메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Design of chimeric antigen receptors with integrated controllable transient functions

Author keywords

[No Author keywords available]

Indexed keywords

AP 21967; CD8 ANTIGEN; CD8 ANTIGEN, ALPHA CHAIN; CHIMERIC PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; RAPAMYCIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TACROLIMUS;

EID: 84954059507     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18950     Document Type: Article
Times cited : (71)

References (36)
  • 1
    • 84927513482 scopus 로고    scopus 로고
    • Genetically modified T cells in cancer therapy: Opportunities and challenges
    • Sharpe, M. & Mount, N. Genetically modified T cells in cancer therapy: opportunities and challenges. Dis Model Mech 8, 337-350 (2015).
    • (2015) Dis Model Mech , vol.8 , pp. 337-350
    • Sharpe, M.1    Mount, N.2
  • 2
    • 84876005284 scopus 로고    scopus 로고
    • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • Brentjens, R. J. et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med 5, 177ra138 (2013).
    • (2013) Sci Transl Med , vol.5 , pp. 177ra138
    • Brentjens, R.J.1
  • 3
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp, S. A. et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 368, 1509-1518 (2013).
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1
  • 4
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos, M. et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med 3, 95ra73 (2011).
    • (2011) Sci Transl Med , vol.3 , pp. 95ra73
    • Kalos, M.1
  • 5
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter, D. L., Levine, B. L., Kalos, M., Bagg, A. & June, C. H. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 365, 725-733 (2011).
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 6
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens, R. J. et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 118, 4817-4828 (2011).
    • (2011) Blood , vol.118 , pp. 4817-4828
    • Brentjens, R.J.1
  • 7
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
    • Davila, M. L. et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med 6, 224ra225 (2014).
    • (2014) Sci Transl Med , vol.6 , pp. 224ra225
    • Davila, M.L.1
  • 8
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan, R. A. et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 18, 843-851 (2010).
    • (2010) Mol Ther , vol.18 , pp. 843-851
    • Morgan, R.A.1
  • 9
    • 84893127616 scopus 로고    scopus 로고
    • Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma
    • Budde, L. E. et al. Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma. PLoS One 8, e82742 (2013).
    • (2013) PLoS One , vol.8
    • Budde, L.E.1
  • 10
    • 77952679687 scopus 로고    scopus 로고
    • Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems
    • Chen, Y. Y., Jensen, M. C. & Smolke, C. D. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci USA 107, 8531-8536 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 8531-8536
    • Chen, Y.Y.1    Jensen, M.C.2    Smolke, C.D.3
  • 11
    • 79953308076 scopus 로고    scopus 로고
    • A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy
    • Narayanan, P. et al. A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy. J Clin Invest 121, 1524-1534 (2011).
    • (2011) J Clin Invest , vol.121 , pp. 1524-1534
    • Narayanan, P.1
  • 12
    • 84876172359 scopus 로고    scopus 로고
    • Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells
    • Marin, V. et al. Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells. Hum Gene Ther Methods 23, 376-386 (2012).
    • (2012) Hum Gene Ther Methods , vol.23 , pp. 376-386
    • Marin, V.1
  • 13
    • 84907373133 scopus 로고    scopus 로고
    • A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
    • Philip, B. et al. A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy. Blood 124, 1277-1287 (2014).
    • (2014) Blood , vol.124 , pp. 1277-1287
    • Philip, B.1
  • 14
    • 19344365874 scopus 로고    scopus 로고
    • An inducible caspase 9 safety switch for T-cell therapy
    • Straathof, K. C. et al. An inducible caspase 9 safety switch for T-cell therapy. Blood 105, 4247-4254 (2005).
    • (2005) Blood , vol.105 , pp. 4247-4254
    • Straathof, K.C.1
  • 15
    • 84863482471 scopus 로고    scopus 로고
    • Biophysical mechanism of T-cell receptor triggering in a reconstituted system
    • James, J. R. & Vale, R. D. Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature 487, 64-69 (2012).
    • (2012) Nature , vol.487 , pp. 64-69
    • James, J.R.1    Vale, R.D.2
  • 16
    • 84945217637 scopus 로고    scopus 로고
    • Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
    • Wu, C. Y., Roybal, K. T., Puchner, E. M., Onuffer, J. & Lim, W. A. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science (2015).
    • (2015) Science
    • Wu, C.Y.1    Roybal, K.T.2    Puchner, E.M.3    Onuffer, J.4    Lim, W.A.5
  • 17
    • 16844385435 scopus 로고    scopus 로고
    • Characterization of the FKBP.rapamycin.FRB ternary complex
    • Banaszynski, L. A., Liu, C. W. & Wandless, T. J. Characterization of the FKBP.rapamycin.FRB ternary complex. J Am Chem Soc 127, 4715-4721 (2005).
    • (2005) J Am Chem Soc , vol.127 , pp. 4715-4721
    • Banaszynski, L.A.1    Liu, C.W.2    Wandless, T.J.3
  • 18
    • 0029055145 scopus 로고
    • Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
    • Chen, J., Zheng, X. F., Brown, E. J. & Schreiber, S. L. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci USA 92, 4947-4951 (1995).
