메뉴 건너뛰기




Volumn 9, Issue 4, 2017, Pages

Fructose‐rich diet affects mitochondrial DNA damage and repair in rats

Author keywords

Fructose rich diet; Mitochondrial biogenesis; Mitochondrial DNA (mtDNA); Oxidative damage; Repair mechanisms

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA ACTIN; DNA DIRECTED DNA POLYMERASE GAMMA; FRUCTOSE; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MYELOPEROXIDASE; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; THIOBARBITURIC ACID REACTIVE SUBSTANCE; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; MESSENGER RNA; MITOCHONDRIAL DNA; PEROXIDASE;

EID: 85016165683     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9040323     Document Type: Article
Times cited : (75)

References (50)
  • 1
    • 66749107383 scopus 로고    scopus 로고
    • National estimates of dietary fructose intake increased from 1977 to 2004 in the United States
    • Marriott, B.P.; Cole, N.; Lee, E. National estimates of dietary fructose intake increased from 1977 to 2004 in the United States. J. Nutr. 2009, 139, 1S–8S.
    • (2009) J. Nutr. , vol.139 , pp. 1S-8S
    • Marriott, B.P.1    Cole, N.2    Lee, E.3
  • 2
    • 0027451819 scopus 로고
    • Manufacturing, composition, and applications of fructose
    • Hanover, L.M.; White, J.S. Manufacturing, composition, and applications of fructose. Am. J. Clin. Nutr. 1993, 58, 724S–732S.
    • (1993) Am. J. Clin. Nutr. , vol.58 , pp. 724S-732S
    • Hanover, L.M.1    White, J.S.2
  • 3
    • 2142815151 scopus 로고    scopus 로고
    • Consumption of high‐fructose corn syrup in beverages may play a role in the epidemic of obesity
    • Bray, G.A.; Nielsen, S.J.; Popkin, B.M. Consumption of high‐fructose corn syrup in beverages may play a role in the epidemic of obesity. Am. J. Clin. Nutr. 2004, 79, 537–543.
    • (2004) Am. J. Clin. Nutr. , vol.79 , pp. 537-543
    • Bray, G.A.1    Nielsen, S.J.2    Popkin, B.M.3
  • 4
    • 77951023327 scopus 로고    scopus 로고
    • Sugar‐sweetened beverages and risk of obesity and type 2 diabetes: Epidemiological evidence
    • Hu, F.B.; Malik, V.S. Sugar‐sweetened beverages and risk of obesity and type 2 diabetes: Epidemiological evidence. Physiol. Behav. 2010, 100, 47–54.
    • (2010) Physiol. Behav. , vol.100 , pp. 47-54
    • Hu, F.B.1    Malik, V.S.2
  • 5
    • 78349283092 scopus 로고    scopus 로고
    • Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome
    • Dekker, M.J.; Su, Q.; Baker, C.; Rutledge, A.C.; Adeli, K. Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. Am. J. Physiol. 2010, 299, E685–E694.
    • (2010) Am. J. Physiol. , vol.299 , pp. E685-E694
    • Dekker, M.J.1    Su, Q.2    Baker, C.3    Rutledge, A.C.4    Adeli, K.5
  • 6
    • 77957652786 scopus 로고    scopus 로고
    • Fructose and metabolic diseases: New findings, new questions
    • Tappy, L.; Le, K.A.; Tran, C.; Paquot, N. Fructose and metabolic diseases: New findings, new questions. Nutrition 2010, 26, 1044–1049.
    • (2010) Nutrition , vol.26 , pp. 1044-1049
    • Tappy, L.1    Le, K.A.2    Tran, C.3    Paquot, N.4
  • 7
    • 84888385693 scopus 로고    scopus 로고
    • Increased skeletal muscle mitochondrial efficiency in rats with fructose‐induced alteration in glucose tolerance
    • Crescenzo, R.; Bianco, F.; Coppola, P.; Mazzoli, A.; Cigliano, L.; Liverini, G.; Iossa, S. Increased skeletal muscle mitochondrial efficiency in rats with fructose‐induced alteration in glucose tolerance. Br. J. Nutr. 2013, 110, 1996–2003.
