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Volumn 8, Issue 2, 2016, Pages 245-263

EGFR and HER2 signaling in breast cancer brain metastasis

Author keywords

Brain Metastasis; Breast Cancer; EGFR; HER2

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN;

EID: 85016135896     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/765     Document Type: Review
Times cited : (65)

References (132)
  • 1
    • 84920837701 scopus 로고    scopus 로고
    • Cancer statistics 2015
    • R. L. Siegel, K. D. Miller and A. Jemal: Cancer statistics, 2015. CA Cancer J Clin, 65(1), 5-29 (2015) DOI: 10.3322/caac.21254
    • (2015) CA Cancer J Clin , vol.65 , Issue.1 , pp. 5-29
    • Siegel, R.L.1    Miller, K.D.2    Jemal, A.3
  • 2
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • I. J. Fidler: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer, 3(6), 453-8 (2003) DOI: 10.1038/nrc1098
    • (2003) Nat Rev Cancer , vol.3 , Issue.6 , pp. 453-458
    • Fidler, I.J.1
  • 3
    • 84865785496 scopus 로고    scopus 로고
    • A methodological approach to unravel organ-specific breast cancer metastasis
    • S. Nola, S. Sin, F. Bonin, R. Lidereau and K. Driouch: A methodological approach to unravel organ-specific breast cancer metastasis. J Mammary Gland Biol Neoplasia, 17(2), 135-45 (2012) DOI: 10.1007/s10911-012-9256-2
    • (2012) J Mammary Gland Biol Neoplasia , vol.17 , Issue.2 , pp. 135-145
    • Nola, S.1    Sin, S.2    Bonin, F.3    Lidereau, R.4    Driouch, K.5
  • 4
    • 31444447160 scopus 로고    scopus 로고
    • Extending survival with chemotherapy in metastatic breast cancer
    • J. O'Shaughnessy: Extending survival with chemotherapy in metastatic breast cancer. Oncologist, 10 Suppl 3, 20-9 (2005) DOI: 10.1634/theoncologist.10-90003-20
    • (2005) Oncologist , vol.10 , pp. 20-29
    • O'Shaughnessy, J.1
  • 7
    • 34250171217 scopus 로고    scopus 로고
    • Cns metastasis: An old problem in a new guise
    • J. B. Aragon-Ching and J. A. Zujewski: CNS metastasis: an old problem in a new guise. Clin Cancer Res, 13(6), 1644-7 (2007) DOI: 10.1158/1078-0432.CCR-07-0096
    • (2007) Clin Cancer Res , vol.13 , Issue.6 , pp. 1644-1647
    • Aragon-Ching, J.B.1    Zujewski, J.A.2
  • 8
    • 79960429096 scopus 로고    scopus 로고
    • Central nervous system metastases in patients with her2-positive metastatic breast cancer: Incidence, treatment, and survival in patients from registher
    • A. M. Brufsky, M. Mayer, H. S. Rugo, P. A. Kaufman, E. Tan-Chiu, D. Tripathy, I. C. Tudor, L. I. Wang, M. G. Brammer, M. Shing, M. U. Yood and D. A. Yardley: Central nervous system metastases in patients with HER2-positive metastatic breast cancer: incidence, treatment, and survival in patients from registHER. Clin Cancer Res, 17(14), 4834-43 (2011) DOI: 10.1158/1078-0432.CCR-10-2962
    • (2011) Clin Cancer Res , vol.17 , Issue.14 , pp. 4834-4843
    • Brufsky, A.M.1    Mayer, M.2    Rugo, H.S.3    Kaufman, P.A.4    Tan-Chiu, E.5    Tripathy, D.6    Tudor, I.C.7    Wang, L.I.8    Brammer, M.G.9    Shing, M.10    Yood, M.U.11    Yardley, D.A.12
  • 11
    • 84877864202 scopus 로고    scopus 로고
    • Breast cancer brain metastases new directions in systemic therapy
    • N. U. Lin: Breast cancer brain metastases: new directions in systemic therapy. Ecancermedicalscience, 7, 307 (2013)
    • (2013) Ecancermedicalscience , vol.7 , pp. 307
    • Lin, N.U.1
  • 12
    • 84893669763 scopus 로고    scopus 로고
    • The peroxisomal proliferator-Activated receptor (PPAR) alpha agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment
    • D. Greene-Schloesser, V. Payne, A. M. Peiffer, F. C. Hsu, D. R. Riddle, W. Zhao, M. D. Chan, L. Metheny-Barlow and M. E. Robbins: The peroxisomal proliferator-Activated receptor (PPAR) alpha agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Radiat Res, 181(1), 33-44 (2014) DOI: 10.1667/RR13202.1
    • (2014) Radiat Res , vol.181 , Issue.1 , pp. 33-44
    • Greene-Schloesser, D.1    Payne, V.2    Peiffer, A.M.3    Hsu, F.C.4    Riddle, D.R.5    Zhao, W.6    Chan, M.D.7    Metheny-Barlow, L.8    Robbins, M.E.9
  • 13
    • 84893679644 scopus 로고    scopus 로고
    • Differential expression of homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury
    • E. D. Moore, M. Kooshki, K. T. Wheeler, L. J. Metheny-Barlow and M. E. Robbins: Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiat Res, 181(1), 21-32 (2014) DOI: 10.1667/RR13475.1
    • (2014) Radiat Res , vol.181 , Issue.1 , pp. 21-32
    • Moore, E.D.1    Kooshki, M.2    Wheeler, K.T.3    Metheny-Barlow, L.J.4    Robbins, M.E.5
  • 16
    • 70450191099 scopus 로고    scopus 로고
    • Basal-like breast cancers: Clinicopathological features and outcome
