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Volumn 13, Issue 8, 2014, Pages 831-840

A genetic interaction network model of a complex neurological disease

Author keywords

Complex trait; Epilepsy; Epistasis; Genetic interaction; Genetic network; Mouse model; Pleiotropy; Quantitative trait analysis; Spike wave discharge; Statistical genetics

Indexed keywords

ABSENCE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C3HEB/FE MOUSE; C57BL 6 MOUSE; CHROMOSOME; CONTROLLED STUDY; EPISTASIS; FEMALE; GENE INTERACTION; GENE LOCUS; GENE MUTATION; MALE; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; SPIKE WAVE; STRAIN DIFFERENCE; ANIMAL; BIOLOGICAL MODEL; DISEASE MODEL; GENE REGULATORY NETWORK; GENETICS; HUMAN; QUANTITATIVE TRAIT LOCUS;

EID: 84911408654     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/gbb.12178     Document Type: Article
Times cited : (13)

References (39)
  • 1
    • 0026666791 scopus 로고
    • Ordering gene function: the interpretation of epistasis in regulatory hierarchies
    • Avery, L. & Wasserman, S. (1992) Ordering gene function: the interpretation of epistasis in regulatory hierarchies. Trends Genet 8, 312-316.
    • (1992) Trends Genet , vol.8 , pp. 312-316
    • Avery, L.1    Wasserman, S.2
  • 2
    • 0031748082 scopus 로고    scopus 로고
    • Epilepsies in twins: genetics of the major epilepsy syndromes
    • Berkovic, S.F., Howell, R.A., Hay, D.A. & Hopper, J.L. (1998) Epilepsies in twins: genetics of the major epilepsy syndromes. Ann Neurol 43, 435-445.
    • (1998) Ann Neurol , vol.43 , pp. 435-445
    • Berkovic, S.F.1    Howell, R.A.2    Hay, D.A.3    Hopper, J.L.4
  • 6
    • 84883252672 scopus 로고    scopus 로고
    • Inferring gene function and network organization in Drosophila signaling by combined analysis of pleiotropy and epistasis
    • Carter, G.W. (2013) Inferring gene function and network organization in Drosophila signaling by combined analysis of pleiotropy and epistasis. G3 3, 807-814.
    • (2013) G3 , vol.3 , pp. 807-814
    • Carter, G.W.1
  • 7
    • 84868117015 scopus 로고    scopus 로고
    • Use of pleiotropy to model genetic interactions in a population
    • Carter, G.W., Hays, M., Sherman, A. & Galitski, T. (2012) Use of pleiotropy to model genetic interactions in a population. PLoS Genet 8, e1003010.
    • (2012) PLoS Genet , vol.8 , pp. e1003010
    • Carter, G.W.1    Hays, M.2    Sherman, A.3    Galitski, T.4
  • 9
    • 0002522876 scopus 로고    scopus 로고
    • Detecting epistasis among quantitative trait loci
    • Wolf, J., Brodie, E., III & Wade, M. (eds), Oxford University Press, New York -.
    • Cheverud, J.M. (2000) Detecting epistasis among quantitative trait loci. In Wolf, J., Brodie, E., III & Wade, M. (eds), Epistasis and the Evolutionary Process. Oxford University Press, New York, pp. 58-81.
    • (2000) Epistasis and the Evolutionary Process , pp. 58-81
    • Cheverud, J.M.1
  • 10
    • 0036584661 scopus 로고    scopus 로고
    • Childhood absence epilepsy: genes, channels, neurons and networks
    • Crunelli, V. & Leresche, N. (2002) Childhood absence epilepsy: genes, channels, neurons and networks. Nat Rev Neurosci 3, 371-382.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 371-382
    • Crunelli, V.1    Leresche, N.2
  • 11
    • 68349141242 scopus 로고    scopus 로고
    • Genetics of complex neurological disease: challenges and opportunities for modeling epilepsy in mice and rats
    • Frankel, W.N. (2009) Genetics of complex neurological disease: challenges and opportunities for modeling epilepsy in mice and rats. Trends Genet 25, 361-367.