    • (2013) Br. J. Nutr. , vol.110 , pp. 1996-2003
    • Crescenzo, R.1    Bianco, F.2    Coppola, P.3    Mazzoli, A.4    Cigliano, L.5    Liverini, G.6    Iossa, S.7
  • 9
    • 84924978525 scopus 로고    scopus 로고
    • Reactive oxygen species‐induced TXNIP drives fructose‐mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation
    • Zhang, X.; Zhang, J.H.; Chen, X.Y.; Hu, Q.H.; Wang, M.X.; Jin, R.; Zhang, Q.Y.; Wang, W.; Wang, R.; Kang, L.L.; et al. Reactive oxygen species‐induced TXNIP drives fructose‐mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid. Redox Signal. 2015, 22, 848–870.
    • (2015) Antioxid. Redox Signal , vol.22 , pp. 848-870
    • Zhang, X.1    Zhang, J.H.2    Chen, X.Y.3    Hu, Q.H.4    Wang, M.X.5    Jin, R.6    Zhang, Q.Y.7    Wang, W.8    Wang, R.9    Kang, L.L.10
  • 10
    • 84901704848 scopus 로고    scopus 로고
    • Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis
    • Su, Q.; Baker, C.; Christian, P.; Naples, M.; Tong, X.; Zhang, K.; Santha, M.; Adeli, K. Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis. Am. J. Physiol. Endocrinol. Metab. 2014, 306, E1264–E1273.
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. E1264-E1273
    • Su, Q.1    Baker, C.2    Christian, P.3    Naples, M.4    Tong, X.5    Zhang, K.6    Santha, M.7    Adeli, K.8
  • 11
    • 84879550625 scopus 로고    scopus 로고
    • Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose
    • Crescenzo, R.; Bianco, F.; Falcone, I.; Coppola, P.; Coppola, P.; Liverini, G.; Iossa, S. Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose. Eur. J. Nutr. 2013, 52, 537–545.
    • (2013) Eur. J. Nutr. , vol.52 , pp. 537-545
    • Crescenzo, R.1    Bianco, F.2    Falcone, I.3    Coppola, P.4    Coppola, P.5    Liverini, G.6    Iossa, S.7
  • 12
    • 75149166672 scopus 로고    scopus 로고
    • Metabolic effects of fructose and the worldwide increase in obesity
    • Tappy, L.; Le, K.A. Metabolic effects of fructose and the worldwide increase in obesity. Physiol. Rev. 2010, 90, 23–46.
    • (2010) Physiol. Rev. , vol.90 , pp. 23-46
    • Tappy, L.1    Le, K.A.2
  • 14
    • 84868327863 scopus 로고    scopus 로고
    • Lipoic acid prevents liver metabolic changes induced by administration of a fructose‐rich diet
    • Castro, M.C.; Massa, M.L.; Schinella, G.; Gagliardino, J.J.; Francini, F. Lipoic acid prevents liver metabolic changes induced by administration of a fructose‐rich diet. Biochim. Biophys. Acta 2013, 1830, 2226–2232.
    • (2013) Biochim. Biophys. Acta , vol.1830 , pp. 2226-2232
    • Castro, M.C.1    Massa, M.L.2    Schinella, G.3    Gagliardino, J.J.4    Francini, F.5
  • 15
    • 84891693360 scopus 로고    scopus 로고
    • Lipoic acid prevents fructose‐induced changes in liver carbohydrate metabolism: Role of oxidative stress
    • Castro, M.C.; Francini, F.; Gagliardino, J.J.; Massa, M.L. Lipoic acid prevents fructose‐induced changes in liver carbohydrate metabolism: Role of oxidative stress. Biochim. Biophys. Acta 2014, 1840, 1145–1151.
