Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer

Carcinogenesis

Volumn 37, Issue 12, 2016, Pages 1180-1189

  Treekitkarnmongkol, Warapen ^a   Katayama, Hiroshi ^a,c   Kai, Kazuharu ^a   Sasai, Kaori ^a,c   Jones, Jennifer Carter ^a,d   Wang, Jing ^a   Shen, Li ^a   Sahin, Aysegul A ^a   Gagea, Mihai ^a   Ueno, Naoto T ^a   Creighton, Chad J ^a,b   Sen, Subrata ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c OKAYAMA UNIVERSITY   (Japan)

^d AGILENT TECHNOLOGIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; BETA LACTOGLOBULIN; BINDING PROTEIN; CYCLIN D1; ERCC5 PROTEIN; ESTROGEN RECEPTOR ALPHA; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLO LIKE KINASE 1; PROTEIN KINASE B; PROTEIN P53; TPX2 PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2; TRANSCRIPTOME; UNCLASSIFIED DRUG; TUMOR MARKER; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST ADENOCARCINOMA; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER INCIDENCE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GAIN OF FUNCTION MUTATION; GENE LOCUS; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; LACTATION; MOUSE; MULTIPLE PREGNANCY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTOMICS; TRANSGENIC MOUSE; TUMOR GENE; UPREGULATION; WHOLE EXOME SEQUENCING; ADENOCARCINOMA; ANIMAL; BIOSYNTHESIS; BREAST TUMOR; EPITHELIUM; EXPERIMENTAL MAMMARY NEOPLASM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PREGNANCY; UDDER;

ADENOCARCINOMA; ANIMALS; AURORA KINASE A; BIOMARKERS, TUMOR; BREAST NEOPLASMS; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, ANIMAL; MICE; NEOPLASM PROTEINS; PREGNANCY;

EID: 85016072303     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgw097     Document Type: Article

References (55)

