메뉴 건너뛰기




Volumn 35, Issue 9, 2017, Pages 984-993

Clinical implications of novel genomic discoveries in chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

CANCER PROGNOSIS; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; GENETIC HETEROGENEITY; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMAN; LEUKEMOGENESIS; PHYLOGENY; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; TREATMENT RESPONSE; WHOLE EXOME SEQUENCING; GENETICS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; PROCEDURES;

EID: 85016327598     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2016.71.0822     Document Type: Review
Times cited : (47)

References (101)
  • 1
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al: Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial. Lancet 376:1164-1174, 2010
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 2
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • Binet JL, Auquier A, Dighiero G, et al: A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 48:198-206, 1981
    • (1981) Cancer , vol.48 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3
  • 3
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Döhner H, Stilgenbauer S, Benner A, et al: Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343:1910-1916, 2000
    • (2000) N Engl J Med , vol.343 , pp. 1910-1916
    • Döhner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 4
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE, et al: Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 369:32-42, 2013
    • (2013) N Engl J Med , vol.369 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 5
    • 84896692766 scopus 로고    scopus 로고
    • Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
    • Furman RR, Sharman JP, Coutre SE, et al: Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 370:997-1007, 2014
    • (2014) N Engl J Med , vol.370 , pp. 997-1007
    • Furman, R.R.1    Sharman, J.P.2    Coutre, S.E.3
  • 6
    • 84955491187 scopus 로고    scopus 로고
    • Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia
    • Roberts AW, Davids MS, Pagel JM, et al: Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. N Engl J Med 374:311-322, 2016
    • (2016) N Engl J Med , vol.374 , pp. 311-322
    • Roberts, A.W.1    Davids, M.S.2    Pagel, J.M.3
  • 7
    • 84875758730 scopus 로고    scopus 로고
    • Lessons from the cancer genome
    • Garraway LA, Lander ES: Lessons from the cancer genome. Cell 153:17-37, 2013
    • (2013) Cell , vol.153 , pp. 17-37
    • Garraway, L.A.1    Lander, E.S.2
  • 8
    • 84879419178 scopus 로고    scopus 로고
    • The biology and clinical significance of acquired genomic copy number aberrations and recurrent gene mutations in chronic lymphocytic leukemia
    • Malek SN: The biology and clinical significance of acquired genomic copy number aberrations and recurrent gene mutations in chronic lymphocytic leukemia. Oncogene 32:2805-2817, 2013
    • (2013) Oncogene , vol.32 , pp. 2805-2817
    • Malek, S.N.1
  • 9
    • 84863957729 scopus 로고    scopus 로고
    • Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia
    • Brown JR, Hanna M, Tesar B, et al: Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia. Clin Cancer Res 18:3791-3802, 2012
    • (2012) Clin Cancer Res , vol.18 , pp. 3791-3802
    • Brown, J.R.1    Hanna, M.2    Tesar, B.3
  • 10
    • 80052936981 scopus 로고    scopus 로고
    • Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia
    • Ouillette P, Collins R, Shakhan S, et al: Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia. Blood 118:3051-3061, 2011
    • (2011) Blood , vol.118 , pp. 3051-3061
    • Ouillette, P.1    Collins, R.2    Shakhan, S.3
  • 11
    • 84870763388 scopus 로고    scopus 로고
    • Highresolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations
    • Edelmann J, Holzmann K, Miller F, et al: Highresolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations. Blood 120:4783-4794, 2012
    • (2012) Blood , vol.120 , pp. 4783-4794
    • Edelmann, J.1    Holzmann, K.2    Miller, F.3
  • 12
    • 84945248976 scopus 로고    scopus 로고
    • Noncoding recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Beà S, Valdés-Mas R, et al: Noncoding recurrent mutations in chronic lymphocytic leukaemia. Nature 526:519-524, 2015
    • (2015) Nature , vol.526 , pp. 519-524
    • Puente, X.S.1    Beà, S.2    Valdés-Mas, R.3
  • 13
    • 79961059215 scopus 로고    scopus 로고
    • Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia
    • Gunnarsson R, Mansouri L, Isaksson A, et al: Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia. Haematologica 96:1161-1169, 2011