    • (2009) Trends Genet , vol.25 , pp. 361-367
    • Frankel, W.N.1
  • 12
    • 84905484561 scopus 로고    scopus 로고
    • Unraveling genetic modifiers in the Gria4 mouse model of absence epilepsy
    • Frankel, W.N., Mahaffey, C.L., McGarr, T.C., Beyer, B.J. & Letts, V.A. (2014) Unraveling genetic modifiers in the Gria4 mouse model of absence epilepsy. PLoS Genet 10, e1004454.
    • (2014) PLoS Genet , vol.10 , pp. e1004454
    • Frankel, W.N.1    Mahaffey, C.L.2    McGarr, T.C.3    Beyer, B.J.4    Letts, V.A.5
  • 13
    • 33749659140 scopus 로고    scopus 로고
    • Exploration of the genetic architecture of idiopathic generalized epilepsies
    • Hempelmann, A., Taylor, K.P., Heils, A., Lorenz, S., Prud'Homme, J.F. et al. (2006) Exploration of the genetic architecture of idiopathic generalized epilepsies. Epilepsia 47, 1682-1690.
    • (2006) Epilepsia , vol.47 , pp. 1682-1690
    • Hempelmann, A.1    Taylor, K.P.2    Heils, A.3    Lorenz, S.4    Prud'Homme, J.F.5
  • 15
    • 0034919724 scopus 로고    scopus 로고
    • Size of donor chromosome segments around introgressed loci and reduction of linkage drag in marker-assisted backcross programs
    • Hospital, F. (2001) Size of donor chromosome segments around introgressed loci and reduction of linkage drag in marker-assisted backcross programs. Genetics 158, 1363-1379.
    • (2001) Genetics , vol.158 , pp. 1363-1379
    • Hospital, F.1
  • 17
    • 61449224751 scopus 로고    scopus 로고
    • A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock
    • Johannesson, M., Lopez-Aumatell, R., Stridh, P., Diez, M., Tuncel, J. et al. (2009) A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res 19, 150-158.
    • (2009) Genome Res , vol.19 , pp. 150-158
    • Johannesson, M.1    Lopez-Aumatell, R.2    Stridh, P.3    Diez, M.4    Tuncel, J.5
  • 19
    • 0033034004 scopus 로고    scopus 로고
    • Quantitative trait loci for early-and late-developing skull characters in mice: a test of the genetic independence model of morphological integration
    • Leamy, L.J., Routman, E.J. & Cheverud, J.M. (1999) Quantitative trait loci for early-and late-developing skull characters in mice: a test of the genetic independence model of morphological integration. Am Nat 153, 201-214.
    • (1999) Am Nat , vol.153 , pp. 201-214
    • Leamy, L.J.1    Routman, E.J.2    Cheverud, J.M.3
  • 20
    • 0037067395 scopus 로고    scopus 로고
    • Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice
    • Leamy, L.J., Pomp, D., Eisen, E. & Cheverud, J.M. (2002) Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice. Physiol Genomics 10, 21-29.
    • (2002) Physiol Genomics , vol.10 , pp. 21-29
    • Leamy, L.J.1    Pomp, D.2    Eisen, E.3    Cheverud, J.M.4
  • 23
    • 0037224654 scopus 로고    scopus 로고
    • Childhood absence epilepsy and febrile seizures: a family with a GABAA receptor mutation
    • Marini, C., Harkin, L.A., Wallace, R.H., Mulley, J.C., Scheffer, I.E. & Berkovic, S.F. (2003) Childhood absence epilepsy and febrile seizures: a family with a GABAA receptor mutation. Brain 126, 230-240.
    • (2003) Brain , vol.126 , pp. 230-240
    • Marini, C.1    Harkin, L.A.2    Wallace, R.H.3    Mulley, J.C.4    Scheffer, I.E.5    Berkovic, S.F.6
  • 25
    • 84899803630 scopus 로고    scopus 로고
    • Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy
    • Oliva, M.K., McGarr, T.C., Beyer, B.J., Gazina, E., Kaplan, D.I. et al. (2014) Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy. Neurobiol Dis 67, 180-190.
    • (2014) Neurobiol Dis , vol.67 , pp. 180-190
    • Oliva, M.K.1    McGarr, T.C.2    Beyer, B.J.3    Gazina, E.4    Kaplan, D.I.5
