메뉴 건너뛰기




Volumn 28, Issue 7, 2014, Pages

Updates on the management of breast cancer brain metastases

(2)  Lim, Elgene a   Lin, Nancy U a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; BEVACIZUMAB; BRCA1 PROTEIN; BRCA2 PROTEIN; CAPECITABINE; CARBOPLATIN; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; ETOPOSIDE; LAPATINIB; NAVELBINE; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROGESTERONE RECEPTOR; TRASTUZUMAB EMTANSINE; VASCULOTROPIN;

EID: 84904431074     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note
Times cited : (36)

References (55)
  • 2
    • 77954740501 scopus 로고    scopus 로고
    • Metastatic behavior of breast cancer subtypes
    • Kennecke H, Yerushalmi R, Woods R, et al. Metastatic behavior of breast cancer subtypes. J Clin Oncol. 2010; 28: 3271-7.
    • (2010) J Clin Oncol , vol.28 , pp. 3271-3277
    • Kennecke, H.1    Yerushalmi, R.2    Woods, R.3
  • 3
    • 84858698969 scopus 로고    scopus 로고
    • Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases
    • Sperduto PW, Kased N, Roberge D, et al. Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases. Int J Radiat Oncol Biol Phys. 2012; 82: 2111-7.
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. 2111-2117
    • Sperduto, P.W.1    Kased, N.2    Roberge, D.3
  • 4
    • 84856475642 scopus 로고    scopus 로고
    • Brain metastases-free survival differs between breast cancer subtypes
    • Berghoff A, Bago-Horvath Z, De Vries C, et al. Brain metastases-free survival differs between breast cancer subtypes. Br J Cancer. 2012; 106: 440-6.
    • (2012) Br J Cancer , vol.106 , pp. 440-446
    • Berghoff, A.1    Bago-Horvath, Z.2    De Vries, C.3
  • 5
    • 84885058143 scopus 로고    scopus 로고
    • The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer
    • Sperduto PW, Kased N, Roberge D, et al. The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer. J Neurooncol. 2013; 112: 467-72.
    • (2013) J Neurooncol , vol.112 , pp. 467-472
    • Sperduto, P.W.1    Kased, N.2    Roberge, D.3
  • 6
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009; 9: 274-84.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 7
    • 59649115878 scopus 로고    scopus 로고
    • An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016)
    • Polli JW, Olson KL, Chism JP, et al. An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016). Drug Metab Dispos. 2009; 37: 439-42.
    • (2009) Drug Metab Dispos , vol.37 , pp. 439-442
    • Polli, J.W.1    Olson, K.L.2    Chism, J.P.3
  • 8
    • 80052622812 scopus 로고    scopus 로고
    • Tissue concentration of systemically administered antineoplastic agents in human brain tumors
    • Pitz MW, Desai A, Grossman SA, Blakeley JO. Tissue concentration of systemically administered antineoplastic agents in human brain tumors. J Neurooncol. 2011; 104: 629-38.
    • (2011) J Neurooncol , vol.104 , pp. 629-638
    • Pitz, M.W.1    Desai, A.2    Grossman, S.A.3    Blakeley, J.O.4
  • 9
    • 84875236228 scopus 로고    scopus 로고
    • CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: A retrospective substudy of the HERA trial (BIG 1-01)
    • Pestalozzi BC, Holmes E, de Azambuja E, et al. CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01). Lancet Oncol. 2013; 14: 244-8.
    • (2013) Lancet Oncol , vol.14 , pp. 244-248
    • Pestalozzi, B.C.1    Holmes, E.2    de Azambuja, E.3
  • 10
    • 84871712684 scopus 로고    scopus 로고
    • Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: A randomised, controlled, phase 3 trial
    • Goss PE, Smith IE, O'Shaughnessy J, et al. Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial. Lancet Oncol. 2013; 14: 88-96.
    • (2013) Lancet Oncol , vol.14 , pp. 88-96
    • Goss, P.E.1    Smith, I.E.2    O'Shaughnessy, J.3
  • 11
    • 79960429096 scopus 로고    scopus 로고
    • Central nervous system metastases in patients with HER2-positive metastatic breast cancer: Incidence, treatment, and survival in patients from registHER
    • Brufsky AM, Mayer M, Rugo HS, et al. Central nervous system metastases in patients with HER2-positive metastatic breast cancer: incidence, treatment, and survival in patients from registHER. Clin Cancer Res. 2011; 17: 4834-43.
