Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic

Current Opinion in Chemical Biology

Volumn 26, Issue , 2015, Pages 1-7

  Yea, Kyungmoo ^b   Xie, Jia ^a   Zhang, Hongkai ^a   Zhang, Wei ^a   Lerner, Richard A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SHANGHAITECH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; ANTIBODY; CELL SURFACE RECEPTOR; DDR1 PROTEIN, HUMAN; MOLECULAR LIBRARY; PEPTIDE LIBRARY; PROTEIN TYROSINE KINASE; UNC5C PROTEIN, HUMAN;

AGONIST; ANTIBODY AGONIST; ANTIBODY LIBRARY; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL SELECTION; COMBINATORIAL LIBRARY; HEMATOPOIETIC STEM CELL; NERVE CELL; OSTEOCLAST; PLEIOTROPY; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; STEM CELL; AGONISTS; BONE MARROW CELL; CHEMISTRY; COMBINATORIAL CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; HUMAN; LENTIVIRINAE; METABOLISM; MOLECULAR LIBRARY; PEPTIDE LIBRARY; PHARMACOLOGY; PROTEIN ENGINEERING;

ANTIBODIES; BONE MARROW CELLS; CELL DIFFERENTIATION; COMBINATORIAL CHEMISTRY TECHNIQUES; GENE EXPRESSION REGULATION; GENETIC VECTORS; HUMANS; LENTIVIRUS; PEPTIDE LIBRARY; PROTEIN ENGINEERING; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STEM CELLS;

EID: 84921508928     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2015.01.002     Document Type: Review

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