-
1
-
-
34848866647
-
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
-
Todaro M, Alea MP, Di Stefano AB, et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 2007;1:389-402.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 389-402
-
-
Todaro, M.1
Alea, M.P.2
Di Stefano, A.B.3
-
2
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-737
-
(1997)
Nat Med
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
3
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
DOI 10.1073/pnas.0530291100
-
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003;100:3983-3988 (Pubitemid 36418143)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.7
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
4
-
-
0141842674
-
Identification of a cancer stem cell in human brain tumors
-
Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-5828 (Pubitemid 37187480)
-
(2003)
Cancer Research
, vol.63
, Issue.18
, pp. 5821-5828
-
-
Singh, S.K.1
Clarke, I.D.2
Terasaki, M.3
Bonn, V.E.4
Hawkins, C.5
Squire, J.6
Dirks, P.B.7
-
5
-
-
33750313208
-
Cancer stem cells-perspectives on current status and future directions: AACR workshop on cancer stem cells
-
Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells-perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res 2006;66:9339-9344
-
(2006)
Cancer Res
, vol.66
, pp. 9339-9344
-
-
Clarke, M.F.1
Dick, J.E.2
Dirks, P.B.3
-
6
-
-
34547193404
-
Phenotypic characterization of human colorectal cancer stem cells
-
Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 2007; 104:10158-10163
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 10158-10163
-
-
Dalerba, P.1
Dylla, S.J.2
Park, I.K.3
-
7
-
-
33846095137
-
Identification and expansion of human colon-cancer-initiating cells
-
Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445: 111-115
-
(2007)
Nature
, vol.445
, pp. 111-115
-
-
Ricci-Vitiani, L.1
Lombardi, D.G.2
Pilozzi, E.3
-
8
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-111
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
9
-
-
34247188473
-
Telomere and telomerase in stem cells
-
Hiyama E, Hiyama K. Telomere and telomerase in stem cells. Br J Cancer 2007;96:1020-1024
-
(2007)
Br J Cancer
, vol.96
, pp. 1020-1024
-
-
Hiyama, E.1
Hiyama, K.2
-
10
-
-
34248347084
-
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: A source of karyotpic instability
-
Mantel C, Guo Y, Lee MR, et al. Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability. Blood 2007;109:4518-4527
-
(2007)
Blood
, vol.109
, pp. 4518-4527
-
-
Mantel, C.1
Guo, Y.2
Lee, M.R.3
-
11
-
-
59849095153
-
A pluripotency and self renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors
-
Conway AE, Lindgren A, Galic Z, et al. A pluripotency and self renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. Stem Cells 2009; 27:18-28.
-
(2009)
Stem Cells
, vol.27
, pp. 18-28
-
-
Conway, A.E.1
Lindgren, A.2
Galic, Z.3
-
13
-
-
33846988313
-
Roles of Aurora kinases in mitosis and tumorigenesis
-
Fu J, Bian M, Jiang Q, Zhang C. Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res 2007;5:1-10.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 1-10
-
-
Fu, J.1
Bian, M.2
Jiang, Q.3
Zhang, C.4
-
14
-
-
16844366286
-
RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells
-
Hata T, Furukawa T, Sunamura M, et al. RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. Cancer Res 2005;65:2899-2905
-
(2005)
Cancer Res
, vol.65
, pp. 2899-2905
-
-
Hata, T.1
Furukawa, T.2
Sunamura, M.3
-
15
-
-
38349169905
-
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype
-
Lentini L, Amato A, Schillaci T, Di Leonardo A. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype. BMC Cancer 2007;7:212.
-
(2007)
BMC Cancer
, vol.7
, pp. 212
-
-
Lentini, L.1
Amato, A.2
Schillaci, T.3
Di Leonardo, A.4
-
16
-
-
73549102150
-
Stable knockdown of Aurora-A by vector-based RNA interference in human esophageal squamous cell carcinoma cell line inhibits tumor cell proliferation, invasion and enhances apoptosis
-
Wang X, Dong L, Xie J, Tong T, Zhan Q. Stable knockdown of Aurora-A by vector-based RNA interference in human esophageal squamous cell carcinoma cell line inhibits tumor cell proliferation, invasion and enhances apoptosis. Cancer Biol Ther 2009;8.