    • (2014) Biochim. Biophys. Acta , vol.1840 , pp. 1145-1151
    • Castro, M.C.1    Francini, F.2    Gagliardino, J.J.3    Massa, M.L.4
  • 16
    • 84869996114 scopus 로고    scopus 로고
    • Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: Potential role in fructose‐dependent and ‐independent fatty liver
    • Lanaspa, M.A.; Sanchez-Lozada, L.G.; Choi, Y.J.; Cicerchi, C.; Kanbay, M.; Roncal-Jimenez, C.A.; Ishimoto, T.; Li, N.; Marek, G.; Duranay, M.; et al. Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: Potential role in fructose‐dependent and ‐independent fatty liver. J. Biol. Chem. 2012, 287, 40732–40744.
    • (2012) J. Biol. Chem , vol.287 , pp. 40732-40744
    • Lanaspa, M.A.1    Sanchez-Lozada, L.G.2    Choi, Y.J.3    Cicerchi, C.4    Kanbay, M.5    Roncal-Jimenez, C.A.6    Ishimoto, T.7    Li, N.8    Marek, G.9    Duranay, M.10
  • 17
    • 67349091737 scopus 로고    scopus 로고
    • Oxidative stress and metabolic syndrome
    • Roberts, C.K.; Sindhu, K.K. Oxidative stress and metabolic syndrome. Life Sci. 2009, 84, 705–712.
    • (2009) Life Sci , vol.84 , pp. 705-712
    • Roberts, C.K.1    Sindhu, K.K.2
  • 18
    • 79551470306 scopus 로고    scopus 로고
    • Oxidative stress, insulin signaling, and diabetes
    • Rains, J.L.; Jain, S.K. Oxidative stress, insulin signaling, and diabetes. Free Rad Biol Med. 2011, 50, 567–575.
    • (2011) Free Rad Biol Med , vol.50 , pp. 567-575
    • Rains, J.L.1    Jain, S.K.2
  • 20
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis, N.; Rosen, E.D.; Lander, E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440, 944–948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 21
    • 46749149676 scopus 로고    scopus 로고
    • Oxidative stress‐induced risk factors associated with the metabolic syndrome: A unifying hypothesis
    • Grattagliano, I.; Palmieri, V.O.; Portincasa, P.; Moschetta, A.; Palasciano, G. Oxidative stress‐induced risk factors associated with the metabolic syndrome: A unifying hypothesis. J. Nutr. Biochem. 2008, 19, 491–504.
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 491-504
    • Grattagliano, I.1    Palmieri, V.O.2    Portincasa, P.3    Moschetta, A.4    Palasciano, G.5
  • 22
    • 84939193121 scopus 로고    scopus 로고
    • Fructose‐drinking water induced nonalcoholic fatty liver disease and ultrastructural alteration of hepatocyte mitochondria in male Wistar rat
    • Mamikutty, N.; Thent, Z.C.; Haji Suhaimi, F. Fructose‐drinking water induced nonalcoholic fatty liver disease and ultrastructural alteration of hepatocyte mitochondria in male Wistar rat. Biomed. Res. Int. 2015, 2015, 895961–895967.
    • (2015) Biomed. Res. Int. , vol.2015 , pp. 1-895967
    • Mamikutty, N.1    Thent, Z.C.2    Haji Suhaimi, F.3
  • 23
    • 84964260863 scopus 로고    scopus 로고
    • Hydroxy‐2‐deoxyguanosine levels and cardiovascular disease: A systematic review and meta‐analysis of the literature
    • Di Minno, A.; Turnu, L.; Porro, B.; Squellerio, I.; Cavalca, V.; Tremoli, E.; Di Minno, M.N. Hydroxy‐2‐deoxyguanosine levels and cardiovascular disease: A systematic review and meta‐analysis of the literature. Antioxid. Redox Signal. 2016, 24, 548–555.