    • (2011) Clin Cancer Res , vol.17 , pp. 4834-4843
    • Brufsky, A.M.1    Mayer, M.2    Rugo, H.S.3
  • 12
    • 0038010542 scopus 로고    scopus 로고
    • Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma
    • Bendell JC, Domchek SM, Burstein HJ, et al. Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer. 2003; 97: 2972-7.
    • (2003) Cancer , vol.97 , pp. 2972-2977
    • Bendell, J.C.1    Domchek, S.M.2    Burstein, H.J.3
  • 13
    • 84878430061 scopus 로고    scopus 로고
    • Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab
    • Olson EM, Abdel-Rasoul M, Maly J, et al. Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab. Ann Oncol. 2013; 24: 1526-33.
    • (2013) Ann Oncol , vol.24 , pp. 1526-1533
    • Olson, E.M.1    Abdel-Rasoul, M.2    Maly, J.3
  • 14
    • 55849132481 scopus 로고    scopus 로고
    • Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: High incidence of central nervous system metastases
    • Lin NU, Claus E, Sohl J, et al. Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases. Cancer. 2008; 113: 2638-45.
    • (2008) Cancer , vol.113 , pp. 2638-2645
    • Lin, N.U.1    Claus, E.2    Sohl, J.3
  • 15
    • 79959939609 scopus 로고    scopus 로고
    • Clinical outcome of triple negative breast cancer in BRCA1 mutation carriers and noncarriers
    • Lee LJ, Alexander B, Schnitt SJ, et al. Clinical outcome of triple negative breast cancer in BRCA1 mutation carriers and noncarriers. Cancer. 2011; 117: 3093-100.
    • (2011) Cancer , vol.117 , pp. 3093-3100
    • Lee, L.J.1    Alexander, B.2    Schnitt, S.J.3
  • 16
    • 84861309946 scopus 로고    scopus 로고
    • The use of bevacizumab among women with metastatic breast cancer: A survey on clinical practice and the ongoing controversy
    • Dawood S, Shaikh AJ, Buchholz TA, et al. The use of bevacizumab among women with metastatic breast cancer: a survey on clinical practice and the ongoing controversy. Cancer. 2012; 118: 2780-6.
    • (2012) Cancer , vol.118 , pp. 2780-2786
    • Dawood, S.1    Shaikh, A.J.2    Buchholz, T.A.3
  • 17
    • 46249099391 scopus 로고    scopus 로고
    • Defining prognosis for women with breast cancer and CNS metastases by HER2 status
    • Dawood S, Broglio K, Esteva FJ, et al. Defining prognosis for women with breast cancer and CNS metastases by HER2 status. Ann Oncol. 2008; 19: 1242-8.
    • (2008) Ann Oncol , vol.19 , pp. 1242-1248
    • Dawood, S.1    Broglio, K.2    Esteva, F.J.3
  • 18
    • 75049085304 scopus 로고    scopus 로고
    • Evidence-based clinical practice parameter guidelines for the treatment of patients with metastatic brain tumors: Introduction
    • Kalkanis SN, Linskey ME. Evidence-based clinical practice parameter guidelines for the treatment of patients with metastatic brain tumors: introduction. J Neurooncol. 2010; 96: 7-10.
    • (2010) J Neurooncol , vol.96 , pp. 7-10
    • Kalkanis, S.N.1    Linskey, M.E.2
  • 19
    • 79951966253 scopus 로고    scopus 로고
    • Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952-26001 study
    • Kocher M, Soffietti R, Abacioglu U, et al. Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol. 2011; 29: 134-41.
    • (2011) J Clin Oncol , vol.29 , pp. 134-141
    • Kocher, M.1    Soffietti, R.2    Abacioglu, U.3
  • 20
    • 0025189608 scopus 로고
    • A randomized trial of surgery in the treatment of single metastases to the brain
    • Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med. 1990; 322: 494-500.
    • (1990) N Engl J Med , vol.322 , pp. 494-500
    • Patchell, R.A.1    Tibbs, P.A.2    Walsh, J.W.3
  • 21
    • 33744954692 scopus 로고    scopus 로고
    • Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial
    • Aoyama H, Shirato H, Tago M, et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA. 2006; 295: 2483-91.
    • (2006) JAMA , vol.295 , pp. 2483-2491
    • Aoyama, H.1    Shirato, H.2    Tago, M.3
  • 22
    • 71249157772 scopus 로고    scopus 로고
    • Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial
    • Chang EL, Wefel JS, Hess KR, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol. 2009; 10: 1037-44.
