Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter

EMBO Molecular Medicine

Volumn 6, Issue 9, 2014, Pages 1175-1190

  Cronin, Therese ^a,b   Vandenberghe, Luk H ^a,c   Hantz, Péter ^b   Juttner, Josephine ^b   Reimann, Andreas ^b   Kacsó, Ágota Eniko ^d   Huckfeldt, Rachel M ^a   Busskamp, Volker ^b,e   Kohler, Hubertus ^b   Lagali, Pamela S ^b,f   Roska, Botond ^b   Bennett, Jean ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^c SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^d BABE BOLYAI UNIVERSITY   (Romania)

^e HARVARD MEDICAL SCHOOL   (United States)

^f OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Adeno associated virus; Capsid library; Multi electrode array; Optogenetics; Promoter optimization

Indexed keywords

ADENO ASSOCIATED VIRUS; ARTICLE; GENE EXPRESSION; MUTAGENESIS; NERVE CELL; NONHUMAN; OPTOGENETICS; PHOTORECEPTOR; PROMOTER REGION; RETINA BIPOLAR GANGLION CELL; SIGNAL TRANSDUCTION; TREATMENT PLANNING; VIRAL TROPISM; VIRUS CAPSID; ANIMAL; C57BL MOUSE; DEPENDOPARVOVIRUS; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HEK293 CELL LINE; HUMAN; MOUSE; PROCEDURES; SITE DIRECTED MUTAGENESIS; VIROLOGY;

ANIMALS; DEPENDOVIRUS; GENETIC VECTORS; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS, GENETIC; RETINAL BIPOLAR CELLS; TRANSDUCTION, GENETIC;

EID: 84916891798     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404077     Document Type: Article

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