    • M. De Brot, F. A. Soares, M. M. Stiepcich, V. S. Curcio and H. Gobbi: (Basal-like breast cancers: clinicopathological features and outcome). Rev Assoc Med Bras, 55(5), 529-34 (2009) DOI: 10.1590/S0104-42302009000500014
    • (2009) Rev Assoc Med Bras , vol.55 , Issue.5 , pp. 529-534
    • De Brot, M.1    Soares, F.A.2    Stiepcich, M.M.3    Curcio, V.S.4    Gobbi, H.5
  • 17
    • 84877856173 scopus 로고    scopus 로고
    • P16 expression correlates with basallike triple-negative breast carcinoma
    • A. A. Abou-Bakr and H. I. Eldweny: p16 expression correlates with basallike triple-negative breast carcinoma. Ecancermedicalscience, 7, 317 (2013)
    • (2013) Ecancermedicalscience , vol.7 , pp. 317
    • Abou-Bakr, A.A.1    Eldweny, H.I.2
  • 18
    • 84922391849 scopus 로고    scopus 로고
    • Treatment and prognosis of breast cancer patients with brain metastases according to intrinsic subtype
    • S. Kuba, M. Ishida, Y. Nakamura, K. Yamanouchi, S. Minami, K. Taguchi, S. Eguchi and S. Ohno: Treatment and prognosis of breast cancer patients with brain metastases according to intrinsic subtype. Jpn J Clin Oncol, 44(11), 1025-31 (2014) DOI: 10.1093/jjco/hyu126
    • (2014) Jpn J Clin Oncol , vol.44 , Issue.11 , pp. 1025-1031
    • Kuba, S.1    Ishida, M.2    Nakamura, Y.3    Yamanouchi, K.4    Minami, S.5    Taguchi, K.6    Eguchi, S.7    Ohno, S.8
  • 19
    • 84858156041 scopus 로고    scopus 로고
    • Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations
    • W. Han and H. W. Lo: Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations. Cancer Lett, 318(2), 124-34 (2012) DOI: 10.1016/j.canlet.2012.01.011
    • (2012) Cancer Lett , vol.318 , Issue.2 , pp. 124-134
    • Han, W.1    Lo, H.W.2
  • 20
    • 0022647432 scopus 로고
    • The product of the human c-ERBB-2 gene: A 185-kilodalton glycoprotein with tyrosine kinase activity
    • T. Akiyama, C. Sudo, H. Ogawara, K. Toyoshima and T. Yamamoto: The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity. Science, 232(4758), 1644-6 (1986) DOI: 10.1126/science.3012781
    • (1986) Science , vol.232 , Issue.4758 , pp. 1644-1646
    • Akiyama, T.1    Sudo, C.2    Ogawara, H.3    Toyoshima, K.4    Yamamoto, T.5
  • 21
    • 0024326947 scopus 로고
    • Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors
    • M. H. Kraus, W. Issing, T. Miki, N. C. Popescu and S. A. Aaronson: Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proceedings of the National Academy of Sciences, 86(23), 9193-9197 (1989) DOI: 10.1073/pnas.86.23.9193
    • (1989) Proceedings of the National Academy of Sciences , vol.86 , Issue.23 , pp. 9193-9197
    • Kraus, M.H.1    Issing, W.2    Miki, T.3    Popescu, N.C.4    Aaronson, S.A.5
  • 23
    • 79151472321 scopus 로고    scopus 로고
    • Nuclear mode of the EGFR signaling network: Biology, prognostic value, and therapeutic implications
    • H. W. Lo: Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications. Discov Med, 10(50), 44-51 (2010)
    • (2010) Discov Med , vol.10 , Issue.50 , pp. 44-51
    • Lo, H.W.1
  • 24
    • 84858156041 scopus 로고    scopus 로고
    • Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations
    • W. Han and H.-W. Lo: Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations. Cancer Letters, 318(2), 124-134 (2012) DOI: 10.1016/j.canlet.2012.01.011
    • (2012) Cancer Letters , vol.318 , Issue.2 , pp. 124-134
    • Han, W.1    Lo, H.-W.2
  • 26
    • 4444342416 scopus 로고    scopus 로고
    • Epidermal growth factor receptor status in breast cancer metastases to the central nervous system. Comparison with her-2/neu status
    • N. L. Grupka, K. C. Lear-Kaul, B. K. Kleinschmidt-DeMasters and M. Singh: Epidermal growth factor receptor status in breast cancer metastases to the central nervous system. Comparison with HER-2/neu status. Arch Pathol Lab Med, 128(9), 974-9 (2004)
    • (2004) Arch Pathol Lab Med , vol.128 , Issue.9 , pp. 974-979
    • Grupka, N.L.1    Lear-Kaul, K.C.2    Kleinschmidt-DeMasters, B.K.3    Singh, M.4
  • 28
    • 11244280137 scopus 로고    scopus 로고
    • Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer
    • H. W. Lo, W. Xia, Y. Wei, M. Ali-Seyed, S. F. Huang and M. C. Hung: Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res, 65(1), 338-48 (2005)
    • (2005) Cancer Res , vol.65 , Issue.1 , pp. 338-348
    • Lo, H.W.1    Xia, W.2    Wei, Y.3    Ali-Seyed, M.4    Huang, S.F.5    Hung, M.C.6
  • 29
    • 75449089516 scopus 로고    scopus 로고
    • Beyond trastuzumab: Small molecule tyrosine kinase inhibitors in her-2-positive breast cancer
    • V. Roy and E. A. Perez: Beyond trastuzumab: small molecule tyrosine kinase inhibitors in HER-2-positive breast cancer. The Oncologist, 14(11), 1061-1069 (2009) DOI: 10.1634/theoncologist.2009-0142
    • (2009) The Oncologist , vol.14 , Issue.11 , pp. 1061-1069
    • Roy, V.1    Perez, E.A.2
  • 30
    • 84904431074 scopus 로고    scopus 로고
