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Volumn 114, Issue 1, 2017, Pages 131-135

Quorum sensing controls the pseudomonas aeruginosa CRISPR-Cas adaptive immune system

Author keywords

Immunity|; Phage|phage defense; Quorum sensing|crispr|

Indexed keywords

BACTERIAL DNA; BAICALEIN; CAS3 PROTEIN; CRISPR ASSOCIATED PROTEIN; N (3 OXODODECANOYL)HOMOSERINE LACTONE; NUCLEASE; PLASMID DNA; PYOCYANINE; UNCLASSIFIED DRUG;

EID: 85007529875     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1617415113     Document Type: Article
Times cited : (227)

References (49)
  • 1
    • 34047118522 scopus 로고    scopus 로고
    • CRISPR provides acquired resistance against viruses in prokaryotes
    • Barrangou R, et al. (2007) CRISPR provides acquired resistance against viruses in prokaryotes. Science 315(5819):1709-1712.
    • (2007) Science , vol.315 , Issue.5819 , pp. 1709-1712
    • Barrangou, R.1
  • 2
    • 57849137502 scopus 로고    scopus 로고
    • CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA
    • Marraffini LA, Sontheimer EJ (2008) CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science 322(5909):1843-1845.
    • (2008) Science , vol.322 , Issue.5909 , pp. 1843-1845
    • Marraffini, L.A.1    Sontheimer, E.J.2
  • 3
    • 49649114086 scopus 로고    scopus 로고
    • Small CRISPR RNAs guide antiviral defense in prokaryotes
    • Brouns SJ, et al. (2008) Small CRISPR RNAs guide antiviral defense in prokaryotes. Science 321(5891):960-964.
    • (2008) Science , vol.321 , Issue.5891 , pp. 960-964
    • Brouns, S.J.1
  • 4
    • 78149261827 scopus 로고    scopus 로고
    • The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
    • Garneau JE, et al. (2010) The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature 468(7320):67-71.
    • (2010) Nature , vol.468 , Issue.7320 , pp. 67-71
    • Garneau, J.E.1
  • 5
    • 84902533278 scopus 로고    scopus 로고
    • Unravelling the structural and mechanistic basis of CRISPR-Cas systems
    • van der Oost J, Westra ER, Jackson RN, Wiedenheft B (2014) Unravelling the structural and mechanistic basis of CRISPR-Cas systems. Nat Rev Microbiol 12(7):479-492.
    • (2014) Nat Rev Microbiol , vol.12 , Issue.7 , pp. 479-492
    • Van Der, O.J.1    Westra, E.R.2    Jackson, R.N.3    Wiedenheft, B.4
  • 6
    • 84943160849 scopus 로고    scopus 로고
    • CRISPR-Cas immunity in prokaryotes
    • Marraffini LA (2015) CRISPR-Cas immunity in prokaryotes. Nature 526(7571):55-61.
    • (2015) Nature , vol.526 , Issue.7571 , pp. 55-61
    • Marraffini, L.A.1
  • 7
    • 84938298616 scopus 로고    scopus 로고
    • Costs of CRISPR-Cas-mediated resistance in streptococcus thermophilus
    • Vale PF, et al. (2015) Costs of CRISPR-Cas-mediated resistance in Streptococcus thermophilus. Proc Biol Sci 282(1812):20151270.
    • (2015) Proc Biol Sci , vol.282 , Issue.1812 , pp. 20151270
    • Vale, P.F.1
  • 8
    • 84928658828 scopus 로고    scopus 로고
    • Parasite exposure drives selective evolution of constitutive versus inducible defense
    • Westra ER, et al. (2015) Parasite exposure drives selective evolution of constitutive versus inducible defense. Curr Biol 25(8):1043-1049.
    • (2015) Curr Biol , vol.25 , Issue.8 , pp. 1043-1049
    • Westra, E.R.1
  • 9
    • 84876845227 scopus 로고    scopus 로고
    • Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands
    • Vercoe RB, et al. (2013) Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands. PLoS Genet 9(4):e1003454.
    • (2013) PLoS Genet , vol.9 , Issue.4 , pp. e1003454
    • Vercoe, R.B.1
  • 10
    • 84922998282 scopus 로고    scopus 로고
    • Cas9 function and host genome sampling in Type II-A CRISPR-Cas adaptation
    • Wei Y, Terns RM, Terns MP (2015) Cas9 function and host genome sampling in Type II-A CRISPR-Cas adaptation. Genes Dev 29(4):356-361.
