter APADB: a database for alternative polyadenylation and microRNA regulation events. Database 2014 2014 1-11
15. L. Wang Z. Feng X. Wang X. Wang X. Zhang DEGseq: an R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics 2010 26 136-138
16. S. Y. Min H. Yang S. G. Seo S. H. Shin M.-Y. Chung J. Kim S. Y. Lee H. J. Lee K. W. Lee Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor Int. J. Obes. 2013 37 584-592
17. J. Y. Park Y. Kim J. A. Im S. You H. Lee Inhibition of adipogenesis by oligonol through Akt-mTOR inhibition in 3 T3-L1 adipocytes Evidence-Based Complementary Altern. Med. 2014 2014, 895272
18. B. Chani V. Puri S. Rc S. Puri Epigallocatechin Gallate Inhibits Mouse Mesenchymal Stem Cell Differentiation to Adipogenic Lineage J. Stem Cells Regen. Med. 2016 12 16-24
19. K. B. Pandey S. I. Rizvi Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longevity 2009 2 270-278
20. S. Etienne-Manneville A. Hall Rho GTPases in cell biology. Nature 2002 420 629-635
21. R. McBeath D. M. Pirone C. M. Nelson K. Bhadriraju C. S. Chen Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment Dev. Cell 2004 6 483-495
22. H. Nobusue N. Onishi T. Shimizu E. Sugihara Y. Oki Y. Sumikawa T. Chiyoda K. Akashi H. Saya K. Kano Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. Nat. Commun. 2014 5 3368
23. B. A. Bryan D. C. Mitchell L. Zhao W. Ma L. J. Stafford B.-B. Teng M. Liu Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT Mol. Cell. Biol. 2005 25 11089-11101
24. S. Dupont L. Morsut M. Aragona E. Enzo S. Giulitti M. Cordenonsi F. Zanconato J. Le Digabel M. Forcato S. Bicciato N. Elvassore S. Piccolo Role of YAP/TAZ in mechanotransduction. Nature 2011 474 179-183
25. E. M. Morandi R. Verstappen M. E. Zwierzina S. Geley G. Pierer C. Ploner ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells Sci. Rep. 2016 6 28889
26. B. Q. Song Y. Chi X. Li W. J. Du Z. B. Han J. J. Tian J. J. Li F. Chen H. H. Wu L. X. Han S. H. Lu Y. Z. Zheng Z. C. Han Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3 K/AKT/mTOR Pathway Cell. Physiol. Biochem. 2015 36 1991-2002
27. D. Lo Furno A. C. E. Graziano S. Caggia R. E. Perrotta M. S. Tarico R. Giuffrida V. Cardile Decrease of apoptosis markers during adipogenic differentiation of mesenchymal stem cells from human adipose tissue Apoptosis 2013 18 578-588
28. A. R. Guntur M. I. Reinhold J. Cuellar M. C. Naski Conditional ablation of Pten in osteoprogenitors stimulates FGF signaling. Development 2011 138 1433-1444
29. D. E. Phelps Y. Xiong Regulation of cyclin-dependent kinase 4 during adipogenesis involves switching of cyclin D subunits and concurrent binding of p18INK4c and p27Kip1. Cell Growth Differ. 1998 9 595-610
30. Z. Hélias-Rodzewicz F. Pédeutour J.-M. Coindre P. Terrier A. Aurias Selective elimination of amplified CDK4 sequences correlates with spontaneous adipocytic differentiation in liposarcoma. Genes, Chromosomes Cancer 2009 48 943-952
31. S.-W. Qian X. Li Y.-Y. Zhang H.-Y. Huang Y. Liu X. Sun Q.-Q. Tang Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow. BMC Dev. Biol. 2010 10 47
32. A. Casado-Díaz J. Anter G. Dorado J. Quesada-Gómez Effects of quercetin, a natural phenolic compound, in the differentiation of human mesenchymal stem cells (MSC) into adipocytes and osteoblasts J. Nutr. Biochem. 2016 32 151-162
33. A. W. Lund J. P. Stegemann G. E. Plopper Mesenchymal Stem Cells Sense Three Dimensional Type I Collagen through Discoidin Domain Receptor 1. Open Stem Cell J. 2009 1 40-53
34. J. L. Crane X. Cao Bone marrow mesenchymal stem cells andTGF-β signaling in bone remodeling J. Clin. Invest. 2014 124 466-472
35. L. Zhao and B. M.Hantash, TGF-β1 Regulates Differentiation of Bone Marrow Mesenchymal Stem Cells, Elsevier Inc., 1st edn, 2011, vol. 87
36. E. J. van Zoelen I. Duarte J. M. Hendriks S. P. van der Woning TGFβ-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation. Stem Cell Res. Ther. 2016 7 123
