Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis

Journal of the American Chemical Society

Volumn 139, Issue 11, 2017, Pages 4195-4201

  Trautman, Eric P ^a   Healy, Alan R ^a   Shine, Emilee E ^a,b   Herzon, Seth B ^a,b   Crawford, Jason M ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSEMBLY; ASSEMBLY MACHINES; BIOSYNTHESIS; ESCHERICHIA COLI; GENES; KETONES; METABOLISM; PROTEINS; REACTION INTERMEDIATES;

CATALYTIC MECHANISMS; MECHANISTIC MODELING; MULTI-DOMAIN ENZYMES; NONRIBOSOMAL PEPTIDE SYNTHETASES; POLYKETIDE SYNTHASES; REACTIVE INTERMEDIATE; SITE DIRECTED MUTAGENESIS; STRUCTURAL CHARACTERIZATION;

BIOCHEMISTRY;

BACTERIAL PROTEIN; CARRIER PROTEIN; COLIBACTIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; PEPTIDASE; POLYKETIDE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; HETEROCYCLIC COMPOUND; PEPTIDE; PEPTIDE SYNTHASE;

ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; CYCLIZATION; ENZYME ACTIVE SITE; ESCHERICHIA COLI; GENE CLUSTER; GENE DUPLICATION; GENE EDITING; METABOLOMICS; NONHUMAN; PROTEIN DOMAIN; PROTEIN HYDROLYSIS; PROTEIN SYNTHESIS; RING OPENING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; CHEMISTRY; CONFORMATION; ENZYMOLOGY; METABOLISM;

ESCHERICHIA COLI; HETEROCYCLIC COMPOUNDS; METABOLOMICS; MOLECULAR CONFORMATION; PEPTIDE SYNTHASES; PEPTIDES; POLYKETIDE SYNTHASES; POLYKETIDES;

EID: 85015889038     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.7b00659     Document Type: Article

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