    • (2011) Haematologica , vol.96 , pp. 1161-1169
    • Gunnarsson, R.1    Mansouri, L.2    Isaksson, A.3
  • 14
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, et al: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99:15524-15529, 2002
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 15
    • 73549103619 scopus 로고    scopus 로고
    • Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages
    • Chapiro E, Leporrier N, Radford-Weiss I, et al: Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages. Leuk Res 34:63-68, 2010
    • (2010) Leuk Res , vol.34 , pp. 63-68
    • Chapiro, E.1    Leporrier, N.2    Radford-Weiss, I.3
  • 16
    • 33846883741 scopus 로고    scopus 로고
    • Genomewide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays
    • Pfeifer D, Pantic M, Skatulla I, et al: Genomewide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood 109:1202-1210, 2007
    • (2007) Blood , vol.109 , pp. 1202-1210
    • Pfeifer, D.1    Pantic, M.2    Skatulla, I.3
  • 17
    • 27644577006 scopus 로고    scopus 로고
    • Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes
    • Rubio-Moscardo F, Blesa D, Mestre C, et al: Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood 106:3214-3222, 2005
    • (2005) Blood , vol.106 , pp. 3214-3222
    • Rubio-Moscardo, F.1    Blesa, D.2    Mestre, C.3
  • 18
    • 79960036578 scopus 로고    scopus 로고
    • Wholegenome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, et al: Wholegenome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475:101-105, 2011
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3
  • 19
    • 84855370035 scopus 로고    scopus 로고
    • SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
    • Wang L, Lawrence MS, Wan Y, et al: SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 365:2497-2506, 2011
    • (2011) N Engl J Med , vol.365 , pp. 2497-2506
    • Wang, L.1    Lawrence, M.S.2    Wan, Y.3
  • 20
    • 84878551940 scopus 로고    scopus 로고
    • POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia
    • Ramsay AJ, Quesada V, Foronda M, et al: POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat Genet 45:526-530, 2013
    • (2013) Nat Genet , vol.45 , pp. 526-530
    • Ramsay, A.J.1    Quesada, V.2    Foronda, M.3
  • 21
    • 84555171449 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
    • Quesada V, Conde L, Villamor N, et al: Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 44:47-52, 2011
    • (2011) Nat Genet , vol.44 , pp. 47-52
    • Quesada, V.1    Conde, L.2    Villamor, N.3
  • 22
    • 84858859064 scopus 로고    scopus 로고
    • Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
    • Rossi D, Fangazio M, Rasi S, et al: Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 119:2854-2862, 2012
    • (2012) Blood , vol.119 , pp. 2854-2862
    • Rossi, D.1    Fangazio, M.2    Rasi, S.3
  • 23
    • 79960353160 scopus 로고    scopus 로고
    • Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
    • Fabbri G, Rasi S, Rossi D, et al: Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation. J Exp Med 208:1389-1401, 2011
    • (2011) J Exp Med , vol.208 , pp. 1389-1401
    • Fabbri, G.1    Rasi, S.2    Rossi, D.3
  • 24
    • 84874102335 scopus 로고    scopus 로고
    • Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
    • Landau DA, Carter SL, Stojanov P, et al: Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 152:714-726, 2013
    • (2013) Cell , vol.152 , pp. 714-726
    • Landau, D.A.1    Carter, S.L.2    Stojanov, P.3
  • 25
    • 84874025843 scopus 로고    scopus 로고
    • Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
    • Cibulskis K, Lawrence MS, Carter SL, et al: Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol 31:213-219, 2013
    • (2013) Nat Biotechnol , vol.31 , pp. 213-219
    • Cibulskis, K.1    Lawrence, M.S.2    Carter, S.L.3
  • 26
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-associated genes
    • Lawrence MS, Stojanov P, Polak P, et al: Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499:214-218, 2013
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1    Stojanov, P.2    Polak, P.3
  • 27
    • 84945302209 scopus 로고    scopus 로고
    • Mutations driving CLL and their evolution in progression and relapse
    • Landau DA, Tausch E, Taylor-Weiner AN, et al: Mutations driving CLL and their evolution in progression and relapse. Nature 526:525-530, 2015
    • (2015) Nature , vol.526 , pp. 525-530
    • Landau, D.A.1    Tausch, E.2    Taylor-Weiner, A.N.3
  • 28
