Gua Lou Gui Zhi decoction exerts neuroprotective effects on post-stroke spasticity via the modulation of glutamate levels and AMPA receptor expression

International Journal of Molecular Medicine

Volumn 31, Issue 4, 2013, Pages 841-848

  Huang, Jia ^a   Tao, Jing ^a   Xue, Xiehua ^a   Yang, Shanli ^a   Han, Ping ^a   Lin, Zhicheng ^a   Xu, Wei ^a   Lin, Jiumao ^a   Peng, Jun ^a   Chen, Lidian ^a  

^a FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid receptors; Cerebral ischemia; Glutamate; Gua Lou Gui Zhi decoction; Spasticity; Traditional Chinese medicine

Indexed keywords

AMPA RECEPTOR; CHINESE DRUG; GLUTAMIC ACID; GUA LOU GUI ZHI; NEUROPROTECTIVE AGENT; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; CEREBROSPINAL FLUID ANALYSIS; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG MECHANISM; HOFFMANN REFLEX; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPASTICITY; TREATMENT OUTCOME;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; CEREBRAL INFARCTION; DRUGS, CHINESE HERBAL; GLUTAMIC ACID; MALE; MUSCLE SPASTICITY; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; REPERFUSION INJURY;

EID: 84875258578     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1262     Document Type: Article

References (25)

1. Mayer NH, Esquenazi A and Childers MK: Common patterns of clinical motor dysfunction. Muscle Nerve Suppl 20: S21-S35, 1997.
2. Lance JW: What is spasticity? Lancet 335: 606, 1990.
3. Lundstrom E, Terent A and Borg J: Prevalence of disabling spasticity 1 year after first-ever stroke. Eur J Neurol 15: 533-539, 2008.
4. Watkins CL, Leathley MJ, Gregson JM, Moore AP, Smith TL and Sharma AK: Prevalence of spasticity post stroke. Clin Rehabil 16: 515-522, 2002.
5. Sommerfeld DK, Eek EU, Svensson AK, Holmqvist LW and von Arbin MH: Spasticity after stroke: its occurrence and association with motor impairments and activity limitations. Stroke 35: 134-139, 2004.
6. Duncan PW, Zorowitz R, Bates B, et al: Management of adult stroke rehabilitation care a clinical practice guideline. Stroke 36: e100-e143, 2005.
7. Gracies JM, Nance P, Elovic E, McGuire J and Simpson DM: Traditional pharmacological treatments for spasticity. Part II: General and regional treatments. Muscle Nerve Suppl 20: S92-S120, 1998.
8. Davidoff RA: Antispasticity drugs: mechanisms of action. Ann Neurol 17: 107-116, 2004.
9. Gottlieb M and Matute C: Expression of ionotropic glutamate receptor subunits in glial cells of the hippocampal CA1 area following transient forebrain ischemia. J Cereb Blood Flow Metab 17: 290-300, 1997.
10. Hefferan MP, Kucharova K, Kinjo K, et al: Spinal astrocyte glutamate receptor 1 overexpression after ischemic insult facilitates behavioral signs of spasticity and rigidity. J Neurosci 27: 11179-11191, 2007.
11. Saulino M and Jacobs BW: The pharmacological management of spasticity. J Neurosci Nurs 38: 456-459, 2006.
12. Hesse S and Werner C: Poststroke motor dysfunction and spasticity: novel pharmacological and physical treatment strategies. CNS Drugs 17: 1093-1107, 2003.
13. Meythaler JM, Guin-Renfroe S, Johnson A and Brunner RM: Prospective assessment of tizanidine for spasticity due to acquired brain injury. Arch Phys Med Rehabil 82: 1155-1163, 2001.
14. Meythaler JM, Guin-Renfroe S, Law C, Grabb P and Hadley MN: Continuously infused intrathecal baclofen over 12 months for spastic hypertonia in adolescents and adults with cerebral palsy. Arch Phys Med Rehabil 82: 155-161, 2001.
15. Ford B, Greene P, Louis ED, et al: Use of intrathecal baclofen in the treatment of patients with dystonia. Arch Neurol 53: 1241-1246, 1996.
16. Sun X: Research on formula treating paralysis and spasticity from 'treatise on febrile and miscellaneous diseases'. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi 8: 644-645, 2010 (In Chinese).
17. Zhang L and Ai H: Effects of Gua Lou Gui Zhi decoction on c-fos and c-jun in epileptic rats. Sichuan Hua xi Zhong Yi Yao Yan Jiu Suo 23: 21-22, 2005 (In Chinese).
18. Yang C, Chen L and Tao J: New usage of a classical formula - Gua Lou Gui Zhi decoction. Liaoning Zhong Yi Za Zhi 8: 166-167, 2012 (In Chinese).
19. Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91, 1989.
20. Guo J, Liu L, Ma C, Xu B, Duan X and Wang B: Effect of restraint stress on depression-like behaviors in rats after transient focal cerebral ischemic injury. Neural Regen Res 2: 390-394, 2007.
21. Parelkar NK and Wang JQ: Upregulation of metabotropic glutamate receptor 8 mRNA expression in the rat forebrain after repeated amphetamine administration. Neurosci Lett 433: 250-254, 2008.
22. Bonde C, Noraberg J, Noer H and Zimmer J: Ionotropic glutamate receptors and glutamate transporters are involved in necrotic neuronal cell death induced by oxygen-glucose deprivation of hippocampal slice cultures. Neuroscience 136: 779-794, 2005.
23. Abbruzzese G: The medical management of spasticity. Eur J Neurol 9 (Suppl 1): S30-S34, 2002.
24. Oshiro M, Hefferan MP, Kakinohana O, et al: Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance. Br J Pharmacol 161: 976-985, 2010.
25. Gómez-Soriano J, Goiriena E and Taylor J: Spasticity therapy reacts to astrocyte GluA1 receptor upregulation following spinal cord injury. Br J Pharmacol 161: 972-975, 2010.