Brain-metastatic triple-negative breast cancer cells regain growth ability by altering gene expression patterns

Cancer Genomics and Proteomics

Volumn 10, Issue 6, 2013, Pages 265-276

  Choi, Youn Kyung ^a   Woo, Sang Mi ^a   Cho, Sung Gook ^a   Moon, Hyo Eun ^b   Yun, Yee Jin ^a   Kim, Jin Wook ^b   Noh, Dong Young ^b   Jang, Bo Hyung ^a   Shin, Yong Chol ^a   Kim, Jeong Hyun ^c   Shin, Hyoung Doo ^c,d   Paek, Sun Ha ^b   Ko, Seong Gyu ^a  

^a Kyung Hee University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Sogang University   (South Korea)

^d SNP Genetics Inc   (South Korea)

Author keywords

Brain metastasis; MAPK13; PPL; Triple negative breast cancer

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 13; PERIPLAKIN;

ARTICLE; BRAIN METASTASIS; CANCER GROWTH; CELL CULTURE; CELL GROWTH; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE ONTOLOGY; GROWTH RATE; IN VITRO STUDY; TRIPLE NEGATIVE BREAST CANCER; UPREGULATION;

BRAIN METASTASIS; MAPK13; PPL; TRIPLE-NEGATIVE BREAST CANCER;

