In vitro and in vivo evaluation of PEDOT microelectrodes for neural stimulation and recording

IEEE Transactions on Neural Systems and Rehabilitation Engineering

Volumn 19, Issue 3, 2011, Pages 307-316

  Venkatraman, Subramaniam ^a   Hendricks, Jeffrey ^b   King, Zachary A ^c   Sereno, Andrew J ^c   Richardson Burns, Sarah ^b   Martin, David ^b,d   Carmena, Jose M ^e  

^a QUALCOMM INC   (United States)

^b Biotectix LLC   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF DELAWARE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biomedical electrodes; conductive polymers; neural prostheses

Indexed keywords

ACCELERATED AGING; BIOMEDICAL ELECTRODES; BIPHASIC; CHARGE-INJECTION LIMITS; COATED ELECTRODES; CONDUCTIVE POLYMER; CONSTANT CURRENT; IN-VITRO; IN-VIVO; IRIDIUM OXIDES; MICROELECTRODE ARRAY; NEURAL ACTIVITY; NEURAL PROSTHESIS; NEURAL STIMULATIONS; PLATINUM-IRIDIUM; POLY(3 ,4-ETHYLENEDIOXYTHIOPHENE); SIGNAL TO NOISE; TRANSFER CAPACITIES; VOLTAGE TRANSIENTS; ZERO VOLTAGE;

CHARGE TRANSFER; COATED WIRE ELECTRODES; CONDUCTING POLYMERS; CYCLIC VOLTAMMETRY; ELECTRIC WELDING; ELECTROCHEMICAL CORROSION; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; ELECTROPHYSIOLOGY; INTERFACES (MATERIALS); ION EXCHANGE; IRIDIUM; IRIDIUM COMPOUNDS; MICROELECTRODES; ORGANIC CONDUCTORS; PLASTIC COATINGS; PLATINUM; PROSTHETICS; TRANSIENT ANALYSIS;

POWER QUALITY;

FUSED HETEROCYCLIC RINGS; IRIDIUM; IRIDIUM OXIDE; POLY(3,4 ETHYLENE DIOXYTHIOPHENE); POLY(3,4-ETHYLENE DIOXYTHIOPHENE); POLYMER;

ANIMAL; ARTICLE; CHEMISTRY; ELECTRODE; ELECTRONICS; ELECTROSTIMULATION; FEMALE; INSTRUMENTATION; MICROELECTRODE; NERVE CELL; NEUROPROSTHESIS; PHYSIOLOGY; PROSTHESIS; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; ELECTRIC STIMULATION; ELECTRODES; ELECTRODES, IMPLANTED; ELECTRONICS; FEMALE; IRIDIUM; MICROELECTRODES; NEURAL PROSTHESES; NEURONS; POLYMERS; PROSTHESIS DESIGN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79958739997     PISSN: 15344320     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNSRE.2011.2109399     Document Type: Article

References (41)

