Mid-life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ-associated pathology and positively influences synaptic and cognitive health in healthy ageing

Journal of Comparative Neurology

Volumn 525, Issue 8, 2017, Pages 1797-1810

  Stuart, Kimberley E ^a   King, Anna E ^a   Fernandez Martos, Carmen M ^a   Dittmann, Justin ^a   Summers, Mathew J ^a,b   Vickers, James C ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b UNIVERSITY OF THE SUNSHINE COAST   (Australia)

Author keywords

Alzheimer's disease; A ; brain derived neurotrophic factor; cognitive function; environmental enrichment; RRID: SCR_002865; RRID:AB_1860491; RRID:AB_2263126; RRID:AB_2278725; RRID:AB_262185; RRID:AB_303248; RRID:AB_476743; RRID:AB_570874; RRID:AB_630940; RRID:MGI_3665286; RRID:SCR_002668; RRID:SCR_003070; transgenic mouse

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; GEPHYRIN; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; MEMBRANE PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPTIC PROTEIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BARNES MAZE TEST; COGNITION; CONTROLLED STUDY; ENVIRONMENTAL ENRICHMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; LONG TERM MEMORY; MALE; MOUSE; MOUSE MODEL; NEOCORTEX; NERVE CELL NETWORK; NEUROPATHOLOGY; NONHUMAN; PREFRONTAL CORTEX; SHORT TERM MEMORY; SYNAPTIC DENSITY; SYNAPTIC TRANSMISSION; WILD TYPE MOUSE; Y-MAZE TEST; ANIMAL; C57BL MOUSE; COGNITION DISORDERS; COMPLICATION; DISEASE MODEL; IMAGE PROCESSING; MAZE TEST; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SYNAPSE; TRANSGENIC MOUSE; WESTERN BLOTTING;

AGING; ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; CA1 REGION, HIPPOCAMPAL; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HOUSING, ANIMAL; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RANDOM ALLOCATION; SYNAPSES;

EID: 85015312533     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.24156     Document Type: Article

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