The rise of plastic bioelectronics

Nature

Volumn 540, Issue 7633, 2016, Pages 379-385

  Someya, Takao ^a,b   Bao, Zhenan ^c   Malliaras, George G ^d  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN Center for Emergent Matter Science   (Japan)

^c Stanford University   (United States)

^d ECOLE DES MINES DE SAINT ETIENNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PLASTIC; POLYMER; BIOMATERIAL;

BIOMECHANICS; BIOTECHNOLOGY; ELECTRONIC EQUIPMENT; INTERFACE; PLASTIC; POLYMER; RESEARCH WORK;

BIOLOGY; ELECTRONIC DEVICE; ELECTRONIC SENSOR; ELECTRONICS; HUMAN; PRIORITY JOURNAL; REVIEW; SEMICONDUCTOR; TRANSISTOR; ANIMAL; BIOENGINEERING; DEVICES; PROSTHESES AND ORTHOSES;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIOENGINEERING; ELECTRONICS; HUMANS; PLASTICS; PROSTHESES AND IMPLANTS; SEMICONDUCTORS;

EID: 85016162901     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21004     Document Type: Review

References (106)

1. Berggren, M. & Richter-Dahlfors, A. Organic bioelectronics. Adv. Mater. 19, 3201-3213 (2007).
2. Rivnay, J., Owens, R. M. & Malliaras, G. G. The rise of organic bioelectronics. Chem. Mater. 26, 679-685 (2014).
3. Wallace, G. G., Moulton, S. E. & Wang, C. Proc. SPI ,7642., 764202,(2010).
4. Liao, C. et al. Flexible organic electronics in biology: materials and devices. Adv. Mater. 27, 7493-7527 (2015).
5. Fitzpatrick, D. Implantable Electronic Medical Devices (Elsevier, 2015).
6. Lay-Ekuakille, A. & Mukhopadhyay, S. C. Wearable and Autonomous Biomedical Devices and Systems for Smart Environment (Springer
7. Embracing the organics world. Nature Mater. 12, 591 (2013).
8. Freed, L. E., Engelmayr, G. C., Borenstein, J. T., Moutos, F. T. & Guilak, F. Advanced material strategies for tissue engineering scaffolds. Adv. Mater. 21, 3410-3418 (2009).
9. Delmas, P., Hao, J. & Rodat-Despoix, L. Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nature Rev. Neurosci. 12, 139-153 (2011).
10. Bredas, J.-L. & Marder, S. R. The WSPC Reference on Organic Electronics: Organic Semiconductors: Organic Semiconductors (World Scientific Publishing 2016).
11. Crawford, G. Flexible Flat Panel Displays (John Wiley, 2005).
12. Rogers, J. A. et al. Paper-like electronic displays: Large-area rubber-stamped plastic sheets of electronics and microencapsulated electrophoretic inks. Proc.Natl Acad. Sci. USA ,98.,4835-4840., 2001
13. Someya, T. et al. A large-area, flexible pressure sensor matrix with organic field-effect transistors for artificial skin applications. Proc. Natl Acad. Sci. USA 101, 9966-9970 (2004)
14. Someya, T. et al. Conformable, flexible, large-area networks of pressure and thermal sensors with organic transistor active matrixes. Proc. Natl Acad. Sci. USA 102, 12321-12325 (2005)
15. Irimia-Vladu, M., Gowacki, E. D., Voss, G., Bauer, S. & Sariciftci, N. S. Green and biodegradable electronics. Mater. Today 15, 340-346 (2012).
16. Gamota, D. R., Brazis, P., Kalyanasundaram, K. & Zhang, J. Printed Organic and Molecular Electronics (Springer Science & Business Media 2013).
17. Benight, S. J., Wang, C., Tok, J. B. H. & Bao, Z. Stretchable and self-healing polymers and devices for electronic skin. Prog. Polym. Sci. 38, 1961-1977 (2013).
18. Wallace, G. G., Moulton, S. E. & Clark, G. M. Electrode-cellular interface. Science 324, 185-186 (2009).
19. Martin, D. C. & Malliaras, G. G. Interfacing electronic and ionic charge transport in bioelectronics. ChemElectroChem 3, 686-688 (2016).
20. Simon, D. T. et al. Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function. Nature Mater. 8, 742-746 (2009).
21. Wessling, B. New insight into organic metal polyaniline morphology and structure. Polymers 2, 786-798 (2010).
22. Groenendaal, L. B., Jonas, F., Freitag, D., Pielartzik, H. & Reynolds, J. R. Poly(3,4-ethylenedioxythiophene) and its derivatives: past, present, and future. Adv. Mater. 12, 481-494 (2000).
23. Worfolk, B. J. et al. Ultrahigh electrical conductivity in solution-sheared polymeric transparent films. Proc. Natl Acad. Sci. USA 112, 14138-14143 (2015).