    • 84926290739 scopus 로고    scopus 로고
    • Transcriptome sequencing reveals potential mechanism of cryptic 39 splice site selection in SF3B1-mutated cancers
    • DeBoever C, Ghia EM, Shepard PJ, et al: Transcriptome sequencing reveals potential mechanism of cryptic 39 splice site selection in SF3B1-mutated cancers. PLOS Comput Biol 11:e1004105, 2015
    • (2015) PLOS Comput Biol , vol.11 , pp. e1004105
    • DeBoever, C.1    Ghia, E.M.2    Shepard, P.J.3
  • 29
    • 84947417142 scopus 로고    scopus 로고
    • Cancer-associated SF3B1 hotspot mutations induce cryptic 39 splice site selection through use of a different branch point
    • Darman RB, Seiler M, Agrawal AA, et al: Cancer-associated SF3B1 hotspot mutations induce cryptic 39 splice site selection through use of a different branch point. Cell Reports 13:1033-1045, 2015
    • (2015) Cell Reports , vol.13 , pp. 1033-1045
    • Darman, R.B.1    Seiler, M.2    Agrawal, A.A.3
  • 30
    • 84929291816 scopus 로고    scopus 로고
    • The impact of SF3B1 mutations in CLL on the DNA-damage response
    • Te Raa GD, Derks IA, Navrkalova V, et al: The impact of SF3B1 mutations in CLL on the DNA-damage response. Leukemia 29:1133-1142, 2015
    • (2015) Leukemia , vol.29 , pp. 1133-1142
    • Te Raa, G.D.1    Derks, I.A.2    Navrkalova, V.3
  • 31
    • 85006150322 scopus 로고    scopus 로고
    • Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia
    • Wang L, Brooks AN, Fan J, et al: Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia. Cancer Cell 30:750-763, 2016
    • (2016) Cancer Cell , vol.30 , pp. 750-763
    • Wang, L.1    Brooks, A.N.2    Fan, J.3
  • 32
    • 34547780475 scopus 로고    scopus 로고
    • FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
    • O'Neil J, Grim J, Strack P, et al: FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med 204:1813-1824, 2007
    • (2007) J Exp Med , vol.204 , pp. 1813-1824
    • O'Neil, J.1    Grim, J.2    Strack, P.3
  • 33
    • 84901408966 scopus 로고    scopus 로고
    • Gene mutations and treatment outcome in chronic lymphocytic leukemia: Results from the CLL8 trial
    • Stilgenbauer S, Schnaiter A, Paschka P, et al: Gene mutations and treatment outcome in chronic lymphocytic leukemia: Results from the CLL8 trial. Blood 123:3247-3254, 2014
    • (2014) Blood , vol.123 , pp. 3247-3254
    • Stilgenbauer, S.1    Schnaiter, A.2    Paschka, P.3
  • 34
    • 36849045647 scopus 로고    scopus 로고
    • Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion
    • Austen B, Skowronska A, Baker C, et al: Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J Clin Oncol 25:5448-5457, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 5448-5457
    • Austen, B.1    Skowronska, A.2    Baker, C.3
  • 35
    • 84855860383 scopus 로고    scopus 로고
    • NOTCH1 mutations in CLL associated with trisomy 12
    • Balatti V, Bottoni A, Palamarchuk A, et al: NOTCH1 mutations in CLL associated with trisomy 12. Blood 119:329-331, 2012
    • (2012) Blood , vol.119 , pp. 329-331
    • Balatti, V.1    Bottoni, A.2    Palamarchuk, A.3
  • 36
    • 84903639208 scopus 로고    scopus 로고
    • Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations
    • Riches JC, O'Donovan CJ, Kingdon SJ, et al: Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations. Blood 123:4101-4110, 2014
    • (2014) Blood , vol.123 , pp. 4101-4110
    • Riches, J.C.1    O'Donovan, C.J.2    Kingdon, S.J.3
  • 37
    • 84912101598 scopus 로고    scopus 로고
    • CRISPR-Cas9 knockin mice for genome editing and cancer modeling
    • Platt RJ, Chen S, Zhou Y, et al: CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell 159:440-455, 2014
    • (2014) Cell , vol.159 , pp. 440-455
    • Platt, R.J.1    Chen, S.2    Zhou, Y.3
  • 38
    • 84911422892 scopus 로고    scopus 로고
    • Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing
    • Heckl D, Kowalczyk MS, Yudovich D, et al: Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing. Nat Biotechnol 32:941-946, 2014
    • (2014) Nat Biotechnol , vol.32 , pp. 941-946
    • Heckl, D.1    Kowalczyk, M.S.2    Yudovich, D.3
  • 39
    • 84991237207 scopus 로고    scopus 로고
    • Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia
    • Wang J, Khiabanian H, Rossi D, et al: Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia. Elife 3:e02869, 2014
    • (2014) Elife , vol.3 , pp. e02869
    • Wang, J.1    Khiabanian, H.2    Rossi, D.3
  • 40
    • 84868198427 scopus 로고    scopus 로고
    • Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
    • Kulis M, Heath S, Bibikova M, et al: Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet 44:1236-1242, 2012
