A Mechanistic Model for Colibactin-Induced Genotoxicity

Journal of the American Chemical Society

Volumn 138, Issue 48, 2016, Pages 15563-15570

  Healy, Alan R ^a   Nikolayevskiy, Herman ^a   Patel, Jaymin R ^a   Crawford, Jason M ^a,b   Herzon, Seth B ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; ESCHERICHIA COLI; GENES; PROPANE;

CYCLO DEHYDRATIONS; CYCLOPROPANE RING OPENING; DNA DOUBLE STRAND BREAKS; EUKARYOTIC CELLS; FERMENTATION PRODUCTS; MECHANISTIC MODELING; NATURAL PRODUCTS; UNSATURATED IMINES;

DNA;

ACETONITRILE; BICARBONATE; BLEOMYCIN; CARBAMIC ACID; CARBOXYLIC ACID; CISPLATIN; COLIBACTIN; COLIBACTIN PEPTIDASE; CYCLOPROPANE; DOUBLE STRANDED DNA; FORMIC ACID; IMINE; LACTAM; MESYLIC ACID METHYL ESTER; METHANOL; NATURAL PRODUCT; PEPTIDASE; POTASSIUM CARBONATE; PYRIDONE DERIVATIVE; TERTIARY AMINE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; CLBP PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; MUTAGENIC AGENT; PEPTIDE; PEPTIDE HYDROLASE; POLYKETIDE;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CORRELATION SPECTROSCOPY; CYCLIZATION; DNA ALKYLATION; DNA BINDING; DNA CROSS LINKING; DNA DAMAGE; DNA DEGRADATION; DNA DENATURATION; DNA STRAND; FERMENTATION; GENOTOXICITY; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MELTING POINT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STATIC ELECTRICITY; SYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DNA CLEAVAGE; DRUG EFFECT; ESCHERICHIA COLI; GENETICS; METABOLISM; MULTIGENE FAMILY; PHENOTYPE;

BIOLOGICAL PRODUCTS; DNA CLEAVAGE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MOLECULAR STRUCTURE; MULTIGENE FAMILY; MUTAGENS; PEPTIDE HYDROLASES; PEPTIDES; PHENOTYPE; POLYKETIDES;

EID: 85002711280     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b10354     Document Type: Article

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