    • Updates on the management of breast cancer brain metastases
    • E. Lim and N. U. Lin: Updates on the management of breast cancer brain metastases. Oncology (Williston Park), 28(7), 572-8 (2014)
    • (2014) Oncology (Williston Park , vol.28 , Issue.7 , pp. 572-578
    • Lim, E.1    Lin, N.U.2
  • 31
    • 84916265276 scopus 로고
    • Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal
    • S. Cohen: Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem, 237, 1555-62 (1962)
    • (1962) J Biol Chem , vol.237 , pp. 1555-1562
    • Cohen, S.1
  • 32
    • 0019332558 scopus 로고
    • Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity
    • S. Cohen, G. Carpenter and L. King, Jr.: Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. J Biol Chem, 255(10), 4834-42 (1980)
    • (1980) J Biol Chem , vol.255 , Issue.10 , pp. 4834-4842
    • Cohen, S.1    Carpenter, G.2    King, L.3
  • 33
    • 0019762636 scopus 로고
    • Epidermal growth factor-receptor-protein kinase interactions
    • S. Cohen, G. Carpenter and L. King, Jr.: Epidermal growth factor-receptor-protein kinase interactions. Prog Clin Biol Res, 66 Pt A, 557-67 (1981)
    • (1981) Prog Clin Biol Res , vol.66 , pp. 557-567
    • Cohen, S.1    Carpenter, G.2    King, L.3
  • 34
    • 0020068317 scopus 로고
    • A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles
    • S. Cohen, H. Ushiro, C. Stoscheck and M. Chinkers: A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. J Biol Chem, 257(3), 1523-31 (1982)
    • (1982) J Biol Chem , vol.257 , Issue.3 , pp. 1523-1531
    • Cohen, S.1    Ushiro, H.2    Stoscheck, C.3    Chinkers, M.4
  • 35
    • 0025681492 scopus 로고
    • Binding of sh2 domains of phospholipase c gamma 1 gap and src to activated growth factor receptors
    • D. Anderson, C. A. Koch, L. Grey, C. Ellis, M. F. Moran and T. Pawson: Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science, 250(4983), 979-82 (1990) DOI: 10.1126/science.2173144
    • (1990) Science , vol.250 , Issue.4983 , pp. 979-982
    • Anderson, D.1    Koch, C.A.2    Grey, L.3    Ellis, C.4    Moran, M.F.5    Pawson, T.6
  • 37
    • 0037429737 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: Mechanisms of activation and signalling
    • R. N. Jorissen, F. Walker, N. Pouliot, T. P. Garrett, C. W. Ward and A. W. Burgess: Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res, 284(1), 31-53 (2003) DOI: 10.1073/pnas.131568898
    • (2003) Exp Cell Res , vol.284 , Issue.1 , pp. 31-53
    • Jorissen, R.N.1    Walker, F.2    Pouliot, N.3    Garrett, T.P.4    Ward, C.W.5    Burgess, A.W.6
  • 38
    • 0030447148 scopus 로고    scopus 로고
    • In vitro activation of stat3 by epidermal growth factorreceptorkinase
    • O. K. Park, T. S. Schaefer and D. Nathans: In vitro activation of Stat3 by epidermal growth factorreceptorkinase. Proceedings of the National Academy of Sciences, 93(24), 13704-13708 (1996) DOI: 10.1073/pnas.93.24.13704
    • (1996) Proceedings of the National Academy of Sciences , vol.93 , Issue.24 , pp. 13704-13708
    • Park, O.K.1    Schaefer, T.S.2    Nathans, D.3
  • 39
    • 36248968708 scopus 로고    scopus 로고
    • Snapshot: EGFR signaling pathway
    • Y. Yarden and B. Z. Shilo: SnapShot: EGFR signaling pathway. Cell, 131(5), 1018 (2007) DOI: 10.1016/j.cell.2007.11.013
    • (2007) Cell , vol.131 , Issue.5 , pp. 1018
    • Yarden, Y.1    Shilo, B.Z.2
  • 42
    • 79957926581 scopus 로고    scopus 로고
    • Targeting ras-raf-erk and its interactive pathways as a novel therapy for malignant gliomas
    • H. W. Lo: Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas. Curr Cancer Drug Targets, 10(8), 840-8 (2010) DOI: 10.2174/156800910793357970
    • (2010) Curr Cancer Drug Targets , vol.10 , Issue.8 , pp. 840-848
    • Lo, H.W.1
  • 43
    • 0035721657 scopus 로고    scopus 로고
    • Pten deficiency: A role in mammary carcinogenesis
    • T. Petrocelli and J. M. Slingerland: PTEN deficiency: a role in mammary carcinogenesis. Breast Cancer Res, 3(6), 356-60 (2001) DOI: 10.1186/bcr322
    • (2001) Breast Cancer Res , vol.3 , Issue.6 , pp. 356-360
    • Petrocelli, T.1    Slingerland, J.M.2
  • 44
    • 0032053709 scopus 로고    scopus 로고
    • Mechanisms and consequences of activation of protein kinase b/akt
    • J. Downward: Mechanisms and consequences of activation of protein kinase B/Akt. Current Opinion in Cell Biology, 10(2), 262-267 (1998) DOI: 10.1016/S0955-0674(98)80149-X
    • (1998) Current Opinion in Cell Biology , vol.10 , Issue.2 , pp. 262-267
    • Downward, J.1
  • 45
    • 0035736487 scopus 로고    scopus 로고
    • Her-2/neu induces p53 ubiquitination via akt-mediated mdm2 phosphorylation
    • B. P. Zhou, Y. Liao, W. Xia, Y. Zou, B. Spohn and M.-C. Hung: HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol, 3(11), 973-982 (2001) DOI: 10.1038/ncb1101-973