1. D. B. McCreery, T. G. H. Yuen, and L. A. Bullara, "Chronic microstimulation in the feline ventral cochlear nucleus: Physiologic and histologic effects", Hearing Res., vol. 149, no. 1-2, pp. 223-238, 2000.
2. K. J. Otto, P. J. Rousche, and D. R. Kipke, "Microstimulation in auditory cortex provides a substrate for detailed behaviors", Hearing Res., vol. 210, no. 1, pp. 112-117, Dec. 2005. (Pubitemid 41628137)
3. E. M. Schmidt, M. J. Bak, F. T. Hambrecht, C. V. Kufta, D. K. O'Rourke, and P. Vallabhanath, "Feasibility of a visual prosthesis for the blind based on intracortical micro stimulation of the visual cortex", Brain, vol. 119, no. 2, pp. 507-522, Apr. 1996. (Pubitemid 26149365)
4. E. J. Tehovnik and W. M. Slocum, "Phosphene inductionbymicrostimulation of macaque V1", Brain Res. Rev., vol. 53, no. 2, pp. 337-343, 2007.
5. N. A. Fitzsimmons, W. Drake, T. L. Hanson, M. A. Lebedev, and M. A. L. Nicolelis, "Primate reaching cued by multichannel spatiotemporal cortical microstimulation", J. Neurosci., vol. 27, no. 21, pp. 5593-5602, 2007. (Pubitemid 350021077)
6. D. Merrill, M. Bikson, and J. Jefferys, "Electrical stimulation of excitable tissue: Design of efficacious and safe protocols", J. Neurosci. Methods, vol. 141, no. 2, pp. 171-198, 2005. (Pubitemid 40136531)
7. S. F. Cogan, "Neural stimulation and recording electrodes", Annu. Rev. Biomed. Eng., vol. 10, no. 1, 275, 2008.
8. J. Weiland, D. Anderson, and M. Humayun, "In vitro electrical properties for iridium oxide versus titanium nitride stimulating electrodes", IEEE Trans. Biomed. Eng., vol. 49, no. 12, pp. 1574-1579, Dec. 2002. (Pubitemid 36055715)
9. S. A. M. Marzouk, S. Ufer, and R. P. Buck, "Electrodeposited iridium oxide pH electrode for measurement of extracellular myocardial acidosis during acute ischemia", Analytical Chem., vol. 70, no. 23, pp. 5054-5061, 1998.
10. L. S. Robblee, J. L. Lefko, and S. B. Brummer, "Activated IR: An electrode suitable for reversible charge injection in saline solution", J. Electrochem. Soc., vol. 130, no. 3, pp. 731-733, Mar. 1983.
11. S. Negi, R. Bhandari, L. Rieth, and F. Solzbacher, "In vitro comparison of sputtered iridium oxide and platinum-coated neural implantable microelectrode arrays", Biomed. Materials, vol. 5, no. 1, p. 015007, 2010.
12. S. Eick, J. Wallys, B. Hofmann, A. van Ooyen, U. Schnakenberg, S. Ingebrandt, and A. Offenhäusser, "Iridium oxide microelectrode arrays for in vitro stimulation of individual rat neurons from dissociated cultures", Frontiers Neuroeng., vol. 2, no. 16, 2009.
13. S. Cogan, T. Plante, and J. Ehrlich, "Sputtered iridium oxide films (SIROFs) for low-impedance neural stimulation and recording electrodes", in Proc. 26th Annu. Int. Conf. IEEE Eng. Med. Biol. Soc., 2004, vol. 2, pp. 4153-4156. (Pubitemid 40035166)
14. S. F. Cogan, P. R. Troyk, J. Ehrlich, and T. D. Plante, "In vitro comparison of charge-injection limits of Activated Iridium Oxide (AIROF) and platinum-iridium microelectrodes", IEEE Trans. Biomed. Eng., vol. 52, no. 9, pp. 1614-1612, Sep. 2005.
15. S. Cogan, J. Ehrlich, T. Plante, and R. Van Wagenen, "Penetrating microelectrode arrays with low-impedance sputtered iridium oxide electrode coatings", in Annu. Int. Conf. IEEE Eng. Med. Biol. Soc., 2009, pp. 7147-7150.
16. S. F. Cogan, A. A. Guzelian, W. F. Agnew, T. G. Yuen, and D. B. McCreery, "Over-pulsing degrades activated iridium oxide films used for intracortical neural stimulation", J. Neurosci. Methods, vol. 137, no. 2, pp. 141-150, 2004. (Pubitemid 38942874)
17. R. A. Green, N. H. Lovell, G. G. Wallace, and L. A. Poole-Warren, "Conducting polymers for neural interfaces: Challenges in developing an effective long-term implant", Biomaterials, vol. 29, no. 24-25, pp. 3393-3399, 2008.
18. X. Cui and D. C. Martin, "Electrochemical deposition and characterization of poly (3, 4-ethylenedioxythiophene) on neural microelectrode arrays", Sensors Actuators B: Chem., vol. 89, no. 1-2, pp. 92-102, 2003.
19. Y. Xiao, X. Cui, and D. C. Martin, "Electrochemical polymerization and properties of PEDOT/S-EDOT on neural microelectrode arrays", J. Electroanalytical Chem., vol. 573, no. 1, pp. 43-48, 2004.
20. X. Cui and D. Zhou, "Poly (3, 4-Ethylenedioxythiophene) for chronic neural stimulation", IEEE Trans. Neural Syst. Rehabil. Eng., vol. 15, no. 4, pp. 502-508, Dec. 2007. (Pubitemid 350274180)