    • (2012) Nat Genet , vol.44 , pp. 1236-1242
    • Kulis, M.1    Heath, S.2    Bibikova, M.3
  • 41
    • 84933278041 scopus 로고    scopus 로고
    • Wholegenome fingerprint of the DNA methylome during human B cell differentiation
    • Kulis M, Merkel A, Heath S, et al: Wholegenome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet 47:746-756, 2015
    • (2015) Nat Genet , vol.47 , pp. 746-756
    • Kulis, M.1    Merkel, A.2    Heath, S.3
  • 42
    • 84959519942 scopus 로고    scopus 로고
    • DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
    • Oakes CC, Seifert M, Assenov Y, et al: DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. Nat Genet 48:253-264, 2016
    • (2016) Nat Genet , vol.48 , pp. 253-264
    • Oakes, C.C.1    Seifert, M.2    Assenov, Y.3
  • 43
    • 84906908742 scopus 로고    scopus 로고
    • Acquired initiating mutations in early hematopoietic cells of CLL patients
    • Damm F, Mylonas E, Cosson A, et al: Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov 4:1088-1101, 2014
    • (2014) Cancer Discov , vol.4 , pp. 1088-1101
    • Damm, F.1    Mylonas, E.2    Cosson, A.3
  • 44
    • 80051589767 scopus 로고    scopus 로고
    • Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia
    • Kikushige Y, Ishikawa F, Miyamoto T, et al: Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell 20:246-259, 2011
    • (2011) Cancer Cell , vol.20 , pp. 246-259
    • Kikushige, Y.1    Ishikawa, F.2    Miyamoto, T.3
  • 45
    • 84958181962 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemia
    • Thompson PA, Tam CS, O'Brien SM, et al: Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemia. Blood 127:303-309, 2016
    • (2016) Blood , vol.127 , pp. 303-309
    • Thompson, P.A.1    Tam, C.S.2    O'Brien, S.M.3
  • 46
    • 84955482904 scopus 로고    scopus 로고
    • Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: Updated results of the CLL8 trial
    • Fischer K, Bahlo J, Fink AM, et al: Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: Updated results of the CLL8 trial. Blood 127:208-215, 2016
    • (2016) Blood , vol.127 , pp. 208-215
    • Fischer, K.1    Bahlo, J.2    Fink, A.M.3
  • 47
    • 84944248903 scopus 로고    scopus 로고
    • Molecular prediction of durable remission after firstline fludarabine-cyclophosphamide-rituximab in chronic lymphocytic leukemia
    • Rossi D, Terzi-di-Bergamo L, De Paoli L, et al: Molecular prediction of durable remission after firstline fludarabine-cyclophosphamide-rituximab in chronic lymphocytic leukemia. Blood 126:1921-1924, 2015
    • (2015) Blood , vol.126 , pp. 1921-1924
    • Rossi, D.1    Terzi-Di-Bergamo, L.2    De Paoli, L.3
  • 48
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissichkov T, Aldaoud A, et al: Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol 27:4378-4384, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 49
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • Kay NE, Geyer SM, Call TG, et al: Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Blood 109:405-411, 2007
    • (2007) Blood , vol.109 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3
  • 50
    • 33745942111 scopus 로고    scopus 로고
    • Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: Report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2)
    • Robak T, Blonski JZ, Gora-Tybor J, et al: Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: Report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2). Blood 108:473-479, 2006
    • (2006) Blood , vol.108 , pp. 473-479
    • Robak, T.1    Blonski, J.Z.2    Gora-Tybor, J.3
  • 51
    • 0022347576 scopus 로고
    • Treatment of chronic lymphocytic leukemia in advanced stages: A randomized trial comparing chlorambucil plus prednisone versus cyclophosphamide, vincristine, and prednisone
    • Montserrat E, Alcalá A, Parody R, et al: Treatment of chronic lymphocytic leukemia in advanced stages: A randomized trial comparing chlorambucil plus prednisone versus cyclophosphamide, vincristine, and prednisone. Cancer 56:2369-2375, 1985
    • (1985) Cancer , vol.56 , pp. 2369-2375
    • Montserrat, E.1    Alcalá, A.2    Parody, R.3
  • 52
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al: Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 343:1750-1757, 2000
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 53
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd JC, Murphy T, Howard RS, et al: Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 19:2153-2164, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3
