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Volumn 22, Issue 3, 2017, Pages

Paeoniflorin attenuates cerebral ischemia-induced injury by regulating Ca2+/CaMKII/CREB signaling pathway

Author keywords

CaMKII; CREB; Ischemic stroke; Middle cerebral artery occlusion; Paeoniflorin

Indexed keywords

CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSIDE; N METHYLASPARTIC ACID; NEUROPROTECTIVE AGENT; PAEONIFLORIN; TERPENE;

EID: 85014445273     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules22030359     Document Type: Article
Times cited : (61)

References (38)
  • 2
    • 84920703518 scopus 로고    scopus 로고
    • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: Asystematic analysis for the Global Burden of Disease Study 2013
    • GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: Asystematic analysis for the Global Burden of Disease Study 2013. Lancet 2015, 385, 117-171.
    • (2015) Lancet , vol.385 , pp. 117-171
  • 3
    • 77952112006 scopus 로고    scopus 로고
    • Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHE Ttrials
    • Lees, K.R.; Bluhmki, E.; von Kummer, R.; Brott, T.G.; Toni, D.; Grotta, J.C.; Albers, G.W.; Kaste, M.; Marler, J.R.; Hamilton, S.A.; et al. Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHE Ttrials. Lancet 2010, 375, 1695-1703.
    • (2010) Lancet , vol.375 , pp. 1695-1703
    • Lees, K.R.1    Bluhmki, E.2    Von Kummer, R.3    Brott, T.G.4    Toni, D.5    Grotta, J.C.6    Albers, G.W.7    Kaste, M.8    Marler, J.R.9    Hamilton, S.A.10
  • 4
    • 79960796056 scopus 로고    scopus 로고
    • Investigational therapies for ischemic stroke: Neuroprotection and neurorecovery
    • Sahota, P.; Savitz, S.I. Investigational therapies for ischemic stroke: Neuroprotection and neurorecovery. Neurotherapeutics 2011, 8, 434-451.
    • (2011) Neurotherapeutics , vol.8 , pp. 434-451
    • Sahota, P.1    Savitz, S.I.2
  • 5
    • 84863371848 scopus 로고    scopus 로고
    • Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice
    • Yu, H.; Zhang, Z.L.; Chen, J.; Pei, A.J.; Hua, F.; Qian, X.C.; He, J.J.; Liu, C.F.; Xu, X.S. Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice. PLoS ONE 2012, 7, e33584.
    • (2012) PLoS ONE , vol.7
    • Yu, H.1    Zhang, Z.L.2    Chen, J.3    Pei, A.J.4    Hua, F.5    Qian, X.C.6    He, J.J.7    Liu, C.F.8    Xu, X.S.9
  • 6
    • 0037423008 scopus 로고    scopus 로고
    • Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization
    • Hiromichi, T.; Hiromichi, F.; Yoshiyuki, M.; Yasufumi, S. Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization. Brain Res. 2003, 962, 41-47.
    • (2003) Brain Res. , vol.962 , pp. 41-47
    • Hiromichi, T.1    Hiromichi, F.2    Yoshiyuki, M.3    Yasufumi, S.4
  • 7
    • 52049115137 scopus 로고    scopus 로고
    • NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway
    • Valera, E.; Sánchez-Martín, F.J.; Ferrer-Montiel, A.V.; Messeguer, A.; Merino, J.M. NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway. Neurochem. Int. 2008, 53, 148-154.
    • (2008) Neurochem. Int. , vol.53 , pp. 148-154
    • Valera, E.1    Sánchez-Martín, F.J.2    Ferrer-Montiel, A.V.3    Messeguer, A.4    Merino, J.M.5
  • 9
    • 0027976921 scopus 로고
    • Calcium/calmodulin-dependent protein kinase II activity in focal ischemia with reperfusion in rats
    • Hanson, S.K.; Grotta, J.C.; Waxham, M.N.; Aronowski, J.; Ostrow, P. Calcium/calmodulin-dependent protein kinase II activity in focal ischemia with reperfusion in rats. Stroke 1994, 25, 466-473.
    • (1994) Stroke , vol.25 , pp. 466-473
    • Hanson, S.K.1    Grotta, J.C.2    Waxham, M.N.3    Aronowski, J.4    Ostrow, P.5
  • 10
    • 0029040992 scopus 로고
    • A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death
