-
1
-
-
33747790218
-
Epidemiology and molecular pathology of glioma
-
quiz 491 p following 516
-
Schwartzbaum JA, Fisher JL, Aldape KD, et al. Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol 2006;2:494-503; quiz 491 p following 516.
-
(2006)
Nat Clin Pract Neurol
, vol.2
, pp. 494-503
-
-
Schwartzbaum, J.A.1
Fisher, J.L.2
Aldape, K.D.3
-
2
-
-
43049117237
-
Translational research in glioblastoma multiforme: molecular criteria for patient selection
-
Rosell R, de Las Penas R, Balana C, et al. Translational research in glioblastoma multiforme: molecular criteria for patient selection. Future Oncol 2008;4:219-28.
-
(2008)
Future Oncol
, vol.4
, pp. 219-228
-
-
Rosell, R.1
de Las Penas, R.2
Balana, C.3
-
3
-
-
84887102623
-
Glioblastoma and other malignant gliomas: a clinical review
-
Omuro A, DeAngelis LM. Glioblastoma and other malignant gliomas: a clinical review. JAMA 2013;310:1842-50.
-
(2013)
JAMA
, vol.310
, pp. 1842-1850
-
-
Omuro, A.1
DeAngelis, L.M.2
-
4
-
-
84904902698
-
EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma
-
Weller M, van den Bent M, Hopkins K, et al. EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol 2014;15:e395-403.
-
(2014)
Lancet Oncol
, vol.15
, pp. e395-403
-
-
Weller, M.1
van den Bent, M.2
Hopkins, K.3
-
5
-
-
0042924349
-
A Critical Review: The Pathology of Cerebral Gliomas
-
Scherer HJ. A Critical Review: The Pathology of Cerebral Gliomas. J Neurol Psychiatry 1940;3:147-77.
-
(1940)
J Neurol Psychiatry
, vol.3
, pp. 147-177
-
-
Scherer, H.J.1
-
6
-
-
84871336632
-
Moving toward molecular classification of diffuse gliomas in adults
-
Theeler BJ, Yung WK, Fuller GN, et al. Moving toward molecular classification of diffuse gliomas in adults. Neurology 2012;79:1917-26.
-
(2012)
Neurology
, vol.79
, pp. 1917-1926
-
-
Theeler, B.J.1
Yung, W.K.2
Fuller, G.N.3
-
7
-
-
67651039919
-
A network model of a cooperative genetic landscape in brain tumors
-
Bredel M, Scholtens DM, Harsh GR, et al. A network model of a cooperative genetic landscape in brain tumors. JAMA 2009;302:261-75.
-
(2009)
JAMA
, vol.302
, pp. 261-275
-
-
Bredel, M.1
Scholtens, D.M.2
Harsh, G.R.3
-
8
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110.
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
Hoadley, K.A.2
Purdom, E.3
-
9
-
-
84905675587
-
Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma
-
Ozawa T, Riester M, Cheng YK, et al. Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma. Cancer Cell 2014;26:288-300.
-
(2014)
Cancer Cell
, vol.26
, pp. 288-300
-
-
Ozawa, T.1
Riester, M.2
Cheng, Y.K.3
-
10
-
-
84883656941
-
Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma
-
Bhat KP, Balasubramaniyan V, Vaillant B, et al. Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma. Cancer Cell 2013;24:331-46.
-
(2013)
Cancer Cell
, vol.24
, pp. 331-346
-
-
Bhat, K.P.1
Balasubramaniyan, V.2
Vaillant, B.3
-
11
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-96.
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
-
12
-
-
0037384037
-
A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma
-
Westphal M, Hilt DC, Bortey E, et al. A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro Oncol 2003;5:79-88.
-
(2003)
Neuro Oncol
, vol.5
, pp. 79-88
-
-
Westphal, M.1
Hilt, D.C.2
Bortey, E.3
-
13
-
-
84905017731
-
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery
-
Santagata S, Eberlin LS, Norton I, et al. Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. Proc Natl Acad Sci U S A 2014;111:11121-6.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 11121-11126
-
-
Santagata, S.1
Eberlin, L.S.2
Norton, I.3
-
14
-
-
84894114159
-
A randomized trial of bevacizumab for newly diagnosed glioblastoma
-
Gilbert MR, Dignam JJ, Armstrong TS, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med 2014;370:699-708.