24. Lee, K. et al. Metallic transport in polyaniline. Nature 441, 65-68 (2006).
25. Luo, C. et al. General strategy for self-assembly of highly oriented nanocrystalline semiconducting polymers with high mobility. Nano Lett. 14, 2764-2771 (2014).
26. Yuan, Y. et al. Ultra-high mobility transparent organic thin film transistors grown by an off-centre spin-coating method. Nature Commun. 5, 3005 (2014).
27. Sundar, V. C. et al. Elastomeric transistor stamps: reversible probing of charge transport in organic crystals. Science 303, 1644-1646 (2004).
28. Kaltenbrunner, M. et al. An ultra-lightweight design for imperceptible plastic electronics. Nature 499, 458-463 (2013).
29. White, M. S. et al. Ultrathin, highly flexible and stretchable PLEDs. Nature Photonics 7, 811-816 (2013).
30. Lipomi, D. J., Tee, B. C. K., Vosgueritchian, M. & Bao, Z. Stretchable organic solar cells. Adv. Mater. 23, 1771-1775 (2011).
31. Lipomi, D. J. et al. Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes. Nature Nanotechnol. 6, 788-792 (2011).
32. Matsuhisa, N. et al. Printable elastic conductors with a high conductivity for electronic textile applications. Nature Commun. 6, 7461 (2015).
33. Kim, Y. et al. Stretchable nanoparticle conductors with self-organized conductive pathways. Nature 500, 59-63 (2013).
34. Liang, J. et al. Intrinsically stretchable and transparent thin-film transistors based on printable silver nanowires, carbon nanotubes and an elastomeric dielectric. Nature Commun. 6, 7647 (2015).
35. Park, M. et al. Highly stretchable electric circuits from a composite material of silver nanoparticles and elastomeric fibres. Nature Nanotechnol. 7, 803-809 (2012).
36. Sekitani, T. et al. A rubberlike stretchable active matrix using elastic conductors. Science 321, 1468-1472 (2008).
37. Vosgueritchian, M., Lipomi, D. J. & Bao, Z. Highly conductive and transparent PEDOT:PSS films with a fluorosurfactant for stretchable and flexible transparent electrodes. Adv. Funct. Mater. 22, 421-428 (2012).
38. Oh, J. Y., Kim, S., Baik, H.-K. & Jeong, U. Conducting polymer dough for deformable electronics. Adv. Mater. 28, 4455-4461 (2016).
39. O'Connor, B. et al. Correlations between mechanical and electrical properties of polythiophenes. ACS Nano 4, 7538-7544 (2010).
40. Savagatrup, S., Printz, A. D., O'Connor, T. F., Zaretski, A. V. & Lipomi, D. J. Molecularly stretchable electronics. Chem. Mater. 26, 3028-3041 (2014).
41. Lipomi, D. J. & Bao, Z. Stretchable, elastic materials and devices for solar energy conversion. Energy Environ. Sci. 4, 3314-3328 (2011).
42. Shin, M. et al. Highly stretchable polymer transistors consisting entirely of stretchable device components. Adv. Mater. 26, 3706-3711 (2014).
43. Chortos, A. et al. Mechanically durable and highly stretchable transistors employing carbon nanotube semiconductor and electrodes. Adv. Mater. 28, 4441-4448 (2016).
44. Bettinger, C. J. & Bao, Z. Organic thin-film transistors fabricated on resorbable biomaterial substrates. Adv. Mater. 22, 651-655 (2010)
45. Campana, A., Cramer, T., Simon, D. T., Berggren, M. & Biscarini, F. Electrocardiographic recording with conformable organic electrochemical transistor fabricated on resorbable bioscaffold. Adv. Mater. 26, 3874-3878 (2014).
46. Tobjork, D. & Osterbacka, R. Paper electronics. Adv. Mater. 23, 1935-1961 (2011).
47. Zheng, Y. F., Gu, X. N. & Witte, F. Biodegradable metals. Mater. Sci. Eng. R. 77, 1-34 (2014).
48. Hwang, S.-W. et al. High-performance biodegradable/transient electronics on biodegradable polymers. Adv. Mater. 26, 3905-3911 (2014).
49. Yu, K. J. et al. Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex. Nature Mater. 15, 782-791 (2016).
50. Kang, S.-K. et al. Bioresorbable silicon electronic sensors for the brain. Nature 530, 71-76 (2016).
51. Tao, H. et al. Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement. Proc. Natl Acad. Sci. USA 111, 17385-17389 (2014).