    • (2001) Nat Cell Biol , vol.3 , Issue.11 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.-C.6
  • 46
    • 0028349735 scopus 로고
    • Stat3: A stat family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Z. Zhong, Z. Wen and J. E. Darnell, Jr.: Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science, 264(5155), 95-8 (1994) DOI: 10.1126/science.8140422
    • (1994) Science , vol.264 , Issue.5155 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 47
    • 0030840464 scopus 로고    scopus 로고
    • Stats and gene regulation
    • J. E. Darnell: STATs and Gene Regulation. Science, 277(5332), 1630-1635 (1997) DOI: 10.1126/science.277.5332.1630
    • (1997) Science , vol.277 , Issue.5332 , pp. 1630-1635
    • Darnell, J.E.1
  • 48
    • 0034722896 scopus 로고    scopus 로고
    • Stat proteins: Novel molecular targets for cancer drug discovery
    • J. Turkson and R. Jove: STAT proteins: novel molecular targets for cancer drug discovery. Oncogene, 19(56), 6613-26 (2000) DOI: 10.1038/sj.onc.1204086
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 50
    • 84898921083 scopus 로고    scopus 로고
    • Stat3 target genes relevant to human cancers
    • R. L. Carpenter and H.-W. Lo: STAT3 Target Genes Relevant to Human Cancers. Cancers, 6(2), 897-925 (2014) DOI: 10.1038/sj.onc.1204086
    • (2014) Cancers , vol.6 , Issue.2 , pp. 897-925
    • Carpenter, R.L.1    Lo, H.-W.2
  • 52
    • 85016159239 scopus 로고    scopus 로고
    • Stat1 gene expression is enhanced by nuclear EGFR and her2 via cooperation with stat3
    • published online 12 JUN
    • W. Han, R. L. Carpenter, X. Cao and H. W. Lo: STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3. Mol Carcinog, published online: 12 JUN 2012
    • (2012) Mol Carcinog
    • Han, W.1    Carpenter, R.L.2    Cao, X.3    Lo, H.W.4
  • 53
    • 77249132723 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-stat3 and EGFRviii-stat3 signaling axes
    • H. W. Lo, X. Cao, H. Zhu and F. Ali-Osman: Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Mol Cancer Res, 8(2), 232-45 (2010) DOI: 10.1158/1541-7786.MCR-09-0391
    • (2010) Mol Cancer Res , vol.8 , Issue.2 , pp. 232-245
    • Lo, H.W.1    Cao, X.2    Zhu, H.3    Ali-Osman, F.4
  • 55
    • 23844442173 scopus 로고    scopus 로고
    • Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis
    • A. Psyrri, Z. Yu, P. M. Weinberger, C. Sasaki, B. Haffty, R. Camp, D. Rimm and B. A. Burtness: Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res, 11(16), 5856-62 (2005) DOI: 10.1158/1078-0432.CCR-05-0420
    • (2005) Clin Cancer Res , vol.11 , Issue.16 , pp. 5856-5862
    • Psyrri, A.1    Yu, Z.2    Weinberger, P.M.3    Sasaki, C.4    Haffty, B.5    Camp, R.6    Rimm, D.7    Burtness, B.A.8
  • 56
    • 67649225203 scopus 로고    scopus 로고
    • Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer
    • W. Xia, Y. Wei, Y. Du, J. Liu, B. Chang, Y. L. Yu, L. F. Huo, S. Miller and M. C. Hung: Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol Carcinog, 48, 610-617 (2009) DOI: 10.1002/mc.20504
    • (2009) Mol Carcinog , vol.48 , pp. 610-617
    • Xia, W.1    Wei, Y.2    Du, Y.3    Liu, J.4    Chang, B.5    Yu, Y.L.6    Huo, L.F.7    Miller, S.8    Hung, M.C.9
  • 57
    • 77953017646 scopus 로고    scopus 로고
    • EGFR and EGFRviii interact with puma to inhibit mitochondrial translocalization of puma and puma-mediated apoptosis independent of EGFR kinase activity
    • H. Zhu, X. Cao, F. Ali-Osman, S. Keir and H. W. Lo: EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. Cancer Lett, 294(1), 101-10 (2010) DOI: 10.1016/j.canlet.2010.01.028
    • (2010) Cancer Lett , vol.294 , Issue.1 , pp. 101-110
    • Zhu, H.1    Cao, X.2    Ali-Osman, F.3    Keir, S.4    Lo, H.W.5
  • 58
    • 79952347920 scopus 로고    scopus 로고
    • EGFR and EGFRviii undergo stress-And EGFR kinase inhibitor-induced mitochondrial translocalization: A potential mechanism of EGFR-driven antagonism of apoptosis
    • X. Cao, H. Zhu, F. Ali-Osman and H. W. Lo: EGFR and EGFRvIII undergo stress-And EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. Mol Cancer, 10, 26 (2011) DOI: 10.1186/1476-4598-10-26 10.1.186/1476-4598-10-26
    • (2011) Mol Cancer , vol.10 , pp. 26
    • Cao, X.1    Zhu, H.2    Ali-Osman, F.3    Lo, H.W.4
  • 59
    • 77952979261 scopus 로고    scopus 로고
    • EGFR-targeted therapy in malignant glioma: Novel aspects and mechanisms of drug resistance
    • H. W. Lo: EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance. Curr Mol Pharmacol, 3(1), 37-52 (2010) DOI: 10.2174/1874467211003010037
    • (2010) Curr Mol Pharmacol , vol.3 , Issue.1 , pp. 37-52
    • Lo, H.W.1
  • 60
    • 33645217263 scopus 로고    scopus 로고
    • EGFR signaling pathway in breast cancers: From traditional signal transduction to direct nuclear translocalization
