Slow degradation and aggregation in vitro of mutant GABAA receptor γ2(Q351X) subunits associated with epilepsy

Journal of Neuroscience

Volumn 30, Issue 41, 2010, Pages 13895-13905

  Kang, Jing Qiong ^a   Shen, Wangzhen ^a   Lee, Melissa ^a   Gallagher, Martin J ^a   Macdonald, Robert L ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BETA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; CYSTEINE; MONOMER; PROTEASOME; UBIQUITIN; 4 AMINOBUTYRIC ACID A RECEPTOR; PROTEIN SUBUNIT;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOGENESIS; BRAIN CELL; CELL TYPE; CONTROLLED STUDY; DISULFIDE BOND; EPILEPSY; HALF LIFE TIME; HIPPOCAMPUS; HUMAN; HUMAN CELL; LYSOSOME; MOLECULAR WEIGHT; NERVE CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANIMAL; BRAIN CORTEX; CELL CULTURE; CONFOCAL MICROSCOPY; CYTOLOGY; GENETICS; METABOLISM; MUTATION; PROTEIN SUBUNIT; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CEREBRAL CORTEX; EPILEPSY; HIPPOCAMPUS; MICROSCOPY, CONFOCAL; MUTATION; NEURONS; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A;

EID: 77958038097     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2320-10.2010     Document Type: Article

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