Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

Cell

Volumn 168, Issue 6, 2017, Pages 1041-1052.e18

  Ho, Chia Chi M ^a,c   Chhabra, Akanksha ^c,f   Starkl, Philipp ^c,d   Schnorr, Peter John ^c,f   Wilmes, Stephan ^b   Moraga, Ignacio ^c   Kwon, Hye Sook ^c,f   Gaudenzio, Nicolas ^c   Sibilano, Riccardo ^c   Wehrman, Tom S ^e   Gakovic, Milica ^c   Sockolosky, Jonathan T ^c   Tiffany, Matthew R ^c   Ring, Aaron M ^c   Piehler, Jacob ^b   Weissman, Irving L ^c,f   Galli, Stephen J ^c   Shizuru, Judith A ^c,f   Garcia, K Christopher ^c  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF OSNABRÜCK   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e Primity Bio   (United States)

^f STANFORD CANCER INSTITUTE   (United States)

Author keywords

anaphylaxis; c Kit; cytokine; hematopoietic stem cells; mast cells; pleiotropy; protein engineering; receptor signaling; receptor tyrosine kinase; stem cell factor

Indexed keywords

PARTIAL AGONIST; PROTEIN VARIANT; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR;

ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; DIMERIZATION; FEMALE; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; MAST CELL; MOUSE; MOUSE MODEL; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING; RADIATION PROTECTION; SIGNAL TRANSDUCTION; STEM CELL EXPANSION; AGONISTS; ANIMAL; C57BL MOUSE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR MODEL;

ANAPHYLAXIS; ANIMALS; DIMERIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; MAST CELLS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PROTEIN ENGINEERING; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION; STEM CELL FACTOR;

EID: 85014840476     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.02.011     Document Type: Article

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