APOPTOSIS; BRAIN NEOPLASMS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 13; PLAKINS; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84890870706     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD et al: Genes that mediate breast cancer metastasis to lung. Nature 436: 518-524, 2005.
2. Masuda S: Breast cancer pathology: the impact of molecular taxonomy on morphological taxonomy. Pathol Int 62: 295-302, 2012.
3. Wilhelm I, Molnar J, Fazakas C, Hasko J and Krizbai IA: Role of the blood-brain barrier in the formation of brain metastases. Int J Mol Sci 14: 1383-1411, 2013.
4. Lim B, Cream LV and Harvey HA: Update on clinical trials: genetic targets in breast cancer. Adv Exp Med Biol 779: 35-54, 2013.
5. Mao Y, Keller ET, Garfield DH, Shen K and Wang J: Stromal cells in tumor microenvironment and breast cancer. Cancer Metastasis Rev, 2012.
6. Scully OJ, Bay BH, Yip G and Yu Y: Breast cancer metastasis. Cancer Genomics & Proteomics 9 : 311-320, 2012.
7. Burstein HJ, Polyak K, Wong JS, Lester SC and Kaelin CM: Ductal carcinoma in situ of the breast. N Eng J Med 350 : 1430-1441, 2004.
8. Sotiriou C and Pusztai L: Gene-expression signatures in breast cancer. N Eng J Med 360: 790-800, 2009.
9. Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. N Eng J Med 363: 1938-1948, 2010.
10. Penault-Llorca F and Viale G: Pathological and molecular diagnosis of triple-negative breast cancer: a clinical perspective. Annals of oncology: official journal of the European Society for Medical Oncology/ESMO 23(Suppl 6) : vi19-22, 2012.
11. Andre F and Zielinski CC: Optimal strategies for the treatment of metastatic triple-negative breast cancer with currently approved agents. Ann Oncol: official journal of the European Society for Medical Oncology/ESMO 23(Suppl 6): vi46-51, 2012.
12. Dogan BE and Turnbull LW: Imaging of triple-negative breast cancer. Ann Oncol: official journal of the European Society for Medical Oncology/ESMO 23(Suppl 6) : vi23-29,2012.
13. Freedman RA, Anders CK. Treatment of Breast Cancer Brain Metastases. Curr Breast Cancer Rep 4 : 1-9, 2012.
14. Espinosa E, Vara JA, Navarro IS, Gamez-Pozo A, Pinto A, Zamora P et al: Gene profiling in breast cancer: time to move forward. Cancer Treat Rev 37: 416-421, 2011.
15. de Ruijter TC, Veeck J, de Hoon JP, van Engeland M and Tjan-Heijnen VC: Characteristics of triple-negative breast cancer. J Cancer Res Clin Oncol 137: 183-192, 2011.
16. Arslan UY, Oksuzoglu B, Aksoy S, Harputluoglu H, Turker I, Ozisik Y et al: Breast cancer subtypes and outcomes of central nervous system metastases. Breast 20: 562-567, 2011.
17. Hines SL, Vallow LA, Tan WW, McNeil RB, Perez EA, Jain A. Clinical outcomes after a diagnosis of brain metastases in patients with estrogen- and/or human epidermal growth factor receptor 2-positive versus triple-negative breast cancer. Ann Oncol: official journal of the European Society for Medical Oncology/ESMO 19: 1561-155, 2008.
18. Lin NU, Claus E, Sohl J, Razzak AR, Arnaout A and Winer EP: Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases. Cancer 113 : 2638-2645, 2008.
19. Kwon HC, Oh SY, Kim SH, Lee S, Kwon KA, Choi YJ et al: Clinical outcomes and breast cancer subtypes in patients with brain metastases. Onkologie 33: 146-152, 2010.
20. Gupta GP, Minn AJ, Kang Y, Siegel PM, Serganova I, Cordon-Cardo C et al : Identifying site-specific metastasis genes and functions. Cold Spring Harb Symp Quant Biol 70: 149-158, 2005.
21. Tseng LM, Hsu NC, Chen SC, Lu YS, Lin CH, Chang DY et al: Distant metastasis in triple-negative breast cancer. Neoplasma 60: 290-294, 2013.
22. Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX et al : Genes that mediate breast cancer metastasis to the brain. Nature 459: 1005-1009, 2009.
23. Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C et al: A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3 : 537-549, 2003.
24. Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P et al: Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol 179 : 1599-1612, 2007.
25. Karashima T, Watt FM. Interaction of periplakin and envoplakin with intermediate filaments. J Cell Sci 115: 5027-5037, 2002.
26. Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM. Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. J Cell Biol 139 : 1835-1849, 1997.
27. Suzuki A, Horiuchi A, Ashida T, Miyamoto T, Kashima H, Nikaido T et al : Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin. J Cell Mol Med 14: 2305-2317, 2010.
28. Tonoike Y, Matsushita K, Tomonaga T, Katada K, Tanaka N, Shimada H et al : Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells. BMC Cell Biol 12: 41, 2011.
29. Nishimori T, Tomonaga T, Matsushita K, Oh-Ishi M, Kodera Y, Maeda T et al : Proteomic analysis of primary esophageal squamous cell carcinoma reveals down-regulation of a cell adhesion protein, periplakin. Proteomics 6 : 1011-1018, 2006.
30. Hatakeyama H, Kondo T, Fujii K, Nakanishi Y, Kato H, Fukuda S et al: Protein clusters associated with carcinogenesis, histological differentiation and nodal metastasis in esophageal cancer. Proteomics 6: 6300-6316, 2006.
31. Tan FL, Ooi A, Huang D, Wong JC, Qian CN, Chao C et al: p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion. Int J Cancer 126: 2353-2361, 2010.
32. Goto Y, Shinjo K, Kondo Y, Shen L, Toyota M, Suzuki H et al: Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. Cancer Res 69 : 9073-9082, 2009.
33. Bigelow RL, Williams BJ, Carroll JL, Daves LK and Cardelli JA: TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro. Breast Cancer Res Treat 117: 31-44, 2009.
34. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K et al: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411: 613-617, 2001.
35. Otsuki Y, Tanaka M, Yoshii S, Kawazoe N, Nakaya K and Sugimura H: Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1. Proc Natl Acad Sci USA 98 : 4385-4390, 2001.
36. Gildea JJ, Seraj MJ, Oxford G, Harding MA, Hampton GM, Moskaluk CA et al: RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res 62: 6418-6423, 2002.
37. Wyszomierski SL and Yu D: A knotty turnabout?: Akt1 as a metastasis suppressor. Cancer Cell 8: 437-439, 2005.
38. Horak CE, Lee JH, Marshall JC, Shreeve SM and Steeg PS: The role of metastasis suppressor genes in metastatic dormancy. Apmis 116: 586-601, 2008.
39. Taylor J, Hickson J, Lotan T, Yamada DS and Rinker-Schaeffer C: Using metastasis suppressor proteins to dissect interactions among cancer cells and their microenvironment. Cancer Metastasis Rev 27 : 67-73, 2008.
40. Xu Z, Schlesinger D, Toulmin S, Rich T and Sheehan J: Impact of triple-negative phenotype on prognosis of patients with breast cancer brain metastases. Int J Radiat Oncol Biol Phys 84 : 612-618, 2012.