    • H. W. Lo, S. C. Hsu and M. C. Hung: EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Res Treat, 95(3), 211-8 (2006) DOI: 10.1007/s10549-005-9011-0
    • (2006) Breast Cancer Res Treat , vol.95 , Issue.3 , pp. 211-218
    • Lo, H.W.1    Hsu, S.C.2    Hung, M.C.3
  • 61
    • 77149162377 scopus 로고    scopus 로고
    • EGFR expression in breast cancer association with biologic phenotype and clinical outcomes
    • M. F. Rimawi, P. B. Shetty, H. L. Weiss, R. Schiff, C. K. Osborne, G. C. Chamness and R. M. Elledge: EGFR Expression in Breast Cancer Association with biologic phenotype and clinical outcomes. Cancer, 116(5), 1234-1242 (2010) DOI: 10.1002/cncr.24816
    • (2010) Cancer , vol.116 , Issue.5 , pp. 1234-1242
    • Rimawi, M.F.1    Shetty, P.B.2    Weiss, H.L.3    Schiff, R.4    Osborne, C.K.5    Chamness, G.C.6    Elledge, R.M.7
  • 62
    • 0022388402 scopus 로고
    • The neu gene: An ERBB-homologous gene distinct from and unlinked to the gene encoding the egf receptor
    • A. L. Schechter, M. C. Hung, L. Vaidyanathan, R. A. Weinberg, T. L. Yang-Feng, U. Francke, A. Ullrich and L. Coussens: The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. Science, 229(4717), 976-8 (1985) DOI: 10.1126/science.2992090
    • (1985) Science , vol.229 , Issue.4717 , pp. 976-978
    • Schechter, A.L.1    Hung, M.C.2    Vaidyanathan, L.3    Weinberg, R.A.4    Yang-Feng, T.L.5    Francke, U.6    Ullrich, A.7    Coussens, L.8
  • 63
    • 0022600388 scopus 로고
    • The neu oncogene encodes an epidermal growth factor receptor-related protein
    • C. I. Bargmann, M. C. Hung and R. A. Weinberg: The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature, 319(6050), 226-30 (1986) DOI: 10.1038/319226a0
    • (1986) Nature , vol.319 , Issue.6050 , pp. 226-230
    • Bargmann, C.I.1    Hung, M.C.2    Weinberg, R.A.3
  • 64
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the her-2/neu oncogene
    • D. J. Slamon, G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich and W. L. McGuire: Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/neu Oncogene. Science, 235(4785), 177-182 (1987) DOI: 10.1126/science.3798106
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 66
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • N. E. Hynes and H. A. Lane: ERBB receptors and cancer: the complexity of targeted inhibitors. Nature Reviews. Cancer, 5(5), 341-354 (2005) DOI: 10.1038/nrc1609
    • (2005) Nature Reviews. Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 67
    • 0029162564 scopus 로고
    • Heregulindependent regulation of her2/neu oncogenic signaling by heterodimerization with her3
    • C. Wallasch, F. U. Weiss, G. Niederfellner, B. Jallal, W. Issing and A. Ullrich: Heregulindependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. The EMBO Journal, 14(17), 4267-4275 (1995)
    • (1995) The EMBO Journal , vol.14 , Issue.17 , pp. 4267-4275
    • Wallasch, C.1    Weiss, F.U.2    Niederfellner, G.3    Jallal, B.4    Issing, W.5    Ullrich, A.6
  • 68
    • 0034638925 scopus 로고    scopus 로고
    • Molecular mechanisms underlying erbb2/her2 action in breast cancer
    • D. Harari and Y. Yarden: Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene, 19(53), 6102-6114 (2000) DOI: 10.1038/sj.onc.1203973
    • (2000) Oncogene , vol.19 , Issue.53 , pp. 6102-6114
    • Harari, D.1    Yarden, Y.2
  • 69
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of bad couples survival signals to the cell-intrinsic death machinery
    • S. R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh and M. E. Greenberg: Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery. Cell, 91(2), 231-241 (1997) DOI: 10.1016/S0092-8674(00)80405-5
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 70
    • 44049104549 scopus 로고    scopus 로고
    • Expression of her-2 in mcf-7 breast cancer cells modulates antiapoptotic proteins survivin and bcl-2 via the extracellular signal-related kinase (erk) and phosphoinositide-3 kinase (pi3k) signalling pathways
    • A. Siddiqa, L. M. Long, L. Li, R. A. Marciniak and I. Kazhdan: Expression of HER-2 in MCF-7 breast cancer cells modulates antiapoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways. BMC Cancer, 8(1) (2008) DOI: 10.1186/1471-2407-8-129
    • (2008) BMC Cancer , vol.8 , pp. 1
    • Siddiqa, A.1    Long, L.M.2    Li, L.3    Marciniak, R.A.4    Kazhdan, I.5
  • 71
    • 78649740898 scopus 로고    scopus 로고
    • Progesterone receptor induces ERBB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ERBB-2 function as a coactivator of stat3
    • W. Beguelin, M. C. Diaz Flaque, C. J. Proietti, F. Cayrol, M. A. Rivas, M. Tkach, C. Rosemblit, J. M. Tocci, E. H. Charreau, R. Schillaci and P. V. Elizalde: Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol Cell Biol, 30(23), 5456-72 (2010) DOI: 10.1128/MCB.00012-10
