Silencing of PKC-α, TRPC1 or NF-κB expression attenuates cisplatin-induced ICAM-1 expression and endothelial dysfunction

Biochemical Pharmacology

Volumn 98, Issue 1, 2015, Pages 78-91

  Bodiga, Vijaya Lakshmi ^a   Kudle, Madhukar Rao ^b   Bodiga, Sreedhar ^b  

^a OSMANIA UNIVERSITY   (India)

^b KAKATIYA UNIVERSITY   (India)

Author keywords

Cisplatin; Endothelium; ICAM; NF B; PKC; SOCE; TRPC

Indexed keywords

ALBUMIN; CALCIUM ION; CISPLATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; PROTEIN KINASE C ALPHA; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; CALCIUM; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY C, MEMBER 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL C;

ARTICLE; CELL ADHESION ASSAY; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ELECTRIC RESISTANCE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTRACELLULAR SIGNALING; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; U937 CELL LINE;

CALCIUM; CISPLATIN; GENE EXPRESSION REGULATION; GENE SILENCING; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; NF-KAPPA B; PROTEIN KINASE C-ALPHA; TRPC CATION CHANNELS; U937 CELLS;

EID: 84943584476     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.08.101     Document Type: Article

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