-
(2009)
Cancer Biol Ther
, pp. 8
-
-
Wang, X.1
Dong, L.2
Xie, J.3
Tong, T.4
Zhan, Q.5
-
17
-
-
0032100685
-
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
-
Bischoff JR, Anderson L, Zhu Y, et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 1998;17:3052-3065
-
(1998)
EMBO J
, vol.17
, pp. 3052-3065
-
-
Bischoff, J.R.1
Anderson, L.2
Zhu, Y.3
-
18
-
-
0031714080
-
Tumour amplified kinase STK15/ BTAK induces centrosome amplification, aneuploidy and transformation
-
Zhou H, Kuang J, Zhong L, et al. Tumour amplified kinase STK15/ BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998;20:189-193
-
(1998)
Nat Genet
, vol.20
, pp. 189-193
-
-
Zhou, H.1
Kuang, J.2
Zhong, L.3
-
19
-
-
0037019736
-
Amplification/overexpression of a mitotic kinase gene in human bladder cancer
-
Sen S, Zhou H, Zhang RD, et al. Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J Natl Cancer Inst 2002;94:1320-1329
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 1320-1329
-
-
Sen, S.1
Zhou, H.2
Zhang, R.D.3
-
20
-
-
4143105611
-
Prognostic relevance of 20q13 gains in sporadic colorectal cancers: A FISH analysis
-
Aust DE, Muders M, Kohler A, et al. Prognostic relevance of 20q13 gains in sporadic colorectal cancers: a FISH analysis. Scand J Gastroenterol 2004;39:766-772
-
(2004)
Scand J Gastroenterol
, vol.39
, pp. 766-772
-
-
Aust, D.E.1
Muders, M.2
Kohler, A.3
-
21
-
-
33751085368
-
Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation
-
Wang X, Zhou YX, Qiao W, et al. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 2006;25:7148-7158
-
(2006)
Oncogene
, vol.25
, pp. 7148-7158
-
-
Wang, X.1
Zhou, Y.X.2
Qiao, W.3
-
22
-
-
9144251019
-
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
-
Katayama H, Sasai K, Kawai H, et al. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet 2004;36:55-62.
-
(2004)
Nat Genet
, vol.36
, pp. 55-62
-
-
Katayama, H.1
Sasai, K.2
Kawai, H.3
-
23
-
-
10644227569
-
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215
-
Liu Q, Kaneko S, Yang L, et al. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem 2004;279:52175-52182
-
(2004)
J Biol Chem
, vol.279
, pp. 52175-52182
-
-
Liu, Q.1
Kaneko, S.2
Yang, L.3
-
24
-
-
0037586498
-
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
-
Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 2003;3:51-62.
-
(2003)
Cancer Cell
, vol.3
, pp. 51-62
-
-
Anand, S.1
Penrhyn-Lowe, S.2
Venkitaraman, A.R.3
-
25
-
-
58149496571
-
Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells
-
Scharer CD, Laycock N, Osunkoya AO, et al. Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells. J Transl Med 2008;6:79.
