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Volumn 2, Issue , 2015, Pages 15016-

Corrigendum to “Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho–/– mouse” (Molecular Therapy - Methods and Clinical Development (2015) 2 (S2329050116300286) (10.1038/mtm.2015.16));Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho−/− mouse

Author keywords

[No Author keywords available]

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR; MESSENGER RNA; RHODOPSIN; BETA ACTIN;

EID: 85015258377     PISSN: None     EISSN: 23290501     Source Type: Journal    
DOI: 10.1038/mtm.2016.32     Document Type: Erratum
Times cited : (19)

References (46)
  • 3
    • 54949104686 scopus 로고    scopus 로고
    • Phase I trial of Leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results
    • 3 Hauswirth, W, Aleman, TS, Kaushal, S, Cideciyan, AV, Schwartz, SB, Wang, L, et al. Phase I trial of Leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results. Hum Gene Ther 19 (2008), 979–990.
    • (2008) Hum Gene Ther , vol.19 , pp. 979-990
    • Hauswirth, W.1    Aleman, T.S.2    Kaushal, S.3    Cideciyan, A.V.4    Schwartz, S.B.5    Wang, L.6
  • 4
    • 0038128347 scopus 로고    scopus 로고
    • Immune response following intraocular delivery of recombinant viral vectors
    • 4 Bennett, J, Immune response following intraocular delivery of recombinant viral vectors. Gene Ther 10 (2003), 977–982.
    • (2003) Gene Ther , vol.10 , pp. 977-982
    • Bennett, J.1
  • 5
    • 84883719513 scopus 로고    scopus 로고
    • Immunology of AAV-mediated gene transfer in the eye
    • 5 Willett, K, Bennett, J, Immunology of AAV-mediated gene transfer in the eye. Front Immunol, 4, 2013, 261.
    • (2013) Front Immunol , vol.4 , pp. 261
    • Willett, K.1    Bennett, J.2
  • 6
    • 84897051037 scopus 로고    scopus 로고
    • Retinal gene therapy in patients with choroideremia: initial findings from a phase ½ clinical trial
    • 6 MacLaren, RE, Groppe, M, Barnard, AR, Cottriall, CL, Tolmachova, T, Seymour, L, et al. Retinal gene therapy in patients with choroideremia: initial findings from a phase ½ clinical trial. Lancet 383 (2014), 1129–1137.
    • (2014) Lancet , vol.383 , pp. 1129-1137
    • MacLaren, R.E.1    Groppe, M.2    Barnard, A.R.3    Cottriall, C.L.4    Tolmachova, T.5    Seymour, L.6
  • 7
    • 0035894739 scopus 로고    scopus 로고
    • Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model
    • 7 Auricchio, A, Kobinger, G, Anand, V, Hildinger, M, O'Connor, E, Maguire, AM, et al. Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model. Hum Mol Genet 10 (2001), 3075–3081.
    • (2001) Hum Mol Genet , vol.10 , pp. 3075-3081
    • Auricchio, A.1    Kobinger, G.2    Anand, V.3    Hildinger, M.4    O'Connor, E.5    Maguire, A.M.6
  • 8
    • 0036140216 scopus 로고    scopus 로고
    • Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity
    • 8 Rabinowitz, JE, Rolling, F, Li, C, Conrath, H, Xiao, W, Xiao, X, et al. Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J Virol 76 (2002), 791–801.
    • (2002) J Virol , vol.76 , pp. 791-801
    • Rabinowitz, J.E.1    Rolling, F.2    Li, C.3    Conrath, H.4    Xiao, W.5    Xiao, X.6
  • 11
    • 32344438754 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
    • 11 Maheshri, N, Koerber, JT, Kaspar, BK, Schaffer, DV, Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nat Biotechnol 24 (2006), 198–204.
    • (2006) Nat Biotechnol , vol.24 , pp. 198-204
    • Maheshri, N.1    Koerber, J.T.2    Kaspar, B.K.3    Schaffer, D.V.4
  • 12
    • 54849391500 scopus 로고    scopus 로고
    • DNA shuffling of adeno-associated virus yields functionally diverse viral progeny
    • 12 Koerber, JT, Jang, JH, Schaffer, DV, DNA shuffling of adeno-associated virus yields functionally diverse viral progeny. Mol Ther 16 (2008), 1703–1709.
