Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A 1 receptor in a manner different from its classical agonists

British Journal of Pharmacology

Volumn 146, Issue 4, 2005, Pages 604-611

  Liu, Da Zhi ^a   Xie, Ke Qiang ^a   Ji, Xin Quan ^a   Ye, Yang ^a   Jiang, Cheng Liang ^a   Zhu, Xing Zu ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Adenosine A 1 receptor; Cardiovascular side effect; Neuroprotective effect; Paeoniflorin; Permanent cerebral ischemia; Transient cerebral ischemia

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; NORADRENALIN; PAEONIA RADIX; PAEONIFLORIN; POTASSIUM ION; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HEART RATE; HISTOPATHOLOGY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; RAT STRAIN;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; BENZOIC ACIDS; BINDING, COMPETITIVE; BRIDGED COMPOUNDS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSIDES; INFARCTION, MIDDLE CEREBRAL ARTERY; INHIBITORY CONCENTRATION 50; ISCHEMIC ATTACK, TRANSIENT; MALE; NEUROPROTECTIVE AGENTS; PAEONIA; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A1; TIME FACTORS; XANTHINES;

EID: 27144558321     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706335     Document Type: Article

References (45)

1. AMES III, A., MAYNARD, K.I. & KAPLAN, S. (1995). Protection against CNS ischemia by temporary interruption of function-related processes of neurons. J. Cereb. Blood. Flow. Metab., 15, 433-439.
2. AMES III, A. (2000). CNS energy metabolism as related to function. Brain Res. Rev., 34, 42-68.
3. AYOUB, I.A., LEE, E.J., OGILVY, C.S., BEAL, M.F. & MAYNARD, K.I. (1999). Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats. Neurosci. Lett., 259, 21-24.
4. BEDERSON, J.B., PITTS, L.H., GERMANO, S.M., NISHIMURA, M.C., DAVIS, R.L. & BARTKOWSKI, H.M. (1986). Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke, 17, 1304-1308.
5. BELAYEV, L., ALONSO, O.F., BUSTO, R., ZHAO, W. & GINSBERG, M.D. (1996). Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke, 27, 1616-1622.
6. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
7. 1 receptors in Wistar rats. Clin. Exp. Pharmacol. Physiol., 26, 815-816.
8. COLLIS, M.G. & HOURANI, S.M. (1993). Adenosine receptor subtypes. Trends Pharmacol. Sci., 14, 360-366.
9. DAVAL, J.L., NEHLIG, A. & NICOLAS, F. (1991). Physiological and pharmacological properties of adenosine: therapeutic implications. Life Sci., 49, 1435-1453.
10. DOLPHIN, A.C. & PRESTWICH, S.A. (1985). Pertussis toxin reverses adenosine inhibition of neuronal glutamate release. Nature, 316, 148-150.
11. FINLAYSON, K., BUTCHER, S.P., SHARKEY, J. & OLVERMAN, H.J. (1997). Detection of adenosine receptor antagonists in rat brain using a modified radioreceptor assay. J. Neurosci. Methods, 77, 135-142.
12. GINSBERG, M.D. (2003). Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture. Stroke, 34, 214-223.
13. GOLDBERG, M.P., MONYER, H., WEISS, J.H. & CHOI, D.W. (1988). Adenosine reduces cortical neuronal injury induced by oxygen or glucose deprivation in vitro. Neurosci. Lett., 89, 323-327.
14. GREENE, R.W. & HAAS, H.L. (1991). The electrophysiology of adenosine in the mammalian central nervous system. Prog. Neurobiol., 36, 329-341.
15. HE, X.H., XING, D.M., DING, Y., LI, Y.P., XIANG, L., WANG, W. & DU, L.J. (2004). Determination of paeoniflorin in rat hippocampus by high-performance liquid chromatography after intravenous administration of Paeoniae Radix extract. J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 802, 277-281.
16. HE, L.N., YANG, J., HE, S.B., WANG, J. & LIU, C. (2000). Protective effect of total paeony glocoside against ischemia injury in cultured primary cortex neurons. Chin. Clin. Pharmacol. Ther., 1, 1-6.
17. HERON, A., LASBENNES, F. & SEYLAZ, J. (1993). Adenosine modulation of amino acid release in rat hippocampus during ischemia and veratridine depolarization. Brain Res., 608, 27-32.
18. 1 adenosine receptor agonist on the neurochemical, behavioral and histological consequences of ischemia. Brain Res., 641, 217-224.
19. KASAI, H. & AOSAKI, T. (1989). Modulation of Ca-channel current by an adenosine analog mediated by a GTP-binding protein in chick sensory neurons. Eur. J. Physiol., 414, 145-149.
20. 1 receptors to increase the translocation of protein kinase C (PKC) and glucose transporter (GLUT 4) in isolated rat white adipocytes. Life Sci., 62, 1591-1595.
