Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26178-26188

  Macdonald Obermann, Jennifer L ^a   Pike, Linda J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; DIMERIZATION; GROWTH KINETICS;

BIOLOGICAL EFFECTS; EPIDERMAL GROWTH FACTORS; HETERODIMER FORMATION; HOMODIMERS; MULTIPLE LIGANDS; RECEPTOR LIGANDS;

LIGANDS;

AMPHIREGULIN; BETACELLULIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HETERODIMER; HOMODIMER; TRANSFORMING GROWTH FACTOR ALPHA; CETUXIMAB; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB2 PROTEIN, HUMAN; LIGAND; MONOCLONAL ANTIBODY; PERTUZUMAB;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; HETERODIMER FORMATION; HOMODIMER FORMATION; HUMAN; LUCIFERASE ASSAY; LUCIFERASE FRAGMENT COMPLEMENTATION IMAGING; NONHUMAN; PARTIAL AGONISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RADIOASSAY; RECEPTOR BINDING ASSAY; AGONISTS; ANIMAL; BINDING SITE; CHO CELL LINE; CRICETULUS; HAMSTER; KINETICS; METABOLISM; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; KINETICS; LIGANDS; PROTEIN MULTIMERIZATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 84907225930     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.586826     Document Type: Article

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