    • (2016) Antioxid. Redox Signal. , vol.24 , pp. 548-555
    • Di Minno, A.1    Turnu, L.2    Porro, B.3    Squellerio, I.4    Cavalca, V.5    Tremoli, E.6    Di Minno, M.N.7
  • 24
    • 33744721699 scopus 로고    scopus 로고
    • Quantitative PCR‐based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells
    • Santos, J.H.; Meyer, J.N.; Mandavilli, B.S.; Van Houten, B. Quantitative PCR‐based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol. Biol. 2006, 314, 183– 199.
    • (2006) Methods Mol. Biol. , vol.314
    • Santos, J.H.1    Meyer, J.N.2    Mandavilli, B.S.3    Van Houten, B.4
  • 25
    • 33748127909 scopus 로고    scopus 로고
    • Tetrandrine concentrations not affecting oxidative phosphorylation protect rat liver mitochondria from oxidative stress
    • Fernandes, M.A.; Custódio, J.B.; Santos, M.S.; Moreno, A.J.; Vicente, J.A. Tetrandrine concentrations not affecting oxidative phosphorylation protect rat liver mitochondria from oxidative stress. Mitochondrion 2006, 6, 176–185.
    • (2006) Mitochondrion , vol.6 , pp. 176-185
    • Fernandes, M.A.1    Custódio, J.B.2    Santos, M.S.3    Moreno, A.J.4    Vicente, J.A.5
  • 26
    • 84863036480 scopus 로고    scopus 로고
    • Investigating intestinal inflammation in DSS‐induced model of IBD
    • Kim, J.J.; Shajib, M.S.; Manocha, M.M.; Khan, W.I. Investigating intestinal inflammation in DSS‐induced model of IBD. J. Vis. Exp. 2012, 60, 3678.
    • (2012) J. Vis. Exp. , vol.60 , pp. 3678
    • Kim, J.J.1    Shajib, M.S.2    Manocha, M.M.3    Khan, W.I.4
  • 27
    • 0021742157 scopus 로고
    • Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models
    • Krawisz, J.E.; Sharon, P.; Stenson, W.F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 1984, 87, 1344–1350.
    • (1984) Gastroenterology , vol.87 , pp. 1344-1350
    • Krawisz, J.E.1    Sharon, P.2    Stenson, W.F.3
  • 28
    • 0026592966 scopus 로고
    • 8‐Hydroxyguanine, an abundant form of oxidative DNA damage, causes G–T and A–C substitutions
    • Cheng, K.C.; Cahill, D.S.; Kasai, H.; Nishimura, S.; Loeb, L.A. 8‐Hydroxyguanine, an abundant form of oxidative DNA damage, causes G–T and A–C substitutions. J. Biol. Chem. 1992, 267, 166–172.
    • (1992) J. Biol. Chem. , vol.267 , pp. 166-172
    • Cheng, K.C.1    Cahill, D.S.2    Kasai, H.3    Nishimura, S.4    Loeb, L.A.5
  • 29
    • 0037036115 scopus 로고    scopus 로고
    • Nuclear activators and coactivators in mammalian mitochondrial biogenesis
    • Scarpulla R.C. Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim. Biophys. Acta 2002, 1576, 1–14.
    • (2002) Biochim. Biophys. Acta , vol.1576 , pp. 1-14
    • Scarpulla, R.C.1
  • 30
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC‐1 family regulatory network
    • Scarpulla R.C. Metabolic control of mitochondrial biogenesis through the PGC‐1 family regulatory network. Biochim. Biophys. Acta 2011, 7, 1269–1278.
    • (2011) Biochim. Biophys. Acta , vol.7 , pp. 1269-1278
    • Scarpulla, R.C.1
  • 31
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • Kelly, D.P.; Scarpulla, R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004, 6, 357–368.