    • (2009) Lancet Oncol , vol.10 , pp. 1037-1044
    • Chang, E.L.1    Wefel, J.S.2    Hess, K.R.3
  • 23
    • 84874640697 scopus 로고    scopus 로고
    • New insights and emerging therapies for breast cancer brain metastases
    • Lim E, Lin NU. New insights and emerging therapies for breast cancer brain metastases. Oncology (Williston Park). 2012; 26: 652-9, 63.
    • (2012) Oncology (Williston Park) , vol.26
    • Lim, E.1    Lin, N.U.2
  • 24
    • 84904417290 scopus 로고    scopus 로고
    • TBCRC 018: Phase II study of iniparib plus chemotherapy to treat triple-negative breast cancer (TNBC) central nervous system (CNS) metastases (mets)
    • abstr 515
    • Anders CK, Deal AM, Abramson VG, et al. TBCRC 018: phase II study of iniparib plus chemotherapy to treat triple-negative breast cancer (TNBC) central nervous system (CNS) metastases (mets). J Clin Oncol. 2013; 31(suppl): abstr 515.
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Anders, C.K.1    Deal, A.M.2    Abramson, V.G.3
  • 25
    • 84894684013 scopus 로고    scopus 로고
    • Downfall of iniparib: A PARP inhibitor that doesn't inhibit PARP after all
    • Sinha G. Downfall of iniparib: a PARP inhibitor that doesn't inhibit PARP after all. J Natl Cancer Inst. 2014; 106: djt447.
    • (2014) J Natl Cancer Inst , vol.106
    • Sinha, G.1
  • 26
    • 27744440126 scopus 로고    scopus 로고
    • Isolated central nervous system metastases in patients with HER2-overexpressing advanced breast cancer treated with first-line trastuzumab-based therapy
    • Burstein HJ, Lieberman G, Slamon DJ, et al. Isolated central nervous system metastases in patients with HER2-overexpressing advanced breast cancer treated with first-line trastuzumab-based therapy. Ann Oncol. 2005; 16: 1772-7.
    • (2005) Ann Oncol , vol.16 , pp. 1772-1777
    • Burstein, H.J.1    Lieberman, G.2    Slamon, D.J.3
  • 27
    • 77951474500 scopus 로고    scopus 로고
    • Biodistribution of 89Zr-trastuzumab and PET imaging of HER2-positive lesions in patients with metastatic breast cancer
    • Dijkers EC, Oude Munnink TH, Kosterink JG, et al. Biodistribution of 89Zr-trastuzumab and PET imaging of HER2-positive lesions in patients with metastatic breast cancer. Clin Pharmacol Ther. 2010; 87: 586-92.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 586-592
    • Dijkers, E.C.1    Oude Munnink, T.H.2    Kosterink, J.G.3
  • 28
    • 62549135630 scopus 로고    scopus 로고
    • Trastuzumab treatment improves brain metastasis outcomes through control and durable prolongation of systemic extracranial disease in HER2-overexpressing breast cancer patients
    • Park YH, Park MJ, Ji SH, et al. Trastuzumab treatment improves brain metastasis outcomes through control and durable prolongation of systemic extracranial disease in HER2-overexpressing breast cancer patients. Br J Cancer. 2009; 100: 894-900.
    • (2009) Br J Cancer , vol.100 , pp. 894-900
    • Park, Y.H.1    Park, M.J.2    Ji, S.H.3
  • 29
    • 84872018758 scopus 로고    scopus 로고
    • Population-based outcomes after brain radiotherapy in patients with brain metastases from breast cancer in the pre-trastuzumab and trastuzumab eras
    • Karam I, Hamilton S, Nichol A, et al. Population-based outcomes after brain radiotherapy in patients with brain metastases from breast cancer in the pre-trastuzumab and trastuzumab eras. Radiat Oncol. 2013; 8: 12.
    • (2013) Radiat Oncol , vol.8 , pp. 12
    • Karam, I.1    Hamilton, S.2    Nichol, A.3
  • 30
    • 84891754753 scopus 로고    scopus 로고
    • Breast cancer brain metastases responding to primary systemic therapy with T-DM1
    • Bartsch R, Berghoff AS, Preusser M. Breast cancer brain metastases responding to primary systemic therapy with T-DM1. J Neurooncol. 2014; 116: 205-6.
    • (2014) J Neurooncol , vol.116 , pp. 205-206
    • Bartsch, R.1    Berghoff, A.S.2    Preusser, M.3
  • 31
    • 84904415157 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab emtansine (T-DM1) vs lapatinib plus capecitabine (XL) in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) and central nervous system (CNS) metastases: Results from a retrospective exploratory analysis of EMILIA
    • P4-12-27
    • Krop I, Lin NU, Blackwell K, et al. Efficacy and safety of trastuzumab emtansine (T-DM1) vs lapatinib plus capecitabine (XL) in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) and central nervous system (CNS) metastases: results from a retrospective exploratory analysis of EMILIA. Cancer Research. 2013; 73: P4-12-27.