    • (2015) Genes Dev , vol.29 , Issue.4 , pp. 356-361
    • Wei, Y.1    Terns, R.M.2    Terns, M.P.3
  • 11
    • 73149087453 scopus 로고    scopus 로고
    • Transcription profile of Thermus thermophilus CRISPR systems after phage infection
    • Agari Y, et al. (2010) Transcription profile of Thermus thermophilus CRISPR systems after phage infection. J Mol Biol 395(2):270-281.
    • (2010) J Mol Biol , vol.395 , Issue.2 , pp. 270-281
    • Agari, Y.1
  • 12
    • 84880586986 scopus 로고    scopus 로고
    • Massive activation of archaeal defense genes during viral infection
    • Quax TE, et al. (2013) Massive activation of archaeal defense genes during viral infection. J Virol 87(15):8419-8428.
    • (2013) J Virol , vol.87 , Issue.15 , pp. 8419-8428
    • Quax, T.E.1
  • 13
    • 84861632698 scopus 로고    scopus 로고
    • Phage-induced expression of CRISPR-associated proteins is revealed by shotgun proteomics in Streptococcus thermophilus
    • Young JC, et al. (2012) Phage-induced expression of CRISPR-associated proteins is revealed by shotgun proteomics in Streptococcus thermophilus. PLoS One 7(5): e38077.
    • (2012) PLoS One , vol.7 , Issue.5 , pp. e38077
    • Young, J.C.1
  • 14
    • 78751680634 scopus 로고    scopus 로고
    • Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli
    • Perez-Rodriguez R, et al. (2011) Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli. Mol Microbiol 79(3):584-599.
    • (2011) Mol Microbiol , vol.79 , Issue.3 , pp. 584-599
    • Perez-Rodriguez, R.1
  • 15
    • 77956621546 scopus 로고    scopus 로고
    • H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO
    • Westra ER, et al. (2010) H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO. Mol Microbiol 77(6):1380-1393.
    • (2010) Mol Microbiol , vol.77 , Issue.6 , pp. 1380-1393
    • Westra, E.R.1
  • 16
    • 84904903516 scopus 로고    scopus 로고
    • H-NS-like nucleoid-associated proteins, mobile genetic elements and horizontal gene transfer in bacteria
    • Dorman CJ (2014) H-NS-like nucleoid-associated proteins, mobile genetic elements and horizontal gene transfer in bacteria. Plasmid 75:1-11.
    • (2014) Plasmid , vol.75 , pp. 1-11
    • Dorman, C.J.1
  • 17
    • 84942279889 scopus 로고    scopus 로고
    • Regulation of the type I-F CRISPR-Cas system by CRP-cAMP and GalM controls spacer acquisition and interference
    • Patterson AG, Chang JT, Taylor C, Fineran PC (2015) Regulation of the type I-F CRISPR-Cas system by CRP-cAMP and GalM controls spacer acquisition and interference. Nucleic Acids Res 43(12):6038-6048.
    • (2015) Nucleic Acids Res , vol.43 , Issue.12 , pp. 6038-6048
    • Patterson, A.G.1    Chang, J.T.2    Taylor, C.3    Fineran, P.C.4
  • 18
    • 84961583797 scopus 로고    scopus 로고
    • Lytic to temperate switching of viral communities
    • Knowles B, et al. (2016) Lytic to temperate switching of viral communities. Nature 531(7595):466-470.
    • (2016) Nature , vol.531 , Issue.7595 , pp. 466-470
    • Knowles, B.1
  • 19
    • 0036097075 scopus 로고    scopus 로고
    • Overcoming the phage replication threshold: A mathematical model with implications for phage therapy
    • Kasman LM, et al. (2002) Overcoming the phage replication threshold: A mathematical model with implications for phage therapy. J Virol 76(11):5557-5564.
    • (2002) J Virol , vol.76 , Issue.11 , pp. 5557-5564
    • Kasman, L.M.1
  • 20
    • 84982121502 scopus 로고    scopus 로고
    • Quorum sensing signal-response systems in Gramnegative bacteria
    • Papenfort K, Bassler BL (2016) Quorum sensing signal-response systems in Gramnegative bacteria. Nat Rev Microbiol 14(9):576-588.