    • (2008) Mol Ther , vol.16 , pp. 1703-1709
    • Koerber, J.T.1    Jang, J.H.2    Schaffer, D.V.3
  • 15
    • 84880540708 scopus 로고    scopus 로고
    • In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous
    • 15 Dalkara, D, Byrne, LC, Klimczak, RR, Visel, M, Yin, L, Merigan, WH, et al. In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Sci Transl Med, 5, 2013, 189ra76.
    • (2013) Sci Transl Med , vol.5 , pp. 189ra76
    • Dalkara, D.1    Byrne, L.C.2    Klimczak, R.R.3    Visel, M.4    Yin, L.5    Merigan, W.H.6
  • 16
    • 84916891798 scopus 로고    scopus 로고
    • Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter
    • 16 Cronin, T, Vandenberghe, LH, Hantz, P, Juttner, J, Reimann, A, Kacsó, AE, et al. Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter. EMBO Mol Med 6 (2014), 1175–1190.
    • (2014) EMBO Mol Med , vol.6 , pp. 1175-1190
    • Cronin, T.1    Vandenberghe, L.H.2    Hantz, P.3    Juttner, J.4    Reimann, A.5    Kacsó, A.E.6
  • 17
    • 84907357528 scopus 로고    scopus 로고
    • Adeno-associated virus: fit to serve
    • 17 Zinn, E, Vandenberghe, LH, Adeno-associated virus: fit to serve. Curr Opin Virol 8 (2014), 90–97.
    • (2014) Curr Opin Virol , vol.8 , pp. 90-97
    • Zinn, E.1    Vandenberghe, L.H.2
  • 18
    • 12244311258 scopus 로고    scopus 로고
    • Efficient trans-splicing in the retina expands the utility of adeno-associated virus as a vector for gene therapy
    • 18 Reich, SJ, Auricchio, A, Hildinger, M, Glover, E, Maguire, AM, Wilson, JM, et al. Efficient trans-splicing in the retina expands the utility of adeno-associated virus as a vector for gene therapy. Hum Gene Ther 14 (2003), 37–44.
    • (2003) Hum Gene Ther , vol.14 , pp. 37-44
    • Reich, S.J.1    Auricchio, A.2    Hildinger, M.3    Glover, E.4    Maguire, A.M.5    Wilson, J.M.6
  • 19
    • 0038420943 scopus 로고    scopus 로고
    • Delivery of adeno-associated virus vectors to the fetal retina: impact of viral capsid proteins on retinal neuronal progenitor transduction
    • 19 Surace, EM, Auricchio, A, Reich, SJ, Rex, T, Glover, E, Pineles, S, et al. Delivery of adeno-associated virus vectors to the fetal retina: impact of viral capsid proteins on retinal neuronal progenitor transduction. J Virol 77 (2003), 7957–7963.
    • (2003) J Virol , vol.77 , pp. 7957-7963
    • Surace, E.M.1    Auricchio, A.2    Reich, S.J.3    Rex, T.4    Glover, E.5    Pineles, S.6
  • 20
    • 84872382925 scopus 로고    scopus 로고
    • Tropisms of AAV for subretinal delivery to the neonatal mouse retina and its application for in vivo rescue of developmental photoreceptor disorders
    • 20 Watanabe, S, Sanuki, R, Ueno, S, Koyasu, T, Hasegawa, T, Furukawa, T, Tropisms of AAV for subretinal delivery to the neonatal mouse retina and its application for in vivo rescue of developmental photoreceptor disorders. PLoS One, 8, 2013, e54146.
    • (2013) PLoS One , vol.8 , pp. e54146
    • Watanabe, S.1    Sanuki, R.2    Ueno, S.3    Koyasu, T.4    Hasegawa, T.5    Furukawa, T.6
  • 21
    • 84875690657 scopus 로고    scopus 로고
    • Evaluation of lateral spread of transgene expression following subretinal AAV-mediated gene delivery in dogs
    • 21 Bruewer, AR, Mowat, FM, Bartoe, JT, Boye, SL, Hauswirth, WW, Petersen-Jones, SM, Evaluation of lateral spread of transgene expression following subretinal AAV-mediated gene delivery in dogs. PLoS One, 8, 2013, e60218.
