Trimethylamine N-oxide in atherogenesis: Impairing endothelial self-repair capacity and enhancing monocyte adhesion

Bioscience Reports

Volumn 37, Issue 2, 2017, Pages

  Ma, GuoHua ^a,c   Pan, Bing ^b   Chen, Yue ^b   Guo, CaiXia ^a   Zhao, MingMing ^b   Zheng, LeMin ^b   Chen, BuXing ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Peking University Health Science Center   (China)

^c SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE C; TRIMETHYLAMINE OXIDE; VASCULAR CELL ADHESION MOLECULE 1; METHYLAMINE; TRIMETHYLOXAMINE;

ANIMAL TISSUE; AORTA WALL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL ADHESION; CELL MIGRATION; CELL MIGRATION ASSAY; CELL PROLIFERATION; CELL REGENERATION; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MONOCYTE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WOUND HEALING; BLOOD; CELL CULTURE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ATHEROSCLEROSIS; CELL ADHESION; CELLS, CULTURED; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; METHYLAMINES; MONOCYTES; NF-KAPPA B; PROTEIN KINASE C; SIGNAL TRANSDUCTION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 85015878336     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20160244     Document Type: Article

References (43)

1. Okwuosa, I.S., Lewsey, S.C., Adesiyun, T., Blumenthal, R.S. and Yancy, C.W. (2015) Worldwide disparities in cardiovascular disease: challenges and solutions. Int. J. Cardiol. 202, 433-440
2. Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., Blaha, M.J., Cushman, M. et al. (2015) Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation 131, e29-e322
3. Santos-Gallego, C.G., Picatoste, B. and Badimon, J.J. (2014) Pathophysiology of acute coronary syndrome. Curr. Atheroscler. Rep. 16, 401
4. Tang, W.H. and Hazen, S.L. (2014) The contributory role of gut microbiota in cardiovascular disease. J. Clin. Invest. 124, 4204-4211
5. Wang, Z., Tang, W.H., Buffa, J.A., Fu, X., Britt, E.B., Koeth, R.A. et al. (2014) Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur. Heart J. 35, 904-910
6. Wang, Z., Klipfell, E., Bennett, B.J., Koeth, R., Levison, B.S., Dugar, B. et al. (2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57-63
7. Tang, W.H., Wang, Z., Fan, Y., Levison, B., Hazen, J.E., Donahue, L.M. et al. (2014) Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J. Am. Coll. Cardiol. 64, 1908-1914
8. Tang, W.H., Wang, Z., Shrestha, K., Borowski, A.G., Wu, Y., Troughton, R.W. et al. (2015) Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. J. Card. Fail. 21, 91-96
9. Tang, W.H., Wang, Z., Levison, B.S., Koeth, R.A., Britt, E.B., Fu, X. et al. (2013) Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 368, 1575-1584
10. Matsuzawa, Y., Guddeti, R.R., Kwon, T.G., Lerman, L.O. and Lerman, A. (2015) Treating coronary disease and the impact of endothelial dysfunction. Prog. Cardiovasc. Dis. 57, 431-442
11. Bonetti, P.O., Lerman, L.O. and Lerman, A. (2003) Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler. Thromb. Vasc. Biol. 23, 168-175
12. Park, K.H. and Park, W.J. (2015) Endothelial dysfunction: clinical implications in cardiovascular disease and therapeutic approaches. J. Korean Med. Sci. 30, 1213-1225
13. Geraldes, P. and King, G.L. (2010) Activation of protein kinase C isoforms and its impact on diabetic complications. Circ. Res. 106, 1319-1331
14. Booth, G., Stalker, T.J., Lefer, A.M. and Scalia, R. (2002) Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes 51, 1556-1564
15. Frey, R.S., Rahman, A., Kefer, J.C., Minshall, R.D. and Malik, A.B. (2002) PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells. Circ. Res. 90, 1012-1019
16. Min, J.K., Kim, Y.M., Kim, S.W., Kwon, M.C., Kong, Y.Y., Hwang, I.K. et al. (2005) TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells. J. Immunol. 175, 531-540
17. Kawakami, A., Aikawa, M., Nitta, N., Yoshida, M., Libby, P. and Sacks, F.M. (2007) Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation. Arterioscler. Thromb. Vasc. Biol. 27, 219-225
18. Takahashi, K., Shimokado, K. and Yoshida, M. (2006) SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition. Eur. J. Pharmacol. 552, 162-169
19. Jiang, R., Teng, Y., Huang, Y., Gu, J. and Li, M. (2010) Protein kinase C-alpha activation induces NF-κB-dependent VCAM-1 expression in cultured human umbilical vein endothelial cells treated with sera from preeclamptic patients. Gynecol. Obstet. Invest. 69, 101-108