-
(2008)
J Transl Med
, vol.6
, pp. 79
-
-
Scharer, C.D.1
Laycock, N.2
Osunkoya, A.O.3
-
26
-
-
33751426181
-
Aurora kinase inhibition downregulates NF-κB and sensitises tumour cells to chemotherapeutic agents
-
Sun C, Chan F, Briassouli P, Linardopoulos S. Aurora kinase inhibition downregulates NF-κB and sensitises tumour cells to chemotherapeutic agents. Biochem Biophys Res Commun 2007;352:220-225
-
(2007)
Biochem Biophys Res Commun
, vol.352
, pp. 220-225
-
-
Sun, C.1
Chan, F.2
Briassouli, P.3
Linardopoulos, S.4
-
27
-
-
66449133562
-
The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model
-
VanderPorten EC, Taverna P, Hogan JN, Ballinger MD, Flanagan WM, Fucini RV. The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol Cancer Ther 2009;8:930-939
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 930-939
-
-
VanderPorten, E.C.1
Taverna, P.2
Hogan, J.N.3
Ballinger, M.D.4
Flanagan, W.M.5
Fucini, R.V.6
-
28
-
-
42949087894
-
Isolation and culture of colon cancer stem cells
-
Cammareri P, Lombardo Y, Francipane MG, Bonventre S, Todaro M, Stassi G. Isolation and culture of colon cancer stem cells. Methods Cell Biol 2008;86:311-324
-
(2008)
Methods Cell Biol
, vol.86
, pp. 311-324
-
-
Cammareri, P.1
Lombardo, Y.2
Francipane, M.G.3
Bonventre, S.4
Todaro, M.5
Stassi, G.6
-
29
-
-
0142219885
-
Thyroid Cancer Resistance to Chemotherapeutic Drugs via Autocrine Production of Interleukin-4 and Interleukin-10
-
Stassi G, Todaro M, Zerilli M, et al. Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10. Cancer Res 2003;63:6784-6790 (Pubitemid 37322959)
-
(2003)
Cancer Research
, vol.63
, Issue.20
, pp. 6784-6790
-
-
Stassi, G.1
Todaro, M.2
Zerilli, M.3
Ricci-Vitiani, L.4
Di Liberto, D.5
Patti, M.6
Florena, A.7
Di Gaudio, F.8
Di Gesu, G.9
De Maria, R.10
-
30
-
-
33846100356
-
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
-
DOI 10.1038/nature05372, PII NATURE05372
-
O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445:106-110 (Pubitemid 46067310)
-
(2007)
Nature
, vol.445
, Issue.7123
, pp. 106-110
-
-
O'Brien, C.A.1
Pollett, A.2
Gallinger, S.3
Dick, J.E.4
-
31
-
-
34247582183
-
Subcellular localization of the spindle proteins Aurora A, Mad2, and BUBR1 assessed by immunohistochemistry
-
Burum-Auensen E, De Angelis PM, Schjolberg AR, Kravik KL, Aure M, Clausen OP. Subcellular localization of the spindle proteins Aurora A, Mad2, and BUBR1 assessed by immunohistochemistry. J Histochem Cytochem 2007;55:477-486
-
(2007)
J Histochem Cytochem
, vol.55
, pp. 477-486
-
-
Burum-Auensen, E.1
De Angelis, P.M.2
Schjolberg, A.R.3
Kravik, K.L.4
Aure, M.5
Clausen, O.P.6
-
32
-
-
0025650332
-
Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: Aneuploidy and immortalization
-
Bischoff FZ, Yim SO, Pathak S, et al. Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization. Cancer Res 1990;50:7979-7984
-
(1990)
Cancer Res
, vol.50
, pp. 7979-7984
-
-
Bischoff, F.Z.1
Yim, S.O.2
Pathak, S.3
-
33
-
-
0029881977
-
Abnormal centrosome amplification in the absence of p53
-
Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF. Abnormal centrosome amplification in the absence of p53. Science 1996;271:1744-1747 (Pubitemid 26102826)
-
(1996)
Science
, vol.271
, Issue.5256
, pp. 1744-1747
-
-
Fukasawa, K.1
Choi, T.2
Kuriyama, R.3
Rulong, S.4
Vande Woude, G.F.5
-
34
-
-
73949087301
-
MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel
-
Shimomura T, Hasako S, Nakatsuru Y, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther 2010;9:157-166
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 157-166
-
-
Shimomura, T.1
Hasako, S.2
Nakatsuru, Y.3
-
35
-
-
33749605644
-
Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells
-
Yang H, He L, Kruk P, Nicosia SV, Cheng JQ. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. Int J Cancer 2006;119:2304-2312
-
(2006)
Int J Cancer
, vol.119
, pp. 2304-2312
-
-
Yang, H.1
He, L.2
Kruk, P.3
Nicosia, S.V.4
Cheng, J.Q.5
-
36
-
-
33846239456
-
Beyond tumorigenesis: Cancer stem cells in metastasis
-
Li F, Tiede B, Massague J, Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 2007;17:3-14.