52. Rivers, T. J., Hudson, T. W. & Schmidt, C. E. Synthesis of a novel, biodegradable electrically conducting polymer for biomedical applications. Adv. Funct. Mater. 12, 33-37 (2002).
53. Yang, Y. & Urban, M. W. Self-healing polymeric materials. Chem. Soc. Rev. 42, 7446-7467 (2013).
54. Williams, K. A., Boydston, A. J. & Bielawski, C. W. Towards electrically conductive, self-healing materials. J. R. Soc. Interface 4, 359-362 (2007).
55. Tee, B. C. K., Wang, C., Allen, R. & Bao, Z. An electrically and mechanically self-healing composite with pressure-and flexion-sensitive properties for electronic skin applications. Nature Nanotechnol. 7, 825-832 (2012).
56. Wang, C. et al. Self-healing chemistry enables the stable operation of silicon microparticle anodes for high-energy lithium-ion batteries. Nature Chem. 5, 1042-1048 (2013).
57. Gong, C. et al. A healable, semitransparent silver nanowire-polymer composite conductor. Adv. Mater. 25, 4186-4191 (2013).
58. Kaltenbrunner, M. et al. Ultrathin and lightweight organic solar cells with high flexibility. Nature Commun. 3, 770 (2012).
59. Myny, K. et al. An 8-bit, 40-instructions-per-second organic microprocessor on plastic foil. IEEE J. Solid-State Circuits 47, 284-291 (2012).
60. Gelinck, G. H. et al. Flexible active-matrix displays and shift registers based on solution-processed organic transistors. Nature Mater. 3, 106-110 (2004).
61. Naber, R. C. G. et al. High-performance solution-processed polymer ferroelectric field-effect transistors. Nature Mater. 4, 243-248 (2005).
62. Subramanian, V. et al. Progress toward development of all-printed RFID tags: materials, processes, and devices. Proc. IEEE 93, 1330-1338 (2005).
63. Khodagholy, D. et al. High transconductance organic electrochemical transistors. Nature Commun. 4, 2133 (2013).
64. Mannsfeld, S. C. B. et al. Highly sensitive flexible pressure sensors with microstructured rubber dielectric layers. Nature Mater. 9, 859-864 (2010).
65. Schwartz, G. et al. Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring. Nature Commun. 4,2013
66. Yokota, T. et al. Ultraflexible, large-area, physiological temperature sensors for multipoint measurements. Proc. Natl Acad. Sci. USA 112, 14533-14538 (2015).
67. Jeon, J., Lee, H.-B.-R. & Bao, Z. Flexible wireless temperature sensors based on Ni microparticle-filled binary polymer composites. Adv. Mater. 25, 850-855 (2013).
68. Mulla, M. Y. et al. Capacitance-modulated transistor detects odorant binding protein chiral interactions. Nature Commun. 6, 6010 (2015).
69. Ramuz, M., Hama, A., Rivnay, J., Leleux, P. & Owens, R. M. Monitoring of cell layer coverage and differentiation with the organic electrochemical transistor. J. Mater. Chem. B 3, 5971-5977 (2015).
70. Lochner, C. M., Khan, Y., Pierre, A. & Arias, A. C. All-organic optoelectronic sensor for pulse oximetry. Nature Commun. 5, 5745 (2014).
71. Yokota, T. et al. Ultraflexible organic photonic skin. Sci. Adv. 2, e1501856 (2016).
72. Sirringhaus, H. et al. High-resolution inkjet printing of all-polymer transistor circuits. Science 290, 2123-2126 (2000).
73. Fukuda, K. et al. Fully-printed high-performance organic thin-film transistors and circuitry on one-micron-thick polymer films. Nature Commun. 5, 4147 (2014).
74. Reichert, W. M. Indwelling Neural Implants: Strategies For Contending With The In Vivo Environment (CRC Press 2007).
75. Asplund, M., Nyberg, T. & Inganäs, O. Electroactive polymers for neural interfaces. Polym. Chem. 1, 1374-1391 (2010).
76. Kozai, T. D. Y. & Kipke, D. R. Insertion shuttle with carboxyl terminated self-assembled monolayer coatings for implanting flexible polymer neural probes in the brain. J. Neurosci. Meth. 184, 199-205 (2009).
77. Minev, I. R. et al. Electronic dura mater for long-term multimodal neural interfaces. Science 347, 159-163 (2015).
78. Ludwig, K. A., Uram, J. D., Yang, J., Martin, D. C. & Kipke, D. R. Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film. J. Neural Eng. 3, 59-70 (2006).