-
(2014)
N Engl J Med
, vol.370
, pp. 699-708
-
-
Gilbert, M.R.1
Dignam, J.J.2
Armstrong, T.S.3
-
15
-
-
84894194756
-
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
-
Chinot OL, Wick W, Mason W, et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med 2014;370:709-22.
-
(2014)
N Engl J Med
, vol.370
, pp. 709-722
-
-
Chinot, O.L.1
Wick, W.2
Mason, W.3
-
16
-
-
44649103829
-
Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature
-
Schnell O, Krebs B, Wagner E, et al. Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature. Brain Pathol 2008;18:378-86.
-
(2008)
Brain Pathol
, vol.18
, pp. 378-386
-
-
Schnell, O.1
Krebs, B.2
Wagner, E.3
-
17
-
-
84874318559
-
Integrin control of the transforming growth factor-beta pathway in glioblastoma
-
Roth P, Silginer M, Goodman SL, et al. Integrin control of the transforming growth factor-beta pathway in glioblastoma. Brain 2013;136:564-76.
-
(2013)
Brain
, vol.136
, pp. 564-576
-
-
Roth, P.1
Silginer, M.2
Goodman, S.L.3
-
18
-
-
84908563697
-
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial
-
Stupp R, Hegi ME, Gorlia T, et al. Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 2014;15:1100-8.
-
(2014)
Lancet Oncol
, vol.15
, pp. 1100-1108
-
-
Stupp, R.1
Hegi, M.E.2
Gorlia, T.3
-
19
-
-
33947191055
-
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
-
Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 2007;13:1253-9.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1253-1259
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon, J.E.3
-
20
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 2009;27:740-5.
-
(2009)
J Clin Oncol
, vol.27
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
-
21
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 2009;27:4733-40.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4733-4740
-
-
Friedman, H.S.1
Prados, M.D.2
Wen, P.Y.3
-
22
-
-
84904913239
-
Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial
-
Taal W, Oosterkamp HM, Walenkamp AM, et al. Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial. Lancet Oncol 2014;15:943-53.
-
(2014)
Lancet Oncol
, vol.15
, pp. 943-953
-
-
Taal, W.1
Oosterkamp, H.M.2
Walenkamp, A.M.3
-
23
-
-
20144370978
-
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
-
Wedge SR, Kendrew J, Hennequin LF, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005;65:4389-400.
-
(2005)
Cancer Res
, vol.65
, pp. 4389-4400
-
-
Wedge, S.R.1
Kendrew, J.2
Hennequin, L.F.3
-
24
-
-
84887116872
-
Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
-
Batchelor TT, Mulholland P, Neyns B, et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol 2013;31:3212-8.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3212-3218
-
-
Batchelor, T.T.1
Mulholland, P.2
Neyns, B.3
-
25
-
-
81255138488
-
Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma
-
Lipson EJ, Drake CG. Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma. Clin Cancer Res 2011;17:6958-62.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6958-6962
-
-
Lipson, E.J.1
Drake, C.G.2
-
26
-
-
77954939175
-
Prostate cancer as a model for tumour immunotherapy
-
Drake CG. Prostate cancer as a model for tumour immunotherapy. Nat Rev Immunol 2010;10:580-93.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 580-593
-
-
Drake, C.G.1
-
27
-
-
78149254368
-
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
-
Sampson JH, Heimberger AB, Archer GE, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol 2010;28:4722-9.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4722-4729
-
-
Sampson, J.H.1
Heimberger, A.B.2
Archer, G.E.3
-
28
-
-
84904391384
-
Immunotherapy for brain cancer: recent progress and future promise
-
Jackson CM, Lim M, Drake CG. Immunotherapy for brain cancer: recent progress and future promise. Clin Cancer Res 2014;20:3651-9.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 3651-3659
-
-
Jackson, C.M.1
Lim, M.2
Drake, C.G.3
-
29
-
-
84916606024
-
A randomized, double-blind, placebo-controlled phase 2 trial of dendritic cell (DC) vaccination with ICT-107 in newly diagnosed glioblastoma (GBM) patients
-
Wen PY, Reardon DA, Phuphanich S, et al. A randomized, double-blind, placebo-controlled phase 2 trial of dendritic cell (DC) vaccination with ICT-107 in newly diagnosed glioblastoma (GBM) patients. J Clin Oncol 2014;32:abstr 2005.