    • (2016) Nat Rev Microbiol , vol.14 , Issue.9 , pp. 576-588
    • Papenfort, K.1    Bassler, B.L.2
  • 21
    • 84946060593 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa biofilm infections: Community structure, antimicrobial tolerance and immune response
    • Rybtke M, Hultqvist LD, Givskov M, Tolker-Nielsen T (2015) Pseudomonas aeruginosa biofilm infections: Community structure, antimicrobial tolerance and immune response. J Mol Biol 427(23):3628-3645.
    • (2015) J Mol Biol , vol.427 , Issue.23 , pp. 3628-3645
    • Rybtke, M.1    Hultqvist, L.D.2    Givskov, M.3    Tolker-Nielsen, T.4
  • 22
    • 79960029056 scopus 로고    scopus 로고
    • RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
    • Wiedenheft B, et al. (2011) RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc Natl Acad Sci USA 108(25):10092-10097.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.25 , pp. 10092-10097
    • Wiedenheft, B.1
  • 23
    • 84868143545 scopus 로고    scopus 로고
    • The CRISPR/ Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phages
    • Cady KC, Bondy-Denomy J, Heussler GE, Davidson AR, O'Toole GA (2012) The CRISPR/ Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phages. J Bacteriol 194(21):5728-5738.
    • (2012) J Bacteriol , vol.194 , Issue.21 , pp. 5728-5738
    • Cady, K.C.1    Bondy-Denomy, J.2    Heussler, G.E.3    Davidson, A.R.4    O'Toole, G.A.5
  • 24
    • 84964433283 scopus 로고    scopus 로고
    • The diversity-generating benefits of a prokaryotic adaptive immune system
    • van Houte S, et al. (2016) The diversity-generating benefits of a prokaryotic adaptive immune system. Nature 532(7599):385-388.
    • (2016) Nature , vol.532 , Issue.7599 , pp. 385-388
    • Van Houte, S.1
  • 25
    • 0029145808 scopus 로고
    • Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1
    • Latifi A, et al. (1995) Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1. Mol Microbiol 17(2):333-343.
    • (1995) Mol Microbiol , vol.17 , Issue.2 , pp. 333-343
    • Latifi, A.1
  • 26
    • 0027535307 scopus 로고
    • LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression
    • Gambello MJ, Kaye S, Iglewski BH (1993) LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression. Infect Immun 61(4):1180-1184.
    • (1993) Infect Immun , vol.61 , Issue.4 , pp. 1180-1184
    • Gambello, M.J.1    Kaye, S.2    Iglewski, B.H.3
  • 27
    • 0028967496 scopus 로고
    • Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: An autoinduction regulatory hierarchy
    • Seed PC, Passador L, Iglewski BH (1995) Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: An autoinduction regulatory hierarchy. J Bacteriol 177(3):654-659.
    • (1995) J Bacteriol , vol.177 , Issue.3 , pp. 654-659
    • Seed, P.C.1    Passador, L.2    Iglewski, B.H.3
  • 28
    • 0030985995 scopus 로고    scopus 로고
    • Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa
    • Pesci EC, Pearson JP, Seed PC, Iglewski BH (1997) Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol 179(10):3127-3132.
    • (1997) J Bacteriol , vol.179 , Issue.10 , pp. 3127-3132
    • Pesci, E.C.1    Pearson, J.P.2    Seed, P.C.3    Iglewski, B.H.4
  • 29
    • 0028953276 scopus 로고
    • A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa
    • Pearson JP, Passador L, Iglewski BH, Greenberg EP (1995) A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc Natl Acad Sci USA 92(5): 1490-1494.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.5 , pp. 1490-1494
    • Pearson, J.P.1    Passador, L.2    Iglewski, B.H.3    Greenberg, E.P.4
  • 30
    • 84964312894 scopus 로고    scopus 로고
    • An evolving perspective on the Pseudomonas aeruginosa orphan quorum sensing regulator QscR
    • Chugani S, Greenberg EP (2014) An evolving perspective on the Pseudomonas aeruginosa orphan quorum sensing regulator QscR. Front Cell Infect Microbiol 4:152.