    • Hajimohammadreza, I.; Probert, A.W.; Coughenour, L.L.; Borosky, S.A.; Marcoux, F.W.; Boxer, P.A.; Wang, K.K. A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death. J. Neurosci. 1995, 15, 4093-4101.
    • (1995) J. Neurosci. , vol.15 , pp. 4093-4101
    • Hajimohammadreza, I.1    Probert, A.W.2    Coughenour, L.L.3    Borosky, S.A.4    Marcoux, F.W.5    Boxer, P.A.6    Wang, K.K.7
  • 11
    • 17044380196 scopus 로고    scopus 로고
    • Increase of Phosphorylation of Calcium/Calmodulin-dependent Protein Kinase-II in Several Brain Regions by Substance P Administered Intrathecally in Mice
    • Choi, S.S.; Seo, Y.J.; Kwon, M.S.; Shim, E.J.; Lee, J.Y.; Ham, Y.O.; Lee, H.K.; Suh, H.W. Increase of Phosphorylation of Calcium/Calmodulin-dependent Protein Kinase-II in Several Brain Regions by Substance P Administered Intrathecally in Mice. Brain Res. Bull. 2005, 65, 375-381.
    • (2005) Brain Res. Bull. , vol.65 , pp. 375-381
    • Choi, S.S.1    Seo, Y.J.2    Kwon, M.S.3    Shim, E.J.4    Lee, J.Y.5    Ham, Y.O.6    Lee, H.K.7    Suh, H.W.8
  • 12
    • 0037470844 scopus 로고    scopus 로고
    • Autophosphorylated Calcium/Calmodulin-dependent Protein Kinase II Alpha (CaMKII alpha) Reversibly Targets to and Phosphorylates N-methyl-D-Aspartate Receptor Subunit 2B (NR2B) in Cerebral Ischemia and Reperfusion in Hippocampus of Rats
    • Meng, F.; Guo, J.; Zhang, Q.; Song, B.; Zhang, G. Autophosphorylated Calcium/Calmodulin-dependent Protein Kinase II Alpha (CaMKII alpha) Reversibly Targets to and Phosphorylates N-methyl-D-Aspartate Receptor Subunit 2B (NR2B) in Cerebral Ischemia and Reperfusion in Hippocampus of Rats. Brain Res. 2003, 967, 161-169.
    • (2003) Brain Res. , vol.967 , pp. 161-169
    • Meng, F.1    Guo, J.2    Zhang, Q.3    Song, B.4    Zhang, G.5
  • 13
    • 5444235900 scopus 로고    scopus 로고
    • Alterations of CaMKII after Hypoxia-ischemia During Brain Development
    • Tang, K.; Liu, C.; Kuluz, J.; Hu, B. Alterations of CaMKII after Hypoxia-ischemia During Brain Development. J. Neurochem. 2004, 91, 429-437.
    • (2004) J. Neurochem. , vol.91 , pp. 429-437
    • Tang, K.1    Liu, C.2    Kuluz, J.3    Hu, B.4
  • 14
    • 0033559004 scopus 로고    scopus 로고
    • Phosphorylation of CREB in Axon-induced Schwann Cell Proliferation
    • Lee, M.M.; Badache, A.; DeVries, G.H. Phosphorylation of CREB in Axon-induced Schwann Cell Proliferation. Neurosci. Res. 1999, 55, 702-712.
    • (1999) Neurosci. Res. , vol.55 , pp. 702-712
    • Lee, M.M.1    Badache, A.2    DeVries, G.H.3
  • 15
    • 0037171782 scopus 로고    scopus 로고
    • Apoptosis, Axonal Growth Defects, and Degeneration of Peripheral Neurons in Mice Lacking CREB
    • Lonze, B.E.; Riccio, A.; Cohen, S.; Ginty, D.D. Apoptosis, Axonal Growth Defects, and Degeneration of Peripheral Neurons in Mice Lacking CREB. Neuron 2002, 34, 371-385.
    • (2002) Neuron , vol.34 , pp. 371-385
    • Lonze, B.E.1    Riccio, A.2    Cohen, S.3    Ginty, D.D.4
  • 16
    • 0037071893 scopus 로고    scopus 로고
    • Calcium Regulation of Dendritic Growth via CaM Kinase IV and CREB-mediated Transcription
    • Redmond, L.; Kashani, A.H.; Ghosh, A. Calcium Regulation of Dendritic Growth via CaM Kinase IV and CREB-mediated Transcription. Neuron 2002, 34, 999-1010.
    • (2002) Neuron , vol.34 , pp. 999-1010
    • Redmond, L.1    Kashani, A.H.2    Ghosh, A.3
  • 18
    • 84879321195 scopus 로고    scopus 로고
    • Paeonia lactiflora Extract Attenuating Cerebral Ischemia and Arterial Intimal Hyperplasia Is Mediated by Paeoniflorin via Modulation of VSMC Migration and Ras/MEK/ERK Signaling Pathway