    • (2004) Genes Dev. , vol.6 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 35
    • 84928883143 scopus 로고    scopus 로고
    • Restriction of glucose and fructose causes mild oxidative stress independently of mitochondrial activity and reactive oxygen species in Drosophila melanogaster
    • Rovenko, B.M.; Kubrak, O.I.; Gospodaryov, D.V.; Yurkevych, I.S.; Sanz, A.; Lushchak, O.V.; Lushchak, V.I. Restriction of glucose and fructose causes mild oxidative stress independently of mitochondrial activity and reactive oxygen species in Drosophila melanogaster. Comp. Biochem. Physiol. 2015, 187, 27–39.
    • (2015) Comp. Biochem. Physiol. , vol.187 , pp. 27-39
    • Rovenko, B.M.1    Kubrak, O.I.2    Gospodaryov, D.V.3    Yurkevych, I.S.4    Sanz, A.5    Lushchak, O.V.6    Lushchak, V.I.7
  • 36
    • 33847656213 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A (TFAM): Roles in maintenance of mtDNA and cellular functions
    • Kang, D.; Kim, S.H.; Hamasaki, N. Mitochondrial transcription factor A (TFAM): Roles in maintenance of mtDNA and cellular functions. Mitochondrion 2007, 7, 39–44.
    • (2007) Mitochondrion , vol.7 , pp. 39-44
    • Kang, D.1    Kim, S.H.2    Hamasaki, N.3
  • 40
    • 84866736015 scopus 로고    scopus 로고
    • Dietary trans-fatty acid induced NASH is normalized following loss of trans‐fatty acids from hepatic lipid pools
    • Neuschwander-Tetri, B.A.; Ford, D.A.; Acharya, S.; Gilkey, G.; Basaranoglu, M.; Tetri, L.H.; Brunt, E.M. Dietary trans-fatty acid induced NASH is normalized following loss of trans‐fatty acids from hepatic lipid pools. Lipids 2012, 47, 941–950.
    • (2012) Lipids , vol.47 , pp. 941-950
    • Neuschwander-Tetri, B.A.1    Ford, D.A.2    Acharya, S.3    Gilkey, G.4    Basaranoglu, M.5    Tetri, L.H.6    Brunt, E.M.7
  • 41
    • 84950149794 scopus 로고    scopus 로고
    • Carbohydrate intake and nonalcoholic fatty liver disease: Fructose as a weapon of mass destruction
    • Basaranoglu, M.; Basaranoglu, G.; Bugianesi, E. Carbohydrate intake and nonalcoholic fatty liver disease: Fructose as a weapon of mass destruction. Hepatobiliary Surg. Nutr. 2015, 4, 109–116.
    • (2015) Hepatobiliary Surg. Nutr. , vol.4 , pp. 109-116
    • Basaranoglu, M.1    Basaranoglu, G.2    Bugianesi, E.3
  • 42
    • 18244375243 scopus 로고    scopus 로고
    • Fructose‐induced fatty liver disease: Hepatic effects of blood pressure and plasma triglyceride reduction
    • Ackerman, Z.; Oron‐Herman, M.; Grozovski, M.; Rosenthal, T.; Pappo, O.; Link, G.; Sela, B.A. Fructose‐induced fatty liver disease: Hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension 2005, 45, 1012–1018.
    • (2005) Hypertension , vol.45 , pp. 1012-1018
    • Ackerman, Z.1    Oron‐Herman, M.2    Grozovski, M.3    Rosenthal, T.4    Pappo, O.5    Link, G.6    Sela, B.A.7
  • 43
    • 84901049783 scopus 로고    scopus 로고
    • Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose‐compared to glucose‐fed mice
    • Nunes, P.M.; Wright, A.J.; Veltien, A.; van Asten, J.J.; Tack, C.J.; Jones, J.G.; Heerschap, A. Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose‐compared to glucose‐fed mice. FASEB J. 2014, 28, 1988–1997.