-
(2014)
J Clin Oncol
, vol.32
-
-
Wen, P.Y.1
Reardon, D.A.2
Phuphanich, S.3
-
31
-
-
0036372109
-
Pneumococcal conjugate vaccine (Prevnar; PNCRM7): a review of its use in the prevention of Streptococcus pneumoniae infection
-
Darkes MJ, Plosker GL. Pneumococcal conjugate vaccine (Prevnar; PNCRM7): a review of its use in the prevention of Streptococcus pneumoniae infection. Paediatr Drugs 2002;4:609-30.
-
(2002)
Paediatr Drugs
, vol.4
, pp. 609-630
-
-
Darkes, M.J.1
Plosker, G.L.2
-
32
-
-
0034745978
-
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide
-
Kokkinakis DM, Bocangel DB, Schold SC, et al. Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide. Clin Cancer Res 2001;7:421-8.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 421-428
-
-
Kokkinakis, D.M.1
Bocangel, D.B.2
Schold, S.C.3
-
33
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005;352:997-1003.
-
(2005)
N Engl J Med
, vol.352
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
-
34
-
-
84862577827
-
STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression
-
Kohsaka S, Wang L, Yachi K, et al. STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression. Mol Cancer Ther 2012;11:1289-99.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 1289-1299
-
-
Kohsaka, S.1
Wang, L.2
Yachi, K.3
-
35
-
-
84891948402
-
mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy
-
Weiler M, Blaes J, Pusch S, et al. mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Proc Natl Acad Sci U S A 2014;111:409-14.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 409-414
-
-
Weiler, M.1
Blaes, J.2
Pusch, S.3
-
36
-
-
84904064217
-
Radiation therapy and concurrent plus adjuvant temsirolimus (CCI-779) versus chemoirradiation with temozolomide in newly diagnosed glioblastoma without methylation of the MGMT gene promoter
-
Wick W, Gorlia T, Van Den Bent MJ, et al. Radiation therapy and concurrent plus adjuvant temsirolimus (CCI-779) versus chemoirradiation with temozolomide in newly diagnosed glioblastoma without methylation of the MGMT gene promoter. J Clin Oncol 2014;32:abstr 2003.
-
(2014)
J Clin Oncol
, vol.32
-
-
Wick, W.1
Gorlia, T.2
Van Den Bent, M.J.3
-
37
-
-
84856233300
-
Balancing repair and tolerance of DNA damage caused by alkylating agents
-
Fu D, Calvo JA, Samson LD. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 2012;12:104-20.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 104-120
-
-
Fu, D.1
Calvo, J.A.2
Samson, L.D.3
-
38
-
-
34247499001
-
Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment
-
Cahill DP, Levine KK, Betensky RA, et al. Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin Cancer Res 2007;13:2038-45.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2038-2045
-
-
Cahill, D.P.1
Levine, K.K.2
Betensky, R.A.3
-
39
-
-
77950059191
-
Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications
-
Zhang J, Stevens MF, Laughton CA, et al. Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications. Oncology 2010;78:103-14.
-
(2010)
Oncology
, vol.78
, pp. 103-114
-
-
Zhang, J.1
Stevens, M.F.2
Laughton, C.A.3
-
40
-
-
10744233628
-
Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells
-
Curtin NJ, Wang LZ, Yiakouvaki A, et al. Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells. Clin Cancer Res 2004;10:881-9.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 881-889
-
-
Curtin, N.J.1
Wang, L.Z.2
Yiakouvaki, A.3
-
41
-
-
22244448679
-
The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death
-
Trivedi RN, Almeida KH, Fornsaglio JL, et al. The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Cancer Res 2005;65:6394-400.
-
(2005)
Cancer Res
, vol.65
, pp. 6394-6400
-
-
Trivedi, R.N.1
Almeida, K.H.2
Fornsaglio, J.L.3
-
42
-
-
84861312943
-
Molecular mechanisms of temozolomide resistance in glioblastoma multiforme
-
Johannessen TC, Bjerkvig R. Molecular mechanisms of temozolomide resistance in glioblastoma multiforme. Expert Rev Anticancer Ther 2012;12:635-42.