    • (2013) PLoS One , vol.8 , pp. e60218
    • Bruewer, A.R.1    Mowat, F.M.2    Bartoe, J.T.3    Boye, S.L.4    Hauswirth, W.W.5    Petersen-Jones, S.M.6
  • 22
    • 35148862553 scopus 로고    scopus 로고
    • Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors
    • 22 Allocca, M, Mussolino, C, Garcia-Hoyos, M, Sanges, D, Iodice, C, Petrillo, M, et al. Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors. J Virol 81 (2007), 11372–11380.
    • (2007) J Virol , vol.81 , pp. 11372-11380
    • Allocca, M.1    Mussolino, C.2    Garcia-Hoyos, M.3    Sanges, D.4    Iodice, C.5    Petrillo, M.6
  • 23
    • 32944459983 scopus 로고    scopus 로고
    • Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9 and Rh10 in the mouse brain
    • 23 Cearley, CN, Wolfe, JH, Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9 and Rh10 in the mouse brain. Mol Ther 13 (2006), 528–537.
    • (2006) Mol Ther , vol.13 , pp. 528-537
    • Cearley, C.N.1    Wolfe, J.H.2
  • 24
    • 77956628142 scopus 로고    scopus 로고
    • RH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene therapy
    • 24 Hu, C, Busuttil, RW, Lipshutz, GS, RH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene therapy. J Gene Med 12 (2010), 766–778.
    • (2010) J Gene Med , vol.12 , pp. 766-778
    • Hu, C.1    Busuttil, R.W.2    Lipshutz, G.S.3
  • 25
    • 84875443169 scopus 로고    scopus 로고
    • Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis
    • 25 Sondhi, D, Johnson, L, Purpura, K, Monette, S, Souweidane, MM, Kaplitt, MG, et al. Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis. Hum Gene Ther Methods 23 (2012), 324–335.
    • (2012) Hum Gene Ther Methods , vol.23 , pp. 324-335
    • Sondhi, D.1    Johnson, L.2    Purpura, K.3    Monette, S.4    Souweidane, M.M.5    Kaplitt, M.G.6
  • 26
    • 78049526068 scopus 로고    scopus 로고
    • Transduction of the inner mouse retina using AAVrh8 and AAVrh10 via intravitreal injection
    • 26 Giove, TJ, Sena-Esteves, M, Eldred, WD, Transduction of the inner mouse retina using AAVrh8 and AAVrh10 via intravitreal injection. Exp Eye Res 91 (2010), 652–659.
    • (2010) Exp Eye Res , vol.91 , pp. 652-659
    • Giove, T.J.1    Sena-Esteves, M.2    Eldred, W.D.3
  • 27
    • 83455206223 scopus 로고    scopus 로고
    • Persistent suppression of ocular neovascularization with intravitreal administration of AAVrh.10 coding for bevacizumab
    • 27 Mao, Y, Kiss, S, Boyer, JL, Hackett, NR, Qiu, J, Carbone, A, et al. Persistent suppression of ocular neovascularization with intravitreal administration of AAVrh.10 coding for bevacizumab. Hum Gene Ther 22 (2011), 1525–1535.
    • (2011) Hum Gene Ther , vol.22 , pp. 1525-1535
    • Mao, Y.1    Kiss, S.2    Boyer, J.L.3    Hackett, N.R.4    Qiu, J.5    Carbone, A.6
  • 28
    • 0031045876 scopus 로고    scopus 로고
    • Retinopathy induced in mice by targeted disruption of the rhodopsin gene
    • 28 Humphries, MM, Rancourt, D, Farrar, GJ, Kenna, P, Hazel, M, Bush, RA, et al. Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet 15 (1997), 216–219.
