The Enhanced Liver Fibrosis (ELF) score: Normal values, influence factors and proposed cut-off values

Journal of Hepatology

Volumn 59, Issue 2, 2013, Pages 236-242

  Lichtinghagen, Ralf ^a   Pietsch, Daniel ^a   Bantel, Heike ^a   Manns, Michael P ^a   Brand, Korbinian ^a   Bahr, Matthias J ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Sana Kliniken GmbH and Co KGaA   (Germany)

Author keywords

Cirrhosis; ELF score; Hyaluronate; Hyaluronic acid; Liver fibrosis; PIIINP; TIMP

Indexed keywords

AMINO TERMINAL PROPEPTIDE OF TYPE III PROCOLLAGEN; HYALURONIC ACID; PROCOLLAGEN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENHANCED LIVER FIBROSIS SCORE; FEMALE; HEPATITIS C; HISTOPATHOLOGY; HUMAN; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NORMAL VALUE; PRIORITY JOURNAL; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY;

ΓGT; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALT; AMINO-TERMINAL PROPEPTIDE OF TYPE III PROCOLLAGEN; AP; AREA UNDER THE CURVE.; ASPARTATE AMINOTRANSFERASE; AST; AUC; CHC; CHRONIC HEPATITIS C; CI; CIRRHOSIS; CONFIDENCE INTERVAL; ECM; ELF; ELF SCORE; ENHANCED LIVER FIBROSIS; EXTRACELLULAR MATRIX; GAMMA-GLUTAMYLTRANSFERASE; HA; HCV; HEPATIC STELLATE CELLS; HEPATITIS C VIRUS; HSC; HYALURONATE; HYALURONIC ACID; KCAL; KILOCALORIES; LIVER FIBROSIS; PIIINP; RECEIVER OPERATING CHARACTERISTICS; ROC; TIMP; TIMP-1; TISSUE INHIBITOR OF METALLOPROTEINASES 1;

ADOLESCENT; ADULT; AGED; ALGORITHMS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; HEPATITIS C, CHRONIC; HUMANS; HYALURONIC ACID; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROCOLLAGEN; REFERENCE VALUES; ROC CURVE; SEVERITY OF ILLNESS INDEX; TISSUE INHIBITOR OF METALLOPROTEINASE-1; YOUNG ADULT;

EID: 84880314303     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.03.016     Document Type: Article

References (29)

1. T. Poynard, V. Ratziu, Y. Benmanov, V. Di Martino, P. Bedossa, and P. Opolon Fibrosis in patients with chronic hepatitis C: detection and significance Semin Liver Dis 20 2000 47 55
2. S.L. Friedman Hepatic fibrosis E.R. Schiff, M.F. Sorrell, W.C. Maddrey, Schiff's diseases of the liver 2003 Lippincott, Williams & Wilkins PS, USA 409 427
3. V. Hernandez-Gea, and S.L. Friedman Pathogenesis of liver fibrosis Annu Rev Pathol 6 2011 425 456
4. G. Ramadori, and B. Saile Mesenchymal cells in the liver - one cell type or two? Liver 22 2002 283 294
5. K. Ishak, A. Baptista, and L. Bianchi Histological grading and staging of chronic hepatitis J Hepatol 22 1995 696 699
6. Anonymous Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Co-operative Study group Hepatology 20 1994 15 20
7. R.G. Knodell, K.G. Ishak, and W.C. Black Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis Hepatology 1 1981 431 435
8. P.J. Scheuer Classification of chronic viral hepatitis: a need for reassessment J Hepatol 13 1991 372 374
9. K.A. Gebo, T.F. Herlong, and M.S. Torbenson Role of liver biopsy on management of chronic hepatitis C: a systematic review Hepatology 36 2002 S161 S172
10. R. Lichtinghagen, and M.J. Bahr Noninvasive diagnosis of fibrosis in chronic liver disease Expert Rev Mol Diagn 4 2004 89 100
11. E. Giannini, and R. Testa Noninvasive diagnosis of fibrosis: the truth is rarely pure and never simple Hepatology 38 2003 1312 1313
12. X. Forns, S. Ampurdanes, and J.M. Llovet Identification of chronic hepatitis C without hepatic fibrosis by a simple predictive model Hepatology 36 2002 986 992
13. C.T. Wai, J.K. Greenson, R.J. Fontana, J.D. Kalbfleisch, J.A. Marrero, and H.S. Conjeevaram A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C Hepatology 38 2003 518 526
14. F. Imbert-Bismut, V. Ratziu, L. Pieroni, F. Charlotte, Y. Benhamou, and T. Poynard Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study Lancet 357 2001 1069 1075
15. W.M. Rosenberg, M. Voelker, R. Thiel, M. Becka, A. Burt, and D. Schuppan Serum markers detect the presence of liver fibrosis: a cohort study Gastroenterology 127 2004 1704 1713
16. G. Hoffmann Forschungsbericht: IT-Werkzeuge zur Auswertung großer labordiagnostischer Datensätze 42 2011 DGKL Mitteilungen p. 124-130. Software-Download: www.trillium.de/content/trillium-software.html
17. P.S. Horn, and A.J. Pesce Reference intervals. A user's guide 2005 AACC Press Washington (DC)
18. E.K. Harris, and J.C. Boyd On diving reference data into subgroups to produce separate reference ranges Clin Chem 36 1990 265 270
19. D. Nguyen, and J.A. Talwalkar Noninvasive assessment of liver fibrosis Hepatology 53 2011 2107 2110
20. A. Baranova, P. Lal, A. Birerdinc, and Z.M. Younossi Non-invasive markers for hepatic fibrosis BMC Gastroenterol 11 2011 91
21. L. Castera Noninvasive methods to assess liver disease in patients with hepatitis B or C Gastroenterology 142 2012 1293 1302
22. I.N. Guha, J. Parkes, P. Roderick, D. Chattopadhyay, R. Cross, and S. Harris Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European Liver Fibrosis Panel and exploring simple markers Hepatology 47 2008 455 460
23. M.J. Mayo, J. Parkes, B. Adams-Huet, B. Combes, A.S. Mills, and R.S. Markin Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay Hepatology 48 2008 1549 1557
24. V. Nobili, J. Parkes, G. Bottazzo, M. Marcellini, R. Cross, and D. Newman Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease Gastroenterology 136 2009 160 167
25. J. Parkes, P. Roderick, S. Harris, C. Day, D. Mutimer, and J. Collier Enhanced liver fibrosis test can predict clinical outcomes in patients with chronic liver disease Gut 59 2010 1245 1251
26. S.M. Martinez, G. Fernández-Varo, P. González, E. Sampson, M. Bruguera, and M. Navasa Assessment of liver fibrosis before and after antiviral therapy by different serum marker panels in patients with chronic hepatitis C Aliment Pharmacol Ther 33 2011 138 148
27. E. Trépo, A. Potthoff, P. Pradat, R. Bakshi, B. Young, and R. Lagier Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease J Hepatol 55 2011 38 44
28. G. Crespo, G. Fernández-Varo, Z. Mariño, G. Casals, R. Miquel, and S.M. Martínez ARFI, FibroScan®, ELF, and their combinations in the assessment of liver fibrosis: a prospective study J Hepatol 57 2012 281 287
29. K. Wahl, W. Rosenberg, B. Vaske, M.P. Manns, K. Schulze-Osthoff, and M.J. Bahr Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography PLoS One 7 2012 e51906