메뉴 건너뛰기




Volumn 30, Issue 11, 2016, Pages 2179-2186

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia

(38)  Parker, H a   Rose Zerilli, M J J a   Larrayoz, M a   Clifford, R b   Edelmann, J c   Blakemore, S a   Gibson, J a   Wang, J d   Ljungstrom V e   Wojdacz, T K a   Chaplin, T d   Roghanian, A a   Davis, Z f   Parker, A f   Tausch, E c   Ntoufa, S g   Ramos, S b   Robbe, P b   Alsolami, R b   Steele, A J a   more..

h CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; HISTONE METHYLTRANSFERASE; MESSENGER RNA; PROTEIN P53; HISTONE LYSINE METHYLTRANSFERASE; SET2 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

EID: 84973622859     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2016.134     Document Type: Article
Times cited : (68)

References (44)
  • 1
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome-biological and translational implications
    • Baylin SB, Jones PA. A decade of exploring the cancer epigenome-biological and translational implications. Nat Rev Cancer 2011; 11: 726-734.
    • (2011) Nat Rev Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 2
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010; 21: 360-363.
    • (2010) Nature , vol.21 , pp. 360-363
    • Dalgliesh, G.L.1    Furge, K.2    Greenman, C.3    Chen, L.4    Bignell, G.5    Butler, A.6
  • 4
    • 84862907593 scopus 로고    scopus 로고
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    • Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012; 481: 157-163.
    • (2012) Nature , vol.481 , pp. 157-163
    • Zhang, J.1    Ding, L.2    Holmfeldt, L.3    Wu, G.4    Heatley, S.L.5    Payne-Turner, D.6
  • 5
    • 84895885401 scopus 로고    scopus 로고
    • Identification of functional cooperative mutations of SETD2 in human acute leukemia
    • Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y et al. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet 2014; 46: 287-293.
    • (2014) Nat Genet , vol.46 , pp. 287-293
    • Zhu, X.1    He, F.2    Zeng, H.3    Ling, S.4    Chen, A.5    Wang, Y.6
  • 6
    • 77953170322 scopus 로고    scopus 로고
    • Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma
    • Duns G, van den Berg E, van Duivenbode I, Osinga J, Hollema H, Hofstra RM et al. Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma. Cancer Res 2010; 70: 4287-4291.
    • (2010) Cancer Res , vol.70 , pp. 4287-4291
    • Duns, G.1    Van Den Berg, E.2    Van Duivenbode, I.3    Osinga, J.4    Hollema, H.5    Hofstra, R.M.6
  • 7
    • 84903451450 scopus 로고    scopus 로고
    • SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability
    • Pfister SX, Ahrabi S, Zalmas LP, Sarkar S, Aymard F, Bachrati CZ et al. SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep 2014; 7: 2006-2018.
    • (2014) Cell Rep , vol.7 , pp. 2006-2018
    • Pfister, S.X.1    Ahrabi, S.2    Zalmas, L.P.3    Sarkar, S.4    Aymard, F.5    Bachrati, C.Z.6
  • 8
    • 84899849011 scopus 로고    scopus 로고
    • SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
    • Carvalho S, Vítor AC, Sridhara SC, Martins FB, Raposo AC, Desterro JM et al. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. Elife 2014, e02482.
    • (2014) Elife , pp. e02482
    • Carvalho, S.1    Vítor, A.C.2    Sridhara, S.C.3    Martins, F.B.4    Raposo, A.C.5    Desterro, J.M.6
  • 9
    • 84947034149 scopus 로고    scopus 로고
    • SETD2 loss-offunction promotes renal cancer branched evolution through replication stress and impaired DNA repair
    • Kanu N, Grönroos E, Martinez P, Burrell RA, YiGoh X, Bartkova J et al. SETD2 loss-offunction promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene 2015; 34: 5699-5708.
    • (2015) Oncogene , vol.34 , pp. 5699-5708
    • Kanu, N.1    Grönroos, E.2    Martinez, P.3    Burrell, R.A.4    YiGoh, X.5    Bartkova, J.6
  • 10
    • 84937856647 scopus 로고    scopus 로고
    • Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia
    • Guièze R, Wu CJ. Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia. Blood 2015; 126: 445-453.
    • (2015) Blood , vol.126 , pp. 445-453
    • Guièze, R.1    Wu, C.J.2
  • 11
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
    • Catovsky D, Richards S, Matutes E, Oscier D, Dyer MJ, Bezares RF et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial. Lancet 2007; 370: 230-239.
