AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells

Journal of Hematology and Oncology

Volumn 8, Issue 1, 2015, Pages

  Fan, Dongmei ^a   Li, Zhenzhen ^a   Zhang, Xiaolong ^a   Yang, Yuqi ^b   Yuan, Xiangfei ^a   Zhang, Xiuli ^a   Yang, Ming ^a   Zhang, Yizhi ^c   Xiong, Dongsheng ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c Central Hospital of Karamay   (China)

Author keywords

AntiCD3Fv; CD123; Fusion proteins; Leukemic stem cells; T cell

Indexed keywords

CD123 ANTIGEN; CD3 ANTIBODY FV INTERLEUKIN 3 FUSION PROTEIN; HYBRID PROTEIN; IMMUNOCYTOKINE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CD3 ANTIGEN; IL3RA PROTEIN, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DISULFIDE BOND; ESCHERICHIA COLI; GENE DELETION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STEM CELL; T LYMPHOCYTE; TUMOR CELL DESTRUCTION; ACUTE MYELOID LEUKEMIA; ANIMAL; CANCER STEM CELL; DRUG SCREENING; FEMALE; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOLOGY; IMMUNOTHERAPY; NONOBESE DIABETIC MOUSE; PATHOLOGY; PROCEDURES; SCID MOUSE; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD3; CELL LINE, TUMOR; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOTHERAPY; INTERLEUKIN-3 RECEPTOR ALPHA SUBUNIT; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84926456239     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-015-0109-5     Document Type: Article

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