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4947-4951
    • Chen, J.1    Zheng, X.F.2    Brown, E.J.3    Schreiber, S.L.4
  • 19
    • 0032970154 scopus 로고    scopus 로고
    • The high-affinity IgE receptor (Fc epsilon RI): From physiology to pathology
    • Kinet, J. P. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu Rev Immunol 17, 931-972 (1999).
    • (1999) Annu Rev Immunol , vol.17 , pp. 931-972
    • Kinet, J.P.1
  • 20
    • 34247572895 scopus 로고    scopus 로고
    • New developments in FcepsilonRI regulation, function and inhibition
    • Kraft, S. & Kinet, J. P. New developments in FcepsilonRI regulation, function and inhibition. Nat Rev Immunol 7, 365-378 (2007).
    • (2007) Nat Rev Immunol , vol.7 , pp. 365-378
    • Kraft, S.1    Kinet, J.P.2
  • 21
    • 60749090900 scopus 로고    scopus 로고
    • Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework
    • Kugler, M. et al. Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework. Protein Eng Des Sel 22, 135-147 (2009).
    • (2009) Protein Eng Des Sel , vol.22 , pp. 135-147
    • Kugler, M.1
  • 22
    • 84942903938 scopus 로고    scopus 로고
    • Multiplex genome edited T-cell manufacturing platform for "off-the-shelf " adoptive T-cell immunotherapies
    • Poirot, L. et al. Multiplex genome edited T-cell manufacturing platform for "off-the-shelf " adoptive T-cell immunotherapies. Cancer Res (2015).
    • (2015) Cancer Res
    • Poirot, L.1
  • 23
    • 84961997810 scopus 로고    scopus 로고
    • Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors
    • Wang, E. et al. Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors. Cancer Immunol Res 3, 815-826 (2015).
    • (2015) Cancer Immunol Res , vol.3 , pp. 815-826
    • Wang, E.1
  • 24
    • 82955195419 scopus 로고    scopus 로고
    • Combining mTor inhibitors with rapamycin-resistant T cells: A two-pronged approach to tumor elimination
    • Huye, L. E. et al. Combining mTor inhibitors with rapamycin-resistant T cells: a two-pronged approach to tumor elimination. Mol Ther 19, 2239-2248 (2011).
    • (2011) Mol Ther , vol.19 , pp. 2239-2248
    • Huye, L.E.1
  • 25
    • 30744467675 scopus 로고    scopus 로고
    • Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity
    • Bayle, J. H. et al. Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chem Biol 13, 99-107 (2006).
    • (2006) Chem Biol , vol.13 , pp. 99-107
    • Bayle, J.H.1
  • 26
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy, T. F. et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 5, e8 (2008).
    • (2008) PLoS Med , vol.5 , pp. e8
    • Cloughesy, T.F.1
  • 27
    • 0000838678 scopus 로고
    • Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin
    • Wilson, K. P. et al. Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin. Acta Crystallogr D Biol Crystallogr 51, 511-521 (1995).
    • (1995) Acta Crystallogr D Biol Crystallogr , vol.51 , pp. 511-521
    • Wilson, K.P.1
  • 28
    • 84885446932 scopus 로고    scopus 로고
    • A new protein-protein interaction sensor based on tripartite split-GFP association
    • Cabantous, S. et al. A new protein-protein interaction sensor based on tripartite split-GFP association. Sci Rep 3, 2854 (2013).
    • (2013) Sci Rep , vol.3 , pp. 2854
    • Cabantous, S.1
  • 29
    • 84940718499 scopus 로고    scopus 로고
    • A Multidrug-resistant engineered CAR T cell for allogeneic combination immunotherapy
    • Valton, J. et al. A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy. Mol Ther (2015).
    • (2015) Mol Ther
    • Valton, J.1
  • 30
    • 84890181067 scopus 로고    scopus 로고
    • Design and development of therapies using chimeric antigen receptor-expressing T cells
    • Dotti, G., Gottschalk, S., Savoldo, B. & Brenner, M. K. Design and development of therapies using chimeric antigen receptor-expressing T cells. Immunol Rev 257, 107-126 (2014).
    • (2014) Immunol Rev , vol.257 , pp. 107-126
    • Dotti, G.1    Gottschalk, S.2    Savoldo, B.3    Brenner, M.K.4
  • 31
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain, M., Brentjens, R. & Riviere, I. The basic principles of chimeric antigen receptor design. Cancer Discov 3, 388-398 (2013).
    • (2013) Cancer Discov , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 33
    • 84937522794 scopus 로고    scopus 로고
    • Synthetic biology in cell-based cancer immunotherapy
    • Chakravarti, D. & Wong, W. W. Synthetic biology in cell-based cancer immunotherapy. Trends Biotechnol 33, 449-461 (2015).
    • (2015) Trends Biotechnol , vol.33 , pp. 449-461
    • Chakravarti, D.1    Wong, W.W.2
  • 34
    • 84996572349 scopus 로고    scopus 로고
    • Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies
    • Beatty, G. L. et al. Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies. Cancer Immunol Res 2, 112-120 (2014).
    • (2014) Cancer Immunol Res , vol.2 , pp. 112-120
    • Beatty, G.L.1
  • 35
    • 84908891854 scopus 로고    scopus 로고
    • Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
    • Adusumilli, P. S. et al. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Sci Transl Med 6, 261ra151 (2014).
    • (2014) Sci Transl Med , vol.6 , pp. 261ra151
    • Adusumilli, P.S.1
  • 36
    • 84922664081 scopus 로고    scopus 로고
    • Biopolymer implants enhance the efficacy of adoptive T-cell therapy
    • Stephan, S. B. et al. Biopolymer implants enhance the efficacy of adoptive T-cell therapy. Nat Biotechnol 33, 97-101 (2015).
    • (2015) Nat Biotechnol , vol.33 , pp. 97-101
    • Stephan, S.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.