    • (2007) Lancet , vol.370 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Matutes, E.3    Oscier, D.4    Dyer, M.J.5    Bezares, R.F.6
  • 12
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, Fink AM, Busch R, Mayer J et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial. Lancet 2010; 376: 1164-1174.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3    Fink, A.M.4    Busch, R.5    Mayer, J.6
  • 13
    • 77957809872 scopus 로고    scopus 로고
    • Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation
    • Oscier D, Wade R, Davis Z, Morilla A, Best G, Richards S et al. Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation. Haematologica 2010; 95: 1705-1712.
    • (2010) Haematologica , vol.95 , pp. 1705-1712
    • Oscier, D.1    Wade, R.2    Davis, Z.3    Morilla, A.4    Best, G.5    Richards, S.6
  • 14
    • 84892529734 scopus 로고    scopus 로고
    • Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma
    • Parry M, Rose-Zerilli MJ, Gibson J, Ennis S, Walewska R, Forster J et al. Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma. PLoS One 2013; 8: e83244.
    • (2013) PLoS One , vol.8 , pp. e83244
    • Parry, M.1    Rose-Zerilli, M.J.2    Gibson, J.3    Ennis, S.4    Walewska, R.5    Forster, J.6
  • 15
    • 79952453663 scopus 로고    scopus 로고
    • 13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia
    • Parker H, Rose-Zerilli M, Parker A, Chaplin T, Chen X, Wade R et al. 13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia. Leukemia 2011; 25: 489-497.
    • (2011) Leukemia , vol.25 , pp. 489-497
    • Parker, H.1    Rose-Zerilli, M.2    Parker, A.3    Chaplin, T.4    Chen, X.5    Wade, R.6
  • 16
    • 84897434576 scopus 로고    scopus 로고
    • ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia, data from the UK LRF CLL4 trial
    • Rose-Zerilli M, Forster J, Parker H, Parker A, Rodriguez A, Chaplin T et al. ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia, data from the UK LRF CLL4 trial. Haematologica 2014; 99: 736-742.
    • (2014) Haematologica , vol.99 , pp. 736-742
    • Rose-Zerilli, M.1    Forster, J.2    Parker, H.3    Parker, A.4    Rodriguez, A.5    Chaplin, T.6
  • 17
    • 84993679871 scopus 로고    scopus 로고
    • High resolution genomic profiling of primary "ultra high risk" and refractory chronic lymphocytic leukemia: Results from the CLL2O Trial
    • Edelmann J, Saub J, Ibach S, Holzmann K, Tausch E, Bloehdorn J et al. High resolution genomic profiling of primary "ultra high risk" and refractory chronic lymphocytic leukemia: results from the CLL2O Trial. Blood (ASH Annual Meeting Abstracts) 2014; 120: 3288.
    • (2014) Blood (ASH Annual Meeting Abstracts) , vol.120 , pp. 3288
    • Edelmann, J.1    Saub, J.2    Ibach, S.3    Holzmann, K.4    Tausch, E.5    Bloehdorn, J.6
  • 18
    • 84870763388 scopus 로고    scopus 로고
    • Highresolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations
    • Edelmann J, Holzmann K, Miller F, Winkler D, Bühler A, Zenz T et al. Highresolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations. Blood 2012; 120: 4783-4794.
    • (2012) Blood , vol.120 , pp. 4783-4794
    • Edelmann, J.1    Holzmann, K.2    Miller, F.3    Winkler, D.4    Bühler, A.5    Zenz, T.6
  • 19
    • 84863785266 scopus 로고    scopus 로고
    • Quantification of subclonal distributions of recurrent genomic aberrations in paired pretreatment and relapse samples from patients with B-cell chronic lymphocytic leukemia
    • Knight SJ, Yau C, Clifford R, Timbs AT, Sadighi Akha E, Dréau HM et al. Quantification of subclonal distributions of recurrent genomic aberrations in paired pretreatment and relapse samples from patients with B-cell chronic lymphocytic leukemia. Leukemia 2012; 26: 1564-1575.
    • (2012) Leukemia , vol.26 , pp. 1564-1575
    • Knight, S.J.1    Yau, C.2    Clifford, R.3    Timbs, A.T.4    Sadighi Akha, E.5    Dréau, H.M.6
  • 20
    • 84897585594 scopus 로고    scopus 로고
    • SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage
    • Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT et al. SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood 2014; 123: 1021-1031.