    • (2014) Front Cell Infect Microbiol , vol.4 , pp. 152
    • Chugani, S.1    Greenberg, E.P.2
  • 31
    • 77953758120 scopus 로고    scopus 로고
    • LuxR homolog-independent gene regulation by acylhomoserine lactones in Pseudomonas aeruginosa
    • Chugani S, Greenberg EP (2010) LuxR homolog-independent gene regulation by acylhomoserine lactones in Pseudomonas aeruginosa. Proc Natl Acad Sci USA 107(23): 10673-10678.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.23 , pp. 10673-10678
    • Chugani, S.1    Greenberg, E.P.2
  • 32
    • 64049118040 scopus 로고    scopus 로고
    • Short motif sequences determine the targets of the prokaryotic CRISPR defence system
    • Mojica FJ, Díez-Villaseñor C, García-Martínez J, Almendros C (2009) Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology 155(Pt 3):733-740.
    • (2009) Microbiology , vol.155 , pp. 733-740
    • Mojica, F.J.1    Díez-Villaseñor, C.2    García-Martínez, J.3    Almendros, C.4
  • 33
    • 0033027260 scopus 로고    scopus 로고
    • Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility
    • Glessner A, Smith RS, Iglewski BH, Robinson JB (1999) Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility. J Bacteriol 181(5):1623-1629.
    • (1999) J Bacteriol , vol.181 , Issue.5 , pp. 1623-1629
    • Glessner, A.1    Smith, R.S.2    Iglewski, B.H.3    Robinson, J.B.4
  • 34
    • 84884696268 scopus 로고    scopus 로고
    • Dealing with the evolutionary downside of CRISPR immunity: Bacteria and beneficial plasmids
    • Jiang W, et al. (2013) Dealing with the evolutionary downside of CRISPR immunity: Bacteria and beneficial plasmids. PLoS Genet 9(9):e1003844.
    • (2013) PLoS Genet , vol.9 , Issue.9 , pp. e1003844
    • Jiang, W.1
  • 35
    • 84864864464 scopus 로고    scopus 로고
    • Molecular memory of prior infections activates the CRISPR/ Cas adaptive bacterial immunity system
    • Datsenko KA, et al. (2012) Molecular memory of prior infections activates the CRISPR/ Cas adaptive bacterial immunity system. Nat Commun 3:945.
    • (2012) Nat Commun , vol.3 , pp. 945
    • Datsenko, K.A.1
  • 36
    • 84955130951 scopus 로고    scopus 로고
    • Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. Aeruginosa-infected macrophages by downregulating the MAPK and NFêB signaltransduction pathways
    • Luo J, et al. (2016) Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFêB signaltransduction pathways. Drug Des Devel Ther 10:183-203.
    • (2016) Drug des Devel Ther , vol.10 , pp. 183-203
    • Luo, J.1
  • 37
    • 84946035741 scopus 로고    scopus 로고
    • Genome-wide RNA sequencing analysis of quorum sensing-controlled regulons in the plant-associated Burkholderia glumae PG1 strain
    • Gao R, et al. (2015) Genome-wide RNA sequencing analysis of quorum sensing-controlled regulons in the plant-associated Burkholderia glumae PG1 strain. Appl Environ Microbiol 81(23):7993-8007.
    • (2015) Appl Environ Microbiol , vol.81 , Issue.23 , pp. 7993-8007
    • Gao, R.1
  • 38
    • 84874584663 scopus 로고    scopus 로고
    • A quorum-sensinginduced bacteriophage defense mechanism
    • Høyland-Kroghsbo NM, Maerkedahl RB, Svenningsen SL (2013) A quorum-sensinginduced bacteriophage defense mechanism. MBio 4(1):e00362-12.
    • (2013) MBio , vol.4 , Issue.1 , pp. e00362-e00412
    • Høyland-Kroghsbo, N.M.1    Maerkedahl, R.B.2    Svenningsen, S.L.3
  • 39
    • 84936980421 scopus 로고    scopus 로고
    • Quorum sensing determines the choice of antiphage defense strategy in Vibrio anguillarum
    • Tan D, Svenningsen SL, Middelboe M (2015) Quorum sensing determines the choice of antiphage defense strategy in Vibrio anguillarum. MBio 6(3):e00627.
