메뉴 건너뛰기




Volumn 120, Issue 4, 2016, Pages 966-974

Quercetin is an effective inhibitor of quorum sensing, biofilm formation and virulence factors in Pseudomonas aeruginosa

Author keywords

Biofilm; Pseudomonas aeruginosa; Quercetin; Quorum sensing; Virulence factors

Indexed keywords

BACTERIA; FLAVONOIDS; PHENOLS; PLANT EXTRACTS;

EID: 84959880597     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/jam.13073     Document Type: Article
Times cited : (217)

References (52)
  • 1
    • 77953379516 scopus 로고    scopus 로고
    • Severe odynophagia in a patient developing after azithromycin intake: a case report
    • Akyuz, U., Erzin, Y., Yalniz, F.F., Senkal, I.V., Ekici, I.D. and Pata, C. (2010) Severe odynophagia in a patient developing after azithromycin intake: a case report. Cases J 3, 48.
    • (2010) Cases J , vol.3 , pp. 48
    • Akyuz, U.1    Erzin, Y.2    Yalniz, F.F.3    Senkal, I.V.4    Ekici, I.D.5    Pata, C.6
  • 3
    • 79951872404 scopus 로고    scopus 로고
    • Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections
    • Bala, A., Kumar, R. and Harjai, K. (2011) Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections. J Med Microbiol 60, 300-306.
    • (2011) J Med Microbiol , vol.60 , pp. 300-306
    • Bala, A.1    Kumar, R.2    Harjai, K.3
  • 4
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: from antioxidant to nutraceutical
    • Boots, A.W., Haenen, G.R. and Bast, A. (2008) Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585, 325-337.
    • (2008) Eur J Pharmacol , vol.585 , pp. 325-337
    • Boots, A.W.1    Haenen, G.R.2    Bast, A.3
  • 5
    • 0028849833 scopus 로고
    • Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family
    • Brint, J.M. and Ohman, D.E. (1995) Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J Bacteriol 177, 7155-7163.
    • (1995) J Bacteriol , vol.177 , pp. 7155-7163
    • Brint, J.M.1    Ohman, D.E.2
  • 8
    • 84890052679 scopus 로고    scopus 로고
    • Effect of traditional Chinese herbal medicine with antiquorum sensing activity on Pseudomonas aeruginosa
    • Chu, W., Zhou, S., Jiang, Y., Zhu, W., Zhuang, X. and Fu, J. (2013) Effect of traditional Chinese herbal medicine with antiquorum sensing activity on Pseudomonas aeruginosa. Evid Based Complement Alternat Med 2013, 648257.
    • (2013) Evid Based Complement Alternat Med , vol.2013 , pp. 648257
    • Chu, W.1    Zhou, S.2    Jiang, Y.3    Zhu, W.4    Zhuang, X.5    Fu, J.6
  • 9
    • 84862641805 scopus 로고    scopus 로고
    • Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing: a randomized controlled trial
    • van Delden, C., Kohler, T., Brunner-Ferber, F., Francois, B., Carlet, J. and Pechere, J.C. (2012) Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing: a randomized controlled trial. Intensive Care Med 38, 1118-1125.
    • (2012) Intensive Care Med , vol.38 , pp. 1118-1125
    • van Delden, C.1    Kohler, T.2    Brunner-Ferber, F.3    Francois, B.4    Carlet, J.5    Pechere, J.C.6
  • 10
    • 84905715090 scopus 로고    scopus 로고
    • Aspirin is an efficient inhibitor of quorum sensing, virulence and toxins in Pseudomonas aeruginosa
    • El-Mowafy, S.A., Abd El Galil, K.H., El-Messery, S.M. and Shaaban, M.I. (2014) Aspirin is an efficient inhibitor of quorum sensing, virulence and toxins in Pseudomonas aeruginosa. Microb Pathog 74, 25-32.
