Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents

Journal of Hepatology

Volumn 66, Issue 5, 2017, Pages 1031-1036

  Mosca, Antonella ^a   Nobili, Valerio ^a   De Vito, Rita ^a   Crudele, Annalisa ^a   Scorletti, Eleonora ^b,c   Villani, Alberto ^a   Alisi, Anna ^a   Byrne, Christopher D ^b,c  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Adolescent; Child; Diet; Fructose; Fructose consumption; Hyperuricemia; Non alcoholic fatty liver disease (NAFLD); Non alcoholic steatohepatitis (NASH); Obesity; Uric acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; FRUCTOSE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; URIC ACID;

ADOLESCENT; ADOLESCENT OBESITY; ARTICLE; BODY MASS; CARBOHYDRATE INTAKE; CHILD; CHILD NUTRITION; CHILDHOOD OBESITY; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONFOUNDING VARIABLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIGESTIVE SYSTEM DISEASE ASSESSMENT; DISEASE ASSOCIATION; FATTY LIVER INHIBITION OF PROGRESSION ALGORITHM; FEMALE; FOOD FREQUENCY QUESTIONNAIRE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; HUMAN TISSUE; HYPERURICEMIA; INDEPENDENT VARIABLE; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; NONALCOHOLIC FATTY LIVER DISEASE ACTIVITY SCORE; PRIORITY JOURNAL; RISK FACTOR; SEX; SYSTOLIC BLOOD PRESSURE; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE; BLOOD; INSULIN RESISTANCE; STATISTICAL MODEL;

ADOLESCENT; CHILD; FEMALE; FRUCTOSE; HUMANS; INSULIN RESISTANCE; LOGISTIC MODELS; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE; URIC ACID;

EID: 85012897319     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2016.12.025     Document Type: Article

References (32)

