The two pathophysiologies of focal brain ischemia: Implications for translational stroke research

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 7, 2012, Pages 1310-1316

  Hossmann, Konstantin Alexander ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Animal models; cell death mechanisms; drug trials; focal ischemia; neuroprotection; reperfusion; thrombolysis

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4 PHOSPHONOMETHYLPIPECOLIC ACID; ALTEPLASE; ANCROD; APTIGANEL; CALCIUM CHANNEL BLOCKING AGENT; CITICOLINE; CLOMETHIAZOLE; DESMOTEPLASE; DIAZEPAM; DISUFENTON SODIUM; ENLIMOMAB; ERYTHROPOIETIN; FIBRINOLYTIC AGENT; FIBROBLAST GROWTH FACTOR 2; FLINDOKALNER; FOSPHENYTOIN SODIUM; GANGLIOSIDE GM1; GLUTAMATE RECEPTOR ANTAGONIST; LUBELUZOLE; MAGNESIUM; NALMEFENE; NEUROPROTECTIVE AGENT; NIMODIPINE; OPIATE ANTAGONIST; SODIUM CHANNEL BLOCKING AGENT; STREPTOKINASE; TIRILAZAD; UNINDEXED DRUG; UROKINASE;

ANOXIA; ANTIOXIDANT ACTIVITY; BLOOD CLOT LYSIS; BRAIN BLOOD FLOW; BRAIN HYPOXIA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN METABOLISM; CELL DEATH; DISEASE COURSE; DRUG MECHANISM; FIBRINOLYTIC THERAPY; HUMAN; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PATHOPHYSIOLOGY; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REPERFUSION; REVIEW; STROKE; TIME; TRANSLATIONAL RESEARCH; TREATMENT OUTCOME;

ANIMALS; BRAIN ISCHEMIA; CLINICAL TRIALS, PHASE III AS TOPIC; DISEASE MODELS, ANIMAL; HUMANS; REPERFUSION INJURY; RESEARCH DESIGN; STROKE; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84863496244     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.186     Document Type: Review

References (26)

1. Astrup J, Symon L, SiesjöBK (1981) Thresholds in cerebral ischemia-The ischemic penumbra. Stroke 12:723-5 (Pubitemid 12227362)
2. Bath PMW, Gray LJ, Bath AJG, Buchan A, Miyata T, Green AR (2009) Effects of NXY-059 in experimental stroke: an individual animal meta-analysis. Br J Pharmacol 157:1157-71
3. Busch E, Krüger K, Allegrini PR, Kerskens CM, Gyngell ML, Hoehn-Berlage M, Hossmann K-A (1998) Reperfusion after thrombolytic therapy of embolic stroke in the rat: magnetic resonance and biochemical imaging. J Cereb Blood Flow Metab 18:407-18 (Pubitemid 28166516)
4. Dirnagl U, Macleod MR (2009) Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice. Br J Pharmacol 157:1154-6
5. Doyle KP, Simon RP, Stenzel-Poore MP (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55: 310-8
6. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW (1996) Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 16:195-201 (Pubitemid 26062810)
7. Endres H, Namura S, Skimizusasamata M, Waeber C, Zhang L, Gomezisla T, Hyman BT, Moskowitz MA (1998) Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab 18:238-47 (Pubitemid 28103631)
8. Fischer EG, Ames A (1972) Studies on mechanisms of impairment of cerebral circulation following ischemia: effect of hemodilution and perfusion pressure. Stroke 3:538-42
9. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH (2009) Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 40:2244-50
10. Hata R, Maeda K, Hermann D, Mies G, Hossmann K-A (2000) Evolution of brain infarction after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 20:937-46 (Pubitemid 30413677)
11. Heiss WD, Sobesky J, Hesselmann V (2004) Identifying thresholds for penumbra and irreversible tissue damage. Stroke 35:2671-4 (Pubitemid 39458364)
12. Hossmann K-A (2008) Cerebral ischemia: models, methods and outcomes. Neuropharmacology 55:257-70
13. Hossmann K-A, Kleihues P (1973) Reversibility of ischemic brain damage. Arch Neurol 29:375-84
14. Internet-Stroke-Center (2011) Stroke Trials Registry of the Internet Stroke Center at Washington University School of Medicine http//www. strokecenter.org/trials
15. Kidwell CS, Alger JR, Saver JL (2003) Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke 34:2729-35 (Pubitemid 37392775)
16. Kilic E, Hermann DM, Hossmann K-A (1999) Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice. Neuroreport 10:107-11 (Pubitemid 29090488)
17. Lauritzen M, Dreier JP, Fabricius M, Hartings JA, Graf R, Strong AJ (2011) Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab 31:17-35
18. Li CY, Jackson RM (2002) Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol-Cell Physiol 282:C227-41 (Pubitemid 34663181)
19. Liebeskind DS (2010) Reperfusion for acute ischemic stroke: arterial revascularization and collateral therapeutics. Curr Opin Neurol 23:36-45
20. Lo EH, Moskowitz MA, Jacobs TP (2005) Exciting, radical, suicidal-How brain cells die after stroke. Stroke 36:189-92 (Pubitemid 40170779)
21. Lust WD, Taylor C, Pundik S, Selman WR, Ratcheson RA (2002) Ischemic cell death: dynamics of delayed secondary energy failure during reperfusion following focal ischemia. Metab Brain Dis 17:113-21 (Pubitemid 34655050)
22. Neumar RW (2000) Molecular mechanisms of ischemic neuronal injury. Ann Emerg Med 36:483-506
23. Petzold GC, Einhäupl KM, Dirnagl U, Dreier JP (2003) Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and hemoglobin in the subarachnoid space. Ann Neurol 54:591-8 (Pubitemid 37346065)
24. Saver JL, Smith EE, Fonarow GC, Reeves MJ, Zhao X, Olson DM, Schwamm LH (2010) The 'Golden Hour' and acute brain ischemia presenting features and lytic therapy in > 30,000 patients arriving within 60 minutes of stroke onset. Stroke 41:1431-9
25. Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener H, Ashwood T, Wasiewski WW, Emeribe U (2007) NXY-059 for the treatment of acute ischemic stroke. N Engl J Med 357:562-71 (Pubitemid 47236281)
26. van der Worp HB, Macleod MR, Kollmar R, European Stroke Research Network for Hypothermia (2010) Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials? J Cereb Blood Flow Metab 30:1079-93