Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Journal of Medicinal Chemistry

Volumn 60, Issue 5, 2017, Pages 1665-1672

  Pye, Cameron R ^a   Hewitt, William M ^a   Schwochert, Joshua ^a   Haddad, Terra D ^a   Townsend, Chad E ^a   Etienne, Lyns ^a   Lao, Yongtong ^a   Limberakis, Chris ^b   Furukawa, Akihiro ^c   Mathiowetz, Alan M ^b   Price, David A ^b   Liras, Spiros ^b   Lokey, R Scott ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PFIZER INC   (United States)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; MACROCYCLIC COMPOUND;

ADSORPTION; ARTICLE; COMBINATORIAL CHEMISTRY; DRUG ADSORPTION; DRUG PENETRATION; HYDROGEN BOND; LIPOPHILICITY; MEMBRANE PERMEABILITY; MOLECULAR LIBRARY; MOLECULAR WEIGHT; PEPTIDE SYNTHESIS; QUANTITATIVE STRUCTURE PROPERTY RELATION; CELL MEMBRANE PERMEABILITY; DRUG EFFECTS; HUMAN;

ADSORPTION; CELL MEMBRANE PERMEABILITY; HUMANS;

EID: 85015084736     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01483     Document Type: Article

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