-
(2012)
Expert Rev Anticancer Ther
, vol.12
, pp. 635-642
-
-
Johannessen, T.C.1
Bjerkvig, R.2
-
43
-
-
75149149167
-
Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage
-
Tang JB, Goellner EM, Wang XH, et al. Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage. Mol Cancer Res 2010;8:67-79.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 67-79
-
-
Tang, J.B.1
Goellner, E.M.2
Wang, X.H.3
-
44
-
-
84905663623
-
NEO212, Temozolomide Conjugated to Perillyl Alcohol, Is a Novel Drug for Effective Treatment of a Broad Range of Temozolomide-Resistant Gliomas
-
Cho HY, Wang W, Jhaveri N, et al. NEO212, Temozolomide Conjugated to Perillyl Alcohol, Is a Novel Drug for Effective Treatment of a Broad Range of Temozolomide-Resistant Gliomas. Mol Cancer Ther 2014;13:2004-17.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2004-2017
-
-
Cho, H.Y.1
Wang, W.2
Jhaveri, N.3
-
45
-
-
84874091180
-
The definition of primary and secondary glioblastoma
-
Ohgaki H, Kleihues P. The definition of primary and secondary glioblastoma. Clin Cancer Res 2013;19:764-72.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 764-772
-
-
Ohgaki, H.1
Kleihues, P.2
-
46
-
-
84907051444
-
IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma
-
Esmaeili M, Hamans BC, Navis AC, et al. IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma. Cancer Res 2014;74:4898-907.
-
(2014)
Cancer Res
, vol.74
, pp. 4898-4907
-
-
Esmaeili, M.1
Hamans, B.C.2
Navis, A.C.3
-
47
-
-
78149249554
-
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas
-
Houillier C, Wang X, Kaloshi G, et al. IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas. Neurology 2010;75:1560-6.
-
(2010)
Neurology
, vol.75
, pp. 1560-1566
-
-
Houillier, C.1
Wang, X.2
Kaloshi, G.3
-
48
-
-
84907045077
-
Mutant IDH1-Driven Cellular Transformation Increases RAD51-Mediated Homologous Recombination and Temozolomide Resistance
-
Ohba S, Mukherjee J, See WL, et al. Mutant IDH1-Driven Cellular Transformation Increases RAD51-Mediated Homologous Recombination and Temozolomide Resistance. Cancer Res 2014;74:4836-44.
-
(2014)
Cancer Res
, vol.74
, pp. 4836-4844
-
-
Ohba, S.1
Mukherjee, J.2
See, W.L.3
-
49
-
-
77956868654
-
Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance
-
Hatanpaa KJ, Burma S, Zhao D, et al. Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance. Neoplasia 2010;12:675-84.
-
(2010)
Neoplasia
, vol.12
, pp. 675-684
-
-
Hatanpaa, K.J.1
Burma, S.2
Zhao, D.3
-
50
-
-
84861760526
-
Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers
-
Barkovich KJ, Hariono S, Garske AL, et al. Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. Cancer Discov 2012;2:450-7.
-
(2012)
Cancer Discov
, vol.2
, pp. 450-457
-
-
Barkovich, K.J.1
Hariono, S.2
Garske, A.L.3
-
51
-
-
84861760527
-
Differential sensitivity of glioma-versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors
-
Vivanco I, Robins HI, Rohle D, et al. Differential sensitivity of glioma-versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer Discov 2012;2:458-71.
-
(2012)
Cancer Discov
, vol.2
, pp. 458-471
-
-
Vivanco, I.1
Robins, H.I.2
Rohle, D.3
-
52
-
-
85052417755
-
Targeting EGFR in glioblastoma: Preclinical testing of dacomitinib
-
Sepúlveda JM, Zahonero C, Hernandez-Lain A, et al. Targeting EGFR in glioblastoma: Preclinical testing of dacomitinib. J Clin Oncol 2014;32:abstr e13015.
-
(2014)
J Clin Oncol
, vol.32
-
-
Sepúlveda, J.M.1
Zahonero, C.2
Hernandez-Lain, A.3
-
53
-
-
84906221718
-
An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII
-
Li L, Chakraborty S, Yang CR, et al. An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII. Oncogene 2014;33:4253-64.