    • (2014) FASEB J , vol.28 , pp. 1988-1997
    • Nunes, P.M.1    Wright, A.J.2    Veltien, A.3    Van Asten, J.J.4    Tack, C.J.5    Jones, J.G.6    Heerschap, A.7
  • 44
    • 77953534278 scopus 로고    scopus 로고
    • The role of high‐fructose corn syrup in metabolic syndrome and hypertension
    • Ferder, L.; Ferder, M.D.; Inserra, F. The role of high‐fructose corn syrup in metabolic syndrome and hypertension. Curr. Hypertens. Rep. 2010, 12, 105–112.
    • (2010) Curr. Hypertens. Rep. , vol.12 , pp. 105-112
    • Ferder, L.1    Ferder, M.D.2    Inserra, F.3
  • 46
    • 84907334403 scopus 로고    scopus 로고
    • Fructose, high‐fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: A systematic review and meta‐analysis
    • Chung, M.; Ma, J.; Patel, K.; Berger, S.; Lau, J.; Lichtenstein, A.H. Fructose, high‐fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: A systematic review and meta‐analysis. Am. J. Clin. Nutr. 2014, 100, 833–849.
    • (2014) Am. J. Clin. Nutr. , vol.100 , pp. 833-849
    • Chung, M.1    Ma, J.2    Patel, K.3    Berger, S.4    Lau, J.5    Lichtenstein, A.H.6
  • 47
    • 85012897319 scopus 로고    scopus 로고
    • Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents
    • Mosca, A.; Nobili, V.; De Vito, R.; Crudele, A.; Scorletti, E.; Villani, A., Alisi, A., Byrne, C.D. Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents. J. Hepatol. 2017, doi:10.1016/j.jhep.2016.12.025.
    • (2017) J. Hepatol.
    • Mosca, A.1    Nobili, V.2    De Vito, R.3    Crudele, A.4    Scorletti, E.5    Villani, A.6    Alisi, A.7    Byrne, C.D.8
  • 48
    • 84911892240 scopus 로고    scopus 로고
    • Mitochondrial proteolysis: Its emerging roles in stress responses
    • Sekine, S.; Ichijo, H. Mitochondrial proteolysis: Its emerging roles in stress responses. Biochim. Biophys. Acta Gen. Subj. 2015, 1850, 274–280.
    • (2015) Biochim. Biophys. Acta Gen. Subj. , vol.1850 , pp. 274-280
    • Sekine, S.1    Ichijo, H.2
  • 49
    • 60649109153 scopus 로고    scopus 로고
    • The role of peroxisome proliferator‐activated receptor gamma coactivator‐1 beta in the pathogenesis of fructose‐induced insulin resistance
    • Nagai, Y.; Yonemitsu, S.; Erion, D.M.; Iwasaki, T.; Stark, R.; Weismann, D.; Dong, J.; Zhang, D.; Jurczak, M.J.; Löffler, M.G.; et al. The role of peroxisome proliferator‐activated receptor gamma coactivator‐1 beta in the pathogenesis of fructose‐induced insulin resistance. Cell Metab. 2009, 9, 252–264.
    • (2009) Cell Metab , vol.9 , pp. 252-264
    • Nagai, Y.1    Yonemitsu, S.2    Erion, D.M.3    Iwasaki, T.4    Stark, R.5    Weismann, D.6    Dong, J.7    Zhang, D.8    Jurczak, M.J.9    Löffler, M.G.10
  • 50
    • 84996551447 scopus 로고    scopus 로고
    • Dietary fructose‐induced hepatocellular carcinoma development manifested in mice lacking apoptosis inhibitor of macrophage (AIM)
    • Ozawa, T.; Maehara, N.; Kai, T.; Arai, S.; Miyazaki, T. Dietary fructose‐induced hepatocellular carcinoma development manifested in mice lacking apoptosis inhibitor of macrophage (AIM). Genes Cells 2016, 21, 1320–1332.
    • (2016) Genes Cells , vol.21 , pp. 1320-1332
    • Ozawa, T.1    Maehara, N.2    Kai, T.3    Arai, S.4    Miyazaki, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.