Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

Gastroenterology

Volumn 152, Issue 5, 2017, Pages 1126-1138.e6

  de Boer, Jan Freark ^a   Schonewille, Marleen ^a   Boesjes, Marije ^a   Wolters, Henk ^a   Bloks, Vincent W ^a   Bos, Trijnie ^a   van Dijk, Theo H ^a   Jurdzinski, Angelika ^a   Boverhof, Renze ^a   Wolters, Justina C ^a   Kuivenhoven, Jan A ^a   van Deursen, Jan M ^b   Oude Elferink, Ronald P J ^c   Moschetta, Antonio ^d   Kremoser, Claus ^e   Verkade, Henkjan J ^a   Kuipers, Folkert ^a   Groen, Albert K ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b MAYO GRADUATE SCHOOL   (United States)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UNIVERSITY OF BARI   (Italy)

^e PHENEX PHARMACEUTICALS AG   (Germany)

Author keywords

ABCG5 G8; Bile Salts; Metabolism; RCT; TICE

Indexed keywords

ACETATE C 13; BILE SALT; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL D5; CHOLESTEROL D7; CHOLESTEROL DERIVATIVE; EZETIMIBE; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR 19; HORMONE RECEPTOR STIMULATING AGENT; OXYGENASE; PX 20606; STEROL 12 ALPHA HYDROXYLASE; TRACER; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 4-(2-(2-CHLORO-4-((5-CYCLOPROPYL-3-(2,6-DICHLOROPHENYL)-4-ISOXAZOLYL)METHOXY)PHENYL)CYCLOPROPYL)BENZOIC ACID; ABC TRANSPORTER G8; ABCG8 PROTEIN, MOUSE; BENZOIC ACID DERIVATIVE; BILE ACID; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15, MOUSE; HYPOCHOLESTEROLEMIC AGENT; ISOXAZOLE DERIVATIVE; LIPOPROTEIN;

ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; ENTEROHEPATIC CIRCULATION; FECES; GENE EXPRESSION; HUMAN; HYDROPHILICITY; HYPERLIPIDEMIA; INTESTINE CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE; STEROL EXCRETION; UPREGULATION; AGONISTS; ANIMAL; BILE DUCT; DRUG EFFECTS; GENETICS; INTESTINAL EXCRETION; INTESTINE; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; SECRETION (PROCESS); TRANSGENIC MOUSE; WISTAR RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY G, MEMBER 8; BENZOATES; BILE ACIDS AND SALTS; BILE DUCTS; CHOLESTEROL; EZETIMIBE; FIBROBLAST GROWTH FACTORS; INTESTINAL ELIMINATION; INTESTINAL MUCOSA; INTESTINES; ISOXAZOLES; LIPOPROTEINS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 85016192338     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.12.037     Document Type: Article

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