Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C

ACS Chemical Biology

Volumn 5, Issue 3, 2010, Pages 287-299

  Shi, Ranxin ^a   Re, Daniel ^a   Dudl, Eric ^a   Cuddy, Michael ^a   Okolotowicz, Karl J ^b   Dahl, Russell ^a,c,d   Su, Ying ^a,c,d   Hurder, Andrew ^a,c,d   Kitada, Shinichi ^a   Peddibhotla, Satyamaheshwar ^b   Roth, Gregory P ^b,c,d   Smith, Layton H ^b,c,d   Kipps, Thomas J ^e   Cosford, Nicholas ^a,c,d   Cashman, John ^b   Reed, John C ^a,c,d  

^a BURNHAM INSTITUTE   (United States)

^b HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

^c Conrad Prebys Center for Chemical Genomics ^*  (United States)

^d University of California San Diego ^*  (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; BISINDOLYLMALEIMIDE; CASPASE 8; CID 2858522; I KAPPA B; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 8; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN; PROTEIN KINASE C; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELL STIMULATION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SELECTIVITY; EMBRYO; FEMALE; GENE EXPRESSION REGULATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; B-LYMPHOCYTES; BENZIMIDAZOLES; CELL LINE; CELL PROLIFERATION; HUMANS; I-KAPPA B KINASE; IMMUNOGLOBULIN M; INTERLEUKIN-2; JURKAT CELLS; MICE; NF-KAPPA B; PROTEIN KINASE C; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES;

EID: 77949845982     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb9003089     Document Type: Article

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