  • 54
    • 38949185742 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study
    • Coiffier B, Lepretre S, Pedersen LM, et al: Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study. Blood 111:1094-1100, 2008
    • (2008) Blood , vol.111 , pp. 1094-1100
    • Coiffier, B.1    Lepretre, S.2    Pedersen, L.M.3
  • 55
    • 84907698941 scopus 로고    scopus 로고
    • Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: Final data from the phase 1/2 GAUGUIN study
    • Cartron G, de Guibert S, Dilhuydy M-S, et al: Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: Final data from the phase 1/2 GAUGUIN study. Blood 124:2196-2202, 2014
    • (2014) Blood , vol.124 , pp. 2196-2202
    • Cartron, G.1    De Guibert, S.2    Dilhuydy, M.-S.3
  • 56
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as firstline therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, et al: Alemtuzumab compared with chlorambucil as firstline therapy for chronic lymphocytic leukemia. J Clin Oncol 25:5616-5623, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 57
    • 84902183019 scopus 로고    scopus 로고
    • Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
    • Woyach JA, Furman RR, Liu T-M, et al: Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N Engl J Med 370:2286-2294, 2014
    • (2014) N Engl J Med , vol.370 , pp. 2286-2294
    • Woyach, J.A.1    Furman, R.R.2    Liu, T.-M.3
  • 58
    • 84891861044 scopus 로고    scopus 로고
    • Clonal evolution in hematological malignancies and therapeutic implications
    • Landau DA, Carter SL, Getz G, et al: Clonal evolution in hematological malignancies and therapeutic implications. Leukemia 28:34-43, 2014
    • (2014) Leukemia , vol.28 , pp. 34-43
    • Landau, D.A.1    Carter, S.L.2    Getz, G.3
  • 59
    • 84869753284 scopus 로고    scopus 로고
    • Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns
    • Schuh A, Becq J, Humphray S, et al: Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns. Blood 120:4191-4196, 2012
    • (2012) Blood , vol.120 , pp. 4191-4196
    • Schuh, A.1    Becq, J.2    Humphray, S.3
  • 60
    • 84988589138 scopus 로고    scopus 로고
    • A quantitative analysis of subclonal and clonal gene mutations before and after therapy in chronic lymphocytic leukemia
    • Amin NA, Seymour E, Saiya-Cork K, et al: A quantitative analysis of subclonal and clonal gene mutations before and after therapy in chronic lymphocytic leukemia. Clin Cancer Res 22:4525-4535, 2016
    • (2016) Clin Cancer Res , vol.22 , pp. 4525-4535
    • Amin, N.A.1    Seymour, E.2    Saiya-Cork, K.3
  • 61
    • 84962344611 scopus 로고    scopus 로고
    • Clinical impact of small subclones harboring NOTCH1, SF3B1 or BIRC3 mutations in chronic lymphocytic leukemia
    • Rasi S, Khiabanian H, Ciardullo C, et al: Clinical impact of small subclones harboring NOTCH1, SF3B1 or BIRC3 mutations in chronic lymphocytic leukemia. Haematologica 101:e135-e138, 2016
    • (2016) Haematologica , vol.101 , pp. e135-e138
    • Rasi, S.1    Khiabanian, H.2    Ciardullo, C.3
  • 62
    • 84927634190 scopus 로고    scopus 로고
    • Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia
    • Malcikova J, Stano-Kozubik K, Tichy B, et al: Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia. Leukemia 29:877-885, 2015
    • (2015) Leukemia , vol.29 , pp. 877-885
    • Malcikova, J.1    Stano-Kozubik, K.2    Tichy, B.3
  • 63
    • 79551504914 scopus 로고    scopus 로고
    • TP53 mutation and survival in chronic lymphocytic leukemia
    • Zenz T, Eichhorst B, Busch R, et al: TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol 28:4473-4479, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 4473-4479
    • Zenz, T.1    Eichhorst, B.2    Busch, R.3
  • 64
    • 54049141334 scopus 로고    scopus 로고
    • Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: Results from a detailed genetic characterization with long-term followup
    • Zenz T, Kröber A, Scherer K, et al: Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: Results from a detailed genetic characterization with long-term followup. Blood 112:3322-3329, 2008
    • (2008) Blood , vol.112 , pp. 3322-3329
    • Zenz, T.1    Kröber, A.2    Scherer, K.3
  • 65
    • 84899087266 scopus 로고    scopus 로고
    • Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia
    • Rossi D, Khiabanian H, Spina V, et al: Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia. Blood 123:2139-2147, 2014
    • (2014) Blood , vol.123 , pp. 2139-2147
    • Rossi, D.1    Khiabanian, H.2    Spina, V.3
  • 66
    • 84981294370 scopus 로고    scopus 로고