    • (2013) Cancer Research , vol.73
    • Krop, I.1    Lin, N.U.2    Blackwell, K.3
  • 32
    • 42949112556 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
    • Lin NU, Carey LA, Liu MC, et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2008; 26: 1993-9.
    • (2008) J Clin Oncol , vol.26 , pp. 1993-1999
    • Lin, N.U.1    Carey, L.A.2    Liu, M.C.3
  • 33
    • 63149110733 scopus 로고    scopus 로고
    • Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer
    • Lin NU, Dieras V, Paul D, et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res. 2009; 15: 1452-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 1452-1459
    • Lin, N.U.1    Dieras, V.2    Paul, D.3
  • 34
    • 82955163167 scopus 로고    scopus 로고
    • Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases
    • Lin NU, Eierman W, Greil R, et al. Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases. J Neurooncol. 2011; 105: 613-20.
    • (2011) J Neurooncol , vol.105 , pp. 613-620
    • Lin, N.U.1    Eierman, W.2    Greil, R.3
  • 35
    • 79952017724 scopus 로고    scopus 로고
    • Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine
    • Metro G, Foglietta J, Russillo M, et al. Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine. Ann Oncol. 2011; 22: 625-30.
    • (2011) Ann Oncol , vol.22 , pp. 625-630
    • Metro, G.1    Foglietta, J.2    Russillo, M.3
  • 36
    • 77949542447 scopus 로고    scopus 로고
    • Treatment of HER2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases-the UK experience
    • Sutherland S, Ashley S, Miles D, et al. Treatment of HER2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases-the UK experience. Br J Cancer. 2010; 102: 995-1002.
    • (2010) Br J Cancer , vol.102 , pp. 995-1002
    • Sutherland, S.1    Ashley, S.2    Miles, D.3
  • 37
    • 84871722407 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): A single-group phase 2 study
    • Bachelot T, Romieu G, Campone M, et al. Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study. Lancet Oncol. 2013; 14: 64-71.
    • (2013) Lancet Oncol , vol.14 , pp. 64-71
    • Bachelot, T.1    Romieu, G.2    Campone, M.3
  • 38
    • 84860222241 scopus 로고    scopus 로고
    • A meta-analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases
    • Tsao M, Xu W, Sahgal A. A meta-analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases. Cancer. 2012; 118: 2486-93.
    • (2012) Cancer , vol.118 , pp. 2486-2493
    • Tsao, M.1    Xu, W.2    Sahgal, A.3
  • 39
    • 84865179740 scopus 로고    scopus 로고
    • Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases
    • Tsao MN, Lloyd N, Wong RK, et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev. 2012; 4: CD003869.
    • (2012) Cochrane Database Syst Rev , vol.4
    • Tsao, M.N.1    Lloyd, N.2    Wong, R.K.3
  • 40
    • 2542489101 scopus 로고    scopus 로고
    • Survival following whole brain radiation treatment for cerebral metastases: An audit of 474 patients
    • Broadbent AM, Hruby G, Tin MM, et al. Survival following whole brain radiation treatment for cerebral metastases: an audit of 474 patients. Radiother Oncol. 2004; 71: 259-65.
    • (2004) Radiother Oncol , vol.71 , pp. 259-265
    • Broadbent, A.M.1    Hruby, G.2    Tin, M.M.3
  • 41
    • 84890439476 scopus 로고    scopus 로고
    • A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases
    • Lin NU, Freedman RA, Ramakrishna N, et al. A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res Treat. 2013; 142: 405-14.
    • (2013) Breast Cancer Res Treat , vol.142 , pp. 405-414
    • Lin, N.U.1    Freedman, R.A.2    Ramakrishna, N.3
  • 42
    • 80053597907 scopus 로고    scopus 로고
    • Preliminary results of whole brain radiotherapy with concurrent trastuzumab for treatment of brain metastases in breast cancer patients
    • Chargari C, Idrissi HR, Pierga JY, et al. Preliminary results of whole brain radiotherapy with concurrent trastuzumab for treatment of brain metastases in breast cancer patients. Int J Radiat Oncol Biol Phys. 2011; 81: 631-6.