    • (1997) Nat Genet , vol.15 , pp. 216-219
    • Humphries, M.M.1    Rancourt, D.2    Farrar, G.J.3    Kenna, P.4    Hazel, M.5    Bush, R.A.6
  • 29
    • 77949733904 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene
    • 29 Palfi, A, Millington-Ward, S, Chadderton, N, O'Reilly, M, Goldmann, T, Humphries, MM, et al. Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene. Hum Gene Ther 21 (2010), 311–323.
    • (2010) Hum Gene Ther , vol.21 , pp. 311-323
    • Palfi, A.1    Millington-Ward, S.2    Chadderton, N.3    O'Reilly, M.4    Goldmann, T.5    Humphries, M.M.6
  • 30
    • 0026463972 scopus 로고
    • Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa
    • 30 Olsson, JE, Gordon, JW, Pawlyk, BS, Roof, D, Hayes, A, Molday, RS, et al. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron 9 (1992), 815–830.
    • (1992) Neuron , vol.9 , pp. 815-830
    • Olsson, J.E.1    Gordon, J.W.2    Pawlyk, B.S.3    Roof, D.4    Hayes, A.5    Molday, R.S.6
  • 31
    • 32544436444 scopus 로고    scopus 로고
    • Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual-reality optokinetic system
    • 31 Douglas, RM, Alam, NM, Silver, BD, McGill, TJ, Tschetter, WW, Prusky, GT, Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual-reality optokinetic system. Vis Neurosci 22 (2005), 677–684.
    • (2005) Vis Neurosci , vol.22 , pp. 677-684
    • Douglas, R.M.1    Alam, N.M.2    Silver, B.D.3    McGill, T.J.4    Tschetter, W.W.5    Prusky, G.T.6
  • 32
    • 84903760379 scopus 로고    scopus 로고
    • Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10
    • 32 Yang, B, Li, S, Wang, H, Guo, Y, Gessler, DJ, Cao, C, et al. Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10. Mol Ther 22 (2014), 1299–1309.
    • (2014) Mol Ther , vol.22 , pp. 1299-1309
    • Yang, B.1    Li, S.2    Wang, H.3    Guo, Y.4    Gessler, D.J.5    Cao, C.6
  • 33
  • 34
    • 84873453664 scopus 로고    scopus 로고
    • Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement
    • 34 Cideciyan, AV, Jacobson, SG, Beltran, WA, Sumaroka, A, Swider, M, Iwabe, S, et al. Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Proc Natl Acad Sci USA 110 (2013), E517–E525.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E517-E525
    • Cideciyan, A.V.1    Jacobson, S.G.2    Beltran, W.A.3    Sumaroka, A.4    Swider, M.5    Iwabe, S.6
  • 35
    • 84902952909 scopus 로고    scopus 로고
    • Intracerebral administration of adeno-associated viral vector serotype rh.10 carrying human SGSH and SUMF1 cDNAs in children with mucopolysaccharidosis type IIIA disease: results of a phase I/II trial
    • 35 Tardieu, M, Zérah, M, Husson, B, de Bournonville, S, Deiva, K, Adamsbaum, C, et al. Intracerebral administration of adeno-associated viral vector serotype rh.10 carrying human SGSH and SUMF1 cDNAs in children with mucopolysaccharidosis type IIIA disease: results of a phase I/II trial. Hum Gene Ther 25 (2014), 506–516.
    • (2014) Hum Gene Ther , vol.25 , pp. 506-516
    • Tardieu, M.1    Zérah, M.2    Husson, B.3    de Bournonville, S.4    Deiva, K.5    Adamsbaum, C.6
  • 37
    • 84896320924 scopus 로고    scopus 로고
    • Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy
    • 37 Ferreira, V, Twisk, J, Kwikkers, K, Aronica, E, Brisson, D, Methot, J, et al. Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy. Hum Gene Ther 25 (2014), 180–188.
    • (2014) Hum Gene Ther , vol.25 , pp. 180-188
    • Ferreira, V.1    Twisk, J.2    Kwikkers, K.3    Aronica, E.4    Brisson, D.5    Methot, J.6
  • 38
    • 84878581647 scopus 로고    scopus 로고
    • Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital Amaurosis type 2
    • 38 Testa, F, Maguire, AM, Rossi, S, Pierce, EA, Melillo, P, Marshall, K, et al. Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital Amaurosis type 2. Ophthalmology 120 (2013), 1283–1291.