    • TP53 mutations are early events in chronic lymphocytic leukemia disease progression and precede evolution to complex karyotypes
    • Lazarian G, Tausch E, Eclache V, et al: TP53 mutations are early events in chronic lymphocytic leukemia disease progression and precede evolution to complex karyotypes. Int J Cancer 139:1759-1763, 2016
    • (2016) Int J Cancer , vol.139 , pp. 1759-1763
    • Lazarian, G.1    Tausch, E.2    Eclache, V.3
  • 67
    • 85016323571 scopus 로고    scopus 로고
    • Quantitative clonal dynamics define mechanisms of CLL evolution in response to combination chemotherapy
    • abstr
    • Landau DA, Tausch E, Böttcher S, et al: Quantitative clonal dynamics define mechanisms of CLL evolution in response to combination chemotherapy. Blood 126:362, 2015 (abstr)
    • (2015) Blood , vol.126 , pp. 362
    • Landau, D.A.1    Tausch, E.2    Böttcher, S.3
  • 68
    • 84945961824 scopus 로고    scopus 로고
    • Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL
    • Guièze R, Robbe P, Clifford R, et al: Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL. Blood 126:2110-2117, 2015
    • (2015) Blood , vol.126 , pp. 2110-2117
    • Guièze, R.1    Robbe, P.2    Clifford, R.3
  • 69
    • 84927656208 scopus 로고    scopus 로고
    • Functional characterization of BTK (C481S) mutation that confers ibrutinib resistance: Exploration of alternative kinase inhibitors
    • Cheng S, Guo A, Lu P, et al: Functional characterization of BTK (C481S) mutation that confers ibrutinib resistance: Exploration of alternative kinase inhibitors. Leukemia 29:895-900, 2015
    • (2015) Leukemia , vol.29 , pp. 895-900
    • Cheng, S.1    Guo, A.2    Lu, P.3
  • 70
    • 84937841721 scopus 로고    scopus 로고
    • Hypermorphic mutation of phospholipase C, g2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation
    • Liu TM, Woyach JA, Zhong Y, et al: Hypermorphic mutation of phospholipase C, g2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation. Blood 126:61-68, 2015
    • (2015) Blood , vol.126 , pp. 61-68
    • Liu, T.M.1    Woyach, J.A.2    Zhong, Y.3
  • 71
    • 84970003155 scopus 로고    scopus 로고
    • Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
    • Burger JA, Landau DA, Taylor-Weiner A, et al: Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition. Nat Commun 7:11589, 2016
    • (2016) Nat Commun , vol.7 , pp. 11589
    • Burger, J.A.1    Landau, D.A.2    Taylor-Weiner, A.3
  • 72
    • 84927732048 scopus 로고    scopus 로고
    • Threeyear follow-up of treatment-näive and previously treated patients with CLL and SLL receiving singleagent ibrutinib
    • Byrd JC, Furman RR, Coutre SE, et al: Threeyear follow-up of treatment-näive and previously treated patients with CLL and SLL receiving singleagent ibrutinib. Blood 125:2497-2506, 2015
    • (2015) Blood , vol.125 , pp. 2497-2506
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 73
    • 85002378033 scopus 로고    scopus 로고
    • Real-world results of ibrutinib in patients with relapsed or refractory chronic lymphocytic leukemia: Data from 95 consecutive patients treated in a compassionate use program-A study from the Swedish Chronic Lymphocytic Leukemia Group
    • Winqvist M, Asklid A, Andersson PO, et al: Real-world results of ibrutinib in patients with relapsed or refractory chronic lymphocytic leukemia: Data from 95 consecutive patients treated in a compassionate use program-A study from the Swedish Chronic Lymphocytic Leukemia Group. Haematologica 101:1573-1580, 2016
    • (2016) Haematologica , vol.101 , pp. 1573-1580
    • Winqvist, M.1    Asklid, A.2    Andersson, P.O.3
  • 74
    • 84943579968 scopus 로고    scopus 로고
    • Complex karyotype is a stronger predictor than del (17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens
    • Thompson PA, O'Brien SM, Wierda WG, et al: Complex karyotype is a stronger predictor than del (17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens. Cancer 121:3612-3621, 2015
    • (2015) Cancer , vol.121 , pp. 3612-3621
    • Thompson, P.A.1    O'Brien, S.M.2    Wierda, W.G.3
  • 75
    • 84924666501 scopus 로고    scopus 로고
    • Targeted next-generation sequencing in chronic lymphocytic leukemia: A high-throughput yet tailored approach will facilitate implementation in a clinical setting
    • Sutton LA, Ljungström V, Mansouri L, et al: Targeted next-generation sequencing in chronic lymphocytic leukemia: A high-throughput yet tailored approach will facilitate implementation in a clinical setting. Haematologica 100:370-376, 2015
    • (2015) Haematologica , vol.100 , pp. 370-376