-
(2014)
Oncogene
, vol.33
, pp. 4253-4264
-
-
Li, L.1
Chakraborty, S.2
Yang, C.R.3
-
54
-
-
34250193662
-
The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization
-
Johns TG, Perera RM, Vernes SC, et al. The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization. Clin Cancer Res 2007;13:1911-25.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1911-1925
-
-
Johns, T.G.1
Perera, R.M.2
Vernes, S.C.3
-
55
-
-
84885356671
-
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
-
Fan QW, Cheng CK, Gustafson WC, et al. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell 2013;24:438-49.
-
(2013)
Cancer Cell
, vol.24
, pp. 438-449
-
-
Fan, Q.W.1
Cheng, C.K.2
Gustafson, W.C.3
-
56
-
-
84905447834
-
EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing
-
Francis JM, Zhang CZ, Maire CL, et al. EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing. Cancer Discov 2014;4:956-71.
-
(2014)
Cancer Discov
, vol.4
, pp. 956-971
-
-
Francis, J.M.1
Zhang, C.Z.2
Maire, C.L.3
-
57
-
-
84905497551
-
Greater Than the Sum of Its Parts: Single-Nucleus Sequencing Identifies Convergent Evolution of Independent EGFR Mutants in GBM
-
Gini B, Mischel PS. Greater Than the Sum of Its Parts: Single-Nucleus Sequencing Identifies Convergent Evolution of Independent EGFR Mutants in GBM. Cancer Discov 2014;4:876-8.
-
(2014)
Cancer Discov
, vol.4
, pp. 876-878
-
-
Gini, B.1
Mischel, P.S.2
-
58
-
-
3042823868
-
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
-
Chakravarti A, Zhai G, Suzuki Y, et al. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol 2004;22:1926-33.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1926-1933
-
-
Chakravarti, A.1
Zhai, G.2
Suzuki, Y.3
-
59
-
-
84861101004
-
An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway
-
Guo D, Reinitz F, Youssef M, et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discov 2011;1:442-56.
-
(2011)
Cancer Discov
, vol.1
, pp. 442-456
-
-
Guo, D.1
Reinitz, F.2
Youssef, M.3
-
60
-
-
33644822862
-
Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas
-
Bredel M, Bredel C, Juric D, et al. Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol 2006;24:274-87.
-
(2006)
J Clin Oncol
, vol.24
, pp. 274-287
-
-
Bredel, M.1
Bredel, C.2
Juric, D.3
-
63
-
-
84872406787
-
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
-
Liang J, Nagahashi M, Kim EY, et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 2013;23:107-20.
-
(2013)
Cancer Cell
, vol.23
, pp. 107-120
-
-
Liang, J.1
Nagahashi, M.2
Kim, E.Y.3
-
64
-
-
77953966511
-
Sphingosine 1-phosphate and cancer
-
Pyne NJ, Pyne S. Sphingosine 1-phosphate and cancer. Nat Rev Cancer 2010;10:489-503.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 489-503
-
-
Pyne, N.J.1
Pyne, S.2
-
65
-
-
77953923379
-
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
-
Alvarez SE, Harikumar KB, Hait NC, et al. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 2010;465:1084-8.
-
(2010)
Nature
, vol.465
, pp. 1084-1088
-
-
Alvarez, S.E.1
Harikumar, K.B.2
Hait, N.C.3
-
66
-
-
33846973661
-
Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells
-
Pilorget A, Demeule M, Barakat S, et al. Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. J Neurochem 2007;100:1203-10.
-
(2007)
J Neurochem
, vol.100
, pp. 1203-1210
-
-
Pilorget, A.1
Demeule, M.2
Barakat, S.3
-
67
-
-
1942453838
-
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A
-
Yang HS, Cho MH, Zakowicz H, et al. A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol 2004;24:3894-906.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3894-3906
-
-
Yang, H.S.1
Cho, M.H.2
Zakowicz, H.3
-
68
-
-
84903998907
-
Tumor suppressor PDCD4 inhibits NF-kappaB-dependent transcription in human glioblastoma cells by direct interaction with p65
-
Hwang SK, Baker AR, Young MR, et al. Tumor suppressor PDCD4 inhibits NF-kappaB-dependent transcription in human glioblastoma cells by direct interaction with p65. Carcinogenesis 2014;35:1469-80.
