Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65

Carcinogenesis

Volumn 35, Issue 7, 2014, Pages 1469-1480

  Hwang, Soon Kyung ^a   Baker, Alyson R ^a   Young, Matthew R ^a   Colburn, Nancy H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROGRAMMED CELL DEATH 4; PROTEIN P50; SYNAPTOTAGMIN I; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER LOCALIZATION; CANCER THERAPY; CELL TRANSPORT; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INFLAMMATORY CELL; LUCIFERASE ASSAY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TRANSPORT; TRANSCRIPTION INITIATION; XENOGRAFT;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; IMMUNOPRECIPITATION; NF-KAPPA B P50 SUBUNIT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 84903998907     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgu008     Document Type: Article

References (45)

1. Shibahara,K. et al. (1995) Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene, 166, 297-301.
2. Cmarik,J.L. et al. (1999) Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc. Natl Acad. Sci. USA, 96, 14037-14042.
3. Hilliard,A. et al. (2006) Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. J. Immunol., 177, 8095-8102.
4. Jansen,A.P. et al. (2005) Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res., 65, 6034-6041.
5. Schmid,T. et al. (2008) Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion. Cancer Res., 68, 1254-1260.
6. Afonja,O. et al. (2004) Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis. Oncogene, 23, 8135-8145.
7. Chen,Y. et al. (2003) Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. J. Pathol., 200, 640-646.
8. Gao,F. et al. (2007) Frequent loss of PDCD4 expression in human glioma:possible role in the tumorigenesis of glioma. Oncol. Rep., 17, 123-128.
9. Hiyoshi,Y. et al. (2009) MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma. Clin. Cancer Res., 15, 1915-1922.
10. Mudduluru,G. et al. (2007) Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. Cancer, 110, 1697-1707.
11. Zhang,H. et al. (2006) Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma. Oncogene, 25, 6101-6112.
12. Jin,H. et al. (2006) Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice. Mol. Cancer Ther., 5, 1041-1049.
13. Gaur,A.B. et al. (2011) Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo. Neuro. Oncol., 13, 580-590.
14. Yang,H.S. et al. (2004) A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol. Cell. Biol., 24, 3894-3906.
15. Yang,H.S. et al. (2003) The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol. Cell. Biol., 23, 26-37.
16. LaRonde-LeBlanc,N. et al. (2007) Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol. Cell. Biol., 27, 147-156.
17. Chang,J.H. et al. (2009) Crystal structure of the eIF4A-PDCD4 complex. Proc. Natl Acad. Sci. USA, 106, 3148-3153.
18. Loh,P.G. et al. (2009) Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J., 28, 274-285.
19. Sonenberg,N. et al. (1998) The mRNA 5' cap-binding protein eIF4E and control of cell growth. Curr. Opin. Cell Biol., 10, 268-275.
20. Singh,P. et al. (2011) Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation. Oncogene, 30, 4864-4873.
21. Wedeken,L. et al. (2011) Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA. J. Biol. Chem., 286, 42855-42862.
22. Liwak,U. et al. (2012) Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2. Mol. Cell. Biol., 32, 1818-1829.
23. Leupold,J.H. et al. (2007) Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Oncogene, 26, 4550-4562.
24. Santhanam,A.N. et al. (2010) Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. Oncogene, 29, 3921-3932.
25. Yang,H.S. et al. (2006) Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Mol. Cell. Biol., 26, 1297-1306.
26. Yang,H.S. et al. (2001) A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation. Oncogene, 20, 669-676.
27. Bitomsky,N. et al. (2004) Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. Oncogene, 23, 7484-7493.
28. Sheedy,F.J. et al. (2010) Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat. Immunol., 11, 141-147.
29. Guo,X. et al. (2011) AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin D1 Expression and Promotes Cell Proliferation. Genes Cancer, 2, 818-828.
30. Dai,C. et al. (2011) Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signaling. J. Biol. Chem., 286, 7052-7059.
31. Adli,M. et al. (2010) IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. PLoS One, 5, e9428.
32. Hayden,M.S. et al. (2004) Signaling to NF-kappaB. Genes Dev., 18, 2195-2224.
33. Ghosh,S. et al. (2002) Missing pieces in the NF-kappaB puzzle. Cell, 109 (suppl.), S81-S96.
34. Nyberg,P. et al. (2002) MMP-9 activation by tumor trypsin-2 enhances in vivo invasion of human tongue carcinoma cells. J. Dent. Res., 81, 831-835.
35. Su,J.L. et al. (2006) The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell, 9, 209-223.
36. Bitomsky,N. et al. (2008) siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression. Oncogene, 27, 4820-4829.
37. Lankat-Buttgereit,B. et al. (2004) Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II. Mol. Cell. Endocrinol., 214, 149-153.
38. Shiota,M. et al. (2009) Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth. Cancer Res., 69, 3148-3156.
39. Liu,Y. et al. (2011) Expression of VEGF and MMP-9 and MRI imaging changes in cerebral glioma. Oncol. Lett., 2, 1171-1175.
40. Zanotto-Filho,A. et al. (2011) NFκB inhibitors induce cell death in glioblastomas. Biochem. Pharmacol., 81, 412-424.
41. Zhang,H.S. et al. (2012) PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells. J. Biol. Chem., 287, 44164-44172.
42. Rosenwald,I.B. et al. (1993) Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol. Cell. Biol., 13, 7358-7363.
43. Arabi,A. et al. (2012) Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. Nat. Commun., 3, 976.
44. Ghose,J. et al. (2011) Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease. PLoS One, 6, e23837.
45. Staudt,L.M. (2010) Oncogenic activation of NF-kappaB. Cold Spring Harb. Perspect. Biol., 2, a000109.