Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing Receptors

Journal of Biological Chemistry

Volumn 292, Issue 10, 2017, Pages 4064-4076

  Paczkowski, Jon E ^a   Mukherjee, Sampriti ^a   McCready, Amelia R ^a   Cong, Jian Ping ^a   Aquino, Christopher J ^b   Kim, Hahn ^a   Henke, Brad R ^c   Smith, Chari D ^a   Bassler, Bonnie L ^a,d  

^a PRINCETON UNIVERSITY   (United States)

^b CJA MedChem   (United States)

^c Opti Mol Consulting LLC   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BINS; CELL SIGNALING; FIGHTER AIRCRAFT; METABOLITES; MOLECULES; PLANTS (BOTANY);

ALLOSTERIC INHIBITION; BACTERIOSTATIC MECHANISM; BIOCHEMICAL ANALYSIS; CELL-CELL COMMUNICATIONS; COLLECTIVE BEHAVIOR; EXTRACELLULAR SIGNALS; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATIONSHIPS;

FLAVONOIDS;

BACTERIAL PROTEIN; CHRYSIN; FLAVONOID; HYDROXYL GROUP; LASR PROTEIN; NARINGENIN; PHLORETIN; RHLR PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR; LASR PROTEIN, PSEUDOMONAS AERUGINOSA; MOLECULAR LIBRARY; RHLR PROTEIN, PSEUDOMONAS AERUGINOSA; TRANSACTIVATOR PROTEIN;

ALLOSTERISM; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; DNA BINDING; DRUG POTENCY; NONHUMAN; PROMOTER REGION; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION; ANTAGONISTS AND INHIBITORS; BIOFILM; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MOLECULAR LIBRARY; PHARMACOLOGY; PHYSIOLOGY; VIRULENCE;

ALLOSTERIC REGULATION; BACTERIAL PROTEINS; BIOFILMS; FLAVONOIDS; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS; VIRULENCE;

EID: 85015016734     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.770552     Document Type: Article

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