  • 26
    • 33644802338 scopus 로고    scopus 로고
    • Analysis of genetically complex epilepsies
    • Ottman, R. (2005) Analysis of genetically complex epilepsies. Epilepsia 46, 7-14.
    • (2005) Epilepsia , vol.46 , pp. 7-14
    • Ottman, R.1
  • 28
    • 78650354438 scopus 로고    scopus 로고
    • The GABAAγ2 (R43Q) mouse model of human genetic epilepsy
    • Petrou, S. (2010) The GABAAγ2 (R43Q) mouse model of human genetic epilepsy. Epilepsia 51 (s5), 63.
    • (2010) Epilepsia , vol.51 , Issue.s5 , pp. 63
    • Petrou, S.1
  • 29
    • 58849149031 scopus 로고    scopus 로고
    • A Cav3.2T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy
    • Powell, K.L., Cain, S.M., Ng, C., Sirdesai, S., David, L.S., Kyi, M., Garcia, E., Tyson, J.R., Reid, C.A., Bahlo, M., Foote, S.J., Snutch, T.P. & O'Brien, T.J. (2009) A Cav3.2T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy. J Neurosci 29, 371-380.
    • (2009) J Neurosci , vol.29 , pp. 371-380
    • Powell, K.L.1    Cain, S.M.2    Ng, C.3    Sirdesai, S.4    David, L.S.5    Kyi, M.6    Garcia, E.7    Tyson, J.R.8    Reid, C.A.9    Bahlo, M.10    Foote, S.J.11    Snutch, T.P.12    O'Brien, T.J.13
  • 30
    • 1842853075 scopus 로고    scopus 로고
    • Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS)
    • Rudolf, G., Bihoreau, M.T., Godfrey, R.F., Wilder, S.P., Cox, R.D., Lathrop, M., Marescaux, C. & Gauguier, D. (2004) Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS). Epilepsia 45, 301-308.
    • (2004) Epilepsia , vol.45 , pp. 301-308
    • Rudolf, G.1    Bihoreau, M.T.2    Godfrey, R.F.3    Wilder, S.P.4    Cox, R.D.5    Lathrop, M.6    Marescaux, C.7    Gauguier, D.8
  • 34
    • 65249098486 scopus 로고    scopus 로고
    • Genetic complexity of absence seizures in substrains of C3H mice
    • Tokuda, S., Beyer, B.J. & Frankel, W.N. (2009) Genetic complexity of absence seizures in substrains of C3H mice. Genes Brain Behav 8, 283-289.
    • (2009) Genes Brain Behav , vol.8 , pp. 283-289
    • Tokuda, S.1    Beyer, B.J.2    Frankel, W.N.3
  • 35
    • 84887290646 scopus 로고    scopus 로고
    • CAPE: an R package for combined analysis of pleiotropy and epistasis
    • Tyler, A.L., Lu, W., Hendrick, J.J., Philip, V.M. & Carter, G.W. (2013) CAPE: an R package for combined analysis of pleiotropy and epistasis. PLoS Comput Biol 9, e1003270.
    • (2013) PLoS Comput Biol , vol.9 , pp. e1003270
    • Tyler, A.L.1    Lu, W.2    Hendrick, J.J.3    Philip, V.M.4    Carter, G.W.5
  • 37
    • 50149107957 scopus 로고    scopus 로고
    • Genetic mechanisms in idiopathic epilepsies
    • Weber, Y.G. & Lerche, H. (2008) Genetic mechanisms in idiopathic epilepsies. Dev Med Child Neurol 50, 648-654.
    • (2008) Dev Med Child Neurol , vol.50 , pp. 648-654
    • Weber, Y.G.1    Lerche, H.2
  • 38
    • 31544444132 scopus 로고    scopus 로고
    • Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice
    • Wolf, J.B., Leamy, L.J., Routman, E.J. & Cheverud, J.M. (2005) Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice. Genetics 171, 683-694.
    • (2005) Genetics , vol.171 , pp. 683-694
    • Wolf, J.B.1    Leamy, L.J.2    Routman, E.J.3    Cheverud, J.M.4
  • 39
    • 33747619846 scopus 로고    scopus 로고
    • The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice
    • Wolf, J.B., Pomp, D., Eisen, E.J., Cheverud, J.M. & Leamy, L.J. (2006) The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice. Evol Dev 8, 468-476.
    • (2006) Evol Dev , vol.8 , pp. 468-476
    • Wolf, J.B.1    Pomp, D.2    Eisen, E.J.3    Cheverud, J.M.4    Leamy, L.J.5


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