    • Chen, Y.F.; Wu, K.J.; Wood, W.G. Paeonia lactiflora Extract Attenuating Cerebral Ischemia and Arterial Intimal Hyperplasia Is Mediated by Paeoniflorin via Modulation of VSMC Migration and Ras/MEK/ERK Signaling Pathway. Evid. Based Complement. Alternat. Med. 2013, 482428.
    • (2013) Evid. Based Complement. Alternat. Med. , pp. 482428
    • Chen, Y.F.1    Wu, K.J.2    Wood, W.G.3
  • 19
    • 27744529453 scopus 로고    scopus 로고
    • Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats
    • Xiao, L.; Wang, Y.Z.; Liu, J.; Luo, X.T.; Ye, Y.; Zhu, X.Z. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. Life Sci. 2005, 78, 413-420.
    • (2005) Life Sci. , vol.78 , pp. 413-420
    • Xiao, L.1    Wang, Y.Z.2    Liu, J.3    Luo, X.T.4    Ye, Y.5    Zhu, X.Z.6
  • 20
    • 77951239196 scopus 로고    scopus 로고
    • The Anti-Inflammatory Effect of Paeoniflorin on Cerebral Infarction Induced by Ischemia-Reperfusion Injury in Sprague-Dawley Rats
    • Tang, N.Y.; Liu, C.H.; Hsieh, C.T.; Hsieh, C.L. The Anti-Inflammatory Effect of Paeoniflorin on Cerebral Infarction Induced by Ischemia-Reperfusion Injury in Sprague-Dawley Rats. Am. J. Chin. Med. 2010, 38, 51-64.
    • (2010) Am. J. Chin. Med. , vol.38 , pp. 51-64
    • Tang, N.Y.1    Liu, C.H.2    Hsieh, C.T.3    Hsieh, C.L.4
  • 21
    • 84869109672 scopus 로고    scopus 로고
    • Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-kB-Mediated Inflammatory Responses
    • Guo, R.B.; Wang, G.F.; Zhao, A.P.; Gu, J.; Sun, X.L.; Hu, G. Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-kB-Mediated Inflammatory Responses. PLoS ONE 2012, 7, e49701.
    • (2012) PLoS ONE , vol.7
    • Guo, R.B.1    Wang, G.F.2    Zhao, A.P.3    Gu, J.4    Sun, X.L.5    Hu, G.6
  • 22
    • 27144558321 scopus 로고    scopus 로고
    • Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists
    • Liu, D.Z.; Xie, K.Q.; Ji, X.Q.; Ye, Y.; Jiang, C.L.; Zhu, X.Z. Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists. Br. J. Pharmacol. 2005, 146, 604-611.
    • (2005) Br. J. Pharmacol. , vol.146 , pp. 604-611
    • Liu, D.Z.1    Xie, K.Q.2    Ji, X.Q.3    Ye, Y.4    Jiang, C.L.5    Zhu, X.Z.6
  • 23
    • 84929177408 scopus 로고    scopus 로고
    • Paeoniflorin, a Monoterpene Glycoside, Protects the Brain from Cerebral Ischemic Injury via Inhibition of Apoptosis
    • Zhang, Y.Q.; Li, H.; Huang, M.Q.; Huang, M.; Chu, K.D.; Xu, W.; Zhang, S.N.; Que, J.H.; Chen, L.D. Paeoniflorin, a Monoterpene Glycoside, Protects the Brain from Cerebral Ischemic Injury via Inhibition of Apoptosis. Am. J. Chin. Med. 2015, 43, 543-557.
    • (2015) Am. J. Chin. Med. , vol.43 , pp. 543-557
    • Zhang, Y.Q.1    Li, H.2    Huang, M.Q.3    Huang, M.4    Chu, K.D.5    Xu, W.6    Zhang, S.N.7    Que, J.H.8    Chen, L.D.9
  • 27
    • 84903365146 scopus 로고    scopus 로고
    • Protective Effect of Paeoniflorin on Ab25-35-Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction
    • Wang, K.; Zhu, L.; Zhu, X.; Zhang, K.; Huang, B.; Zhang, J.; Zhang, Y.; Zhu, L.; Zhou, B.; Zhou, F. Protective Effect of Paeoniflorin on Ab25-35-Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction. Cell. Mol. Neurobiol. 2014, 34, 227-234.
    • (2014) Cell. Mol. Neurobiol. , vol.34 , pp. 227-234
    • Wang, K.1    Zhu, L.2    Zhu, X.3    Zhang, K.4    Huang, B.5    Zhang, J.6    Zhang, Y.7    Zhu, L.8    Zhou, B.9    Zhou, F.10
  • 28
    • 84879843846 scopus 로고    scopus 로고
    • Paeoniflorin, monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brainmicroglial inflammatory response
    • Nam, K.N.; Yae, C.G.; Hong, J.W.; Cho, D.H.; Lee, J.H.; Lee, E.H. Paeoniflorin, monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brainmicroglial inflammatory response. Biotechnol. Lett. 2013, 35, 1183-1189.
    • (2013) Biotechnol. Lett. , vol.35 , pp. 1183-1189