    • (2011) Int J Radiat Oncol Biol Phys , vol.81 , pp. 631-636
    • Chargari, C.1    Idrissi, H.R.2    Pierga, J.Y.3
  • 43
    • 84883011191 scopus 로고    scopus 로고
    • Challenges relating to solid tumour brain metastases in clinical trials, part 1: Patient population, response, and progression. A report from the RANO group
    • Lin NU, Lee EQ, Aoyama H, et al. Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group. Lancet Oncol. 2013; 14: e396-406.
    • (2013) Lancet Oncol , vol.14
    • Lin, N.U.1    Lee, E.Q.2    Aoyama, H.3
  • 44
    • 84882951377 scopus 로고    scopus 로고
    • Challenges relating to solid tumour brain metastases in clinical trials, part 2: Neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group
    • Lin NU, Wefel JS, Lee EQ, et al. Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group. Lancet Oncol. 2013; 14: e407-16.
    • (2013) Lancet Oncol , vol.14
    • Lin, N.U.1    Wefel, J.S.2    Lee, E.Q.3
  • 45
    • 79958728268 scopus 로고    scopus 로고
    • PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer
    • Gonzalez-Angulo AM, Ferrer-Lozano J, Stemke-Hale K, et al. PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol Cancer Ther. 2011; 10: 1093-101.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1093-1101
    • Gonzalez-Angulo, A.M.1    Ferrer-Lozano, J.2    Stemke-Hale, K.3
  • 46
    • 82355160843 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases
    • Adamo B, Deal AM, Burrows E, et al. Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases. Breast Cancer Res. 2011; 13: R125.
    • (2011) Breast Cancer Res , vol.13
    • Adamo, B.1    Deal, A.M.2    Burrows, E.3
  • 47
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K, Horlings HM, Hennessy BT, et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. 2007; 12: 395-402.
    • (2007) Cancer Cell , vol.12 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3
  • 48
    • 84878770155 scopus 로고    scopus 로고
    • PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells
    • Jegg AM, Ward TM, Iorns E, et al. PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells. Breast Cancer Res Treat. 2012; 136: 683-92.
    • (2012) Breast Cancer Res Treat , vol.136 , pp. 683-692
    • Jegg, A.M.1    Ward, T.M.2    Iorns, E.3
  • 49
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med. 2012; 366: 520-9.
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 50
    • 84885420714 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3)
    • abstr 505
    • O'Regan R, Ozguroglu M, Andre F, et al. Phase III, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3). J Clin Oncol. 2013; 31(suppl): abstr 505.
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • O'Regan, R.1    Ozguroglu, M.2    Andre, F.3
  • 51
    • 84904409263 scopus 로고    scopus 로고
    • Phase II trial of the phosphatidyinositol-3 kinase inhibitor BKM120 in recurrent glioblastoma
    • abstr 2015
    • Wen PY, Yung WKA, Mellinghoff IK, et al. Phase II trial of the phosphatidyinositol-3 kinase inhibitor BKM120 in recurrent glioblastoma. J Clin Oncol. 2013; 31(suppl): abstr 2015.
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Wen, P.Y.1    Yung, W.K.A.2    Mellinghoff, I.K.3
  • 53
    • 84871735461 scopus 로고    scopus 로고
    • Bevacizumab, etoposide, and cisplatin (BEEP) in brain metastases of breast cancer progressing from radiotherapy: Results of the first stage of a multicenter phase II study
    • abstr 1079
    • Lu YS, Chen WW, Lin CH, et al. Bevacizumab, etoposide, and cisplatin (BEEP) in brain metastases of breast cancer progressing from radiotherapy: results of the first stage of a multicenter phase II study. J Clin Oncol. 2012; 30(suppl): abstr 1079.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Lu, Y.S.1    Chen, W.W.2    Lin, C.H.3
  • 54
    • 84856004336 scopus 로고    scopus 로고
    • Stumbling blocks on the path to personalized medicine in breast cancer: The case of PARP inhibitors for BRCA1/2-associated cancers
    • Balmana J, Domchek SM, Tutt A, Garber JE. Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers. Cancer Discov. 2011; 1: 29-34.
    • (2011) Cancer Discov , vol.1 , pp. 29-34
    • Balmana, J.1    Domchek, S.M.2    Tutt, A.3    Garber, J.E.4
  • 55
    • 33646428682 scopus 로고    scopus 로고
    • The basal phenotype of BRCA1-related breast cancer: Past, present and future
    • Tischkowitz MD, Foulkes WD. The basal phenotype of BRCA1-related breast cancer: past, present and future. Cell Cycle. 2006; 5: 963-7.
    • (2006) Cell Cycle , vol.5 , pp. 963-967
    • Tischkowitz, M.D.1    Foulkes, W.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.