21. K. A. Ludwig, J. D. Uram, J. Yang, D. C. Martin, and D. R. Kipke, "Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly (3, 4-ethylenedioxythiophene) (PEDOT) film", J. Neural Eng., vol. 3, no. 1, pp. 59-70, 2006. (Pubitemid 43332372)
22. S. J. Wilks, S. M. Richardson-Burns, J. L. Hendricks, D. C. Martin, and K. J. Otto, "Poly (3, 4-ethylene dioxythiophene) (PEDOT) as a microneural interface material for electrostimulation", Frontiers Neuroeng., vol. 2, no. 7, 2009.
23. D. Hukins, A. Mahomed, and S. Kukureka, "Accelerated aging for testing polymeric biomaterials and medical devices", Med. Eng. Phys., vol. 30, no. 10, pp. 1270-1274, 2008.
24. Standard Practice for Accelerated Aging of Ultra-High Molecular Weight Polyethylene after Gamma Irradiation in Air, ASTM F2003-02 (2008).
25. Standard Guide for Accelerated Aging of Sterile Barrier Systems for Medical Devices, ASTM F1980-07.
26. S. Venkatraman and J. M. Carmena, "Behavioral modulation of stimulus-evoked oscillations in barrel cortex of alert rats", Front. Integr. Neurosci., vol. 3, no. 10, 2009.
27. W. Franks, I. Schenker, P. Schmutz, and A. Hierlemann, "Impedance characterization and modeling of electrodes for biomedical applications", IEEE Trans. Biomed. Eng., vol. 52, no. 7, pp. 1295-1302, Jul. 2005. (Pubitemid 40961380)
28. M. R. Abidian and D. C. Martin, "Experimental and theoretical characterization of implantable neural microelectrodes modified with conducting polymer nanotubes", Biomaterials, vol. 29, no. 9, pp. 1273-1283, Mar. 2008.
29. S. F. Cogan, P. R. Troyk, J. Ehrlich, C. Gasbarro, and T. D. Plante, "The influence of electrolyte composition on the in vitro charge-injection limits of activated iridium oxide (AIROF) stimulation electrodes", J. Neural Eng., vol. 4, no. 2, p. 79, 2007.
30. B. Friedel, P. E. Keivanidis, T. J. K. Brenner, A. Abrusci, C. R. Mc-Neill, R. H. Friend, and N. C. Greenham, "Effects of layer thickness and annealing of PEDOT:PSS layers in organic photodetectors", Macromolecules, vol. 42, no. 17, pp. 6741-6747, 2009.
31. E. M. Thaning, M. L. M. Asplund, T. A. Nyberg, O. W. Inganäs, and H. von Holst, "Stability of poly (3, 4-ethylene dioxythiophene) materials intended for implants", J. Biomed. Materials Res. Part B: Appl.d Biomaterials, vol. 93, no. 2, pp. 407-415, 2010.
32. V. Polikov, P. Tresco, and W. Reichert, "Response of brain tissue to chronically implanted neural electrodes", J. Neurosci. Methods, vol. 148, no. 1, pp. 1-18, 2005. (Pubitemid 41423453)
33. S. F. Cogan, "In vivo and in vitro differences in charge-injection and electrochemical properties of iridium oxide electrodes", in Proc. IEEE Eng. Med. Biol. Soc., 2006, pp. 82-885.
34. X. Beebe and T. Rose, "Charge injection limits of activated iridium oxide electrodes with 0.2 ms pulses inbicarbonate buffered saline (neurological stimulation application)", IEEE Trans. Biomed. Eng., vol. 35, no. 6, pp. 494-495, Jun. 1988.
35. J. Freeman, "An electronic stimulus artifact suppressor", Electroencephalogr. Clin. Neurophysiol., vol. 31, no. 2, pp. 170-172, 1971.
36. Y. Jimbo, N. Kasai, K. Torimitsu, T. Tateno, and H. P. C. Robinson, "A system for MEA-based multisite stimulation", IEEE Trans. Biomed. Eng., vol. 50, no. 2, pp. 241-248, Feb. 2003. (Pubitemid 36330922)
37. K. C. McGill, K. L. Cummins, L. J. Dorfman, B. B. Berlizot, K. Leutkemeyer, D. G. Nishimura, and B. Widrow, "On the nature and elimination of stimulus artifact in nerve signals evoked and recorded using surface electrodes", IEEE Trans. Biomed. Eng., vol. 29, no. 2, pp. 129-137, Feb. 1982.
38. S. Butovas and C. Schwarz, "Spatiotemporal effects of microstimulation in rat neocortex: A parametric study using multielectrode recordings", J. Neurophysiol., vol. 90, no. 5, pp. 3024-3039, 2003. (Pubitemid 37430003)
39. S. Venkatraman, K. Elkabany, J. D. Long, Y. Yao, and J. M. Carmena, "A system for neural recordings and closed-loop intracortical microstimulation in awake rodents", IEEE Trans. Biomed. Eng., vol. 56, no. 1, pp. 15-22, Jan. 2009.
40. R. A. Green, N. H. Lovell, and L. A. Poole-Warren, "Cell attachment functionality of bioactive conducting polymers for neural interfaces", Biomaterials, vol. 30, no. 22, pp. 3637-3644, 2009.
41. M. Abidian, D. Kim, and D. Martin, "Conducting-polymer nanotubes for controlled drug release", Adv. Materials, vol. 18, no. 4, pp. 405-409, 2006.