    • (2014) Microb Pathog , vol.74 , pp. 25-32
    • El-Mowafy, S.A.1    Abd El Galil, K.H.2    El-Messery, S.M.3    Shaaban, M.I.4
  • 11
    • 84873724269 scopus 로고    scopus 로고
    • Synergistic activity and mechanism of action of ceftazidime and apigenin combination against ceftazidime-resistant Enterobacter cloacae
    • Eumkeb, G. and Chukrathok, S. (2013) Synergistic activity and mechanism of action of ceftazidime and apigenin combination against ceftazidime-resistant Enterobacter cloacae. Phytomedicine 20, 262-269.
    • (2013) Phytomedicine , vol.20 , pp. 262-269
    • Eumkeb, G.1    Chukrathok, S.2
  • 12
    • 55249095744 scopus 로고    scopus 로고
    • Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators
    • Geske, G.D., Mattmann, M.E. and Blackwell, H.E. (2008) Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. Bioorg Med Chem Lett 18, 5978-5981.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 5978-5981
    • Geske, G.D.1    Mattmann, M.E.2    Blackwell, H.E.3
  • 14
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • Harwood, M., Danielewska-Nikiel, B., Borzelleca, J.F., Flamm, G.W., Williams, G.M. and Lines, T.C. (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45, 2179-2205.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 17
    • 34948850804 scopus 로고    scopus 로고
    • Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice
    • Hoffmann, N., Lee, B., Hentzer, M., Rasmussen, T.B., Song, Z., Johansen, H.K., Givskov, M. and Hoiby, N. (2007) Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice. Antimicrob Agents Chemother 51, 3677-3687.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3677-3687
    • Hoffmann, N.1    Lee, B.2    Hentzer, M.3    Rasmussen, T.B.4    Song, Z.5    Johansen, H.K.6    Givskov, M.7    Hoiby, N.8
  • 18
    • 34249741550 scopus 로고    scopus 로고
    • Inhibition of quorum sensing in Pseudomonas aeruginosa by N-acyl cyclopentylamides
    • Ishida, T., Ikeda, T., Takiguchi, N., Kuroda, A., Ohtake, H. and Kato, J. (2007) Inhibition of quorum sensing in Pseudomonas aeruginosa by N-acyl cyclopentylamides. Appl Environ Microbiol 73, 3183-3188.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 3183-3188
    • Ishida, T.1    Ikeda, T.2    Takiguchi, N.3    Kuroda, A.4    Ohtake, H.5    Kato, J.6
  • 19
    • 84868527976 scopus 로고    scopus 로고
    • New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches
    • Jorge, P., Lourenco, A. and Pereira, M.O. (2012) New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches. Biofouling 28, 1033-1061.
    • (2012) Biofouling , vol.28 , pp. 1033-1061
    • Jorge, P.1    Lourenco, A.2    Pereira, M.O.3
  • 20
    • 84891599395 scopus 로고    scopus 로고
    • Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer
    • Jung, M., Bu, S.Y., Tak, K.H., Park, J.E. and Kim, E. (2013) Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer. Nutr Res Pract 7, 439-445.
    • (2013) Nutr Res Pract , vol.7 , pp. 439-445
    • Jung, M.1    Bu, S.Y.2    Tak, K.H.3    Park, J.E.4    Kim, E.5
  • 21
    • 58549114035 scopus 로고    scopus 로고
    • Quorum sensing in Pseudomonas aeruginosa biofilms
    • de Kievit, T.R. (2009) Quorum sensing in Pseudomonas aeruginosa biofilms. Environ Microbiol 11, 279-288.
    • (2009) Environ Microbiol , vol.11 , pp. 279-288
    • de Kievit, T.R.1
  • 23
    • 84860157551 scopus 로고    scopus 로고
    • Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium aromaticum) bud extract
    • Krishnan, T., Yin, W.F. and Chan, K.G. (2012) Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium aromaticum) bud extract. Sensors (Basel) 12, 4016-4030.
    • (2012) Sensors (Basel) , vol.12 , pp. 4016-4030
    • Krishnan, T.1    Yin, W.F.2    Chan, K.G.3
  • 24
    • 80055117047 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A
    • Kuang, Z., Hao, Y., Walling, B.E., Jeffries, J.L., Ohman, D.E. and Lau, G.W. (2011) Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A. PLoS One 6, e27091.
