Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA

Nature

Volumn 417, Issue 6892, 2002, Pages 971-974

  Zhang, Rong guang ^a   Pappas, Terina ^b   Brace, Jennifer L ^a   Miller, Paula C ^c,d   Oulmassov, Tim ^c   Molyneaux, John M ^c,d   Anderson, John C ^c   Bashkin, James K ^c,d   Wlnans, Stephen C ^b   Joachimiak, Andrzej ^a  

^a ARGONNE NATIONAL LABORATORY   (United States)

^b Department of Population Medicine and Diagnostic Sciences   (United States)

^c MONSANTO COMPANY   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOFILMS; BIOLUMINESCENCE; HYDROGEN BONDS; HYDROPHOBICITY;

PATHOGENESIS;

DNA;

PHEROMONE; RNA POLYMERASE; TRANSCRIPTION FACTOR;

DNA; GENETICS; PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; DNA STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; PATHOGENESIS; POPULATION DENSITY; PRIORITY JOURNAL; PROTEIN DOMAIN; RHIZOBIUM RADIOBACTER;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA, BACTERIAL; DNA-BINDING PROTEINS; HELIX-TURN-HELIX MOTIFS; HOMOSERINE; HYDROGEN BONDING; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHEROMONES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RHIZOBIUM; TRANSCRIPTION FACTORS;

AGROBACTERIUM; AGROBACTERIUM TUMEFACIENS; BACTERIA (MICROORGANISMS); PROTEOBACTERIA; VIBRIO; VIBRIO FISCHERI;

EID: 0037182879     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00833     Document Type: Article

References (28)

1. Quorum-sensing in Gram-negative bacteria
2. Regulation of gene expression by cell-to-cell communication: Acyl-homoserine lactone quorum sensing
3. Evidence that the N-terminal region of the Vibrio fischeri LuxR protein constitutes an autoinducer-binding domain
4. Genetic evidence for multimerization of LuxR, the transcriptional regulator of Vibrio fischeri luminescence
5. The C-terminal region of the Vibrio fischeri LuxR protein contains an inducer-independent lux gene-activating domain
6. Synergistic binding of the Vibrio fischeri LuxR transcriptional activator domain and RNA polymerase to the lux promoter region
7. A LuxR-LuxI type regulatory system activates Agrobacterium Ti plasmid conjugal transfer in the presence of a plant tumour metabolite
8. Conversion of the Vibrio fischeri transcriptional activator, LuxR, to a repressor
9. Signal-dependent DNA binding and functional domains of the quorum-sensing activator TraR as identified by repressor activity
10. A defective TraR-like protein of Agrobacterium tumefaciens forms heterodimers with TraR in vitro, thereby blocking TraR-mediated quorum sensing
11. Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases traR turnover rates in whole cells
12. The quorum-sensing regulator TraR of Agrobacterium tumefaciens requires autoinducer for protein folding, dimerization, and protease resistance
13. Quorum-sensing signal binding results in dimerization of TraR and its release from membranes into the cytoplasm
14. Sexual attraction in the silkworm moth: Structure of the pheromone-binding-protein-bombykol complex
15. N-acyl homoserine lactone binding to the CarR receptor determines quorum-sensing specificity in Erwinia
16. A negative regulator mediates quorum-sensing control of exopolysaccharide production in Pantoea stewartii subsp
17. Structure and function of DNA-binding proteins
18. NarL dimerization? Suggestive evidence from a new crystal form
19. The antiactivator TraM interferes with the autoinducer-dependent binding of TraR to DNA by interacting with the C-terminal region of the quorum-sensing activator
20. Quorum sensing in Vibrio fischeri: Analysis of the LuxR DNA binding region by alanine-scanning mutagenesis
21. Theromsensitive step associated with transfer of the Ti plasmid during conjugation: Possible relation to transformation in crown gall
22. Crystallization of protein-DNA complexes
23. Taking MAD to the extreme: Ultrafast protein structure determination
24. MAD data collection-current trends
25. Processing of x-ray diffraction data collected in oscillation mode
26. Crystallography and NMR system: A new software suite for macromolecular structure determination
27. Automated protein model building combined with iterative structure refinement