-
(2007)
Cell Res
, vol.17
, pp. 3-14
-
-
Li, F.1
Tiede, B.2
Massague, J.3
Kang, Y.4
-
37
-
-
35948938922
-
Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells
-
Guan Z, Wang XR, Zhu XF, et al. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res 2007;67:10436-10444
-
(2007)
Cancer Res
, vol.67
, pp. 10436-10444
-
-
Guan, Z.1
Wang, X.R.2
Zhu, X.F.3
-
38
-
-
34548253898
-
High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers
-
Nishida N, Nagasaka T, Kashiwagi K, Boland CR, Goel A. High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biol Ther 2007;6:525-533
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 525-533
-
-
Nishida, N.1
Nagasaka, T.2
Kashiwagi, K.3
Boland, C.R.4
Goel, A.5
-
39
-
-
40849130815
-
Aurora kinase expression in colorectal adenocarcinoma: Correlations with clinicopathological features, p16 expression, and telomerase activity
-
Lam AK, Ong K, Ho YH. Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity. Hum Pathol 2008;39:599-604.
-
(2008)
Hum Pathol
, vol.39
, pp. 599-604
-
-
Lam, A.K.1
Ong, K.2
Ho, Y.H.3
-
40
-
-
65949085377
-
Aurora-A expression is independently associated with chromosomal instability in colorectal cancer
-
Baba Y, Nosho K, Shima K, et al. Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. Neoplasia 2009;11:418-425
-
(2009)
Neoplasia
, vol.11
, pp. 418-425
-
-
Baba, Y.1
Nosho, K.2
Shima, K.3
-
41
-
-
70349690448
-
Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers
-
Lassmann S, Danciu M, Muller M, et al. Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers. Mod Pathol 2009;22:1385-1397
-
(2009)
Mod Pathol
, vol.22
, pp. 1385-1397
-
-
Lassmann, S.1
Danciu, M.2
Muller, M.3
-
42
-
-
16844368698
-
Tumour stem cells and drug resistance
-
Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5:275-284
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 275-284
-
-
Dean, M.1
Fojo, T.2
Bates, S.3
-
43
-
-
33845317573
-
Glioma stem cells promote radio-resistance by preferential activation of the DNA damage response
-
Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radio-resistance by preferential activation of the DNA damage response. Nature 2006;444:756-760
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
-
44
-
-
33845874094
-
Cancer stem cells and radiotherapy: New insights into tumor radioresistance
-
Diehn M, Clarke MF. Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst 2006;98: 1755-1757
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1755-1757
-
-
Diehn, M.1
Clarke, M.F.2
-
45
-
-
33646154663
-
Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line
-
Wang XX, Liu R, Jin SQ, Fan FY, Zhan QM. Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line. Cell Res 2006;16: 356-366
-
(2006)
Cell Res
, vol.16
, pp. 356-366
-
-
Wang, X.X.1
Liu, R.2
Jin, S.Q.3
Fan, F.Y.4
Zhan, Q.M.5
-
46
-
-
70349123829
-
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
-
Cicalese A, Bonizzi G, Pasi CE, et al. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 2009;138:1083-1095
-
(2009)
Cell
, vol.138
, pp. 1083-1095
-
-
Cicalese, A.1
Bonizzi, G.2
Pasi, C.E.3
-
47
-
-
77953151378
-
ENMD-2076 exerts antiangiogenic and antiproliferative activity against human colorectal cancer (CRC) xenograft models
-
Presented at
-
Tentler JJ, Bradshaw-Pierce EL, Serkova NJ, et al. ENMD-2076 exerts antiangiogenic and antiproliferative activity against human colorectal cancer (CRC) xenograft models. Presented at 20th EORTC-NCI-AACR symposium, Molecular Targets and Cancer Therapeutics; 2001 Oct 21-24, 2008; Geneva, Switzerland.
-
20th EORTC-NCI-AACR Symposium, Molecular Targets and Cancer Therapeutics; 2001 Oct 21-24, 2008; Geneva, Switzerland
-
-
Tentler, J.J.1
Bradshaw-Pierce, E.L.2
Serkova, N.J.3
-
48
-
-
77953143567
-
An open-label, dose escalation, safety, and pharmacokinetic study of ENMD-2076 administered orally to patients with advanced cancer
-
Presented at (abstract 3520). Available from
-
Bastos BR. Diamond J, Hansen R, et al. An open-label, dose escalation, safety, and pharmacokinetic study of ENMD-2076 administered orally to patients with advanced cancer. Presented at ASCO Annual Meeting 2009 (abstract 3520). Available from: http:// www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst- detail- view&confID=65&abstractID=34778.
-
ASCO Annual Meeting 2009
-
-
Bastos, B.R.1
Diamond, J.2
Hansen, R.3
|