    • (2010) Mol Cell Biol , vol.30 , Issue.23 , pp. 5456-5472
    • Beguelin, W.1    Diaz Flaque, M.C.2    Proietti, C.J.3    Cayrol, F.4    Rivas, M.A.5    Tkach, M.6    Rosemblit, C.7    Tocci, J.M.8    Charreau, E.H.9    Schillaci, R.10    Elizalde, P.V.11
  • 72
    • 84893606200 scopus 로고    scopus 로고
    • Her2 phosphorylates and destabilizes pro-Apoptotic puma, leading to antagonized apoptosis in cancer cells
    • R. L. Carpenter, W. Han, I. Paw and H. W. Lo: HER2 phosphorylates and destabilizes pro-Apoptotic PUMA, leading to antagonized apoptosis in cancer cells. PLoS One, 8(11), e78836 (2013) DOI: 10.1371/journal.pone.0078836
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e78836
    • Carpenter, R.L.1    Han, W.2    Paw, I.3    Lo, H.W.4
  • 75
    • 4444309305 scopus 로고    scopus 로고
    • The egf receptor family as therapeutic targets in breast cancer
    • M. A. Lemmon: The EGF receptor family as therapeutic targets in breast cancer. Breast Disease, 18, 33-43 (2003)
    • (2003) Breast Disease , vol.18 , pp. 33-43
    • Lemmon, M.A.1
  • 83
    • 77951139631 scopus 로고    scopus 로고
    • Genome remodelling in a basallike breast cancer metastasis and xenograft
    • L. Ding, M. J. Ellis, S. Li, D. E. Larson, K. Chen, J. W. Wallis, C. C. Harris, M. D. McLellan, R. S. Fulton, L. L. Fulton, R. M. Abbott, J. Hoog, D. J. Dooling, D. C. Koboldt, H. Schmidt, J. Kalicki, Q. Zhang, L. Chen, L. Lin, M. C. Wendl, J. F. McMichael, V. J. Magrini, L. Cook, S. D. McGrath, T. L. Vickery, E. Appelbaum, K. Deschryver, S. Davies, T. Guintoli, L. Lin, R. Crowder, Y. Tao, J. E. Snider, S. M. Smith, A. F. Dukes, G. E. Sanderson, C. S. Pohl, K. D. Delehaunty, C. C. Fronick, K. A. Pape, J. S. Reed, J. S. Robinson, J. S. Hodges, W. Schierding, N. D. Dees, D. Shen, D. P. Locke, M. E. Wiechert, J. M. Eldred, J. B. Peck, B. J. Oberkfell, J. T. Lolofie, F. Du, A. E. Hawkins, M. D. O'Laughlin, K. E. Bernard, M. Cunningham, G. Elliott, M. D. Mason, D. M. Thompson, Jr., J. L. Ivanovich, P. J. Goodfellow, C. M. Perou, G. M. Weinstock, R. Aft, M. Watson, T. J. Ley, R. K. Wilson and E. R. Mardis: Genome remodelling in a basallike breast cancer metastasis and xenograft. Nature, 464(7291), 999-1005 (2010) DOI: 10.1038/nature08989
    • (2010) Nature , vol.464 , Issue.7291 , pp. 999-1005
    • Ding, L.1    Ellis, M.J.2    Li, S.3    Larson, D.E.4    Chen, K.5    Wallis, J.W.6    Harris, C.C.7    McLellan, M.D.8    Fulton, R.S.9    Fulton, L.L.10    Abbott, R.M.11
  • 85
    • 31444440292 scopus 로고    scopus 로고
    • Nuclear EGFR signalling network in cancers: Linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival
    • H. W. Lo and M. C. Hung: Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. British Journal of Cancer, 94(2), 184-188 (2006) DOI: 10.1038/sj.bjc.6602941
    • (2006) British Journal of Cancer , vol.94 , Issue.2 , pp. 184-188
    • Lo, H.W.1    Hung, M.C.2
  • 90
    • 84964694241 scopus 로고    scopus 로고
    • Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer
    • L. Zhang, J. A. Ngo, M. D. Wetzel and D. Marchetti: Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer()(). Neoplasia (New York, N.Y.), 17(1), 101-113 (2015) DOI: 10.1016/j.neo.2014.11.007
    • (2015) Neoplasia (New York, N.Y , vol.17 , Issue.1 , pp. 101-113
    • Zhang, L.1    Ngo, J.A.2    Wetzel, M.D.3    Marchetti, D.4
  • 91
    • 84901407297 scopus 로고    scopus 로고
    • Heparanase multiple effects in cancer
    • Y. Nadir and B. Brenner: Heparanase multiple effects in cancer. Thromb Res, 133 Suppl 2, S90-4 (2014) DOI: 10.1016/S0049-3848(14)50015-1
    • (2014) Thromb Res , vol.133 , pp. S90-S94
    • Nadir, Y.1    Brenner, B.2
  • 92
    • 77249112379 scopus 로고    scopus 로고
    • Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase i activity in brain metastatic breast cancer
    • L. Zhang, P. Sullivan, J. Suyama and D. Marchetti: Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer. Mol Cancer Res, 8(2), 278-90 (2010) DOI: 10.1158/1541-7786.MCR-09-0375
    • (2010) Mol Cancer Res , vol.8 , Issue.2 , pp. 278-290
    • Zhang, L.1    Sullivan, P.2    Suyama, J.3    Marchetti, D.4
  • 95
    • 77956301181 scopus 로고    scopus 로고
    • Matrix metalloproteinases (mmps) and tissue inhibitors of metalloproteinases (timps): Positive and negative regulators in tumor cell adhesion
    • D. Bourboulia and W. G. Stetler-Stevenson: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Semin Cancer Biol, 20(3), 161-8 (2010) DOI: 10.1016/j.semcancer.2010.05.002
    • (2010) Semin Cancer Biol , vol.20 , Issue.3 , pp. 161-168
    • Bourboulia, D.1    Stetler-Stevenson, G.W.2
  • 96
    • 34547183458 scopus 로고    scopus 로고
