Differential molecular and behavioural alterations in mouse models of GABRG2 haploinsufficiency versus dominant negative mutations associated with human epilepsy

Human Molecular Genetics

Volumn 25, Issue 15, 2016, Pages 3192-3207

  Warner, Timothy A ^a   Shen, Wangzhen ^a   Huang, Xuan ^b   Liu, Zhong ^a   Macdonald, Robert L ^a,b   Kang, Jing Qiong ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; DIAZEPAM; GLUTAMIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; GABRG2 PROTEIN, MOUSE;

ABSENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BIOGENESIS; BRAIN DISEASE; COMORBIDITY; CONTROLLED STUDY; DENDRITE; DISEASE SEVERITY; DOMINANT GENE; EPILEPSY; EPILEPTIC ENCEPHALOPATHY; GENE EXPRESSION; GENETIC ASSOCIATION; HAPLOINSUFFICIENCY; HETEROZYGOSITY; HUMAN; HUMAN CELL; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MOLECULAR GENETICS; MOUSE; MUTANT; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN SUBUNIT; SEIZURE; SYNAPSE; SYNAPTOSOME; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; MISSENSE MUTATION;

AMINO ACID SUBSTITUTION; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; EPILEPSY; GENES, DOMINANT; HAPLOINSUFFICIENCY; HUMANS; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; RECEPTORS, GABA-A;

EID: 85014367937     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddw168     Document Type: Article

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