21. LEE, E.J., CHEN, H.Y., WU, T.S., CHEN, T.Y., AYOUB, I.A. & MAYNARD, K.I. (2002). Acute administration of Ginkgo biloba extract (EGb 761) affords neuroprotection against permanent and transient focal cerebral ischemia in Sprague-Dawley rats. J. Neurosci. Res., 68, 636-645.
22. LIU, W., WU, H.P., ZHU, X.G., MING, L., DONG, S.Y. & TONG, X.H. (2001). Protective effect of TGP on acute cerebral ischemia in mice and rat. Acta. Univ. Med. Anhui, 36, 186-188.
23. 1 receptor agonist N6-cyclopentyladenosine in the rat. J. Pharmacol. Exp. Ther., 268, 616-624.
24. MAYNARD, K.I., KAWAMATA, T., OGILVY, C.S., PEREZ, F., ARANGO, P.M. & AMES III, A. (1998). Avoiding stroke during cerebral arterial occlusion by temporarily blocking neuronal functions in the rabbit. J. Stroke Cerebrovasc. Dis., 7, 287-295.
25. MAYNARD, K.I., QUINONES-HINOJOSA, A. & MALEK, J.Y. (1999). Neuroprotection against ischemia by metabolic inhibition revisited: a comparison of hypothermia, a pharmacologic cocktail and magnesium plus mexiletine. Ann. NY Acad. Sci., 890, 240-254.
26. MOGUL, D.J., ADAMS, M.E. & FOX, A.P. (1993). Differential activation of adenosine receptors decreases N-type but potentiates P-type current in hippocampal CA3 neurons. Neuron, 10, 327-334.
27. MORI, M., NISHIZAKI, T. & OKADA, Y. (1992). Protective effect of adenosine on the anoxic damage of hippocampal slice. Neuroscience, 46, 301-307.
28. NIESSEN, F., HILGER, T., HOEHN, M. & HOSSMANN, K.A. (2002). Thrombolytic treatment of clot embolism in rat: comparison of intra-arterial and intravenous application of recombinant tissue plasminogen activator. Stroke, 33, 2999-3005.
29. RICHARD, G.A., ODERGREN, T. & ASHWOOD, T. (2003). Animal models of stroke: do they have value for discovering neuroprotective agents? Trends Pharmacol. Sci., 24, 402-408.
30. RUDOLPHI, K.A., SCHUBERT, P., PARKINSON, F.E. & FREDHOLM, B.B. (1992). Neuroprotective role of adenosine in cerebral ischemia. Trends Pharmocol. Sci., 13, 439-445.
31. SCHUBERT, P., RUDOLPHI, K.A., FREDHOLM, B.B. & NAKAMURA, Y. (1994). Modulation of nerve and glial function by adenosine-role in the development of ischemic damage. Int. J. Biochem., 26, 1227-1236.
32. SMALL, D.L. & BUCHAN, A.M. (1996). Mechanisms of cerebral ischemia: intracellular cascades and therapeutic interventions. J. Cardiothorac. Vasc. Anesth., 10, 139-146.
33. SNYDER, S.H. (1985). Adenosine as a neuromodulator. Ann. Rev. Neurosci., 8, 103-124.
34. SWEENEY, M.I. (1997). Neuroprotective effects of adenosine in cerebral ischemia: window of opportunity. Neurosci. Biobehav. Rev., 21, 207-217.
35. SYDSERFF, S.G., BORELLI, A.R., GREEN, A.R. & CROSS, A.J. (2002). Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br. J. Pharmacol., 135, 103-112.
36. TAKANO, K., TATLISUMAK, T., BERGMANN, A.G., GIBSON III, D.G. & FISHER, M. (1997). Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats. J. Neurol. Sci., 153, 8-11.
37. TANG, L.M., LIU, I.M. & CHENG, J.T. (2003). Stimulatory effect of paeoniflorin on adenosine release to increase the glucose uptake into white adipocytes of Wistar rat. Planta Med., 69, 332-336.
38. TAKEDA, S., ISONO, T., WAKUI, Y., MATSUZAKI, Y., SASAKI, H., AMAGAYA, S. & MARUNO, M. (1995). Absorption and excretion of paeoniflorin in rats. J. Pharm. Pharmacol., 47, 1036-1040.
39. TAKEDA, S., ISONO, T., WAKUI, Y., MIZUHARA, Y., AMAGAYA, S., MARUNO, M. & HATTORI, M. (1997). In-vivo assessment of extrahepatic metabolism of paeoniflorin in rats: relevance to intestinal floral metabolism. J. Pharm. Pharmacol., 49, 35-39.
40. 1 adenosine receptor mediates specific agonist binding. J. Biol. Chem., 269, 2373-2376.
41. TSAI, H.Y., LIN, Y.T., CHEN, C.F., TSAI, C.H. & CHEN, Y.F. (1999). Effects of veratrine and paeoniflorin on the isolated rat aorta. J. Ethnopharmacol., 66, 249-255.
42. 1 receptors in vivo. J. Pharmacol. Exp. Ther., 283, 800-808.
43. 1 receptor agonist. Eur. J. Pharmacol., 302, 43-48.
44. WU, H.P. & ZHU, X.G. (2001). Protective effect of TGP on local cerebral ischemia in rat. Chin. Pharmacol. Bull., 17, 223-225.
45. YANG, J., HE, L.N., HE, S.B. & LI, G.R. (2001). Protective effect of paeoniflorin on calcium overloading injury in cultured primary cortex neurons. Chin. J. Pharmacol. Toxicol., 15, 164-168.