20. Bodiga, V.L., Kudle, M.R. and Bodiga, S. (2015) Silencing of PKC-α, TRPC1 or NF-κB expression attenuates cisplatin-induced ICAM-1 expression and endothelial dysfunction. Biochem. Pharmacol. 98, 78-91
21. Li, L., Xu, S., Yan, J., Li, Y., Wang, X., Du, R. et al. (2015) Mechanism of PKC activity affecting the adhesion reaction of endothelial cells with monocytes. Int. J. Cardiol. 182, 361-367
22. Jaffe, E.A., Nachman, R.L., Becker, C.G. and Minick, C.R. (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52, 2745-2756
23. Wei, C., Zhu, P., Shah, S.J. and Blair, I.A. (2009) 15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation. Mol. Pharmacol. 76, 516-525
24. Dong, S., Kong, J., Kong, J., Shen, Q., Kong, F., Sun, W. et al. (2015) Low concentration of caffeine inhibits the progression of the hepatocellular carcinoma via Akt signaling pathway. Anticancer Agents Med. Chem. 15, 484-492
25. Pan, B., Ren, H., Lv, X., Zhao, Y., Yu, B., He, Y. et al. (2012) Hypochlorite-induced oxidative stress elevates the capability of HDL in promoting breast cancer metastasis. J. Transl. Med. 10, 65
26. Gamble, J.R. and Vadas, M.A. (1988) A new assay for the measurement of the attachment of neutrophils and other cell types to endothelial cells. J. Immunol. Methods 109, 175-184
27. Durpes, M.C., Morin, C., Paquin-Veillet, J., Beland, R., Pare, M., Guimond, M.O. et al. (2015) PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis. Cardiovasc. Res. 106, 303-313
28. Pan, B., Ma, Y., Ren, H., He, Y., Wang, Y., Lv, X. et al. (2012) Diabetic HDL is dysfunctional in stimulating endothelial cell migration and proliferation due to down regulation of SR-BI expression. PLoS ONE 7, e48530
29. 2-induced human umbilical vein endothelial cell (HUVEC) injury and apolipoprotein E knockout (ApoE-/-) atherosclerotic mice. Int. J. Clin. Exp. Pathol. 8, 6301-6311
30. Galkina, E. and Ley, K. (2007) Vascular adhesion molecules in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27, 2292-2301
31. Zhao, Y., Howatt, D.A., Gizard, F., Nomiyama, T., Findeisen, H.M., Heywood, E.B. et al. (2010) Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Circ. Res. 107, 501-511
32. Brown, J.M. and Hazen, S.L. (2014) Metaorganismal nutrient metabolism as a basis of cardiovascular disease. Curr. Opin. Lipidol. 25, 48-53
33. Koeth, R.A., Wang, Z., Levison, B.S., Buffa, J.A., Org, E., Sheehy, B.T. et al. (2013) Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 19, 576-585
34. Tang, W.H., Wang, Z., Kennedy, D.J., Wu, Y., Buffa, J.A., Agatisa-Boyle, B. et al. (2015) Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ. Res. 116, 448-455
35. Gao, X., Liu, X., Xu, J., Xue, C., Xue, Y. and Wang, Y. (2014) Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J. Biosci. Bioeng. 118, 476-481
36. Ufnal, M., Jazweic, R., Dadlez, M., Drapala, A., Sikora, M. and Skrzypecki, J. (2014) Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats. Can. J. Cardiol. 30, 1700-1705
37. Seldin, M.M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S.L. et al. (2016) Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-κB. J. Am. Heart Assoc. 5, e002767
38. Xu, Q. (2009) Disturbed flow-enhanced endothelial turnover in atherosclerosis. Trends Cardiovasc. Med. 19, 191-195
39. Shi, R., Re, D., Dudl, E., Cuddy, M., Okolotowicz, K.J., Dahl, R. et al. (2010) Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C. ACS Chem. Biol. 5, 287-299
40. Majdalawieh, A. and Ro, H.S. (2010) Regulation of IκBα function and NF-κB signaling: AEBP1 is a novel proinflammatory mediator in macrophages. Mediators Inflamm. 2010, 823821
41. Devlin, G.L., Parfrey, H., Tew, D.J., Lomas, D.A. and Bottomley, S.P. (2001) Prevention of polymerization of M and Z alpha1-antitrypsin (alpha1-AT) with trimethylamine N-oxide. Implications for the treatment of alpha1-at deficiency. Am. J. Respir. Cell Mol. Biol. 24, 727-732
42. Song, J.L. and Chuang, D.T. (2001) Natural osmolyte trimethylamine N-oxide corrects assembly defects of mutant branched-chain alpha-ketoacid decarboxylase in maple syrup urine disease. J. Biol. Chem. 276, 40241-40246
43. Lim, S.T., Longley, R.L., Couchman, J.R. and Woods, A. (2003) Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha. J. Biol. Chem. 278, 13795-13802