Inhibitory effects of oleoylethanolamide (OEA) on H2O2-induced human umbilical vein endothelial cell (HUVEC) injury and apolipoprotein E knockout (ApoE-/-) atherosclerotic mice

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 6, 2015, Pages 6301-6311

  Ma, Li ^a   Guo, Xiaobing ^a   Chen, Wei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Atherosclerosis; Endothelial cell; OEA; Oxidative stress

Indexed keywords

ANTIOXIDANT; APOLIPOPROTEIN E; ENDOCANNABINOID; HYDROGEN PEROXIDE; N OLEOYLETHANOLAMINE; OLEIC ACID;

ANIMAL; APOPTOSIS; ATHEROSCLEROSIS; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; HUMAN; KNOCKOUT MOUSE; MALE; MOUSE; OXIDATIVE STRESS; PATHOLOGY; TUNEL ASSAY; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; APOLIPOPROTEINS E; APOPTOSIS; ATHEROSCLEROSIS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENDOCANNABINOIDS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLEIC ACIDS; OXIDATIVE STRESS;

EID: 84938592277     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D and Turner MB. Executive summary: heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation 2014; 129: 399-410.
2. Ross R and Kariya B. Morphogenesis of vascular smooth muscle in atherosclerosis and cell culture. Comprehensive Physiology 2011.
3. Griendling KK and FitzGerald GA. Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation 2003; 108: 1912-1916.
4. Griendling KK and FitzGerald GA. Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation 2003; 108: 2034-2040.
5. Li H, Horke S and Förstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 2014; 237: 208-219.
6. Ray R and Shah AM. NADPH oxidase and endothelial cell function. Clin Sci (Lond) 2005; 109: 217-226.
7. Dimmeler S and Zeiher AM. Endothelial cell apoptosis in angiogenesis and vessel regression. Circulation research 2000; 87: 434-439.
8. Boatright KM and Salvesen GS. Mechanisms of caspase activation. Curr Opin Cell Biol 2003; 15: 725-731.
9. Fan A, Wu X, Wu H, Li L, Huang R, Zhu Y, Qiu Y, Fu J, Ren J and Zhu C. Atheroprotective Effect of Oleoylethanolamide (OEA) Targeting Oxidi-zed LDL. PLoS One 2014; 9: e85337.
10. Fu J, Astarita G, Gaetani S, Kim J, Cravatt BF, Mackie K and Piomelli D. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J Biol Chem 2007; 282: 1518-1528.
11. Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodriguez De Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G and Piomelli D. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 2003; 425: 90-93.
12. Grosshans M, Schwarz E, Bumb JM, Schaefer C, Rohleder C, Vollmert C, Vollstadt-Klein S, Tost H, Meyer-Lindenberg A, Kiefer F and Leweke FM. Oleoylethanolamide and human neural responses to food stimuli in obesity. JAMA Psychiatry 2014; 71: 1254-61.
13. Wang M, Sun GB, Sun X, Wang HW, Meng XB, Qin M, Sun J, Luo Y and Sun XB. Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway. Toxicol Lett 2013; 216: 100-107.
14. Sun GB, Qin M, Ye JX, Pan RL, Meng XB, Wang M, Luo Y, Li ZY, Wang HW and Sun XB. Inhibitory effects of myricitrin on oxidative stress-induced endothelial damage and early atherosclerosis in ApoE-/- mice. Toxicol Appl Pharmacol 2013; 271: 114-126.
15. Harauma A, Murayama T, Ikeyama K, Sano H, Arai H, Takano R, Kita T, Hara S, Kamei K and Yokode M. Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun 2007; 358: 751-756.
16. Katayama Y, Inaba T, Nito C, Ueda M and Katsura K. Neuroprotective effects of erythromycin on cerebral ischemia reperfusion-injury and cell viability after oxygen-glucose deprivation in cultured neuronal cells. Brain Res 2014; 1588: 159-67.
17. Harrison CM, Pompilius M, Pinkerton KE and Ballinger SW. Mitochondrial oxidative stress significantly influences atherogenic risk and cytokine-induced oxidant production. Environ Health Perspect 2011; 119: 676-681.
18. Nakashima Y, Plump AS, Raines EW, Breslow JL and Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb 1994; 14: 133-140.
19. Xi H, Akishita M, Nagai K, Yu W, Hasegawa H, Eto M, Kozaki K and Toba K. Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis. Atherosclerosis 2007; 191: 281-289.
20. Halliwell B, Clement MV and Long LH. Hydrogen peroxide in the human body. FEBS Lett 2000; 486: 10-13.
21. Dali-Youcef N, Mecili M, Ricci R and Andres E. Metabolic inflammation: connecting obesity and insulin resistance. Ann Med 2013; 45: 242-253.
22. Urbanski K, Nowak M and Guzik TJ. [Oxidative stress and vascular function]. Postepy Biochem 2013; 59: 424-431.
23. Romano A, Coccurello R, Giacovazzo G, Bedse G, Moles A and Gaetani S. Oleoylethanolamide: a novel potential pharmacological alternative to cannabinoid antagonists for the control of appetite. Biomed Res Int 2014; 2014: 203425.
24. Gonzalez-Aparicio R, Blanco E, Serrano A, Pavon FJ, Parsons LH, Maldonado R, Robledo P, Fernandez-Espejo E and de Fonseca FR. The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism. Int J Neuropsychopharmacol 2014; 17: 455-468.
25. Montecucco F, Matias I, Lenglet S, Petrosino S, Burger F, Pelli G, Braunersreuther V, Mach F, Steffens S and Di Marzo V. Regulation and possible role of endocannabinoids and related mediators in hypercholesterolemic mice with atherosclerosis. Atherosclerosis 2009; 205: 433-441.
26. Jo H, Song H and Mowbray A. Role of NADPH oxidases in disturbed flow- and BMP4- induced inflammation and atherosclerosis. Antioxid Redox Signal 2006; 8: 1609-1619.
27. Franczyk-Zarow M, Kostogrys RB, Szymczyk B, Jawien J, Gajda M, Cichocki T, Wojnar L, Chlopicki S and Pisulewski PM. Functional effects of eggs, naturally enriched with conjugated linoleic acid, on the blood lipid profile, development of atherosclerosis and composition of atherosclerotic plaque in apolipoprotein E and low-density lipoprotein receptor double-knockout mice (apoE/LDLR-/-). Br J Nutr 2008; 99: 49-58.
28. Veniant MM, Beigneux AP, Bensadoun A, Fong LG and Young SG. Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models. Curr Drug Targets 2008; 9: 174-189.
29. Lopez FL, Agarwal SK, MacLehose RF, Soliman EZ, Sharrett AR, Huxley RR, Konety S, Ballantyne CM and Alonso A. Blood lipid levels, lipid-lowering medications, and the incidence of atrial fibrillation: the atherosclerosis risk in communities study. Circ Arrhythm Electro-physiol 2012; 5: 155-162.
30. Kriszbacher I, Koppan M and Bodis J. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 353: 429-430.