    • (2011) PLoS One , vol.6 , pp. e27091
    • Kuang, Z.1    Hao, Y.2    Walling, B.E.3    Jeffries, J.L.4    Ohman, D.E.5    Lau, G.W.6
  • 25
    • 57249103373 scopus 로고    scopus 로고
    • A new method for determination of myricetin and quercetin using solid phase microextraction-high performance liquid chromatography-ultra violet/visible system in grapes, vegetables and red wine samples
    • Kumar, A., Malik, A.K. and Tewary, D.K. (2009) A new method for determination of myricetin and quercetin using solid phase microextraction-high performance liquid chromatography-ultra violet/visible system in grapes, vegetables and red wine samples. Anal Chim Acta 631, 177-181.
    • (2009) Anal Chim Acta , vol.631 , pp. 177-181
    • Kumar, A.1    Malik, A.K.2    Tewary, D.K.3
  • 26
    • 84859891023 scopus 로고    scopus 로고
    • Pharmacokinetics of quercetin absorption from apples and onions in healthy humans
    • Lee, J. and Mitchell, A.E. (2012) Pharmacokinetics of quercetin absorption from apples and onions in healthy humans. J Agric Food Chem 60, 3874-3881.
    • (2012) J Agric Food Chem , vol.60 , pp. 3874-3881
    • Lee, J.1    Mitchell, A.E.2
  • 27
    • 84926121285 scopus 로고    scopus 로고
    • Phytochemistry and pharmacology of the genus pedicularis used in traditional Chinese medicine
    • Li, M.X., He, X.R., Tao, R. and Cao, X. (2014) Phytochemistry and pharmacology of the genus pedicularis used in traditional Chinese medicine. Am J Chin Med 42, 1071-1098.
    • (2014) Am J Chin Med , vol.42 , pp. 1071-1098
    • Li, M.X.1    He, X.R.2    Tao, R.3    Cao, X.4
  • 29
    • 0035235198 scopus 로고    scopus 로고
    • Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity. A case report
    • Mamikoglu, B. and Mamikoglu, O. (2001) Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity. A case report. Ann Otol Rhinol Laryngol 110, 102.
    • (2001) Ann Otol Rhinol Laryngol , vol.110 , pp. 102
    • Mamikoglu, B.1    Mamikoglu, O.2
  • 30
    • 3242659216 scopus 로고    scopus 로고
    • Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae)
    • Martini, N.D., Katerere, D.R. and Eloff, J.N. (2004) Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae). J Ethnopharmacol 93, 207-212.
    • (2004) J Ethnopharmacol , vol.93 , pp. 207-212
    • Martini, N.D.1    Katerere, D.R.2    Eloff, J.N.3
  • 31
    • 84895091713 scopus 로고    scopus 로고
    • Responses of Pseudomonas aeruginosa to antimicrobials
    • Morita, Y., Tomida, J. and Kawamura, Y. (2014) Responses of Pseudomonas aeruginosa to antimicrobials. Front Microbiol 4, 422.
    • (2014) Front Microbiol , vol.4 , pp. 422
    • Morita, Y.1    Tomida, J.2    Kawamura, Y.3
  • 32
    • 84867689592 scopus 로고    scopus 로고
    • Quorum sensing inhibition in Pseudomonas aeruginosa PAO1 by antagonistic compound phenylacetic acid
    • Musthafa, K.S., Sivamaruthi, B.S., Pandian, S.K. and Ravi, A.V. (2012) Quorum sensing inhibition in Pseudomonas aeruginosa PAO1 by antagonistic compound phenylacetic acid. Curr Microbiol 65, 475-480.
    • (2012) Curr Microbiol , vol.65 , pp. 475-480
    • Musthafa, K.S.1    Sivamaruthi, B.S.2    Pandian, S.K.3    Ravi, A.V.4
  • 33
    • 33646452555 scopus 로고    scopus 로고
    • Quorum-sensing antagonistic activities of azithromycin in Pseudomonas aeruginosa PAO1: a global approach
    • Nalca, Y., Jansch, L., Bredenbruch, F., Geffers, R., Buer, J. and Haussler, S. (2006) Quorum-sensing antagonistic activities of azithromycin in Pseudomonas aeruginosa PAO1: a global approach. Antimicrob Agents Chemother 50, 1680-1688.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1680-1688
    • Nalca, Y.1    Jansch, L.2    Bredenbruch, F.3    Geffers, R.4    Buer, J.5    Haussler, S.6
  • 34
    • 32944472519 scopus 로고    scopus 로고
    • Safety of quercetin for clinical application (Review)
    • Okamoto, T. (2005) Safety of quercetin for clinical application (Review). Int J Mol Med 16, 275-278.