    • (2014) Blood , vol.123 , pp. 1021-1031
    • Clifford, R.1    Louis, T.2    Robbe, P.3    Ackroyd, S.4    Burns, A.5    Timbs, A.T.6
  • 21
    • 84942742967 scopus 로고    scopus 로고
    • Genetics and prognostication in splenic marginal zone lymphoma: Revelations from deep sequencing
    • Parry M, Rose-Zerilli MJJ, Ljungström V, Gibson J, Wang J, Walewska R et al. Genetics and prognostication in splenic marginal zone lymphoma: revelations from deep sequencing. Clin Cancer Res 2015; 21: 4174-4183.
    • (2015) Clin Cancer Res , vol.21 , pp. 4174-4183
    • Parry, M.1    Rose-Zerilli, M.J.J.2    Ljungström, V.3    Gibson, J.4    Wang, J.5    Walewska, R.6
  • 22
    • 84993673781 scopus 로고    scopus 로고
    • Comprehensive Genome-wide Analysis of CLL Samples from UK 1st Line and Relapsed/Refractory
    • EHA Annual Meeting Abstracts, 2013:EHA18ABSSUB-4559
    • Robbe P, Clifford R, Timbs A, Burns A, Titsias M, Cabes M et al. Comprehensive Genome-wide Analysis of CLL Samples from UK 1st Line and Relapsed/Refractory. Clinical Trials. EHA Annual Meeting Abstracts, 2013:EHA18ABSSUB-4559.
    • Clinical Trials
    • Robbe, P.1    Clifford, R.2    Timbs, A.3    Burns, A.4    Titsias, M.5    Cabes, M.6
  • 24
    • 55949125130 scopus 로고    scopus 로고
    • Variable breakpoints target PAX5 in patients with dicentric chromosomes: A model for the basis of unbalanced translocations in cancer
    • An Q, Wright SL, Konn ZJ, Matheson E, Minto L, Moorman AV et al. Variable breakpoints target PAX5 in patients with dicentric chromosomes: A model for the basis of unbalanced translocations in cancer. Proc Natl Acad Sci USA 2008; 105: 17050-17054.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17050-17054
    • An, Q.1    Wright, S.L.2    Konn, Z.J.3    Matheson, E.4    Minto, L.5    Moorman, A.V.6
  • 25
    • 76049087341 scopus 로고    scopus 로고
    • Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks
    • Ouillette P, Fossum S, Parkin B, Ding L, Bockenstedt P, Al-Zoubi A et al. Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks. Clin Cancer Res 2010; 16: 835-847.
    • (2010) Clin Cancer Res , vol.16 , pp. 835-847
    • Ouillette, P.1    Fossum, S.2    Parkin, B.3    Ding, L.4    Bockenstedt, P.5    Al-Zoubi, A.6
  • 26
    • 79955166265 scopus 로고    scopus 로고
    • GISTIC2. 0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
    • Mermel CH, Schumacher SE, Hill B, Meyerson ML, Beroukhim R, Getz G. GISTIC2. 0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol 2011; 12: R41.
    • (2011) Genome Biol , vol.12 , pp. R41
    • Mermel, C.H.1    Schumacher, S.E.2    Hill, B.3    Meyerson, M.L.4    Beroukhim, R.5    Getz, G.6
  • 27
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
    • Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res 2011; 39: D945-D950.
    • (2011) Nucleic Acids Res , vol.39 , pp. D945-D950
    • Forbes, S.A.1    Bindal, N.2    Bamford, S.3    Cole, C.4    Kok, C.Y.5    Beare, D.6
  • 31
    • 38549139593 scopus 로고    scopus 로고
    • Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
    • Edmunds JW, Mahadevan LC, Clayton AL. Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J 2008; 27: 406-420.
    • (2008) EMBO J , vol.27 , pp. 406-420
    • Edmunds, J.W.1    Mahadevan, L.C.2    Clayton, A.L.3
  • 32
    • 58049206591 scopus 로고    scopus 로고
    • The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYP/Setd2-mediated histone H3K36 methylation
    • Yoh SM, Lucas JS, Jones KA. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYP/Setd2-mediated histone H3K36 methylation. Gene Dev 2008; 22: 3422-3434.