-
(2014)
Carcinogenesis
, vol.35
, pp. 1469-1480
-
-
Hwang, S.K.1
Baker, A.R.2
Young, M.R.3
-
70
-
-
72249101914
-
Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes
-
Sarkar D, Emdad L, Lee SG, et al. Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes. Cancer Res 2009;69:8529-35.
-
(2009)
Cancer Res
, vol.69
, pp. 8529-8535
-
-
Sarkar, D.1
Emdad, L.2
Lee, S.G.3
-
71
-
-
73949102954
-
Astrocyte elevated gene-1: a novel target for human glioma therapy
-
Emdad L, Sarkar D, Lee SG, et al. Astrocyte elevated gene-1: a novel target for human glioma therapy. Mol Cancer Ther 2010;9:79-88.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 79-88
-
-
Emdad, L.1
Sarkar, D.2
Lee, S.G.3
-
72
-
-
33751257780
-
Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc
-
Lee SG, Su ZZ, Emdad L, et al. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci U S A 2006;103:17390-5.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 17390-17395
-
-
Lee, S.G.1
Su, Z.Z.2
Emdad, L.3
-
73
-
-
72249107698
-
Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis
-
Emdad L, Lee SG, Su ZZ, et al. Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci U S A 2009;106:21300-5.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 21300-21305
-
-
Emdad, L.1
Lee, S.G.2
Su, Z.Z.3
-
74
-
-
80054024743
-
Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity
-
Lee SG, Kim K, Kegelman TP, et al. Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity. Cancer Res 2011;71:6514-23.
-
(2011)
Cancer Res
, vol.71
, pp. 6514-6523
-
-
Lee, S.G.1
Kim, K.2
Kegelman, T.P.3
-
75
-
-
33645821049
-
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival
-
Vajkoczy P, Knyazev P, Kunkel A, et al. Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival. Proc Natl Acad Sci U S A 2006;103:5799-804.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5799-5804
-
-
Vajkoczy, P.1
Knyazev, P.2
Kunkel, A.3
-
76
-
-
77952205519
-
Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity
-
Keating AK, Kim GK, Jones AE, et al. Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. Mol Cancer Ther 2010;9:1298-307.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1298-1307
-
-
Keating, A.K.1
Kim, G.K.2
Jones, A.E.3
-
77
-
-
84867509134
-
Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase
-
Ott M, Litzenburger UM, Sahm F, et al. Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase. PloS One 2012;7:e47663.
-
(2012)
PloS One
, vol.7
-
-
Ott, M.1
Litzenburger, U.M.2
Sahm, F.3
-
78
-
-
79959416877
-
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells
-
Orzan F, Pellegatta S, Poliani PL, et al. Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells. Neuropathol Appl Neurobiol 2011;37:381-94.
-
(2011)
Neuropathol Appl Neurobiol
, vol.37
, pp. 381-394
-
-
Orzan, F.1
Pellegatta, S.2
Poliani, P.L.3
-
79
-
-
84879000598
-
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
-
Kim E, Kim M, Woo DH, et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 2013;23:839-52.
-
(2013)
Cancer Cell
, vol.23
, pp. 839-852
-
-
Kim, E.1
Kim, M.2
Woo, D.H.3
-
80
-
-
0037417996
-
Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma
-
Charest A, Kheifets V, Park J, et al. Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma. Proc Natl Acad Sci U S A 2003;100:916-21.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 916-921
-
-
Charest, A.1
Kheifets, V.2
Park, J.3
-
81
-
-
84888362036
-
Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target
-
Saborowski A, Saborowski M, Davare MA, et al. Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target. Proc Natl Acad Sci U S A 2013;110:19513-8.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 19513-19518
-
-
Saborowski, A.1
Saborowski, M.2
Davare, M.A.3
-
82
-
-
84865805666
-
Transforming fusions of FGFR and TACC genes in human glioblastoma
-
Singh D, Chan JM, Zoppoli P, et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 2012;337:1231-5.
-
(2012)
Science
, vol.337
, pp. 1231-1235
-
-
Singh, D.1
Chan, J.M.2
Zoppoli, P.3
-
83
-
-
84905694120
-
Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility
-
Zhu Z, Liu Y, Li K, et al. Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. Carcinogenesis 2014;35:1901-10.