    • (2005) Int J Mol Med , vol.16 , pp. 275-278
    • Okamoto, T.1
  • 35
    • 84907236707 scopus 로고    scopus 로고
    • Antibacterial effect of crude extract and metabolites of Phytolacca americana on pathogens responsible for periodontal inflammatory diseases and dental caries
    • Patra, J.K., Kim, E.S., Oh, K., Kim, H.J., Kim, Y. and Baek, K.H. (2014) Antibacterial effect of crude extract and metabolites of Phytolacca americana on pathogens responsible for periodontal inflammatory diseases and dental caries. BMC Complement Altern Med 14, 343.
    • (2014) BMC Complement Altern Med , vol.14 , pp. 343
    • Patra, J.K.1    Kim, E.S.2    Oh, K.3    Kim, H.J.4    Kim, Y.5    Baek, K.H.6
  • 36
    • 84885357710 scopus 로고    scopus 로고
    • Antioxidant study of quercetin and their metal complex and determination of stability constant by spectrophotometry method
    • Ravichandran, R., Rajendran, M. and Devapiriam, D. (2014) Antioxidant study of quercetin and their metal complex and determination of stability constant by spectrophotometry method. Food Chem 146, 472-478.
    • (2014) Food Chem , vol.146 , pp. 472-478
    • Ravichandran, R.1    Rajendran, M.2    Devapiriam, D.3
  • 37
    • 77954180134 scopus 로고    scopus 로고
    • Anti-biofilm and resistance suppression activities of CXA-101 against chronic respiratory infection phenotypes of Pseudomonas aeruginosa strain PAO1
    • Riera, E., Macia, M.D., Mena, A., Mulet, X., Perez, J.L., Ge, Y. and Oliver, A. (2010) Anti-biofilm and resistance suppression activities of CXA-101 against chronic respiratory infection phenotypes of Pseudomonas aeruginosa strain PAO1. J Antimicrob Chemother 65, 1399-1404.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1399-1404
    • Riera, E.1    Macia, M.D.2    Mena, A.3    Mulet, X.4    Perez, J.L.5    Ge, Y.6    Oliver, A.7
  • 38
    • 41849114939 scopus 로고    scopus 로고
    • Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models
    • Rudrappa, T. and Bais, H.P. (2008) Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models. J Agric Food Chem 56, 1955-1962.
    • (2008) J Agric Food Chem , vol.56 , pp. 1955-1962
    • Rudrappa, T.1    Bais, H.P.2
  • 40
    • 33644853806 scopus 로고    scopus 로고
    • A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa
    • Schuster, M. and Greenberg, E.P. (2006) A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa. Int J Med Microbiol 296, 73-81.
    • (2006) Int J Med Microbiol , vol.296 , pp. 73-81
    • Schuster, M.1    Greenberg, E.P.2
  • 41
    • 84891736535 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa biofilm: potential therapeutic targets
    • Sharma, G., Rao, S., Bansal, A., Dang, S., Gupta, S. and Gabrani, R. (2014) Pseudomonas aeruginosa biofilm: potential therapeutic targets. Biologicals 42, 1-7.
    • (2014) Biologicals , vol.42 , pp. 1-7
    • Sharma, G.1    Rao, S.2    Bansal, A.3    Dang, S.4    Gupta, S.5    Gabrani, R.6
  • 43
    • 84907933033 scopus 로고    scopus 로고
    • Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) syndrome associated with azithromycin presenting like septic shock: a case report
    • Sriratanaviriyakul, N., Nguyen, L.P., Henderson, M.C. and Albertson, T.E. (2014) Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) syndrome associated with azithromycin presenting like septic shock: a case report. J Med Case Rep 8, 332.