    • Mmp2 role in breast cancer brain metastasis development and its regulation by timp2 and erk1/2
    • O. Mendes, H. T. Kim, G. Lungu and G. Stoica: MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. Clin Exp Metastasis, 24(5), 341-51 (2007) DOI: 10.1007/s10585-007-9071-0
    • (2007) Clin Exp Metastasis , vol.24 , Issue.5 , pp. 341-351
    • Mendes, O.1    Kim, H.T.2    Lungu, G.3    Stoica, G.4
  • 97
    • 79955799333 scopus 로고    scopus 로고
    • A functional nuclear epidermal growth factor receptor src and stat3 heteromeric complex in pancreatic cancer cells
    • S. Jaganathan, P. Yue, D. C. Paladino, J. Bogdanovic, Q. Huo and J. Turkson: A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells. PLoS One, 6(5), e19605 (2011) DOI: 10.1371/journal.pone.0019605
    • (2011) PLoS One , vol.6 , Issue.5 , pp. e19605
    • Jaganathan, S.1    Yue, P.2    Paladino, D.C.3    Bogdanovic, J.4    Huo, Q.5    Turkson, J.6
  • 98
    • 0034855942 scopus 로고    scopus 로고
    • Nuclear localization of egf receptor and its potential new role as a transcription factor
    • S. Y. Lin, K. Makino, W. Xia, A. Matin, Y. Wen, K. Y. Kwong, L. Bourguignon and M. C. Hung: Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol, 3(9), 802-8 (2001) DOI: 10.1038/ncb0901-802
    • (2001) Nat Cell Biol , vol.3 , Issue.9 , pp. 802-808
    • Lin, S.Y.1    Makino, K.2    Xia, W.3    Matin, A.4    Wen, Y.5    Kwong, K.Y.6    Bourguignon, L.7    Hung, M.C.8
  • 99
    • 48349140762 scopus 로고    scopus 로고
    • Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (stat5) in activating aurora-A gene expression
    • L. Y. Hung, J. T. Tseng, Y. C. Lee, W. Xia, Y. N. Wang, M. L. Wu, Y. H. Chuang, C. H. Lai and W. C. Chang: Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids Res, 36(13), 4337-51 (2008) DOI: 10.1093/nar/gkn417
    • (2008) Nucleic Acids Res , vol.36 , Issue.13 , pp. 4337-4351
    • Hung, L.Y.1    Tseng, J.T.2    Lee, Y.C.3    Xia, W.4    Wang, Y.N.5    Wu, M.L.6    Chuang, Y.H.7    Lai, C.H.8    Chang, W.C.9
  • 100
    • 79957982003 scopus 로고    scopus 로고
    • Nuclear translocation of epidermal growth factor receptor by akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells
    • W. C. Huang, Y. J. Chen, L. Y. Li, Y. L. Wei, S. C. Hsu, S. L. Tsai, P. C. Chiu, W. P. Huang, Y. N. Wang, C. H. Chen, W. C. Chang, W. C. Chang, A. J. Chen, C. H. Tsai and M. C. Hung: Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. J Biol Chem, 286(23), 20558-68 (2011) DOI: 10.1074/jbc.M111.240796
    • (2011) J Biol Chem , vol.286 , Issue.23 , pp. 20558-20568
    • Huang, W.C.1    Chen, Y.J.2    Li, L.Y.3    Wei, Y.L.4    Hsu, S.C.5    Tsai, S.L.6    Chiu, P.C.7    Huang, W.P.8    Wang, Y.N.9    Chen, C.H.10    Chang, W.C.11    Chang, W.C.12    Chen, A.J.13    Tsai, C.H.14    Hung, M.C.15
  • 101
    • 35148832569 scopus 로고    scopus 로고
    • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelialmesenchymal transition in cancer cells via up-regulation of twist gene expression
    • H. W. Lo, S. C. Hsu, W. Xia, X. Cao, J. Y. Shih, Y. Wei, J. L. Abbruzzese, G. N. Hortobagyi and M. C. Hung: Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelialmesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res, 67(19), 9066-76 (2007)
    • (2007) Cancer Res , vol.67 , Issue.19 , pp. 9066-9076
    • Lo, H.W.1    Hsu, S.C.2    Xia, W.3    Cao, X.4    Shih, J.Y.5    Wei, Y.6    Abbruzzese, J.L.7    Hortobagyi, G.N.8    Hung, M.C.9
  • 102
    • 0021932240 scopus 로고
    • Amplification, enhanced expression and possible rearrangement of egf receptor gene in primary human brain tumours of glial origin
    • T. A. Libermann, H. R. Nusbaum, N. Razon, R. Kris, I. Lax, H. Soreq, N. Whittle, M. D. Waterfield, A. Ullrich and J. Schlessinger: Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature, 313(5998), 144-7 (1985)
    • (1985) Nature , vol.313 , Issue.5998 , pp. 144-147
    • Libermann, T.A.1    Nusbaum, H.R.2    Razon, N.3    Kris, R.4    Lax, I.5    Soreq, H.6    Whittle, N.7    Waterfield, M.D.8    Ullrich, A.9    Schlessinger, J.10
  • 103
    • 7144227965 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials
    • B. R. Voldborg, L. Damstrup, M. Spang-Thomsen and H. S. Poulsen: Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. Ann Oncol, 8(12), 1197-206 (1997)
    • (1997) Ann Oncol , vol.8 , Issue.12 , pp. 1197-1206
    • Voldborg, B.R.1    Damstrup, L.2    Spang-Thomsen, M.3    Poulsen, H.S.4
  • 106
    • 58149144782 scopus 로고    scopus 로고
    • Constitutively activated stat3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting stat3 sensitizes them to iressa and alkylators
    • H. W. Lo, X. Cao, H. Zhu and F. Ali-Osman: Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clin Cancer Res, 14(19), 6042-54 (2008)
