In vivo polymerization of poly(3,4-ethylenedioxythiophene) in the living rat hippocampus does not cause a significant loss of performance in a delayed alternation task

Journal of Neural Engineering

Volumn 11, Issue 2, 2014, Pages

  Ouyang, Liangqi ^a   Shaw, Crystal L ^a   Kuo, Chin Chen ^a   Griffin, Amy L ^a   Martin, David C ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

conducting polymer; glial scar; impedance; in vivo polymerization; neural probes

Indexed keywords

BRAIN; CONDUCTING POLYMERS; DEPOSITION; ELECTRIC IMPEDANCE; PROBES; SURGERY; TISSUE;

DEPOSITION CONDITIONS; GLIAL SCAR; HIPPOCAMPAL FUNCTIONS; IMMUNOHISTOCHEMISTRY; IN-VIVO; NEURAL PROBES; POLY(3 ,4 ETHYLENEDIOXYTHIOPHENE) (PEDOT); POLY-3 ,4-ETHYLENEDIOXYTHIOPHENE;

LIVING POLYMERIZATION;

POLY(3,4 ETHYLENEDIOXYTHIOPHENE); STAINLESS STEEL; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; POLY(3,4-ETHYLENE DIOXYTHIOPHENE); POLYMER;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CANNULA; CONTROLLED STUDY; ELECTROCHEMICAL ANALYSIS; ELECTRODE; HIPPOCAMPAL CA1 REGION; IMMUNOHISTOCHEMISTRY; IMPEDANCE; IMPLANTATION; IN VIVO STUDY; MICROGLIA; NERVOUS TISSUE; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; TISSUE REACTION; ANIMAL; DRUG EFFECTS; ELECTRODE IMPLANT; HIPPOCAMPUS; MALE; METABOLISM; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; TIME;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; ELECTRODES, IMPLANTED; HIPPOCAMPUS; MALE; POLYMERIZATION; POLYMERS; PSYCHOMOTOR PERFORMANCE; RATS; TIME FACTORS;

EID: 84897508937     PISSN: 17412560     EISSN: 17412552     Source Type: Journal    
DOI: 10.1088/1741-2560/11/2/026005     Document Type: Article

References (48)