1. Ciriello, G. et al. (2013) Emerging landscape of oncogenic signatures across human cancers. Nat. Genet., 45, 1127-1133.
2. Sen, S. et al. (2002) Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J. Natl. Cancer Inst., 94, 1320-1329.
3. Aust, D.E. et al. (2004) Prognostic relevance of 20q13 gains in sporadic colorectal cancers: a FISH analysis. Scand. J. Gastroenterol., 39, 766-772.
4. Sen, S. et al. (1997) A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene, 14, 2195-2200.
5. Zhou, H. et al. (1998) Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet., 20, 189-193.
6. Bischoff, J.R. et al. (1998) A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J., 17, 3052-3065.
7. Ewart-Toland, A. et al. (2003) Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat. Genet., 34, 403-412.
8. Katayama, H. et al. (2004) Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat. Genet., 36, 55-62.
9. Liu, Q. et al. (2004) Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J. Biol. Chem., 279, 52175-52182.
10. Katayama, H. et al. (2012) Aurora kinase-A inactivates DNA damageinduced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell, 21, 196-211.
11. Lee, D.F. et al. (2012) Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell, 11, 179-194.
12. Croker, A.K. et al. (2008) Cancer stem cells: implications for the progression and treatment of metastatic disease. J. Cell. Mol. Med., 12, 374-390.
13. Ye, X. et al. (2015) Epithelial-mesenchymal plasticity: a central regulator of cancer progression. Trends Cell Biol., 25, 675-686.
14. Cammareri, P. et al. (2010) Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells. Cancer Res., 70, 4655-4665.
15. Lim, K.H. et al. (2010) Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol. Cell. Biol., 30, 508-523.
16. Otto, T. et al. (2009) Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell, 15, 67-78.
17. Dar, A.A. et al. (2009) The aurora kinase A regulates GSK-3beta in gastric cancer cells. Oncogene, 28, 866-875.
18. Tanaka, T. et al. (1999) Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res., 59, 2041-2044.
19. Miyoshi, Y. et al. (2001) Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int. J. Cancer, 92, 370-373.
20. Zhang, D. et al. (2004) Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene, 23, 8720-8730.
21. Zhang, D. et al. (2008) Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice. Oncogene, 27, 4305-4314.
22. Wang, X. et al. (2006) Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene, 25, 7148-7158.
23. Whitelaw, C.B. et al. (1992) Position-independent expression of the ovine beta-lactoglobulin gene in transgenic mice. Biochem. J., 286 (Pt 1), 31-39.
24. Webster, J. et al. (1995) Tissue-specific, temporally regulated expression mediated by the proximal ovine beta-lactoglobulin promoter in transgenic mice. Cell. Mol. Biol. Res., 41, 11-15.
25. Hofmann, W.A. et al. (2009) Analysis of array-CGH data using the R and Bioconductor software suite. Comp Funct Genomics, 201325.
26. Venkatraman, E.S. et al. (2007) A faster circular binary segmentation algorithm for the analysis of array CGH data. Bioinformatics, 23, 657-663.
27. Wang, K. et al. (2009) Estimation of tumor heterogeneity using CGH array data. BMC Bioinformatics, 10, 12.
28. Krupke, D.M. et al. (2008) The mouse tumor biology database. Nat. Rev. Cancer, 8, 459-465.
29. Ciriello, G., et al. (2015) Comprehensive molecular portraits of invasive lobular breast cancer. Cell, 163, 506-519.
30. Cancer Genome Atlas Network. (2012) Comprehensive molecular portraits of human breast tumours. Nature, 490, 61-70.
31. Buyse, M. et al. (2006) Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J. Natl Cancer Inst., 98, 1183-1192.
32. Cardiff, R.D. et al. (2000) The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene, 19, 968-988.
33. Rosner, A. et al. (2002) Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am. J. Pathol., 161, 1087-1097.
34. Taga, M. et al. (2009) Essential roles of mTOR/Akt pathway in Aurora-A cell transformation. Int. J. Biol. Sci., 5, 444-450.
35. De Luca, M. et al. (2006) A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association. Cell Cycle, 5, 296-303.
36. Seki, A. et al. (2008) Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science, 320, 1655-1658.
37. Macurek, L. et al. (2008) Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature, 455, 119-123.
38. Carter, S.L. et al. (2006) A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat. Genet., 38, 1043-1048.
39. Scotto, L. et al. (2008) Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression. Genes. Chromosomes Cancer, 47, 755-765.
40. Weichert, W. et al. (2005) Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications. Virchows Arch., 446, 442-450.
41. Katayama, H. et al. (2011) Functional significance of Aurora kinase A regulatory interactions with p53-ERa complex in human breast cancer cells. Horm. Cancer, 2, 117-124.
42. Ben-David, U. et al. (2016) The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis. Nat. Commun., 7, 12160.
43. Prabhu, V.V. et al. (2012) Therapeutic targeting of the p53 pathway in cancer stem cells. Expert Opin. Ther. Targets, 16, 1161-1174.
44. Cicalese, A. et al. (2009) The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell, 138, 1083-1095.
45. Torchia, E.C. et al. (2009) A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Res., 69, 7207-7215.
46. Santarius, T. et al. (2010) GLO1-A novel amplified gene in human cancer. Genes. Chromosomes Cancer, 49, 711-725.
47. Walsh, C.S. et al. (2008) ERCC5 is a novel biomarker of ovarian cancer prognosis. J. Clin. Oncol., 26, 2952-2958.
48. Yin, Y. et al. (2008) PTEN: a new guardian of the genome. Oncogene, 27, 5443-5453.
49. Knobbe, C.B. et al. (2008) The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey. Oncogene, 27, 5398-5415.
50. Kwon, Y.W. et al. (2012) Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol. Cancer Res., 10, 834-844.
51. Shulewitz, M. et al. (2006) Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer. Oncogene, 25, 4361-4369.
52. Nishiyama, M. et al. (2012) Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-ß-catenin signaling pathway. Mol. Cell. Biol., 32, 501-512.
53. Mukherjee, N. et al. (2016) Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: clinical and prognostic significance. Biochim. Biophys. Acta, 1862, 1472-1484.
54. Sinha, S. et al. (2008) Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early-and late-onset breast carcinoma. Mol. Cancer, 7, 84.
55. Bonilla, X. et al. (2016) Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma. Nat. Genet., 48, 398-406.