    • Sutton, L.A.1    Ljungström, V.2    Mansouri, L.3
  • 76
    • 84958606331 scopus 로고    scopus 로고
    • Single-cell genome sequencing: Current state of the science
    • Gawad C, Koh W, Quake SR: Single-cell genome sequencing: Current state of the science. Nat Rev Genet 17:175-188, 2016
    • (2016) Nat Rev Genet , vol.17 , pp. 175-188
    • Gawad, C.1    Koh, W.2    Quake, S.R.3
  • 77
    • 84905455426 scopus 로고    scopus 로고
    • Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing
    • Hughes A E O, Magrini V, Demeter R, et al: Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. PLoS Genet 10:e1004462, 2014
    • (2014) PLoS Genet , vol.10 , pp. e1004462
    • Hughes, A.E.O.1    Magrini, V.2    Demeter, R.3
  • 78
    • 84943395444 scopus 로고    scopus 로고
    • Single-cell analysis in cancer genomics
    • Saadatpour A, Lai S, Guo G, et al: Single-cell analysis in cancer genomics. Trends Genet 31:576-586, 2015
    • (2015) Trends Genet , vol.31 , pp. 576-586
    • Saadatpour, A.1    Lai, S.2    Guo, G.3
  • 79
    • 0016740933 scopus 로고
    • Clinical staging of chronic lymphocytic leukemia
    • Rai KR, Sawitsky A, Cronkite EP, et al: Clinical staging of chronic lymphocytic leukemia. Blood 46:219-234, 1975
    • (1975) Blood , vol.46 , pp. 219-234
    • Rai, K.R.1    Sawitsky, A.2    Cronkite, E.P.3
  • 80
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al: Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94:1840-1847, 1999
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 81
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V (H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, et al: Unmutated Ig V (H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94:1848-1854, 1999
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 82
    • 84922529491 scopus 로고    scopus 로고
    • Recurrent mutations refine prognosis in chronic lymphocytic leukemia
    • Baliakas P, Hadzidimitriou A, Sutton LA, et al: Recurrent mutations refine prognosis in chronic lymphocytic leukemia. Leukemia 29:329-336, 2015
    • (2015) Leukemia , vol.29 , pp. 329-336
    • Baliakas, P.1    Hadzidimitriou, A.2    Sutton, L.A.3
  • 83
    • 84874428346 scopus 로고    scopus 로고
    • Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Spina V, et al: Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 121:1403-1412, 2013
    • (2013) Blood , vol.121 , pp. 1403-1412
    • Rossi, D.1    Rasi, S.2    Spina, V.3
  • 84
    • 84872469222 scopus 로고    scopus 로고
    • The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
    • Oscier DG, Rose-Zerilli MJ, Winkelmann N, et al: The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial. Blood 121:468-475, 2013
    • (2013) Blood , vol.121 , pp. 468-475
    • Oscier, D.G.1    Rose-Zerilli, M.J.2    Winkelmann, N.3
  • 85
    • 84966746552 scopus 로고    scopus 로고
    • An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): A meta-analysis of individual patient data
    • International CLL-IPI Working Group: An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): A meta-analysis of individual patient data. Lancet Oncol 17:779-790, 2016
    • (2016) Lancet Oncol , vol.17 , pp. 779-790
  • 86
    • 84891866590 scopus 로고    scopus 로고
    • SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients
    • Jeromin S, Weissmann S, Haferlach C, et al: SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients. Leukemia 28:108-117, 2014
    • (2014) Leukemia , vol.28 , pp. 108-117
    • Jeromin, S.1    Weissmann, S.2    Haferlach, C.3
  • 87
    • 84873567287 scopus 로고    scopus 로고
    • NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia
    • Mansouri L, Cahill N, Gunnarsson R, et al: NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia. Leukemia 27:512-514, 2013
    • (2013) Leukemia , vol.27 , pp. 512-514
    • Mansouri, L.1    Cahill, N.2    Gunnarsson, R.3
  • 88
    • 84895798179 scopus 로고    scopus 로고
    • On the way towards a "CLL prognostic index": Focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort
    • Cortese D, Sutton LA, Cahill N, et al: On the way towards a "CLL prognostic index": Focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort. Leukemia 28:710-713, 2014
    • (2014) Leukemia , vol.28 , pp. 710-713
    • Cortese, D.1    Sutton, L.A.2    Cahill, N.3
  • 89
    • 84879173666 scopus 로고    scopus 로고
    • TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: Six-year follow-up of the GCLLSG CLL3X trial