    • (2014) J Med Case Rep , vol.8 , pp. 332
    • Sriratanaviriyakul, N.1    Nguyen, L.P.2    Henderson, M.C.3    Albertson, T.E.4
  • 44
    • 84885912278 scopus 로고    scopus 로고
    • Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database
    • Tan, S.Y., Chua, S.L., Chen, Y., Rice, S.A., Kjelleberg, S., Nielsen, T.E., Yang, L. and Givskov, M. (2013) Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database. Antimicrob Agents Chemother 57, 5629-5641.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 5629-5641
    • Tan, S.Y.1    Chua, S.L.2    Chen, Y.3    Rice, S.A.4    Kjelleberg, S.5    Nielsen, T.E.6    Yang, L.7    Givskov, M.8
  • 46
    • 79959955735 scopus 로고    scopus 로고
    • The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1
    • Vandeputte, O.M., Kiendrebeogo, M., Rasamiravaka, T., Stevigny, C., Duez, P., Rajaonson, S., Diallo, B., Mol, A. et al. (2011) The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. Microbiology 157, 2120-2132.
    • (2011) Microbiology , vol.157 , pp. 2120-2132
    • Vandeputte, O.M.1    Kiendrebeogo, M.2    Rasamiravaka, T.3    Stevigny, C.4    Duez, P.5    Rajaonson, S.6    Diallo, B.7    Mol, A.8
  • 47
    • 84958040153 scopus 로고    scopus 로고
    • Anti-quorum sensing activity of flavonoid-rich fraction from Centella asiatica L. against Pseudomonas aeruginosa PAO1
    • Epub ahead of print
    • Vasavi, H.S., Arun, A.B. and Rekha, P.D. (2014) Anti-quorum sensing activity of flavonoid-rich fraction from Centella asiatica L. against Pseudomonas aeruginosa PAO1. J Microbiol Immunol Infect doi: 10.1016/j.jmii.2014.03.012. [Epub ahead of print].
    • (2014) J Microbiol Immunol Infect
    • Vasavi, H.S.1    Arun, A.B.2    Rekha, P.D.3
  • 48
    • 77952651846 scopus 로고    scopus 로고
    • Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis
    • Wang, Q., Sun, F.J., Liu, Y., Xiong, L.R., Xie, L.L. and Xia, P.Y. (2010) Enhancement of biofilm formation by subinhibitory concentrations of macrolides in icaADBC-positive and -negative clinical isolates of Staphylococcus epidermidis. Antimicrob Agents Chemother 54, 2707-2711.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2707-2711
    • Wang, Q.1    Sun, F.J.2    Liu, Y.3    Xiong, L.R.4    Xie, L.L.5    Xia, P.Y.6
  • 49
    • 57449113839 scopus 로고    scopus 로고
    • The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections
    • Winstanley, C. and Fothergill, J.L. (2009) The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections. FEMS Microbiol Lett 290, 1-9.
    • (2009) FEMS Microbiol Lett , vol.290 , pp. 1-9
    • Winstanley, C.1    Fothergill, J.L.2
  • 50
    • 84871781678 scopus 로고    scopus 로고
    • A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa
    • Yang, Y.X., Xu, Z.H., Zhang, Y.Q., Tian, J., Weng, L.X. and Wang, L.H. (2012) A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa. J Microbiol 50, 987-993.
    • (2012) J Microbiol , vol.50 , pp. 987-993
    • Yang, Y.X.1    Xu, Z.H.2    Zhang, Y.Q.3    Tian, J.4    Weng, L.X.5    Wang, L.H.6
  • 52
    • 42149131438 scopus 로고    scopus 로고
    • Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa
    • Zeng, Z., Qian, L., Cao, L., Tan, H., Huang, Y., Xue, X., Shen, Y. and Zhou, S. (2008) Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa. Appl Microbiol Biotechnol 79, 119-126.
    • (2008) Appl Microbiol Biotechnol , vol.79 , pp. 119-126
    • Zeng, Z.1    Qian, L.2    Cao, L.3    Tan, H.4    Huang, Y.5    Xue, X.6    Shen, Y.7    Zhou, S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.