37. A. Chow C. L. Arteaga S. E. Wang When tumor suppressor TGFβ meets the HER2 (ERBB2) oncogene. J. Mammary Gland Biol. Neoplasia 2011 16 81-88
38. V. Cervelli M. G. Scioli P. Gentile E. Doldo E. Bonanno L. G. Spagnoli A. Orlandi Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance. Stem Cells Transl. Med. 2012 1 206-220
39. A. W. James Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation. Scientifica 2013 2013 684736
40. S. Khalil G. A. Tan D. D. Giri X. K. Zhou L. R. Howe Activation status of Wnt/β-catenin signaling in normal and neoplastic breast tissues: Relationship to HER2/neu expression in human and mouse PLoS One 2012 7 1-10
41. B. Schade R. Lesurf V. Sanguin-Gendreau T. Bui G. Deblois S. A. O'Toole E. K. A. Millar S. J. Zardawi E. Lopez-Knowles R. L. Sutherland V. Giguère M. Kahn M. Hallett W. J. Muller β-catenin signaling is a critical event in ErbB2-mediated mammary tumor progression Cancer Res. 2013 73 4474-4487
42. G. D'Uva A. Aharonov M. Lauriola D. Kain Y. Yahalom-Ronen S. Carvalho K. Weisinger E. Bassat D. Rajchman O. Yifa M. Lysenko T. Konfino J. Hegesh O. Brenner M. Neeman Y. Yarden J. Leor R. Sarig R. P. Harvey E. Tzahor ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation Nat. Cell Biol. 2015 17 627-638
43. S. Zhou K. Eid J. Glowacki Cooperation Between TGF-β and Wnt Pathways During Chondrocyte and Adipocyte Differentiation of Human Marrow Stromal Cells J. Bone Miner. Res. 2004 19 463-470
44. L. Cheng C. Zhang D. Li J. Zou J. Wang Transforming Growth Factor-β1 (TGF-β1) Induces Mouse Precartilaginous Stem Cell Proliferation through TGF-β Receptor II (TGFRII)-Akt-β-Catenin Signaling Int. J. Mol. Sci. 2014 15 12665-12676
45. J. Qian M. Niu X. Zhai Q. Zhou Y. Zhou β-Catenin pathway is required for TGF-β1 inhibition of PPARγ expression in cultured hepatic stellate cells Pharmacol. Res. 2012 66 219-225
46. B. Tu Z. X. Peng Q. M. Fan L. Du W. Yan T. T. Tang Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-β/Smad2/3 pathway Exp. Cell Res. 2014 320 164-173
47. F. Zhang R. T. Wu J. Niu Small concentrations of TGF-β1 promote proliferation of bone marrow-derived mesenchymal stem cells via activation of Wnt/β-catenin pathway Indian J. Exp. Biol. 2015 53 508-513
48. S. Park Y. Choi S. J. Um S. K. Yoon T. Park Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice J. Hepatol. 2011 54 984-993
49. T. Tong N. Kim T. Park Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin PLoS One 2015 10 e0129578
50. M. J. Ryu S. J. Kim M. J. Choi Y. K. Kim M. H. Lee S. E. Lee H. K. Chung S. B. Jung H.-J. Kim K. S. Kim Y. S. Jo G. R. Kweon C.-H. Lee M. Shong Mitochondrial oxidative phosphorylation reserve is required for hormone-and PPARγ agonist-induced adipogenesis. Mol. Cells 2013 35 134-141
51. A. D. Hofmann M. Beyer U. Krause-Buchholz M. Wobus M. Bornhäuser G. Rödel Oxphos supercomplexes as a hallmark of the mitochondrial phenotype of adipogenic differentiated human MSCS PLoS One 2012 7 e35160
52. K. V. Tormos E. Anso R. B. Hamanaka J. Eisenbart J. Joseph B. Kalyanaraman N. S. Chandel Mitochondrial complex III ROS regulate adipocyte differentiation Cell Metab. 2011 14 537-544
53. A. Missiou D. Wolf I. Platzer S. Ernst C. Walter P. Rudolf K. Zirlik N. Köstlin F. K. Willecke C. Münkel U. Schönbeck P. Libby C. Bode N. Varo A. Zirlik CD40L induces inflammation and adipogenesis in adipose cells-a potential link between metabolic and cardiovascular disease. Thromb. Haemostasis 2010 103 788-796
54. Q. Kang W.-X. Song Q. Luo N. Tang J. Luo X. Luo J. Chen Y. Bi B.-C. He J. K. Park W. Jiang Y. Tang J. Huang Y. Su G.-H. Zhu Y. He H. Yin Z. Hu Y. Wang L. Chen G.-W. Zuo X. Pan J. Shen T. Vokes R. R. Reid R. C. Haydon H. H. Luu T.-C. He A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev. 2009 18 545-559
55. Y. Liu Y. Liu R. Zhang X. Wang F. Huang Z. Yan M. Nie J. Huang Y. Wang Y. Wang L. Chen L. Yin B. He Z. Deng All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways Int. J. Biochem. Cell Biol. 2014 47 47-56