    • Nam, K.N.1    Yae, C.G.2    Hong, J.W.3    Cho, D.H.4    Lee, J.H.5    Lee, E.H.6
  • 29
    • 84863496244 scopus 로고    scopus 로고
    • The two pathophysiologies of focal brain ischemia: Implications for translational stroke research
    • Hossmann, K.A. The two pathophysiologies of focal brain ischemia: Implications for translational stroke research. J. Cereb. Blood Flow MeTable 2012, 32, 1310-1316.
    • (2012) J. Cereb. Blood Flow MeTable , vol.32 , pp. 1310-1316
    • Hossmann, K.A.1
  • 30
    • 84926301477 scopus 로고    scopus 로고
    • Neuronal polarity: An evolutionary perspective
    • Rolls, M.M.; Egla, T.J. Neuronal polarity: An evolutionary perspective. J. Exp. Biol. 2015, 218, 572-580.
    • (2015) J. Exp. Biol. , vol.218 , pp. 572-580
    • Rolls, M.M.1    Egla, T.J.2
  • 32
    • 33646395679 scopus 로고    scopus 로고
    • Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons
    • Wang, W.P.; Iyo, A.H.; Miguel-Hidalgo, J.; Regunathan, S.; Zhu, M.Y. Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res. 2006, 1084, 210-216.
    • (2006) Brain Res. , vol.1084 , pp. 210-216
    • Wang, W.P.1    Iyo, A.H.2    Miguel-Hidalgo, J.3    Regunathan, S.4    Zhu, M.Y.5
  • 33
    • 20744432586 scopus 로고    scopus 로고
    • Aspirin prevention of NMDA-induced neuronal death by direct protein kinase Cf inhibition
    • Crisanti, P.; Leon, A.; Lim, D.M.; Omri, B. Aspirin prevention of NMDA-induced neuronal death by direct protein kinase Cf inhibition. J. Neurochem. 2005, 93, 1587-1593.
    • (2005) J. Neurochem. , vol.93 , pp. 1587-1593
    • Crisanti, P.1    Leon, A.2    Lim, D.M.3    Omri, B.4
  • 34
    • 84866975430 scopus 로고    scopus 로고
    • Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway
    • Sun, R.; Wang, K.; Wu, D.; Li, X.; Ou, Y. Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway. Folia Neuropathol. 2012, 50, 270-276.
    • (2012) Folia Neuropathol. , vol.50 , pp. 270-276
    • Sun, R.1    Wang, K.2    Wu, D.3    Li, X.4    Ou, Y.5
  • 35
    • 84885179749 scopus 로고    scopus 로고
    • Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells
    • Wang, D.; Tan, Q.R.; Zhang, Z.J. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J. Mol. Neurosci. 2013, 51, 581-590.
    • (2013) J. Mol. Neurosci. , vol.51 , pp. 581-590
    • Wang, D.1    Tan, Q.R.2    Zhang, Z.J.3
  • 36
    • 84901390214 scopus 로고    scopus 로고
    • Effect of Gua Lou Gui Zhi decoction on focal cerebral ischemia-reperfusion injury through regulating the expression of excitatory amino acids and their receptors
    • Chen, X.W.; Li, H.; Huang, M.Q.; Huang, M.; Xu, W.; Chu, K.D.; Chen, L.D.; Zhang, Y.Q. Effect of Gua Lou Gui Zhi decoction on focal cerebral ischemia-reperfusion injury through regulating the expression of excitatory amino acids and their receptors. Mol. Med. Rep. 2014, 10, 248-254.
    • (2014) Mol. Med. Rep. , vol.10 , pp. 248-254
    • Chen, X.W.1    Li, H.2    Huang, M.Q.3    Huang, M.4    Xu, W.5    Chu, K.D.6    Chen, L.D.7    Zhang, Y.Q.8
  • 37
    • 84875258578 scopus 로고    scopus 로고
    • Gua Lou Gui Zhi decoction exerts neuroprotective effects on post-stroke spasticity via the modulation of glutamate levels and AMPA receptor expression
    • Huang, J.; Tao, J.; Xue, X.; Yang, S.; Han, P.; Lin, Z.; Xu, W.; Lin, J.; Peng, J.; Chen, L.D. Gua Lou Gui Zhi decoction exerts neuroprotective effects on post-stroke spasticity via the modulation of glutamate levels and AMPA receptor expression. Int. J. Mol. Med. 2013, 31, 841-848.
    • (2013) Int. J. Mol. Med. , vol.31 , pp. 841-848
    • Huang, J.1    Tao, J.2    Xue, X.3    Yang, S.4    Han, P.5    Lin, Z.6    Xu, W.7    Lin, J.8    Peng, J.9    Chen, L.D.10


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