    • (2008) Gene Dev , vol.22 , pp. 3422-3434
    • Yoh, S.M.1    Lucas, J.S.2    Jones, K.A.3
  • 33
    • 84856120332 scopus 로고    scopus 로고
    • Understanding the language of Lys36 methylation at histone H3
    • Wagner EJ, Carpenter PB. Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol 2012; 13: 115-126.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 115-126
    • Wagner, E.J.1    Carpenter, P.B.2
  • 34
    • 84876943255 scopus 로고    scopus 로고
    • The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutS
    • Li F, Mao G, Tong D, Huang J, Gu L, Yang W et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutS. Cell 2013; 153: 590-600.
    • (2013) Cell , vol.153 , pp. 590-600
    • Li, F.1    Mao, G.2    Tong, D.3    Huang, J.4    Gu, L.5    Yang, W.6
  • 36
    • 27444436367 scopus 로고    scopus 로고
    • Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase
    • Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH et al. Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem 2005; 280: 35261-35271.
    • (2005) J Biol Chem , vol.280 , pp. 35261-35271
    • Sun, X.J.1    Wei, J.2    Wu, X.Y.3    Hu, M.4    Wang, L.5    Wang, H.H.6
  • 37
    • 84907304074 scopus 로고    scopus 로고
    • The landscape of somatic mutations in epigenetic regulators across 1, 000 paediatric cancer genomes
    • Huether R, Dong L, Chen X, Wu G, Parker M, Wei L et al. The landscape of somatic mutations in epigenetic regulators across 1, 000 paediatric cancer genomes. Nat Commun 2014; 3: 3630.
    • (2014) Nat Commun , vol.3 , pp. 3630
    • Huether, R.1    Dong, L.2    Chen, X.3    Wu, G.4    Parker, M.5    Wei, L.6
  • 38
    • 84907418637 scopus 로고    scopus 로고
    • Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia
    • Mar BG, Bullinger LB, McLean KM, Grauman PV, Harris MH, Stevenson K et al. Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia. Nat Commun 2014; 5: 3469.
    • (2014) Nat Commun , vol.5 , pp. 3469
    • Mar, B.G.1    Bullinger, L.B.2    McLean, K.M.3    Grauman, P.V.4    Harris, M.H.5    Stevenson, K.6
  • 39
    • 84897133117 scopus 로고    scopus 로고
    • MOSAIK: A hash-based algorithm for accurate next-generation sequencing short-read mapping
    • Lee WP, Stromberg MP, Ward A, Stewart C, Garrison EP, Marth GT. MOSAIK: A hash-based algorithm for accurate next-generation sequencing short-read mapping. PLoS One 2014; 9: e90581.
    • (2014) PLoS One , vol.9 , pp. e90581
    • Lee, W.P.1    Stromberg, M.P.2    Ward, A.3    Stewart, C.4    Garrison, E.P.5    Marth, G.T.6
  • 41
    • 84868198427 scopus 로고    scopus 로고
    • Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
    • Kulis M, Heath S, Bibikova M, Queirós AC, Navarro A, Clot G et al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet 2012; 44: 1236-1242.
    • (2012) Nat Genet , vol.44 , pp. 1236-1242
    • Kulis, M.1    Heath, S.2    Bibikova, M.3    Queirós, A.C.4    Navarro, A.5    Clot, G.6
  • 42
    • 33847246805 scopus 로고    scopus 로고
    • Oncomine 3. 0: Genes, pathways, and networks in a collection of 18, 000 cancer gene expression profiles
    • Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB et al. Oncomine 3. 0: genes, pathways, and networks in a collection of 18, 000 cancer gene expression profiles. Neoplasia 2007; 9: 166-180.
    • (2007) Neoplasia , vol.9 , pp. 166-180
    • Rhodes, D.R.1    Kalyana-Sundaram, S.2    Mahavisno, V.3    Varambally, R.4    Yu, J.5    Briggs, B.B.6
  • 43
    • 46849115153 scopus 로고    scopus 로고
    • Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes
    • Xie P, Tian C, An L, Nie J, Lu K, Xing G et al. Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes. Cell Signal 2008; 20: 1671-1678.
    • (2008) Cell Signal , vol.20 , pp. 1671-1678
    • Xie, P.1    Tian, C.2    An, L.3    Nie, J.4    Lu, K.5    Xing, G.6
  • 44
    • 84922394461 scopus 로고    scopus 로고
    • Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss
    • Gross AM, Orosco RK, Shen JP, Egloff AM, Carter H, Hofree M et al. Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss. Nat Genet 2014; 46: 939-943.
    • (2014) Nat Genet , vol.46 , pp. 939-943
    • Gross, A.M.1    Orosco, R.K.2    Shen, J.P.3    Egloff, A.M.4    Carter, H.5    Hofree, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.