79. Venkatraman, S. et al. In vitro and In vivo evaluation of PEDOT microelectrodes for neural stimulation and recording. IEEE Trans. Neural Syst. Rehabil. Eng. 19, 307-316 (2011).
80. Green, R. & Abidian, M. R. Conducting polymers for neural prosthetic and neural interface applications. Adv. Mater. 27, 7620-7637 (2015).
81. Khodagholy, D. et al. In vivo recordings of brain activity using organic transistors. Nature Commun. 4, 1575 (2013).
82. Khodagholy, D. et al. NeuroGrid: recording action potentials from the surface of the brain. Nature Neurosci. 18, 310-315 (2015).
83. Xu, L. et al. Materials and fractal designs for 3D multifunctional integumentary membranes with capabilities in cardiac electrotherapy. Adv. Mater. 27, 1731-1737 (2015).
84. Park, D.-W. et al. Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications. Nature Commun. 5, 5258 (2014).
85. Ouyang, L., Shaw, C. L., Kuo, C.-c., Griffin, A. L. & Martin, D. C. In vivo polymerization of poly (3, 4-ethylenedioxythiophene) (PEDOT) in the living rat hippocampus does not cause a significant loss of performance in a delayed alternation (DA) task. J. Neural Eng. 11, 026005 (2014).
86. Hassarati, R. T., Marcal, H., Foster, L. J. R. & Green, R. A. Biofunctionalization of conductive hydrogel coatings to support olfactory ensheathing cells at implantable electrode interfaces. J. Biomed. Mater. Res. B 104, 712-722 (2016).
87. Richardson, R. T. et al. Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons. Biomaterials 30, 2614-2624 (2009).
88. Jonsson, A. et al. Therapy using implanted organic bioelectronics. Sci. Adv. 1, e1500039 (2015).
89. Williamson, A. et al. Controlling epileptiform activity with organic electronic ion pumps. Adv. Mater. 27, 3138-3144 (2015).
90. Schmidt, C. E., Shastri, V. R., Vacanti, J. P. & Langer, R. Stimulation of neurite outgrowth using an electrically conducting polymer. Proc. Natl Acad. Sci. USA 94, 8948-8953 (1997).
91. Huang, J. et al. Electrical stimulation to conductive scaffold promotes axonal regeneration and remyelination in a rat model of large nerve defect. PLoS ONE 7, e39526 (2012).
92. 9Wong, J. Y., Langer, R. & Ingber, D. E. Electrically conducting polymers can noninvasively control the shape and growth of mammalian-cells. Proc. Natl Acad. Sci. USA 91, 3201-3204 (1994).
93. Wan, A. M.-D. et al. 3D conducting polymer platforms for electrical control of protein conformation and cellular functions. J. Mater. Chem. B 3, 5040-5048 (2015).
94. Ghezzi, D. et al. A polymer optoelectronic interface restores light sensitivity in blind rat retinas. Nature Photonics 7, 400-406 (2013).
95. Qiu, F. et al. Magnetic helical microswimmers functionalized with lipoplexes for targeted gene delivery. Adv. Funct. Mater. 25, 1666-1671 (2015).
96. Tee, B. C. K. et al. A skin-inspired organic digital mechanoreceptor. Science 350, 313-316 (2015).
97. Xu, S. et al. Soft microfluidic assemblies of sensors, circuits, and radios for the skin. Science 344, 70-74 (2014).
98. Takei, K. et al. Nanowire active-matrix circuitry for low-voltage macroscale artificial skin. Nature Mater. 9, 821-826 (2010).
99. Someya, T. Building bionic skin. IEEE Spectrum 50, 50-56 (2013).
100. Irimia-Vladu, M. et al. Indigo-a natural pigment for high performance ambipolar organic field effect transistors and circuits. Adv. Mater. 24, 375-380 (2012)
101. Buchko, C. J., Slattery, M. J., Kozloff, K. M. & Martin, D. C. Mechanical properties of biocompatible protein polymer thin films. J. Mater. Res. 15, 231-242 (2000).
102. Shackelford, J. F., Han, Y.-H., Kim, S. & Kwon, S.-H. CRC Materials Science and Engineering Handbook (CRC Press2016).
103. Kim, D.-H. et al. Epidermal electronics. Science 333, 838-843 (2011).
104. Webb, R. C. et al. Ultrathin conformal devices for precise and continuous thermal characterization of human skin. Nature Mater. 12, 938-944 (2013).
105. Park, S. I. et al. Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Nature Biotechnol. 33, 1280-1286 (2015).
106. Viventi, J. et al. Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo. Nature Neurosci. 14, 1599-1605 (2011).