    • (2008) Clin Cancer Res , vol.14 , Issue.19 , pp. 6042-6054
    • Lo, H.W.1    Cao, X.2    Zhu, H.3    Ali-Osman, F.4
  • 107
    • 78249232963 scopus 로고    scopus 로고
    • Factors associated with the development of brain metastases: Analysis of 975 patients with early stage nonsmall cell lung cancer
    • J. L. Hubbs, J. A. Boyd, D. Hollis, J. P. Chino, M. Saynak and C. R. Kelsey: Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer. Cancer, 116(21), 5038-46 (2010)
    • (2010) Cancer , vol.116 , Issue.21 , pp. 5038-5046
    • Hubbs, J.L.1    Boyd, J.A.2    Hollis, D.3    Chino, J.P.4    Saynak, M.5    Kelsey, C.R.6
  • 116
    • 84911972745 scopus 로고    scopus 로고
    • Her2 mediated de novo production of tgfbeta leads to snail driven epithelial-to-mesenchymal transition and metastasis of breast cancer
    • P. Gupta and S. K. Srivastava: HER2 mediated de novo production of TGFbeta leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer. Mol Oncol, 8(8), 1532-47 (2014)
    • (2014) Mol Oncol , vol.8 , Issue.8 , pp. 1532-1547
    • Gupta, P.1    Srivastava, S.K.2
  • 117
    • 79961211320 scopus 로고    scopus 로고
    • The crosstalk of ras with the tgf-β family during carcinoma progression and its implications for targeted cancer therapy
    • M. Grusch, M. Petz, T. Metzner, D. Öztürk, D. Schneller and W. Mikulits: The Crosstalk of RAS with the TGF-β Family During Carcinoma Progression and its Implications for Targeted Cancer Therapy. Current cancer drug targets, 10(8), 849-857 (2010)
    • (2010) Current Cancer Drug Targets , vol.10 , Issue.8 , pp. 849-857
    • Grusch, M.1    Petz, M.2    Metzner, T.3    Öztürk, D.4    Schneller, D.5    Mikulits, W.6
  • 118
    • 79959510568 scopus 로고    scopus 로고
    • When tumor suppressor tgfbeta meets the her2 (erbb2) oncogene
    • A. Chow, C. L. Arteaga and S. E. Wang: When tumor suppressor TGFbeta meets the HER2 (ERBB2) oncogene. J Mammary Gland Biol Neoplasia, 16(2), 81-8 (2011)
    • (2011) J Mammary Gland Biol Neoplasia , vol.16 , Issue.2 , pp. 81-88
    • Chow, A.1    Arteaga, C.L.2    Wang, S.E.3
  • 119
    • 70350741359 scopus 로고    scopus 로고
    • Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors
    • S. C. Wang and M. C. Hung: Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors. Clin Cancer Res, 15(21), 6484-9 (2009)
    • (2009) Clin Cancer Res , vol.15 , Issue.21 , pp. 6484-6489
    • Wang, S.C.1    Hung, M.C.2
  • 121
    • 0035419867 scopus 로고    scopus 로고
    • Erbb2/neu kinase modulates cellular p27(kip1) and cyclin d1 through multiple signaling pathways
    • A. E. Lenferink, D. Busse, W. M. Flanagan, F. M. Yakes and C. L. Arteaga: ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res, 61(17), 6583-91 (2001)
    • (2001) Cancer Res , vol.61 , Issue.17 , pp. 6583-6591
    • Lenferink, A.E.1    Busse, D.2    Flanagan, W.M.3    Yakes, F.M.4    Arteaga, C.L.5
  • 125
    • 84879533925 scopus 로고    scopus 로고
    • Metastasis of breast tumor cells to brain is suppressed by phenethyl isothiocyanate in a novel in vivo metastasis model
    • P. Gupta, C. Adkins, P. Lockman and S. K. Srivastava: Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In vivo Metastasis Model. PLoS ONE, 8(6), e67278 (2013)
    • (2013) PLoS ONE , vol.8 , Issue.6 , pp. e67278
    • Gupta, P.1    Adkins, C.2    Lockman, P.3    Srivastava, S.K.4
  • 126
  • 127
    • 84974575822 scopus 로고    scopus 로고
    • Abstract 1827: Inhibition of src her2 and EGFR by the multi-kinase inhibitor kd019 overcomes trastuzumab resistance in breast cancer
    • R. Mo, N. Rao, J. Tonra, S. Waksal and M. Poyurovsky: Abstract 1827: Inhibition of Src, HER2, and EGFR by the multi-kinase inhibitor KD019 overcomes trastuzumab resistance in breast cancer. Cancer Research, 74(19 Supplement), 1827 (2014)
    • (2014) Cancer Research , vol.74 , Issue.19 , pp. 1827
    • Mo, R.1    Rao, N.2    Tonra, J.3    Waksal, S.4    Poyurovsky, M.5
  • 132
    • 85032043179 scopus 로고    scopus 로고
    • Rtog 1119: Phase II randomized study of whole brain radiotherapy with concurrent lapatinib in patients with brain metastasis from her2-positive breast cancer-A collaborative study of rtog and krog (nct01622868
    • D. M. Peereboom, K. A. Winter, I. A. Kim, J. F. De Los Santos, P. W. Sperduto, J. R. White and M. P. Mehta: RTOG 1119: Phase II randomized study of whole brain radiotherapy with concurrent lapatinib in patients with brain metastasis from HER2-positive breast cancer-A collaborative study of RTOG and KROG (NCT01622868). ASCO Meeting Abstracts, 32(15-suppl), TPS664 (2014)
    • (2014) ASCO Meeting Abstracts , vol.32 , Issue.15 , pp. TPS664
    • Peereboom, D.M.1    Winter, K.A.2    Kim, I.A.3    Santos Los De, J.F.4    Sperduto, P.W.5    White, J.R.6    Mehta, M.P.7


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