    • (2013) Ophthalmology , vol.120 , pp. 1283-1291
    • Testa, F.1    Maguire, A.M.2    Rossi, S.3    Pierce, E.A.4    Melillo, P.5    Marshall, K.6
  • 40
    • 84891743727 scopus 로고    scopus 로고
    • Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain
    • 40 Swain, GP, Prociuk, M, Bagel, JH, O'Donnell, P, Berger, K, Drobatz, K, et al. Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain. Gene Ther 21 (2014), 28–36.
    • (2014) Gene Ther , vol.21 , pp. 28-36
    • Swain, G.P.1    Prociuk, M.2    Bagel, J.H.3    O'Donnell, P.4    Berger, K.5    Drobatz, K.6
  • 41
    • 84896315121 scopus 로고    scopus 로고
    • Adeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdala
    • 41 Holehonnur, R, Luong, JA, Chaturvedi, D, Ho, A, Lella, SK, Hosek, MP, et al. Adeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdala. BMC Neurosci, 15, 2014, 28.
    • (2014) BMC Neurosci , vol.15 , pp. 28
    • Holehonnur, R.1    Luong, J.A.2    Chaturvedi, D.3    Ho, A.4    Lella, S.K.5    Hosek, M.P.6
  • 42
    • 0036805547 scopus 로고    scopus 로고
    • Fast and reliable titration of recombinant adeno-associated virus type-2 using quantitative real-time PCR
    • 42 Rohr, UP, Wulf, MA, Stahn, S, Steidl, U, Haas, R, Kronenwett, R, Fast and reliable titration of recombinant adeno-associated virus type-2 using quantitative real-time PCR. J Virol Methods 106 (2002), 81–88.
    • (2002) J Virol Methods , vol.106 , pp. 81-88
    • Rohr, U.P.1    Wulf, M.A.2    Stahn, S.3    Steidl, U.4    Haas, R.5    Kronenwett, R.6
  • 43
    • 0347089037 scopus 로고    scopus 로고
    • Electroporation and RNA interference in the rodent retina in vivo and in vitro
    • 43 Matsuda, T, Cepko, CL, Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc Natl Acad Sci USA 101 (2004), 16–22.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16-22
    • Matsuda, T.1    Cepko, C.L.2
  • 44
    • 63949087144 scopus 로고    scopus 로고
    • Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy
    • 44 Chadderton, N, Millington-Ward, S, Palfi, A, O'Reilly, M, Tuohy, G, Humphries, MM, et al. Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy. Mol Ther 17 (2009), 593–599.
    • (2009) Mol Ther , vol.17 , pp. 593-599
    • Chadderton, N.1    Millington-Ward, S.2    Palfi, A.3    O'Reilly, M.4    Tuohy, G.5    Humphries, M.M.6
  • 45
    • 23844529037 scopus 로고    scopus 로고
    • Toward a gene therapy for dominant disease: validation of an RNA interference-based mutation-independent approach
    • 45 Kiang, AS, Palfi, A, Ader, M, Kenna, PF, Millington-Ward, S, Clark, G, et al. Toward a gene therapy for dominant disease: validation of an RNA interference-based mutation-independent approach. Mol Ther 12 (2005), 555–561.
    • (2005) Mol Ther , vol.12 , pp. 555-561
    • Kiang, A.S.1    Palfi, A.2    Ader, M.3    Kenna, P.F.4    Millington-Ward, S.5    Clark, G.6
  • 46
    • 84871188632 scopus 로고    scopus 로고
    • Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy
    • 46 Chadderton, N, Palfi, A, Millington-Ward, S, Gobbo, O, Overlack, N, Carrigan, M, et al. Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy. Eur J Hum Genet 21 (2013), 62–68.
    • (2013) Eur J Hum Genet , vol.21 , pp. 62-68
    • Chadderton, N.1    Palfi, A.2    Millington-Ward, S.3    Gobbo, O.4    Overlack, N.5    Carrigan, M.6


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