    • Dreger P, Schnaiter A, Zenz T, et al: TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: Six-year follow-up of the GCLLSG CLL3X trial. Blood 121:3284-3288, 2013
    • (2013) Blood , vol.121 , pp. 3284-3288
    • Dreger, P.1    Schnaiter, A.2    Zenz, T.3
  • 90
    • 84855854025 scopus 로고    scopus 로고
    • Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Fabbri G, et al: Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 119:521-529, 2012
    • (2012) Blood , vol.119 , pp. 521-529
    • Rossi, D.1    Rasi, S.2    Fabbri, G.3
  • 91
    • 84953366342 scopus 로고    scopus 로고
    • NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: Evidence for a NOTCH1 mutation-driven epigenetic dysregulation
    • Pozzo F, Bittolo T, Arruga F, et al: NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: Evidence for a NOTCH1 mutation-driven epigenetic dysregulation. Leukemia 30:182-189, 2016
    • (2016) Leukemia , vol.30 , pp. 182-189
    • Pozzo, F.1    Bittolo, T.2    Arruga, F.3
  • 92
    • 27644450586 scopus 로고    scopus 로고
    • Mutations in the ATM gene lead to impaired overall and treatmentfree survival that is independent of IGVH mutation status in patients with B-CLL
    • Austen B, Powell JE, Alvi A, et al: Mutations in the ATM gene lead to impaired overall and treatmentfree survival that is independent of IGVH mutation status in patients with B-CLL. Blood 106:3175-3182, 2005
    • (2005) Blood , vol.106 , pp. 3175-3182
    • Austen, B.1    Powell, J.E.2    Alvi, A.3
  • 93
    • 84871798242 scopus 로고    scopus 로고
    • Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial
    • Skowronska A, Parker A, Ahmed G, et al: Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial. J Clin Oncol 30:4524-4532, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 4524-4532
    • Skowronska, A.1    Parker, A.2    Ahmed, G.3
  • 94
    • 84979500512 scopus 로고    scopus 로고
    • Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy
    • Herling CD, Klaumunzer M, Rocha CK, et al: Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy. Blood 128:395-404, 2016
    • (2016) Blood , vol.128 , pp. 395-404
    • Herling, C.D.1    Klaumunzer, M.2    Rocha, C.K.3
  • 95
    • 84922702326 scopus 로고    scopus 로고
    • Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia
    • Kampjarvi K, Jarvinen TM, Heikkinen T, et al: Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia. Oncotarget 6:1884-1888, 2015
    • (2015) Oncotarget , vol.6 , pp. 1884-1888
    • Kampjarvi, K.1    Jarvinen, T.M.2    Heikkinen, T.3
  • 96
    • 84973622859 scopus 로고    scopus 로고
    • Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia
    • Parker H, Rose-Zerilli MJ, Larrayoz M, et al: Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. Leukemia 30:2179-2186, 2016
    • (2016) Leukemia , vol.30 , pp. 2179-2186
    • Parker, H.1    Rose-Zerilli, M.J.2    Larrayoz, M.3
  • 97
    • 84973879698 scopus 로고    scopus 로고
    • Genomic classification and prognosis in acute myeloid leukemia
    • Papaemmanuil E, Gerstung M, Bullinger L, et al: Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med 374:2209-2221, 2016
    • (2016) N Engl J Med , vol.374 , pp. 2209-2221
    • Papaemmanuil, E.1    Gerstung, M.2    Bullinger, L.3
  • 98
    • 84863778287 scopus 로고    scopus 로고
    • ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia
    • Pospisilova S, Gonzalez D, Malcikova J, et al: ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia 26:1458-1461, 2012
    • (2012) Leukemia , vol.26 , pp. 1458-1461
    • Pospisilova, S.1    Gonzalez, D.2    Malcikova, J.3
  • 99
    • 84928253067 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment
    • Hallek M: Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. Am J Hematol 90:446-460, 2015
    • (2015) Am J Hematol , vol.90 , pp. 446-460
    • Hallek, M.1
  • 100
    • 33845543049 scopus 로고    scopus 로고
    • Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus
    • Dreger P, Corradini P, Kimby E, et al: Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia 21:12-17, 2007
    • (2007) Leukemia , vol.21 , pp. 12-17
    • Dreger, P.1    Corradini, P.2    Kimby, E.3
  • 101
    • 84970032000 scopus 로고    scopus 로고
    • Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: A multicentre, openlabel, phase 2 study
    • Stilgenbauer S, Eichhorst B, Schetelig J, et al: Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: A multicentre, openlabel, phase 2 study. Lancet Oncol 17:768-778, 2016
    • (2016) Lancet Oncol , vol.17 , pp. 768-778
    • Stilgenbauer, S.1    Eichhorst, B.2    Schetelig, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.