1. [1] Alisi, A., Carpino, G., Nobili, V., Pediatric nonalcoholic fatty liver disease. Curr Opin Gastroenterol 29 (2013), 279–284.
2. [2] Kleiner, D.E., Makhlouf, H.R., Histology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in adults and children. Clin Liver Dis 20 (2016), 293–312.
3. [3] Byrne, C.D., Targher, G., NAFLD: a multisystem disease. J Hepatol 62 (2015), S47–S64.
4. [4] Yki-Järvinen, H., Nutritional modulation of non-alcoholic fatty liver disease and insulin resistance. Nutrients 7 (2015), 9127–9138.
5. [5] Huang, Q., Yu, J., Zhang, X., Liu, S., Ge, Y., Association of the serum uric acid level with liver histology in biopsy-proven non-alcoholic fatty liver disease. Biomed Rep 5 (2016), 188–192.
6. [6] Cardoso, A.S., Gonzaga, N.C., Medeiros, C.C., Carvalho, D.F., Association of uric acid levels with components of metabolic syndrome and non-alcoholic fatty liver disease in overweight or obese children and adolescents. J Pediatr (Rio J) 89 (2013), 412–418.
7. [7] Sullivan, J.S., Le, M.T., Pan, Z., Rivard, C., Love-Osborne, K., Robbins, K., et al. Oral fructose absorption in obese children with non-alcoholic fatty liver disease. Pediatr Obes 10 (2015), 188–195.
8. [8] Scorletti, E., Calder, P.C., Byrne, C.D., Non-alcoholic fatty liver disease and cardiovascular risk: metabolic aspects and novel treatments. Endocrine 40 (2011), 332–343.
9. [9] Vos, M.B., Lavine, J.E., Dietary fructose in nonalcoholic fatty liver disease. Hepatology 57 (2013), 2525–2531.
10. [10] Cortez-Pinto, H., Chatham, J., Chacko, V.P., Arnold, C., Rashid, A., Diehl, A.M., Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA 282 (1999), 1659–1664.
11. [11] Wang, C.C., Tseng, T.C., Hsieh, T.C., Hsu, C.S., Wang, P.C., Lin, H.H., et al. Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk. Kaohsiung J Med Sci 28 (2012), 151–160.
12. [12] World Health Organization, WHO child growth standards: methods and development [monograph on the Internet]. 2006, World Health Organization, Geneva (Switzerland) Available from: http://www.who.int/childgrowth/standards/technical_report/en/.
13. [13] Nobili, V., Marcellini, M., Devito, R., Ciampalini, P., Piemonte, F., Comparcola, D., et al. NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology 44 (2006), 458–465.
14. [14] World Health Organization (WHO), International Diabetes Federation (IDF). Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Report of a WHO/IDF Consultation, 2006.
15. [15] Vajro, P., Lenta, S., Socha, P., Dhawan, A., McKiernan, P., Baumann, U., et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr 54 (2012), 700–713.
16. [16] Dezsőfi, A., Baumann, U., Dhawan, A., Durmaz, O., Fischler, B., Hadzic, N., et al. Liver biopsy in children: position paper of the ESPGHAN hepatology committee. J Pediatr Gastroenterol Nutr 60 (2015), 408–420.
17. [17] Pietrobattista, A., Fruwirth, R., Natali, G., Monti, L., Devito, R., Nobili, V., Is juvenile liver biopsy unsafe? Putting an end to a common misapprehension. Pediatr Radiol 39 (2009), 959–961.
18. [18] Kleiner, D.E., Brunt, E.M., Van Natta, M., Behling, C., Contos, M.J., Cummings, O.W., et al., Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005), 1313–1321.
19. [19] Bedossa, P., Poitou, C., Veyrie, N., Bouillot, J.L., Basdevant, A., Paradis, V., et al. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology 56 (2012), 1751–1759.
20. [20] Bedossa, P., FLIP Pathology Consortium. Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease. Hepatology 60 (2014), 565–575.
21. [21] Nobili, V., Liccardo, D., Bedogni, G., Salvatori, G., Gnani, D., Bersani, I., et al. Influence of dietary pattern, physical activity, and I148M PNPLA3 on steatosis severity in at-risk adolescents. Gene Nutr, 9, 2014, 32.
22. [22] Food Composition Table, available from http://nut.entecra.it/646/tabelle_di_composizione_degli_alimenti.html.
23. [23] Cho, S.M., Lee, S.G., Kim, H.S., Kim, J.H., Establishing pediatric reference intervals for 13 biochemical analytes derived from normal subjects in a pediatric endocrinology clinic in Korea. Clin Biochem 47 (2014), 268–271.
24. [24] Kanbay, M., Jensen, T., Solak, Y., Le, M., Roncal-Jimenez, C., Rivard, C., et al. Uric acid in metabolic syndrome: From an innocent bystander to a central player. Eur J Intern Med 29 (2016), 3–8.
25. [25] Lombardi, R., Pisano, G., Fargion, S., Role of serum uric acid and ferritin in the development and progression of NAFLD. Int J Mol Sci, 17, 2016, 548.
26. [26] Liu, J., Xu, C., Ying, L., Zang, S., Zhuang, Z., Lv, H., et al. Relationship of serum uric acid level with non-alcoholic fatty liver disease and its inflammation progression in non-obese adults. Hepatol Res, 2016, 10.1111/hepr.12734.
27. [27] Ouyang, X., Cirillo, P., Sautin, Y., McCall, S., Bruchette, J.L., Diehl, A.M., et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 48 (2008), 993–999.
28. [28] Lanaspa, M.A., Sanchez-Lozada, L.G., Cicerchi, C., Li, N., Roncal-Jimenez, C.A., Ishimoto, T., et al. Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLoS One, 7, 2012, e47948.
29. [29] Abdelmalek, M.F., Lazo, M., Horska, A., Bonekamp, S., Lipkin, E.W., Balasubramanyam, A., et al. Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology 56 (2012), 952–960.
30. [30] Bobridge, K.S., Haines, G.L., Mori, T.A., Beilin, L.J., Oddy, W.H., Sherriff, J., et al. Dietary fructose in relation to blood pressure and serum uric acid in adolescent boys and girls. J Hum Hypertens 27 (2013), 217–224.
31. [31] Sirota, J.C., McFann, K., Targher, G., Johnson, R.J., Choncchol, M., Jalai, D.I., Elevated serum acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States. Liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism 62 (2013), 392–399.
32. [32] Crane, J.K., Mongiardo, K.M., Pro-inflammatory effects of uric acid in the gastrointestinal tract. Immunol Invest 43 (2014), 255–266.