1. Ainge J A, Van Der Meer M A, Langston R F and Wood E R 2007 Exploring the role of context-dependent hippocampal activity in spatial alternation behavior Hippocampus 17 988-1002
2. Azemi E, Lagenaur C F and Cui X T 2011 The surface immobilization of the neural adhesion molecule L1 on neural probes and its effect on neuronal density and gliosis at the probe/tissue interface Biomaterials 32 681-92
3. Biran R, Martin D C and Tresco P A 2005 Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays Exp. Neurol. 195 115-26
4. Buzsáki G 2004 Large-scale recording of neuronal ensembles Nature Neurosci. 7 446-51
5. Cogan S F 2008 Neural stimulation and recording electrodes Annu. Rev. Biomed. Eng. 10 275-309
6. Elkin B S, Azeloglu E U, Costa K D and Morrison B 2007 Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation J. Neurotrauma 24 812-22
7. Frampton J P, Hynd M R, Shuler M L and Shain W 2010 Effects of glial cells on electrode impedance recorded from neural prosthetic devices in vitro Ann. Biomed. Eng. 38 1031-47
8. Hallock H L, Arreola A C, Shaw C L and Griffin A L 2013a Dissociable roles of the dorsal striatum and dorsal hippocampus in conditional discrimination and spatial alternation T-maze tasks Neurobiol. Learn. Mem. 100 108-16
9. Hallock H L, Wang A, Shaw C L and Griffin A L 2013b Transient inactivation of the thalamic nucleus reuniens and rhomboid nucleus produces deficits of a working-memory dependent tactile-visual conditional discrimination task Behav. Neurosci. 127 860-6
10. Harris J P, Capadona J R, Miller R H, Healy B C, Shanmuganathan K, Rowan S J, Weder C and Tyler D J 2011a Mechanically adaptive intracortical implants improve the proximity of neuronal cell bodies J. Neural Eng. 8 066011
11. Harris J P, Hess A E, Rowan S J, Weder C, Zorman C A, Tyler D J and Capadona J R 2011b In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes J. Neural Eng. 8 046010
12. Hatsopoulos N G and Donoghue J P 2009 The science of neural interface systems Annu. Rev. Neurosci. 32 249-66
13. Kim D-H and Martin D C 2006 Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery Biomaterials 27 3031-7
14. Kozai T D Y, Marzullo T C, Hooi F, Langhals N B, Majewska A K, Brown E B and Kipke D R 2010 Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping J. Neural Eng. 7 046011
15. Ladeby R, Wirenfeldt M, Garcia-Ovejero D, Fenger C, Dissing-Olesen L, Dalmau I and Finsen B 2005 Microglial cell population dynamics in the injured adult central nervous system Brain Res. Brain Res. Rev. 48 196-206
16. Lehrmann E, Christensen T, Zimmer J, Diemer N H and Finsen B 1997 Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion J. Comp. Neurol. 386 461-76 www.ncbi.nlm.nih.gov/pubmed/9303429
17. Lind G, Linsmeier C E, Thelin J and Schouenborg J 2010 Gelatine-embedded electrodes - a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes J. Neural Eng. 7 046005
18. Liu X, McCreery D B, Bullara L A and Agnew W F 2006 Evaluation of the stability of intracortical microelectrode arrays IEEE Trans. Neural Syst. Rehabil. Eng. 14 91-100
19. Ludwig K A, Miriani R M, Langhals N B, Joseph M D, Anderson D J and Kipke D R 2009 Using a common average reference to improve cortical neuron recordings from microelectrode arrays J. Neurophysiol. 101 1679-89
20. Ludwig K A, Uram J D, Yang J, Martin D C and Kipke D R 2006 Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film J. Neural Eng. 3 59-70
21. McConnell G C, Butera R J and Bellamkonda R V 2009 Bioimpedance modeling to monitor astrocytic response to chronically implanted electrodes J. Neural Eng. 6 055005
22. Nicolelis M A L, Dimitrov D, Carmena J M, Crist R, Lehew G, Kralik J D and Wise S P 2003 Chronic, multisite, multielectrode recordings in macaque monkeys Proc. Natl Acad. Sci. USA 100 11041-6
23. Oliver C and Jamur M C 2010 Immunocytochemical Methods and Protocols 3rd edn (New York: Springer) pp 55-61
24. Otto K J, Johnson M D and Kipke D R 2006 Voltage pulses change neural interface properties and improve unit recordings with chronically implanted microelectrodes IEEE Trans. Biomed. Eng. 53 333-40
25. Ouyang L, Green R, Feldman K E and Martin D C 2011 Direct local polymerization of poly(3,4-ethylenedioxythiophene) in rat cortex Prog. Brain Res. 194 263-71
26. Paxinos G and Watson C 2004 The Rat Brain in Stereotaxic Coordinates - The New Coronal Set 5th edn (Salt Lake City, UT: Academic Press)
27. Polikov V S, Tresco P A and Reichert W M 2005 Response of brain tissue to chronically implanted neural electrodes J. Neurosci. Methods 148 1-18
28. Potter K A, Buck A C, Self W K, Callanan M E, Sunil S and Capadona J R 2013 The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes Biomaterials 34 7001-15
29. Potter K A, Buck A C, Self W K and Capadona J R 2012 Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses J. Neural Eng. 9 046020
30. Povlich L K, Cho J C, Leach M K, Corey J M, Kim J and Martin D C 2013 Synthesis, copolymerization and peptide-modification of carboxylic acid-functionalized 3,4-ethylenedioxythiophene (EDOTacid) for neural electrode interfaces Biochim. Biophys. Acta 1830 4288-93
31. Prasad A and Sanchez J C 2012 Quantifying long-term microelectrode array functionality using chronic in vivo impedance testing J. Neural Eng. 9 026028
32. Prasad A, Xue Q-S, Sankar V, Nishida T, Shaw G, Streit W J and Sanchez J C 2012 Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants J. Neural Eng. 9 056015
33. Richardson-Burns S M, Hendricks J L, Foster B, Povlich L K, Kim D-H and Martin D C 2007a Polymerization of the conducting polymer poly(3,4- ethylenedioxythiophene) (PEDOT) around living neural cells Biomaterials 28 1539-52
34. Richardson-Burns S M, Hendricks J L and Martin D C 2007b Electrochemical polymerization of conducting polymers in living neural tissue J. Neural Eng. 4 L6-13
35. Ryu S I and Shenoy K V 2009 Human cortical prostheses: lost in translation? Neurosurg. Focus 27 E5
36. Schindelin J et al 2012 Fiji: an open-source platform for biological-image analysis Nature Methods 9 676-82
37. Schwartz A B 2004 Cortical neural prosthetics Annu. Rev. Neurosci. 27 487-507
38. Seymour J P and Kipke D R 2007 Neural probe design for reduced tissue encapsulation in CNS Biomaterials 28 3594-607
39. Streit B W J et al 2012 Electrode failure IEEE Pulse 3 30-33
40. Sykova E and Nicholson C 2008 Diffusion in brain extracellular space Physiol. Rev. 6 1277-340
41. Taylor D M, Tillery S I H and Schwartz A B 2003 Information conveyed through brain-control: cursor versus robot IEEE Trans. Neural Syst. Rehabil. Eng. 11 195-9
42. Turner J N, Shain W, Szarowski D H, Andersen M, Martins S, Isaacson M and Craighead H 1999 Cerebral astrocyte response to micromachined silicon implants Exp. Neurol. 156 33-49
43. Vetter R J, Williams J C, Hetke J F, Nunamaker E A and Kipke D R 2004 Chronic neural recording using silicon-substrate microelectrode arrays implanted in cerebral cortex IEEE Trans. Biomed. Eng. 51 896-904
44. Wilks S J, Woolley A J, Ouyang L, Martin D C and Otto K J 2011 In vivo polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in rodent cerebral cortex Proc. Annu. Int. Conf. of the IEEE Engineering in Medicine and Biology Society pp 5412-5
45. Williams J C, Hippensteel J A, Dilgen J, Shain W and Kipke D R 2007 Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants J. Neural Eng. 4 410-23
46. Winslow B D, Christensen M B, Yang W-K, Solzbacher F and Tresco P A 2010 A comparison of the tissue response to chronically implanted Parylene-C-coated and uncoated planar silicon microelectrode arrays in rat cortex Biomaterials 31 9163-72
47. Winslow B D and Tresco P A 2010 Quantitative analysis of the tissue response to chronically implanted microwire electrodes in rat cortex Biomaterials 31 1558-67
48. Zhong Y and Bellamkonda R V 2005 Controlled release of anti-inflammatory agent alpha-MSH from neural implants J. Control. Release 106 309-18