-
(2014)
Carcinogenesis
, vol.35
, pp. 1901-1910
-
-
Zhu, Z.1
Liu, Y.2
Li, K.3
-
84
-
-
84867269916
-
Receptor protein tyrosine phosphatases and cancer: new insights from structural biology
-
Nikolaienko RM, Agyekum B, Bouyain S. Receptor protein tyrosine phosphatases and cancer: new insights from structural biology. Cell Adh Migr 2012;6:356-64.
-
(2012)
Cell Adh Migr
, vol.6
, pp. 356-364
-
-
Nikolaienko, R.M.1
Agyekum, B.2
Bouyain, S.3
-
85
-
-
80054848955
-
TRIM proteins and cancer. Nature reviews
-
Hatakeyama S. TRIM proteins and cancer. Nature reviews. Cancer 2011;11:792-804.
-
(2011)
Cancer
, vol.11
, pp. 792-804
-
-
Hatakeyama, S.1
-
86
-
-
0035251689
-
Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5
-
El-Husseini AE, Fretier P, Vincent SR. Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5. Genomics 2001;71:363-7.
-
(2001)
Genomics
, vol.71
, pp. 363-367
-
-
El-Husseini, A.E.1
Fretier, P.2
Vincent, S.R.3
-
87
-
-
84905968776
-
Human Brat Ortholog TRIM3 Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma
-
Chen G, Kong J, Tucker-Burden C, et al. Human Brat Ortholog TRIM3 Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma. Cancer Res 2014;74:4536-48.
-
(2014)
Cancer Res
, vol.74
, pp. 4536-4548
-
-
Chen, G.1
Kong, J.2
Tucker-Burden, C.3
-
88
-
-
77956443293
-
A cancer fate in the hands of a samurai
-
Moore MA. A cancer fate in the hands of a samurai. Nat Med 2010;16:963-5.
-
(2010)
Nat Med
, vol.16
, pp. 963-965
-
-
Moore, M.A.1
-
89
-
-
77957599565
-
New insight into cancer therapeutics: induction of differentiation by regulating the Musashi/Numb/Notch pathway
-
Nishimoto Y, Okano H. New insight into cancer therapeutics: induction of differentiation by regulating the Musashi/Numb/Notch pathway. Cell Res 2010;20:1083-5.
-
(2010)
Cell Res
, vol.20
, pp. 1083-1085
-
-
Nishimoto, Y.1
Okano, H.2
-
90
-
-
84858009529
-
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways
-
Muto J, Imai T, Ogawa D, et al. RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways. PloS One 2012;7:e33431.
-
(2012)
PloS One
, vol.7
-
-
Muto, J.1
Imai, T.2
Ogawa, D.3
-
91
-
-
84898657562
-
Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule
-
Kitambi SS, Toledo EM, Usoskin D, et al. Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule. Cell 2014;157:313-28.
-
(2014)
Cell
, vol.157
, pp. 313-328
-
-
Kitambi, S.S.1
Toledo, E.M.2
Usoskin, D.3
-
92
-
-
84898606305
-
Driving glioblastoma to drink
-
Gilbertson RJ. Driving glioblastoma to drink. Cell 2014;157:289-90.
-
(2014)
Cell
, vol.157
, pp. 289-290
-
-
Gilbertson, R.J.1
-
93
-
-
84858032579
-
Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death
-
Robinson MW, Overmeyer JH, Young AM, et al. Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death. J Med Chem 2012;55:1940-56.
-
(2012)
J Med Chem
, vol.55
, pp. 1940-1956
-
-
Robinson, M.W.1
Overmeyer, J.H.2
Young, A.M.3
-
94
-
-
83355169749
-
Rare phenomenon of extracranial metastasis of glioblastoma
-
Fonkem E, Lun M, Wong ET. Rare phenomenon of extracranial metastasis of glioblastoma. J Clin Oncol 2011;29:4594-5.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4594-4595
-
-
Fonkem, E.1
Lun, M.2
Wong, E.T.3
-
95
-
-
84908464028
-
Hematogenous dissemination of glioblastoma multiforme
-
Müller C, Holtschmidt J, Auer M, et al. Hematogenous dissemination of glioblastoma multiforme. Sci Transl Med 2014;6:247ra101.
-
(2014)
Sci Transl Med
, vol.6
-
-
Müller, C.1
Holtschmidt, J.2
Auer, M.3
|