    • (2015) MBio , vol.6 , Issue.3 , pp. e00627
    • Tan, D.1    Svenningsen, S.L.2    Middelboe, M.3
  • 40
    • 77955085897 scopus 로고    scopus 로고
    • Self-targeting by CRISPR: Gene regulation or autoimmunity?
    • Stern A, Keren L, Wurtzel O, Amitai G, Sorek R (2010) Self-targeting by CRISPR: Gene regulation or autoimmunity? Trends Genet 26(8):335-340.
    • (2010) Trends Genet , vol.26 , Issue.8 , pp. 335-340
    • Stern, A.1    Keren, L.2    Wurtzel, O.3    Amitai, G.4    Sorek, R.5
  • 41
    • 84928473578 scopus 로고    scopus 로고
    • CRISPR adaptation biases explain preference for acquisition of foreign DNA
    • Levy A, et al. (2015) CRISPR adaptation biases explain preference for acquisition of foreign DNA. Nature 520(7548):505-510.
    • (2015) Nature , vol.520 , Issue.7548 , pp. 505-510
    • Levy, A.1
  • 42
    • 84990860399 scopus 로고    scopus 로고
    • Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR-Cas system
    • Staals RH, et al. (2016) Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR-Cas system. Nat Commun 7:12853.
    • (2016) Nat Commun , vol.7 , pp. 12853
    • Staals, R.H.1
  • 43
    • 84866416261 scopus 로고    scopus 로고
    • Current dilemmas in antimicrobial therapy in cystic fibrosis
    • Jain K, Smyth AR (2012) Current dilemmas in antimicrobial therapy in cystic fibrosis. Expert Rev Respir Med 6(4):407-422.
    • (2012) Expert Rev Respir Med , vol.6 , Issue.4 , pp. 407-422
    • Jain, K.1    Smyth, A.R.2
  • 44
    • 84887034499 scopus 로고    scopus 로고
    • A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation
    • O'Loughlin CT, et al. (2013) A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc Natl Acad Sci USA 110(44):17981-17986.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.44 , pp. 17981-17986
    • O'Loughlin, C.T.1
  • 45
    • 84860511608 scopus 로고    scopus 로고
    • Bacteriophages öMR299-2 and öNH-4 can eliminate Pseudomonas aeruginosa in the murine lung and on cystic fibrosis lung airway cells
    • Alemayehu D, et al. (2012) Bacteriophages öMR299-2 and öNH-4 can eliminate Pseudomonas aeruginosa in the murine lung and on cystic fibrosis lung airway cells. MBio 3(2):e00029-12.
    • (2012) MBio , vol.3 , Issue.2 , pp. e00029-e00112
    • Alemayehu, D.1
  • 46
    • 67349270900 scopus 로고    scopus 로고
    • Enzymatic assembly of DNA molecules up to several hundred kilobases
    • Gibson DG, et al. (2009) Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods 6(5):343-345.
    • (2009) Nat Methods , vol.6 , Issue.5 , pp. 343-345
    • Gibson, D.G.1
  • 47
    • 20344403312 scopus 로고    scopus 로고
    • ExsE, a secreted regulator of type III secretion genes in pseudomonas aeruginosa
    • Rietsch A, Vallet-Gely I, Dove SL, Mekalanos JJ (2005) ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proc Natl Acad Sci USA 102(22): 8006-8011.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.22 , pp. 8006-8011
    • Rietsch, A.1    Vallet-Gely, I.2    Dove, S.L.3    Mekalanos, J.J.4
  • 48
    • 79960393323 scopus 로고    scopus 로고
    • Non-identity-mediated CRISPR-bacteriophage interaction mediated via the Csy and Cas3 proteins
    • Cady KC, O'Toole GA (2011) Non-identity-mediated CRISPR-bacteriophage interaction mediated via the Csy and Cas3 proteins. J Bacteriol 193(14):3433-3445.
    • (2011) J Bacteriol , vol.193 , Issue.14 , pp. 3433-3445
    • Cady, K.C.1    O'Toole, G.A.2
  • 49
    • 84872607723 scopus 로고    scopus 로고
    • Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
    • Bondy-Denomy J, Pawluk A, Maxwell KL, Davidson AR (2013) Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system. Nature 493(7432):429-432.
    • (2013) Nature , vol.493 , Issue.7432 , pp. 429-432
    • Bondy-Denomy, J.1    Pawluk, A.2    Maxwell, K.L.3    Davidson, A.R.4


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